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What Is The Meaning Of Acidosis?

What Is Metabolic Acidosis?

What Is Metabolic Acidosis?

Metabolic acidosis happens when the chemical balance of acids and bases in your blood gets thrown off. Your body: Is making too much acid Isn't getting rid of enough acid Doesn't have enough base to offset a normal amount of acid When any of these happen, chemical reactions and processes in your body don't work right. Although severe episodes can be life-threatening, sometimes metabolic acidosis is a mild condition. You can treat it, but how depends on what's causing it. Causes of Metabolic Acidosis Different things can set up an acid-base imbalance in your blood. Ketoacidosis. When you have diabetes and don't get enough insulin and get dehydrated, your body burns fat instead of carbs as fuel, and that makes ketones. Lots of ketones in your blood turn it acidic. People who drink a lot of alcohol for a long time and don't eat enough also build up ketones. It can happen when you aren't eating at all, too. Lactic acidosis. The cells in your body make lactic acid when they don't have a lot of oxygen to use. This acid can build up, too. It might happen when you're exercising intensely. Big drops in blood pressure, heart failure, cardiac arrest, and an overwhelming infection can also cause it. Renal tubular acidosis. Healthy kidneys take acids out of your blood and get rid of them in your pee. Kidney diseases as well as some immune system and genetic disorders can damage kidneys so they leave too much acid in your blood. Hyperchloremic acidosis. Severe diarrhea, laxative abuse, and kidney problems can cause lower levels of bicarbonate, the base that helps neutralize acids in blood. Respiratory acidosis also results in blood that's too acidic. But it starts in a different way, when your body has too much carbon dioxide because of a problem with your lungs. Continue reading >>

5.1 - Metabolic Acidosis : Definition

5.1 - Metabolic Acidosis : Definition

Acid-Base Physiology A metabolic acidosis is an abnormal primary process or condition leading to an increase in fixed acids in the blood. This causes the arterial plasma bicarbonate to fall to a level lower than expected. The fall in plasma bicarbonate is due to titration of HCO3- by H+. Secondary or compensatory processes which cause a fall in plasma bicarbonate should not be confused with primary processes. A fall in bicarbonate occurring in response to a chronic respiratory alkalosis should be referred to as a compensatory response and never as a �secondary metabolic acidosis�. This distinction between a primary process and a secondary one has been discussed previously in section 3.1.2 when discussing terminology of acid-base disorders. It is of course possible for a patient to have a mixed acid-base disorder with both a metabolic acidosis and a respiratory alkalosis. An example would be an adult presenting following a salicylate overdose. In this situation, direct stimulation of the respiratory centre occurs resulting in a respiratory alkalosis as well as the salicylate-related metabolic acidosis. 'Acid-base pHysiology' by Kerry Brandis -from Acid-Base Physiology 5.2.1 Classification by Patho-physiological Mechanism A decrease in plasma bicarbonate can be caused by two mechanisms: A gain of strong acid A loss of base All causes of a metabolic acidosis must work by these mechanisms. The gain of strong acid may be endogenous (eg ketoacids from lipid metabolism) or exogenous (NH4Cl infusion). Bicarbonate loss may occur via the bowel (diarrhoea, small bowel fistulas) or via the kidneys (carbonic anhydrase inhibitors, renal tubular acidosis). An alternative to the above, is to classify the causes of metabolic acidosis into two groups depending on whether the anion ga Continue reading >>

What Are The Dangers Of High Or Low Ph Levels?

What Are The Dangers Of High Or Low Ph Levels?

A woman is getting her heartbeat listened to.Photo Credit: Medioimages/Photodisc/Photodisc/Getty Images What Are the Dangers of High or Low PH Levels? Joseph Pritchard graduated from Our Lady of Fatima Medical School with a medical degree. He has spent almost a decade studying humanity. Dr. Pritchard writes as a San Francisco biology expert for a prominent website and thoroughly enjoys sharing the knowledge he has accumulated. Your body needs to maintain an optimum acid-base balance, or pH level, to ensure the various processes within your body occur without problems, according to the University of Maryland Medical Center. When your bodys pH level becomes high, the condition is known as alkalosis. When your bodys pH level becomes low, the condition is called acidosis. Both alkalosis and acidosis can have dangerous consequences if untreated. Alkalosis can cause arrhythmia, or an irregular heartbeat, notes the New York Times Health Guide. This may occur when your body hyperventilates. The consequent irregularity in breathing can cause the heart to beat at irregular intervals as well. In order to diagnosis alkalosis, doctors will check carbon dioxide and sodium bicarbonate levels in your blood. These two chemicals help regulate breathing, heart rate and organ function. If you have high pH levels, your carbon dioxide will be low and sodium bicarbonate levels will be high. This will cause an increase in your breathing rate and cardiac arrhythmia. You may experience difficulty breathing, chest pain and palpitations. Alkalosis can induce a coma if pH levels are sufficiently high, notes the New York Times Health Guide. This may be a consequence of breathing difficulties typical of alkalosis. The risk of an alkalosis-induced coma may be affected by other factors, such as the le Continue reading >>

Arterial Blood Gases (blood Gases), Acidosis And Alkalosis

Arterial Blood Gases (blood Gases), Acidosis And Alkalosis

Sample The better choice is the Radial artery. The sample may be taken from the femoral artery or brachial. The tests are done immediately because oxygen and carbon dioxide are unstable. Arterial blood is better than the venous blood. For arterial blood don't use the tourniquet and no pull on the syringe plunger. For venous blood syringe or tubes are completely filled and apply a tourniquet for few seconds. Arterial VS Venous blood Arterial blood gives good mixture of blood from various areas of the body. Venous blood gives information of the local area from where the blood sample is taken. Metabolism of the extremity varies from area to area. Arterial blood measurement gives the better status of the lung oxygenating the blood. Arterial blood gives information about the ability of the lung to regulate the acid-base balance through retention or release of CO2. Precautions for the collection of blood Avoid pain and anxiety to the patient which will lead to hyperventilation. Hyperventilation due to any cause leads to decreased CO2 and increased pH. Keep blood cool during transit. Don't clench finger or fist. This will leads to lower CO2 and increased acid metabolites. pCO2 values are lower in the sitting or standing position in comparison with the supine position. Don't delay the performance of the test. Avoid air bubbles in the syringe. Excess of heparin decreases the pCO2 may be 40% less. Not proper mixing of the blood before running the test. Purpose of the test This test is done on the mostly hospitalized patient. Mostly the patients are on ventilator or unconscious. For patients in pulmonary distress. To assess the metabolic (renal) acid-base and electrolytes imbalance. Its primary use is to monitor arterial blood gases and pH of blood. Also used to monitor oxygenatio Continue reading >>

Anabolic Alkalinity The Benefits Of Decreasing Your Bodys Acidity

Anabolic Alkalinity The Benefits Of Decreasing Your Bodys Acidity

Anabolic Alkalinity The Benefits of Decreasing Your Bodys Acidity Posted on December 23, 2011 by Derek Charlebois Your high-protein diet is great for building muscle and burning fat, but its not so great for your bodys acid balance. The body functions optimally when it is in equilibrium. Cells operate best when they are within a specific pH (potential of hydrogen) range, which varies depending on the cell type. The pH of the body is a measure of its acid:alkaline ratio which is measured on a scale of 0-14. A rating of seven is neutral, while any more means you are in a state of alkalinity and any less means you are acidic, becomes too acidic normal body functions are compromised. The problem is, many of the foods that compromise even healthy peoples diets are acidic! For example, chicken and oatmeal, two common bodybuilding foods, are acidic. When the body becomes too acidic due to dietary influences its called metabolic acidosis. In order to stabilize an acidic pH level the body must neutralize the excess dietary acid load. The two main ways the body does this is by taking calcium and other minerals from bones and glutamine from skeletal muscle. Both of these corrective mechanisms have negative consequences for your health and physique. This is a fifty-cent word that refers to having high calcium levels in your urine. Bone contains the bodys greatest calcium stores and calcium is a strong base meaning it is able to neutralize acids. During metabolic acidosis calcium is released from bone in an attempt to neutralize the excess acids and stabilize the bodys pH level. The calcium and acids are then excreted in the urine. This calcium loss leads to weak, brittle bones. Skeletal muscle contains the bodys greatest glutamine stores. Glutamine binds to hydrogen ions (H+) to c Continue reading >>

Acidosis

Acidosis

What is acidosis? Acidosis is a serious metabolic imbalance in which there is an excess of acidic molecules in the body. This can occur as a result of acid overproduction, impaired acid transport, acid underexcretion, or any combination. With overproduction, the body makes too much acid. This can occur in sepsis, a life-threatening widespread infection in which the body makes too much lactic acid. With underexcretion, the body is unable to rid itself of excess acid. This can occur in renal failure and various lung diseases. In renal failure, the kidneys are unable to cleanse the blood of acid. In pulmonary diseases, the lungs are unable to exhale sufficient carbon dioxide. Carbon dioxide is a gaseous form of acid that builds up in the bloodstream. Both conditions may coexst in a number of serious diseases, such as pneumonia and pulmonary edema (fluid in the lungs), which is seen in a particularly severe form of heart failure. Doctors diagnose acidosis with blood tests, the most common of which is known as a pH test. The normal pH of the body is 7.4 (a lower pH value is more acidic, higher pH is more alkaline). Acidosis is defined as a pH less than 7.4. Specific blood tests may be used to identify particular acids, such as lactic acid. The treatment of acidosis depends on its cause. Therapy may range from simple interventions, such as oral medications and intravenous fluids, to invasive measures, such as dialysis and surgery. The outcome of acidosis depends on its severity. Seek immediate medical care (call 911) for serious symptoms, such as rapid breathing, confusion, shortness of breath, and lethargy, especially in the setting of lung disease, kidney disease, or other diseases that can cause acidosis. Seek prompt medical care if you are being treated for chronic acidos Continue reading >>

Feline Chronic Kidney Disease

Feline Chronic Kidney Disease

Home > Key Issues > Metabolic Acidosis Overview Metabolic acidosis means that the levels of acid in the cat's body are too high. It is extremely common in CKD cats, usually cats in Stage IV, and can make the cat feel ill and the CKD progress faster. It can be tricky to diagnose, but fortunately it is relatively easy to treat. What is Metabolic Acidosis? There is a delicate balance within the body known as acid-base balance (pH): Metabolic acidosis means that this balance is disrupted, in that levels of acid in the cat's body are too high, so the blood pH is too low (acidic). Acid is produced in the body as a result of diet. In healthy cats, the kidneys help to balance acid levels in the body in two ways: Bicarbonate ions (which are alkaline) in the kidneys help protect against acid build-up in the body; Any excess acids that do arise are flushed from the body by the kidneys. Unfortunately the excessive urine flow of CKD washes the protective bicarbonate ions out of the kidneys. On the other hand, the damaged kidneys may no longer flush the acids from the body properly. As a result of these damaged mechanisms, acidity levels in the blood rise, and the body’s pH becomes too low. This is known as acidosis. "Metabolic" means that the acidosis is caused by kidney disease. This is to differentiate it from another type of acidosis known as respiratory acidosis, which is caused by the lungs not expelling carbon dioxide properly. I know a lot of people get confused by the word "acidosis" and think it is the same thing as excess stomach acid, but that is not the case. Gastrin is a gastrointestinal hormone which stimulates the secretion of gastric acid, which helps the stomach digest food. The kidneys are responsible for the excretion of gastrin, but in CKD this function may not Continue reading >>

Definitions

Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition n. An abnormal increase in the acidity of the body's fluids, caused either by accumulation of acids or by depletion of bicarbonates. from Wiktionary, Creative Commons Attribution/Share-Alike License n. An abnormally increased acidity of the blood. from the GNU version of the Collaborative International Dictionary of English n. abnormally high acidity of the blood and other body fluids. from The Century Dictionary and Cyclopedia n. Poisoning by certain acids, such as uric acid or the fatty acids, formed within the body under various morbid conditions, such as cancer, diabetes, or fever. Also called acid intoxication. from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved. n. abnormally high acidity (excess hydrogen-ion concentration) of the blood and other body tissues Continue reading >>

Acidosis Vs. Acidemia

Acidosis Vs. Acidemia

Watch short & fun videos Start Your Free Trial Today An error occurred trying to load this video. Try refreshing the page, or contact customer support. You must create an account to continue watching Start Your Free Trial To Continue Watching As a member, you'll also get unlimited access to over 70,000 lessons in math, English, science, history, and more. Plus, get practice tests, quizzes, and personalized coaching to help you succeed. Coming up next: Polycythemia: Symptoms & Treatment Log in or sign up to add this lesson to a Custom Course. Custom Courses are courses that you create from Study.com lessons. Use them just like other courses to track progress, access quizzes and exams, and share content. Organize and share selected lessons with your class. Make planning easier by creating your own custom course. Create a new course from any lesson page or your dashboard. Click "Add to" located below the video player and follow the prompts to name your course and save your lesson. Click on the "Custom Courses" tab, then click "Create course". Next, go to any lesson page and begin adding lessons. Edit your Custom Course directly from your dashboard. Name your Custom Course and add an optional description or learning objective. Create chapters to group lesson within your course. Remove and reorder chapters and lessons at any time. Share your Custom Course or assign lessons and chapters. Share or assign lessons and chapters by clicking the "Teacher" tab on the lesson or chapter page you want to assign. Students' quiz scores and video views will be trackable in your "Teacher" tab. You can share your Custom Course by copying and pasting the course URL. Only Study.com members will be able to access the entire course. Create an account to start this course today Are you confused Continue reading >>

Types Of Acidosis And Foods To Avoid- Easy Health Options

Types Of Acidosis And Foods To Avoid- Easy Health Options

Easy Health Options Home Healthy Living Full body acid: Whats eating you? You want to feel vibrant. We all do. But something is eating away at you and causing many of the ailments you potentially face, ranging from lack of energy to cancer Acidosis is when your bodys internal environment meaning all its blood, cells, tissues and organs are in an acidic state. Healthy humans are alkaline humans. An alkaline state is the opposite of an acidic state. So overcoming a chronic state of acidosis and replacing it with a natural, balanced state of alkalinity, is the way to restore health and vibrancy. To do that, you need to look at the pH of your body, the foods that go into it and the other outside factors that can tip that balance Your pH (potential of hydrogen) is a reflection of your bodys balance between its alkaline and acidic state. That pH is measured on a logarithmic scale in which 7.0 is neutral. The lower the reading on the scale the more acidic the body is and the higher the reading, above 7, the more alkaline the body. When the body maintains a high pH you feel vibrant, at ease and well. However, when the environment of the body is acidic, with a low pH reading, inflammation, pain, disease, and other unhealthful issues arise. Indeed, acidic blood can cause stroke, heart attack, atherosclerosis and high blood pressure. An acidic body can even lead to depression and obesity because of how the body is hampered in its ability to process nutrients, expel heavy metals and metabolize wastes. Diseases like cancer cannot thrive in an alkaline environment. But an acidic body does allow cancer cells to proliferate. Many other diseases, including arthritis, emphysema, and diabetes can begin, progress faster and thrive in an acidic environment. An acidic environment in the bod Continue reading >>

Metabolic Acidosis

Metabolic Acidosis

Patient professional reference Professional Reference articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use. You may find one of our health articles more useful. See also separate Lactic Acidosis and Arterial Blood Gases - Indications and Interpretations articles. Description Metabolic acidosis is defined as an arterial blood pH <7.35 with plasma bicarbonate <22 mmol/L. Respiratory compensation occurs normally immediately, unless there is respiratory pathology. Pure metabolic acidosis is a term used to describe when there is not another primary acid-base derangement - ie there is not a mixed acid-base disorder. Compensation may be partial (very early in time course, limited by other acid-base derangements, or the acidosis exceeds the maximum compensation possible) or full. The Winter formula can be helpful here - the formula allows calculation of the expected compensating pCO2: If the measured pCO2 is >expected pCO2 then additional respiratory acidosis may also be present. It is important to remember that metabolic acidosis is not a diagnosis; rather, it is a metabolic derangement that indicates underlying disease(s) as a cause. Determination of the underlying cause is the key to correcting the acidosis and administering appropriate therapy[1]. Epidemiology It is relatively common, particularly among acutely unwell/critical care patients. There are no reliable figures for its overall incidence or prevalence in the population at large. Causes of metabolic acidosis There are many causes. They can be classified according to their pathophysiological origin, as below. The table is not exhaustive but lists those that are most common or clinically important to detect. Increased acid Continue reading >>

Acidosis

Acidosis

ac·i·do·sis pl. -·ses· an abnormal condition in the body, often due to faulty metabolism in which excessive acid, or a loss of alkali, lowers the pH of the blood and tissue Origin of acidosis ModL: see acid and -osis acidosis noun Abnormally high acidity of the blood and body tissues caused by a deficiency of bicarbonates or an excess of acids other than carbonic acid. It can result from any of various acute or chronic disorders or from the ingestion of certain drugs and toxins. Also called metabolic acidosis . Abnormally high acidity of the blood and body tissues caused by an excess of carbon dioxide due to hypoventilation. Also called respiratory acidosis . Related Forms: ac′i·dot′ic THE AMERICAN HERITAGE® DICTIONARY OF THE ENGLISH LANGUAGE, FIFTH EDITION by the Editors of the American Heritage Dictionaries. Copyright © 2016, 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved. acidosis Continue reading >>

Uncompensated, Partially Compensated, Or Combined Abg Problems

Uncompensated, Partially Compensated, Or Combined Abg Problems

Arterial Blood Gas (ABG) analysis requires in-depth expertise. If the results are not understood right, or are wrongly interpreted, it can result in wrong diagnosis and end up in an inappropriate management of the patient. ABG analysis is carried out when the patient is dealing with the following conditions: • Breathing problems • Lung diseases (asthma, cystic fibrosis, COPD) • Heart failure • Kidney failure ABG reports help in answering the following questions: 1. Is there acidosis or alkalosis? 2. If acidosis is present, whether it is in an uncompensated state, partially compensated state, or in fully compensated state? 3. Whether acidosis is respiratory or metabolic? ABG reports provide the following descriptions: PaCO2 (partial pressure of dissolved CO2 in the blood) and PaO2 (partial pressure of dissolved O2 in the blood) describe the efficiency of exchange of gas in the alveolar level into the blood. Any change in these levels causes changes in the pH. HCO3 (bicarbonate in the blood) maintains the pH of the blood within normal range by compensatory mechanisms, which is either by retaining or increasing HCO3 excretion by the kidney. When PaCO2 increases, HCO3 decreases to compensate the pH. The following table summarizes the changes: ABG can be interpreted using the following analysis points: Finding acidosis or alkalosis: • If pH is more it is acidosis, if pH is less it is alkalosis. Finding compensated, partially compensated, or uncompensated ABG problems: • When PaCO2 is high, but pH is normal instead of being acidic, and if HCO3 levels are also increased, then it means that the compensatory mechanism has retained more HCO3 to maintain the pH. • When PaCO2 and HCO3 values are high but pH is acidic, then it indicates partial compensation. It means t Continue reading >>

Too Much Acid In The Body In Cats

Too Much Acid In The Body In Cats

From 560 quotes ranging from $500 - 5,000 First, the kidneys produce bicarbonate ions, which are alkaline and counter acid. The kidneys also flush out excess acid in the urine. Too much acid in the body in cats, also known as metabolic acidosis, occurs when the kidneys cease to perform this function, allowing acid to build up in the blood and body and causing a variety of harmful symptoms. The body of your cat is made up of a delicate balance of acid and base, or alkaline, materials. Your cat takes in acid through nutrition, meaning food. In a healthy cat, the kidneys and lungs will balance out or eliminate excess acid. The kidneys are mostly responsible for eliminating excess acid from the body through two separate functions. Symptoms of Too Much Acid in the Body in Cats When the acid levels in the body in your cat start to rise, many different symptoms begin to develop. As the acid levels increase, symptoms begin to escalate rapidly in severity. If not treated, high acid levels will eventually cause organ problems and shutdown. Diagnosis of Too Much Acid in the Body in Cats As with any serious condition, diagnosis of metabolic acidosis will begin with a thorough physical examination by your veterinarian. Your vet will examine gum color and eyes for any discoloration. They will also physically manipulate the abdomen of your cat, feeling manually for any lumps, bumps or swelling. As a pet owner, it will be important that you provide your veterinarian with a thorough medical history. Underlying conditions, such as chronic kidney failure or diabetes, are primary causes of too much acid in the body. It is very important that you disclose the presence of these conditions so that your cat gets the proper care. There are several blood and urine tests available to diagnoses m Continue reading >>

Respiratory Acidosis

Respiratory Acidosis

LABORATORY TESTS The following lab tests can be used to interpret and explain acidosis and alkalosis conditions. All are measured on blood samples. 1. pH: This measures hydrogen ions - Normal pH = 7.35-7.45 2. pCO2= Partial Pressure of Carbon Dioxide: Although this is a pressure measurement, it relates to the concentration of GASEOUS CO2 in the blood. A high pCO2 may indicate acidosis. A low pCO2 may indicate alkalosis. 3. HCO3- = Bicarbonate: This measures the concentration of HCO3- ion only. High values may indicate alkalosis since bicarbonate is a base. Low values may indicate acidosis. 4. CO2 = Carbon Dioxide Content: This is a measure of ALL CO2 liberated on adding acid to blood plasma. This measure both carbon dioxide dissolved and bicarbonate ions and is an older test. Do not confuse with pCO2 Typically, dissolved carbon dioxide = l.2-2.0 mmoles/L and HCO3- = 22-28 mmoles/L Therefore, although it is listed as CO2 content, the lab test really reflects HCO3- concentration. Respiratory Acidosis .ABNORMAL pH IN THE BODY: ACIDOSIS AND ALKALOSIS: INTRODUCTION: Normal blood pH is maintained between 7.35 and 7.45 by the regulatory systems. The lungs regulate the amount of carbon dioxide in the blood and the kidneys regulate the bicarbonate. When the pH decreases to below 7.35 an acidosis condition is present. Acidosis means that the hydrogen ions are increased and that pH and bicarbonate ions are decreased. A greater number of hydrogen ions are present in the blood than can be absorbed by the buffer systems. Alkalosis results when the pH is above 7.45. This condition results when the buffer base (bicarbonate ions) is greater than normal and the concentration of hydrogen ions are decreased. Both acidosis and alkalosis can be of two different types: respiratory and metabol Continue reading >>

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