[kinetics Of The Compensation Of Respiratory Acidosis Induced By Experimentalchronic Hypercapnia In Man (author's Transl)].
1. Bull Eur Physiopathol Respir. 1976 Jan-Feb;12(1):87-101. [Kinetics of the compensation of respiratory acidosis induced by experimentalchronic hypercapnia in man (author's transl)]. Radziszewski E, Guillerm R, Badre R, Abran C. Four groups of male volunteers have been exposed in a tight climatical chamber toPICO2 of 14, 21, 28 and 32 torr; exposure periods varied from two to 30 days,between two reference periods in normal air. The results deal with the evolution of arterial blood acid-base equilibrium and that of renal response in relation toPICO2. In all exposures, the carbon dioxide alveolar overload increases byseveral torr during the first 24 hours on account of attenuation of the initialhyperventilation. Kinetics of the respiratory acidosis compensation differsaccording to hypercapnia which is moderate (PICO2 of 14 and 21 torr) orrelatively severe (PICO2 of 28 and 32 torr). The decrease in arterial pH lessens as early as the 24th hour at PICO2 28 and 32 torr, and only after two days atPICO2 14 and 21 torr. The renal response is characterized by a significantincrease in aciduria during the first 24 hours at PICO2 28 and 32 torr; thechanges are smaller and start latter at PIC Continue reading >>