Not to be confused with Ketoacidosis. Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides energy. Ketosis is a result of metabolizing fat to provide energy. Ketosis is a nutritional process characterised by serum concentrations of ketone bodies over 0.5 mM, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder. Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet (ketogenic diet), and deliberately induced ketosis serves as a medical intervention for various conditions, such as intractable epilepsy, and the various types of diabetes. In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is sometimes referred to as the body's "fat burning" mode. Ketosis and ketoacidosis are similar, but ketoacidosis is an acute life-threatening state requiring prompt medical intervention while ketosis can be physiological. However, there are situations (such as treatment-resistant Continue reading >>
Tweet Ketosis is a state the body may find itself in either as a result of raised blood glucose levels or as a part of low carb dieting. Low levels of ketosis is perfectly normal. However, high levels of ketosis in the short term can be serious and the long term effects of regular moderate ketosis are only partially known at the moment. What is ketosis? Ketosis is a state the body goes into if it needs to break down body fat for energy. The state is marked by raised levels of ketones in the blood which can be used by the body as fuel. Ketones which are not used for fuel are excreted out of the body via the kidneys and the urine. Is ketosis the same as ketoacidosis? There is often confusion as to the difference between ketosis and ketoacidosis. Ketosis is the state whereby the body is producing ketones. In ketosis, the level of ketones in the blood can be anything between normal to very high. Diabetic ketoacidosis, also known as DKA, only describes the state in which the level of ketones is either high or very high. In ketoacidosis, the amount of ketones in the blood is sufficient to turn the blood acidic, which is a dangerous medical state. When does ketosis occur? Ketosis will take place when the body needs energy and there is not sufficient glucose available for the body. This can typically happen when the body is lacking insulin and blood glucose levels become high. Other causes can be the result of being on a low carb diet. A low level of carbohydrate will lead to low levels of insulin, and therefore the body will produce ketones which do not rely on insulin to get into and fuel the body’s cells. A further cause of ketosis, less relevant to people with diabetes, is a result of excessive alcohol consumption. Is ketosis dangerous? The NHS describes ketosis as a pote Continue reading >>
When My Boyfriend Drinks Alcohol He Smells Like Oranges. Is There A Reason For This?
Thanks for the A2A. He may be experiencing ketosis. Ketosis occurs when your body does not have sufficient glucose to use as fuel, and starts to use alternatives such as proteins and fats instead. It's not necessarily harmful (low carb diets will induce ketosis) but it can be associated with conditions such as diabetes and over-active thyroid. He should discuss this with a doctor. More What Is Ketosis? Ketosis Continue reading >>
Is The Keto Diet Effective?
Turns out Keto/ketosis can be very effective in a variety of applications. There is pretty awesome keto research happening right now, too. Seizures: Several thousand years ago, doctors weren't sure why fasting was such an effective treatment for children with seizures. Turns out, restricting carbohydrates and surviving on ketones is something the brain really likes. Obviously, fasting isn't an effective long-term solution, but nutritional ketosis (restricting net carbs to 20g-40g per day) is a great alternative, can be maintained indefinitely, and has helped children (and adults) control their seizures in cases where medicine couldn't. (90% achieved better management of their seizures, and about half of those were able to eliminate seizures entirely). Oxygen Toxicity: I was listening to a Tim Ferriss podcast with Dom D'Agostino (Dom D’Agostino on Fasting, Ketosis, and the End of Cancer ) and D'Agostino mentioned an experiment he conducted to test the limits of a body in ketosis when exposed to oxygen toxicity. Essentially, imagine a Navy SEAL team that has to remain underwater in a pond to evade detection. Their scuba gear cannot release bubbles, so they use a "rebreather" to recirculate the exhaled gas, but one of the risks in that situation is oxygen toxicity (see: Rebreather diving). The experiment involved inducing ketosis in rats, placed them in a pressurized environment to simulate the pressure of being underwater, and exposed them to 100% oxygen. Normally the rats would experience seizures after 15 minutes, however the keto-adapted rats were seizure-free for more than an hour! I suspect the mechanism that creates seizures in this situation is different from the mechanism that creates seizures in children, however the "treatment" of ketosis is identical and pret Continue reading >>
Do I Have To Stay At 20g Of Carbs A Day To Lose Weight And Enter Ketosis?
While in ketosis, your body effectively uses fat for fuel. In general, the daily intake of net carbs required to enter ketosis could vary from 20 to 100 grams per day (and very rarely over 100 grams per day). Most people, who have experienced ketosis, claim to have reached that state at about 20-50 grams of net carbs per day. I'd suggest you start at 20-30 grams and see how you can adjust it for your needs. There are two ways to find your ideal net carbs intake: Low to high method Start from a low level of net carbs to ensure you quickly enter ketosis (~ 20 grams of net carbs per day). When you detect ketosis after about 2-3 days, start adding net carbs (about 5 grams each week) until you detect a very low-level or no ketones (using Ketostix or blood ketone meter). This is usually the most reliable and quickest way to discover your net carbs limit. It could be a bit hard the first couple of days, as you have to give up almost all carbs from one day to another but it will be worth it. This method is highly recommended. High to low method Assuming you're not in ketosis, start from a relatively high level of net carbs (~ 50 grams) and keep reducing (about 5 grams each week) until you detect presence of ketones. This is a less difficult approach but not recommended, as you may spend a long time out of ketosis before you find you net carbs limit. If you can't see any ketones, be patient. It typically takes 2-3 days for your body to deplete glycogen stores, so don't expect to be in ketosis after just a day of low-carb. Remember, ketosis is a favourable condition and an indication that your body uses fat for fuel but you can lose weight even without being in ketosis. Diet high in fat, adequate in protein and low in carbohydrates is naturally sating, making you less hungry and, Continue reading >>
Ketosis: What Is Ketosis?
Ketosis is a normal metabolic process. When the body does not have enough glucose for energy, it burns stored fats instead; this results in a build-up of acids called ketones within the body. Some people encourage ketosis by following a diet called the ketogenic or low-carb diet. The aim of the diet is to try and burn unwanted fat by forcing the body to rely on fat for energy, rather than carbohydrates. Ketosis is also commonly observed in patients with diabetes, as the process can occur if the body does not have enough insulin or is not using insulin correctly. Problems associated with extreme levels of ketosis are more likely to develop in patients with type 1 diabetes compared with type 2 diabetes patients. Ketosis occurs when the body does not have sufficient access to its primary fuel source, glucose. Ketosis describes a condition where fat stores are broken down to produce energy, which also produces ketones, a type of acid. As ketone levels rise, the acidity of the blood also increases, leading to ketoacidosis, a serious condition that can prove fatal. People with type 1 diabetes are more likely to develop ketoacidosis, for which emergency medical treatment is required to avoid or treat diabetic coma. Some people follow a ketogenic (low-carb) diet to try to lose weight by forcing the body to burn fat stores. What is ketosis? In normal circumstances, the body's cells use glucose as their primary form of energy. Glucose is typically derived from dietary carbohydrates, including: sugar - such as fruits and milk or yogurt starchy foods - such as bread and pasta The body breaks these down into simple sugars. Glucose can either be used to fuel the body or be stored in the liver and muscles as glycogen. If there is not enough glucose available to meet energy demands, th Continue reading >>
Ketosis, Ketones, And How It All Works
Ketosis is a process that the body does on an everyday basis, regardless of the number of carbs you eat. Your body adapts to what is put in it, processing different types of nutrients into the fuels that it needs. Proteins, fats, and carbs can all be processed for use. Eating a low carb, high fat diet just ramps up this process, which is a normal and safe chemical reaction. When you eat carbohydrate based foods or excess amounts of protein, your body will break this down into sugar – known as glucose. Why? Glucose is needed in the creation of ATP (an energy molecule), which is a fuel that is needed for the daily activities and maintenance inside our bodies. If you’ve ever used our keto calculator to determine your caloric needs, you will see that your body uses up quite a lot of calories. It’s true, our bodies use up much of the nutrients we intake just to maintain itself on a daily basis. If you eat enough food, there will likely be an excess of glucose that your body doesn’t need. There are two main things that happen to excess glucose if your body doesn’t need it: Glycogenesis. Excess glucose will be converted to glycogen and stored in your liver and muscles. Estimates show that only about half of your daily energy can be stored as glycogen. Lipogenesis. If there’s already enough glycogen in your muscles and liver, any extra glucose will be converted into fats and stored. So, what happens to you once your body has no more glucose or glycogen? Ketosis happens. When your body has no access to food, like when you are sleeping or when you are on a ketogenic diet, the body will burn fat and create molecules called ketones. We can thank our body’s ability to switch metabolic pathways for that. These ketones are created when the body breaks down fats, creating Continue reading >>
What Would The Effect Of A 30-day Water Fast Be? My Friend Wants To Do A 30-day Water Fast To Detox, But I Am Kind Of Concerned About It. She Has Never Done A Water Fast Before, So 30 Days Seems A Bit Overkill.
First off, Don’t worry too much that your friend will actually make it 30 days. If she has never fasted before, it is extremely unlikely she makes it that long. I have been fasting pretty hardcore on and off for 5 years and my personal best is 13 days. Here’s a video of my early days if you think I’m full of BS. That being said, here is what happens in the body when you fast. The body burns any food that was eaten recently, turning it into an easily burned form of energy called glycogen. Next, the body turns to stored glycogen stored in the liver. Most people seem to have 2–3 days worth of “easy-access” glycogen in the blood stream and liver. Over the first, give or take, 3 days of the fast you deplete the glycogen stores and then your body turns to an alternate source: fat stores. This is an alternate metabolic pathway that all humans (if not hindered in some rare genetically related manner) have the capability of. Often referred to as “being in ketosis” your body produces chemicals that break down fat to ketone bodies (often just called ketones). The body is also able to produce a small amount of glycogen, through a process called gluconeogenesis. When you combine the ketones and the tiny amount of glucose created from your fat stores, you body runs incredibly efficiently for a very long time. The amount of time is directly tied to how much fat your body has stored. So, that is what is happening in the body. But what will your friend experience: Massive weight loss. Let me reiterate, you are burning only your fat stores for energy, so that beer belly is going away. Loss of water weight. A lot of water is stored in fat. When this breaks down it is easy to get dehydrated. Tell your friend to drink water like it is her day job. If she is going 30 days (ag Continue reading >>
Farming: Why Are Most Cows Fed Corn Instead Of Grass?
Most cows are not fed corn. As a matter of fact most cattle aren't even on a high-grain diet for most, if not all, of their lives. Most cattle are actually grass-fed. Just not grass-finished. There's around 89 million beef cattle in the US, 9.3 million dairy cattle and 12.1 million cattle currently in the feedlot being finished (that according to USDA statistics from July 1, 2015). The 89 million beef cattle are breeding cattle: Beef cows, replacement heifers, and bulls. The 9.3 million dairy cattle are primarily dairy cows used in milk production. And the 12.1 million cattle and calves in the feedlot are both beef and dairy of various ages. Now, look at the 89 million number again. That's 95% of the total cattle herd inventory of the United States (which is currently sitting at 93.4 million cattle). That equates to "most cows/cattle." And what most people don't know (nor have most acknowledged here, except for one) is that those 89 million cattle are grass or forage-fed. That means that those cattle are on pasture or range from spring until fall and fed hay in the winter. They are being fed and eating grass and forbs on either an extensive or intensive (all depending on grazing management, most operations choose an extensive to a happy medium between extensive and intensive) grazing system. Corn or other grains are optional, and only fed when and if the animals need it if feed supplies are low and straw is only to be fed (cattle can do quite well on straw if supplemented with grain for added carbohydrate and protein) but never as a main constituent of their diet. Certainly not like finisher or dairy cattle. The other interesting thing most people miss is that cattle in the feedlot have not been raised in the feedlot. Most cattle, which are largely beef with only maybe Continue reading >>
- Woodford and Swinburn offer new evidence that type-1 diabetes is linked to the level of A1 beta-casein in most types of cows milk
- Formula made with cows milk does not increase diabetes risk
- Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet
What Are The Dangers Of The Ketosis Diet?
In the late 1990s and early 2000s, when the "Atkins" and low carb dieting thing was just coming on in a big way, there was a terrific number of idiotic claims made about the dangers of it -- many of them confusing (as the questioner points out) diabetic ketoacidosis, a serious condition, with voluntary nutritional ketosis, even though there is no relation whatever. But, leaving all that aside, some caution is in order. The diet seems to stress the adrenals. This has been noted anecdotally by many people who've followed the diet. It was also noted by Dr Wolfgang Lutz, one of the early pioneers of the diet, who personally practiced the diet for 40-odd years, as well as advocated the diet to thousands of his patients. He noted in his book on the subject ("Life Without Bread" was the title, though it was published later I believe under a different title) that some patients would suffer mild autoimmune reactions that required small doses of corticosteroids to control. This sounds like what would happen if the adrenals are failing to produce a normal amount of steroids. You can find a lot more of a mostly-anecdotal nature by searching for "ketogenic jaminet". Paul Jaminet is a popular health blogger who has written about what he perceives to be problems with the ketogenic diet, including the possibility of deficiency of mucus and other key glycoproteins. He has some scientific backing for what he is saying, but it is far from air-tight. Read and judge for yourself. You can also learn a lot from the comments below his posts. Jaminet and others have also written about the risk of kidney stones on the ketogenic diet, and this is a serious concern, albeit a rare occurence. As far as the kidney stress goes: this would I believe be easy to avert simply by taking some alkali during Continue reading >>
What Is Ketosis?
"Ketosis" is a word you'll probably see when you're looking for information on diabetes or weight loss. Is it a good thing or a bad thing? That depends. Ketosis is a normal metabolic process, something your body does to keep working. When it doesn't have enough carbohydrates from food for your cells to burn for energy, it burns fat instead. As part of this process, it makes ketones. If you're healthy and eating a balanced diet, your body controls how much fat it burns, and you don't normally make or use ketones. But when you cut way back on your calories or carbs, your body will switch to ketosis for energy. It can also happen after exercising for a long time and during pregnancy. For people with uncontrolled diabetes, ketosis is a sign of not using enough insulin. Ketosis can become dangerous when ketones build up. High levels lead to dehydration and change the chemical balance of your blood. Ketosis is a popular weight loss strategy. Low-carb eating plans include the first part of the Atkins diet and the Paleo diet, which stress proteins for fueling your body. In addition to helping you burn fat, ketosis can make you feel less hungry. It also helps you maintain muscle. For healthy people who don't have diabetes and aren't pregnant, ketosis usually kicks in after 3 or 4 days of eating less than 50 grams of carbohydrates per day. That's about 3 slices of bread, a cup of low-fat fruit yogurt, or two small bananas. You can start ketosis by fasting, too. Doctors may put children who have epilepsy on a ketogenic diet, a special high-fat, very low-carb and protein plan, because it might help prevent seizures. Adults with epilepsy sometimes eat modified Atkins diets. Some research suggests that ketogenic diets might help lower your risk of heart disease. Other studies show sp Continue reading >>
How Much Weight Will I Lose If I Don't Eat For 3 Days?
It depends. You can do the math using calories and come up with a specific number - but calories are only 1 factor at play when you fast. You have to consider the hormonal and physiological effects of fasting. There are 5 stages to fasting. But basically your body depletes your blood glucose, then depletes your glycogen stores, and only then does it begin to burn fat as it transitions into ketosis. The process of depleting your glycogen stores to get into the metabolic state of ketosis takes about 3 days. What that means for fasting as a weight loss technique: If you want to lose fat, you should fast for a minimum of 3 days. Preferably 5. This is how you achieve permanent weight loss, because day 4 and 5 is when your body starts burning fat for energy Otherwise the weight you lose will be regained as your body replenishes your glycogen stores upon refeeding Glycogen also holds a lot of water, which accounts for the water weight loss people often talk about Fasting for a minimum of 3 days will improve your Insulin Sensitivity So when you resume feeding, your body will be more efficient at shuttling nutrients where they are needed (muscles and organ function) instead of storing it as fat Think more sustainable weight loss Lastly, let’s debunk the myth that fasting will cause your body to store more fat for next time. First off, your body can’t store more fat while you are fasting because you aren’t eating, thus there is nothing to be converted into fat. Some may then say, “but it will upon refeeding”. This may occur, but only for people at extremely low body fat percentages (below 5%). Also, I mentioned above that your body will store less fat because it will be more efficient as utilizing nutrients after fasting Your body has two metabolic states Glycolysis - h Continue reading >>
Ketosis: Symptoms, Signs & More
Every cell in your body needs energy to survive. Most of the time, you create energy from the sugar (glucose) in your bloodstream. Insulin helps regulate glucose levels in the blood and stimulate the absorption of glucose by the cells in your body. If you don’t have enough glucose or insufficient insulin to get the job done, your body will break down fat instead for energy. This supply of fat is an alternative energy source that keeps you from starvation. When you break down fat, you produce a compound called a ketone body. This process is called ketosis. Insulin is required by your cells in order to use the glucose in your blood, but ketones do not require insulin. The ketones that don’t get used for energy pass through your kidneys and out through your urine. Ketosis is most likely to occur in people who have diabetes, a condition in which the body produces little or no insulin. Ketosis and Ketoacidosis: What You Need To Know Ketosis simply means that your body is producing ketone bodies. You’re burning fat instead of glucose. Ketosis isn’t necessarily harmful to your health. If you don’t have diabetes and you maintain a healthy diet, it’s unlikely to be a problem. While ketosis itself isn’t particularly dangerous, it’s definitely something to keep an eye on, especially if you have diabetes. Ketosis can be a precursor to ketoacidosis, also known as diabetic ketoacidosis. Ketoacidosis is a condition in which you have both high glucose and high ketone levels. Having ketoacidosis results in your blood becoming too acidic. It’s more common for those with type 1 diabetes rather than type 2. Once symptoms of ketoacidosis begin, they can escalate very quickly. Symptoms include: breath that smells fruity or like nail polish or nail polish remover rapid breat Continue reading >>
The Beginners Guide To Ketosis: Investigating Low-carb, High-fat Eating
The only hard and fast rule of health is that health is personal and what works well for one person may not work for someone else. Aside from that rule, there are “frameworks” that seem to benefit large groups of people. One more level down from that are alternative strategies that benefit smaller groups. Ketosis is likely one of those alternative strategies that works well for certain, smaller groups of people. So, right off the bat I want you to understand that Ketosis might not be for everyone. I’m going to lay out the case for potential benefits of Ketosis. If it sounds interesting and beneficial to you, then consider trying it. (see our free cheat sheet to help you). What is Ketosis Ketosis occurs when liver glycogen gets depleted and the body burns fatty acids for fuel. The primary driver of this state is a very low carbohydrate intake. Often, it also requires a low protein, higher fat intake. You can also achieve a state of ketosis by not eating altogether. The creation of ketones is a byproduct of this metabolic state. Ketones are a source of fuel, just as glucose is a source of fuel. Ketones tend to have some added benefits, though. What role does Ketosis play in human health? Ketosis allows our bodies to function in the absence of carbohydrates, both physically and mentally. Instead of burning carbohydrates, or converting protein to glucose, the body burns ketones. This is pretty much a survival mechanism. It allows your body to function in a state of caloric deprivation. This is why ketosis often gets bad press (as it’s linked to “starvation”). Being a survival mechanism doesn’t make it invalid as a strategy, though. There can still be potential benefits to be had. Let’s cover a few of them… Ketosis and Accelerated Fat Loss Being in ketosis Continue reading >>
There is a lot of confusion about the term ketosis among medical professionals as well as laypeople. It is important to understand when and why nutritional ketosis occurs, and why it should not be confused with the metabolic disorder we call ketoacidosis. Ketosis is a metabolic state where the liver produces small organic molecules called ketone bodies. Most cells in the body can use ketone bodies as a source of energy. When there is a limited supply of external energy sources, such as during prolonged fasting or carbohydrate restriction, ketone bodies can provide energy for most organs. In this situation, ketosis can be regarded as a reasonable, adaptive physiologic response that is essential for life, enabling us to survive periods of famine. Nutritional ketosis should not be confused with ketoacidosis, a metabolic condition where the blood becomes acidic as a result of the accumulation of ketone bodies. Ketoacidosis can have serious consequences and may need urgent medical treatment. The most common forms are diabetic ketoacidosis and alcoholic ketoacidosis. What Is Ketosis? The human body can be regarded as a biologic machine. Machines need energy to operate. Some use gasoline, others use electricity, and some use other power resources. Glucose is the primary fuel for most cells and organs in the body. To obtain energy, cells must take up glucose from the blood. Once glucose enters the cells, a series of metabolic reactions break it down into carbon dioxide and water, releasing energy in the process. The body has an ability to store excess glucose in the form of glycogen. In this way, energy can be stored for later use. Glycogen consists of long chains of glucose molecules and is primarily found in the liver and skeletal muscle. Liver glycogen stores are used to mai Continue reading >>