Can Metformin Help With Weight Loss?
Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizzi Continue reading >>
Metformin For Diabetes
Information about this medicine What are the most important things you need to know about your medicines? Make sure you know about each of the medicines you take. This includes why you take it, how to take it, what you can expect while you're taking it, and any warnings about the medicine. The information provided here is general. So be sure to read the information that came with your medicine. If you have any questions or concerns, talk to your pharmacist or doctor. Why is metformin used? Metformin is a medicine used to treat prediabetes, type 2 diabetes, and gestational diabetes. It helps control your blood sugar. It is also used to treat polycystic ovarian syndrome. Metformin works very well and is generally safe. What are some examples of metformin? Here are some examples of metformin. For each item in the list, the generic name is first, followed by any brand names. metformin (Glucophage) long-acting metformin (Glumetza) Sometimes metformin is combined with other diabetes medicine. Avandamet is a combination of metformin and rosiglitazone. Janumet is a combination of metformin and sitagliptin. Jentadueto is a combination of metformin and linagliptin. This is not a complete list. What about side effects? When they first start taking metformin or start taking a larger dose, some people feel sick to their stomach or have diarrhea for a short time. Over time, blood levels of vitamin B12 can decrease in some people who take metformin. Your body needs this B vitamin to make blood cells and to keep your nervous system healthy. If you have been taking metformin for more than a few years, ask your doctor if you need a B12 blood test to measure the amount of vitamin B12 in your blood. General information on side effects All medicines can cause side effects. Many people don't Continue reading >>
Drug That Can Prevent The Onset Of Diabetes Is Rarely Used
Few doctors are prescribing a low-cost drug that has been proven effective in preventing the onset of diabetes, according to a UCLA study. The study, published in the peer-reviewed journal Annals of Internal Medicine, found that only 3.7 percent of U.S. adults with pre-diabetes were prescribed metformin during a recent three-year period. Metformin and lifestyle changes both can prevent the onset of diabetes, but people often struggle to adopt healthier habits, according to Dr. Tannaz Moin, the study’s lead author and an assistant professor of medicine in the division of endocrinology at the David Geffen School of Medicine at UCLA and at VA Greater Los Angeles. “Diabetes is prevalent, but pre-diabetes is even more prevalent and we have evidence-based therapies like metformin that are very safe and that work,” Moin said. “Metformin is rarely being used for diabetes prevention among people at risk for developing it. This is something that patients and doctors need to be talking about and thinking about.” It is estimated that about one-third of adults in the U.S. have pre-diabetes, which is marked by higher-than-normal blood sugar levels. The American Diabetes Association in 2008 added metformin to its annual “Standards for Medical Care in Diabetes” guidelines for use in diabetes prevention for those at very high risk who are under age 60, are severely obese, or have a history of gestational diabetes. Under the guidelines, metformin may also be considered for patients whose blood sugar is above normal but not yet in the diabetes range. The researchers examined data from 2010 to 2012 from UnitedHealthcare, the nation’s largest private insurer, for a national sample of 17,352 adults aged 19 to 58 with pre-diabetes. They also found: The prevalence of metformin Continue reading >>
Should Physicians Prescribe Metformin To Women With Polycystic Ovary Syndrome Pcos?
Abstract 1. Metformin is not efficient enough in order to regulate menstrual cycles. 2.Metformin is not efficient enough in order to treat hyperandrogenism. 3. Metformin should not be used as a first-line treatment in order to treat infertility. Clomiphene citrate (CC) is the reference treatment. 4. Metformin in addition to CC is not recommended as a second line treatment, after the failure of CC alone. 5. Metformin should not be used during pregnancy in non diabetic women with PCOS, in order to prevent the risk of gestational diabetes. 6. Metformin should be prescribed to PCOS women when they are diabetic, in order to prevent their cardiovascular risk, after lifestyle modification. 7. Metformin should not be used in PCOS non diabetic women in order to lose weight. Metformin should not be used in order to treat dyslipidemia in women with PCOS. 8. In PCOS women, without diabetes, but with fasting hyperglycemia or carbohydrate intolerance, metformin should be prescribed if: BMI>35. Continue reading >>
'can I Take Metformin If I Want To Lose Weight?'
Metformin is a drug designed to treat patients with Type 2 diabetes, but it comes with an interesting side effect: weight loss. And Reddit is filled with stories from people who have lost weight on the drug. “Was trying to lose weight for a long time with no success,” one person wrote of being prescribed metformin. “I’m on 1000 mg a day and am down 10 pounds.” “I saw weight loss at first with 500 mg twice per day,” another wrote. “The difference was almost immediate.” While some people say the drug didn’t do much for them, others swear by it—even those that don’t have Type 2 diabetes, says Fatima Cody Stanford, M.D., an instructor of medicine and pediatrics at Harvard Medical School and obesity medicine physician at Massachusetts General Hospital. In fact, Cody Stanford says that she often prescribes the medication to overweight or obese people who don't have Type 2 diabetes. Here’s what you need to know about the drug. (Hit the reset button—and burn fat like crazy with The Body Clock Diet!) How It Works Metformin causes a decrease in the release of glucose from a person’s liver. This helps to lower a person’s blood sugar when it’s too high and restore the way someone uses food to make energy, according to the Mayo Clinic. "Weight loss can occur because it decreases appetite in some people who take it," says women's health expert Jennifer Wider, M.D. In order for the prescription to work effectively, the amount of metformin you take must be balanced against your diet and exercise because it helps level out your blood sugar, the clinic says. For that reason, if you change your diet or exercise, you doctor may need to change the amount of metformin you take. Check out these moves that can help you light those calories up! Can It Help You Continue reading >>
Why Good Doctors No Longer Prescribe Metformin
Until recently, diabetics looking for doctor-approved, drug-free treatment options were out of luck. But a growing number of health experts believe those days are behind us. Dr. Marlene Merritt (LAc, DOM(NM), MS Nutrition), an Austin-based doctor who used to suffer high blood sugar herself, made a recent announcement that is sending shockwaves through the medical community. Dr. Merritt knew all too well that commonly-prescribed diabetes drugs like Metformin came with a host of unwanted side effects, and was determined to find a natural, drug-free solution that could actually eliminate the disease, not just treat its symptoms. After months of research, Dr. Merritt developed a simple diet and exercise regimen that had a profound success rate in treating and even reversing type II diabetes. Despite the regimen’s clear effectiveness, medical journals were slow to publish her findings, perhaps due in part, some have speculated, to financial ties to the pharmaceutical industry. In response, Dr. Merritt took matters in to her own hands and shocked the medical community by partnering with independent health publisher Primal Health to make her diabetes-reversing regimen available to everyone in the form of an online presentation. Several viewers have noted the simplicity of the regimen, along with how non-restrictive the diet sounds. Unsurprisingly, many in the pharmaceutical industry have taken issue with the presentation’s drug-free emphasis, but many doctors who have wished for a natural, drug-free treatment to share with their diabetic patients have been quick to embrace it. Dr. Merritt herself cautions viewers to exercise common sense and only go off your medication with the approval of your doctor. Never underestimate the influence you have on those around you. Your wo Continue reading >>
Years Of Taking Popular Diabetes Drug Tied To Risk Of B12 Deficiency
(Reuters Health) – - People taking metformin, a common type 2 diabetes medication, for several years may be at heightened risk of vitamin B12 deficiency and anemia, according to a new analysis of long-term data. Metformin helps to control the amount of sugar, or glucose, in the blood by reducing how much glucose is absorbed from food and produced by the liver, and by increasing the body’s response to the hormone insulin, according to the National Institutes of Health. “Metformin is the most commonly used drug to treat type 2 diabetes, so many millions of people are taking it, usually for a prolonged period (many years),” said senior study author Dr. Jill P Crandall of Albert Einstein College of Medicine in New York City, by email. “Smaller numbers of people take metformin for prevention of diabetes or treatment of polycystic ovary syndrome,” Crandall told Reuters Health. The researchers used data from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study, which followed participants at high risk for type 2 diabetes for more than 10 years. The study began with more than 3,000 people age 25 years and older with high blood sugar. The participants were randomly assigned to receive either 850 milligrams of metformin twice daily, placebo medication or an intensive lifestyle program than did not include medication. For the new analysis only those taking placebo or metformin were considered, and about 50 participants were excluded after having weight-loss surgery, which would affect their diabetes outcomes. During follow-up, the participants provided blood samples at the five- and 13-year points. Using these blood samples, the researchers found that at year five, average B12 levels were lower in the metformin group than the placebo group Continue reading >>
Alternative To Metformin – Why Doctors In The Know No Longer Prescribe Metformin
Alternative to Metformin – Side Effects of Metformin? Urgent news about Metformin – #1 Lie About Diabetes Meds Metformin Side Effects – Alternative to Metformin, Until recently, diabetics looking for doctor-approved, drug-free treatment options were out of luck. Type II Diabetes sufferers may soon be tossing their test strips, lancet needles, and prescription pills as you now have top rate Alternative to Metformin. But a growing number of health experts believe those days are behind us. A discovery by an Austin-based doctor may change how Type II Diabetes is treated and could even be a cure. Dr. Marlene Merritt suffered from high blood sugar for years and was determined to find a natural solution. “My motivation,” she says, “was to cast off the shackles of the daily monitoring, the shots and pills, and the drug side effects. I wanted to live a normal life again.” After two years of research and trial and error experiments, Dr. Marlene Merritt hit upon a practical diet and exercise regimen that doesn’t just control Type II Diabetes but actually reverses it. While the regimen eliminates a few foods, it most importantly adds a single food that has shown to have a big impact on the disease. The announcement of her discovery has sent shockwaves through the medical community, with some progressive doctors enthusiastically embracing it, and many conventional doctors taking a “wait and see” approach. Within weeks of adopting her own regimen, Dr. Merritt’s condition completely reversed. “It was just gone, and I had my life back,” she says. I then prescribed this drug-free solution to my diabetic patients and, in most cases, they too saw success in a matter of weeks.” Dr. Marlene Merritt (LAc, DOM(NM), MS Nutrition), an Austin-based doctor who used to Continue reading >>
**Metformin controls the insulin resistance of people who have type 2 diabetes so well that, if possible, all of us should be taking it. That’s what Roderic Crist, M.D., told me at the annual convention of the American Society of Bariatric Physicians in Denver this weekend. Dr. Crist specializes in family medicine in Cape Girardeau, Missouri. "Not everybody can take every drug," he added, when I followed up our conversation by calling him at his office after he returned home. "But most of the time people can take metformin if they take it carefully." Doctors increasingly prescribe it not only for type 2 diabetes but also for insulin resistance, polycystic ovary syndrome, and non-alcoholic fatty liver disease. Roughly one-third of Dr. Crist’s patients have diabetes. Well over half, if not two-thirds of the people he sees are insulin resistant. "I treat insulin resistance with that drug even if they aren’t fully diabetic." he says. "If they have high triglyceride levels and low HDL levels, particularly if they are centrally obese, they should probably be on metformin. It helps slow the progression of the disease from one thing to the next." But he goes further. He prescribes metformin to almost all of his patients who have type 2 diabetes – no matter how low their A1C level is. And he tells his patients that their levels should be 5.0 or less – not the American Diabetes Association’s less stringent recommendation of 7.0 or less. "If their A1C is at 5, their diabetes is in complete remission. So I have that as a goal." And he still prescribes metformin to them after they reach that goal. "The two important issues are that it will prevent progression and it should be used in the earliest phases of insulin resistance. We vastly underutilize metformin." But he has Continue reading >>
Why Doctors In The Know No Longer Prescribe Metformin
A discovery by an Austin-based doctor may change how Type II Diabetes is treated and could even be a cure. Dr. Marlene Merritt suffered from high blood sugar for years and was determined to find a natural solution. “My motivation,” she says, “was to cast off the shackles of the daily monitoring, the shots and pills, and the drug side effects. I wanted to live a normal life again.” After two years of research and trial and error experiments, Dr. Marlene Merritt hit upon a practical diet and exercise regimen that doesn’t just control Type II Diabetes but actually reverses it. While the regimen eliminates a few foods, it most importantly adds a single food that has shown to have a big impact on the disease. The announcement of her discovery has sent shockwaves through the medical community, with some progressive doctors enthusiastically embracing it, and many conventional doctors taking a “wait and see” approach. Within weeks of adopting her own regimen, Dr. Merritt’s condition completely reversed. “It was just gone, and I had my life back,” she says. I then prescribed this drug-free solution to my diabetic patients and, in most cases, they too saw success in a matter of weeks.” Despite the regimen’s effectiveness, medical journals have been slow to publish her findings. And Dr. Merritt suspects the reluctance is due to the outsized influence of the pharmaceutical industry, which stands to lose billions of dollars on lost drug sales. The makers of Metformin, one of several drugs Dr. Merritt’s natural regimen would replace, had no comment. All diabetes drug sales are expected to reach $32 billion in 2017, according to industry analyst, Morder Intelligence. Dr. Merritt says “Diabetics need to know about this safer option.” To get the word out, s Continue reading >>
The Diabetes Drug That Could Be An Anti-aging Miracle
In a slew of recent flashy endeavors, scientists, academics and exceptionally rich people have taken on the aging process. In 2013, Google launched Calico, its billion-dollar anti-aging research and development arm, which the following year formed a partnership with pharmaceutical giant AbbVie. Meanwhile, another major drug company, Novartis, is developing a patentable form of rapamycin—a biological agent discovered in the soil on Easter Island—which has been shown to boost immune function, and the company hopes it could become the first viable anti-aging pill. But, according to Dr. Nir Barzilai, a scientist based in the Albert Einstein College of Medicine in New York City’s Bronx borough, we might already have the drug we need to slow the aging process—and it’s dirt cheap. Metformin is an old, generic diabetes drug, known for its blood sugar–lowering properties and for being quite safe. It’s common, and it costs about 35 cents per pill. It has also been found to stall the aging process in animal studies. In June, Barzilai, along with academics from the not-for-profit American Federation for Aging Research (AFAR), approached the Food and Drug Administration with an idea: the Targeting Aging With Metformin (TAME) study, to see if metformin could do for humans what it does for animals. It would be the first clinical trial to test if a drug could slow human aging. The FDA said yes, and since that June meeting the media has exploded with excitement over the purported “fountain of youth” drug, with rumors that it could extend human life span up to 120 years. The problem, though, is that no one has agreed to front the capital required to get TAME off the ground. That’s not surprising: There are plenty of reasons Big Pharma won’t fund a study that would m Continue reading >>
Why Isn’t Metformin Prescribed More?
Since its debut in the United States in 1995, metformin has become the most popular oral drug for Type 2 diabetes in the country — and the rest of the world. Current guidelines by the American Diabetes Association state that unless there are special risks in a particular person, metformin should be the first drug prescribed to people with Type 2 diabetes. Yet perhaps due in part to its popularity, metformin isn’t free of controversy. As we’ve discussed previously here at Diabetes Flashpoints, there are concerns about prescribing metformin in people with kidney disease, and some doctors even question whether metformin deserves its status as the universally recommended first-line drug for Type 2 diabetes. In addition, there’s debate about whether metformin should be taken by more people with prediabetes. A recent study sought to explore the reasons why metformin isn’t prescribed as widely as clinical guidelines suggest it should be. Published last month in the journal Therapeutic Advances in Chronic Disease, the study notes that only roughly 65% of people with newly diagnosed Type 2 diabetes are prescribed metformin — and that over time, this number drops to just 25% of people with the condition. As noted in a Pharmacy Times article on the study, researchers from the University of Colorado put together focus groups of relevant people — doctors, pharmacists, and other medical personnel — to ask about their perceptions regarding metformin. Based on these focus groups, the researchers found that three main factors affected how doctors prescribed metformin: concerns about when to start the drug, concerns about the drug’s known risks, and whether procedures were in place to notice and deal with any adverse reactions caused by the drug. Based on the focus grou Continue reading >>
Why Is Metformin Considered The Drug Of Choice For Type 2 Diabetes?
Gunda Siska, PharmD, has worked in various fields within the pharmaceutical industry as a licensed pharmacist for more than 20 years. She is currently a staff hospital pharmacist assisting nurses and doctors with drug prescribing, administration, and dispensing, as well as independently monitoring and dosing highly toxic and dangerous drugs. For 2 years, she was concurrently a consultant pharmacist for skilled nursing facilities and nursing homes. Dr. Siska is a member of the New Mexico Society of Health-System Pharmacists and the American Academy of Anti-Aging Medicine. Follow her on Twitter @GundaSiska Metformin is a medication that I believe is underappreciated by the general public. Many people ttell me that their doctor prescribed this drug for them, but they took themselves off of it, but if they knew what I know about metformin, they would have stayed on the medication. This is what I know: metformin extends life. It’s been proven in animal studies1 and in humans. A prospective observational study of nearly 20,000 people with type 2 diabetes mellitus (T2DM) and arteriosclerosis found that metformin use was associated with 24% lower all-cause mortality compared to patients who were not taking metformin.2 It is also the number one go-to medication for type 2 diabetes for several years, despite all the new designer medications coming on the market trying to replace it. How does metformin save lives? Mainly through cardioprotection. Metformin reduces cardiovascular risk in humans.3 Most people with T2DM will most likely die from a cardiovascular event, especially if they are not on metformin.4,5,6 Metformin has so many positive effects on the body, no one really knows for sure all the ways it preserves life. It produces modest weight loss in the near term5 and blun Continue reading >>
Fda Drug Safety Communication: Fda Revises Warnings Regarding Use Of The Diabetes Medicine Metformin In Certain Patients With Reduced Kidney Function
[ 4-8-2016 ] The U.S. Food and Drug Administration (FDA) is requiring labeling changes regarding the recommendations for metformin-containing medicines for diabetes to expand metformin’s use in certain patients with reduced kidney function. The current labeling strongly recommends against use of metformin in some patients whose kidneys do not work normally. We were asked1,2 to review numerous medical studies regarding the safety of metformin use in patients with mild to moderate impairment in kidney function,3-14 and to change the measure of kidney function in the metformin drug labeling that is used to determine whether a patient can receive metformin. We have concluded our review, and are requiring changes to the labeling of all metformin-containing medicines to reflect this new information. Health care professionals should follow the latest recommendations when prescribing metformin-containing medicines to patients with impaired kidney function. Patients should talk to their health care professionals if they have any questions or concerns about taking metformin. Metformin-containing medicines are available by prescription only and are used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes. When untreated, type 2 diabetes can lead to serious problems, including blindness, nerve and kidney damage, and heart disease. Metformin-containing medicines are available as single-ingredient products and also in combination with other drugs used to treat diabetes (see FDA Approved metformin-containing Medicines). The current drug labeling strongly recommends against metformin use in some patients whose kidneys do not work normally because use of metformin in these patients can increase the risk of developing a serious and potentially dead Continue reading >>