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Why Are Ketones Produced?

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Ketone Bodies: A Review Of Physiology, Pathophysiology And Application Of Monitoring To Diabetes.

Abstract Ketone bodies are produced by the liver and used peripherally as an energy source when glucose is not readily available. The two main ketone bodies are acetoacetate (AcAc) and 3-beta-hydroxybutyrate (3HB), while acetone is the third, and least abundant, ketone body. Ketones are always present in the blood and their levels increase during fasting and prolonged exercise. They are also found in the blood of neonates and pregnant women. Diabetes is the most common pathological cause of elevated blood ketones. In diabetic ketoacidosis (DKA), high levels of ketones are produced in response to low insulin levels and high levels of counterregulatory hormones. In acute DKA, the ketone body ratio (3HB:AcAc) rises from normal (1:1) to as high as 10:1. In response to insulin therapy, 3HB levels commonly decrease long before AcAc levels. The frequently employed nitroprusside test only detects AcAc in blood and urine. This test is inconvenient, does not assess the best indicator of ketone body levels (3HB), provides only a semiquantitative assessment of ketone levels and is associated with false-positive results. Recently, inexpensive quantitative tests of 3HB levels have become availab Continue reading >>

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Popular Questions

  1. Miss_Mielle

    I'm new to Keto, 33 days in, also new to Reddit. My appetite has decreased by the week, and have to remind myself to eat at this point. My stomach will growl eventually, but I drink a gallon of water a day, so the majority of the time my stomach has water in it which I'm sure decreases the hungry feeling. I've used MFP to log my food for a long time, and every day since I started Keto, but more and more not only do I not meet the calories it gives, but I don't hit 1200 either. I'm down 13 lbs from my starting weight even though I was eating WAY more carbs when I started than I do now (started at 100g and tapered down. I average 30-40 right now). Since obviously fat loss is the goal, and I'm trying to lose 113 lbs, Does it matter how many calories I eat or whether or not I eat at all?

  2. bidnow

    Yes, calories matter. But hormones matter more. Eat low carb and low calorie and you will lose weight. Pretty simple.

  3. JuneStrawberries

    Calories do matter.
    Hit your protein macro every day. Limit carbs and use fat as a lever to keep your deficit to about 20%.
    If you eat too little, you will effectively be crash dieting - not good!

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