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What Is The Cause Of Ketosis?

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What is BASAL METABOLIC RATE? What does BASAL METABOLIC RATE mean? BASAL METABOLIC RATE meaning - BASAL METABOLIC RATE definition - BASAL METABOLIC RATE explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Basal metabolic rate (BMR) is the minimal rate of energy expenditure per unit time by endothermic animals at rest. It is reported in energy units per unit time ranging from watt (joule/second) to ml O2/min or joule per hour per kg body mass J/(hkg)). Proper measurement requires a strict set of criteria be met. These criteria include being in a physically and psychologically undisturbed state, in a thermally neutral environment, while in the post-absorptive state (i.e., not actively digesting food). In bradymetabolic animals, such as fish and reptiles, the equivalent term standard metabolic rate (SMR) is used. It follows the same criteria as BMR, but requires the documentation of the temperature at which the metabolic rate was measured. This makes BMR a variant of standard metabolic rate measurement that excludes the temperature data, a practice that has led to problems in defining "standard" rates of metabolism for many mamma

Toxigenic And Metabolic Causes Of Ketosis And Ketoacidotic Syndromes.

Abstract Ketoacidotic syndromes are frequently encountered in acute care medicine. This article focuses on ketosis and ketoacidotic syndromes associated with intoxications, alcohol abuse, starvation, and certain dietary supplements as well as inborn errors of metabolism. Although all of these various processes are characterized by the accumulation of ketone bodies and metabolic acidosis, there are differences in the mechanisms, clinical presentations, and principles of therapy for these heterogeneous disorders. Pathophysiologic mechanisms that account for these disorders are presented, as well as guidance regarding identification and management. Continue reading >>

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  1. Courtney Schumacher

    Ketoacidosis

    Comas

    Medical Treatments

    Medical Conditions and Diseases


    Neuroscience

    Medicine and Healthcare



    Why does Ketoacidosis cause coma? How is it treated?




    1 Answer







    I’m assuming that you do know that ketoacidosis does not have to mean that you have high blood sugar. It means that you have a high level of ketones in your blood, which are usually by-products of your body trying to break down fatty acids for fuel it’s not getting from your food intake.
    It is usually treated with fluids, electrolytes, and insulin. It is much more common in those with type 1 diabetes then type 2, but it can still occur.

    You can look up more specific information on diabetes at the Mayo Clinic site.

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Islet Cell Dysfunction in Type 2 DM- Causes, consequences & Treatment

Ketosis- Causes And Consequences

1. KETOSIS- CAUSESAND 10/21/2012CONSEQUENCES Biochemistry For MedicsBiochemistry for Medicswww.namrata.co 1 2. Ketone Bodies• Ketone bodies can be regarded as water-soluble, transportable form of acetyl units. Fatty acids are released by 10/21/2012 adipose tissue and converted into acetyl units by the liver, which then exports them as ketone bodies.• Acetoacetate, D(-3) –hydroxy butyrate (Beta hydroxy Biochemistry For Medics butyrate), and acetone are often referred to as ketone bodies 2 3. KetogenesisKetogenesis takes place in liver using Acetyl co A as a substrate or a precursor molecule. 10/21/2012 Enzymes responsible for ketone body formation are associated mainly with the mitochondria Biochemistry For MedicsStepsTwo molecules of acetyl CoA condense to form acetoacetyl CoA. This reaction, which is catalyzed by thiolase, is the reverse of the thiolysis step in the oxidation of fatty acids. 3 4. Ketogenesis Acetoacetyl CoA then reacts with acetyl CoA and water to give 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) and 10/21/2012 CoASH. The reaction is catalyzed by HMG co A synthase. Biochemistry For Medics This enzyme is exclusively present in liver mitochondria Continue reading >>

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  1. manohman

    Why can't fat be converted into Glucose?

    So the reason cited is that beta oxidation/metabolism of fats leads to formation of acetyl coa, a 2 carbon molecule, and that because of that it cannot be converted back into glucose.
    Why exactly is that the case?
    If Glucogenic amino acids can be converted into citric acid cycle intermediates and then turn back into glucose via gluconeogensis, then why cant Fatty Acids which yield Acetyl Coa. Can't you just have Acetyl Coa enter the citric acid cycle and produce the same intermediates that the glucogenic amino acids creat?

  2. Czarcasm

    manohman said: ↑
    So the reason cited is that beta oxidation/metabolism of fats leads to formation of acetyl coa, a 2 carbon molecule, and that because of that it cannot be converted back into glucose.
    Why exactly is that the case?
    If Glucogenic amino acids can be converted into citric acid cycle intermediates and then turn back into glucose via gluconeogensis, then why cant Fatty Acids which yield Acetyl Coa. Can't you just have Acetyl Coa enter the citric acid cycle and produce the same intermediates that the glucogenic amino acids creat?
    Click to expand... Both glucose and fatty acids can be stored in the body as either glycogen for glucose (stored mainly in the liver or skeletal cells) or for FA's, as triacylglycerides (stored in adipose cells). We cannot store excess protein. It's either used to make other proteins, or flushed out of the body if in excess; that's generally the case but we try to make use of some of that energy instead of throwing it all away.
    When a person is deprived of nutrition for a period of time and glycogen stores are depleted, the body will immediately seek out alternative energy sources. Fats (stored for use) are the first priority over protein (which requires the breakdown of tissues such as muscle). We can mobilize these FA's to the liver and convert them to Acetyl-CoA to be used in the TCA cycle and generate much needed energy. On the contrary, when a person eats in excess (a fatty meal high in protein), it's more efficient to store fatty acids as TAG's over glycogen simply because glycogen is extremely hydrophilic and attracts excess water weight; fatty acids are largely stored anhydrously and so you essentially get more bang for your buck. This is evolutionary significant and why birds are able to stay light weight but fly for periods at a time, or why bears are able to hibernate for months at a time. Proteins on the other hand may be used anabolically to build up active tissues (such as when your working out those muscles), unless you live a sedentary lifestyle (less anabolism and therefore, less use of the proteins). As part of the excretion process, protein must be broken down to urea to avoid toxic ammonia and in doing so, the Liver can extract some of that usable energy for storage as glycogen.
    Also, it is worth noting that it is indeed possible to convert FA's to glucose but the pathway can be a little complex and so in terms of energy storage, is not very efficient. The process involves converting Acetyl-CoA to Acetone (transported out of mitochondria to cytosol) where it's converted to Pyruvate which can then be used in the Gluconeogenesis pathway to make Glucose and eventually stored as Glycogen. Have a look for yourself if your interested: http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002116.g003/originalimage (and this excludes the whole glycogenesis pathway, which hasn't even begun yet).
    TLDR: it's because proteins have no ability to be stored in the body, but we can convert them to glycogen for storage during the breakdown process for excretion. Also, in terms of energy, it's a more efficient process than converting FA's to glycogen for storage.

  3. soccerman93

    This is where biochem comes in handy. Czarcasm gives a really good in depth answer, but a simpler approach is to count carbons. The first step of gluconeogenesis(formation of glucose) requires pyruvate, a 3 carbon molecule. Acetyl Co-A is a 2 carbon molecule, and most animals lack the enzymes (malate synthase and isocitrate lyase) required to convert acetyl co-A into a 3 carbon molecule suitable for the gluconeogenesis pathway. The ketogenic pathway is not efficient, as czarcasm pointed out. While acetyl co-A can indeed be used to form citric acid intermediates, these intermediates will be used in forming ATP, not glucose. Fatty acid oxidation does not yield suitable amounts of pyruvate, which is required for gluconeogenesis. This is part of why losing weight is fairly difficult for those that are overweight, we can't efficiently directly convert fat to glucose, which we need a fairly constant supply of. Sorry, that got a little long-winded

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------- We Recommend This NATURAL TREATMENT. Learn more now - click here: http://thesweatcure.org ------- As featured on Rachel Ray, SweatBlock is the top recommended treatment for sweaty armpits, hands, palms, and feet. - They stand by their 100% Satisfaction Guarantee. --- http://uwebp.com/sweatblock ------- The most common reason I see is caused by a condition known as hyperhidrosis. This condition causes the nervous system to activate the bodys sweat glands more than necessary. Often times, this can occur even when there is no physical activity being committed that would raise ones body temperature. Those with hyperhidrosis often experience excessive sweating under the arms hands, back, groin, feet, and even the face. There are other conditions that could cause excessive sweating as a side effect, such as diabetes, gout, hyperthyroidism, or obesity. However, hyperhidrosis usually occurs in people who are healthy. Whatever the cause, it is important to note that profuse sweating can be treated naturally by addressing the root cause of the issue. A long term solution can only come from controlling the nutritional, hormonal, psychology, and environmental triggers in ones everyday

Causes Of Ketosis

What is ketosis and what are the main symptoms? Ketosis is a medical term related to the metabolism, which refers to the increased levels of ketone bodies in the blood. Ketones are used as energy by our body, and they are created when the stores of glycogen in the liver have been emptied, because then the body begins to burn fats instead of glucose, which means that it is the way in which body reacts to a crisis. This is why ketosis may be a very serious condition once the level of ketones in the blood is too high. When it comes to symptoms, they may last for a few days, or even a week sometimes, but the fact is that they will disappear once the body gets used to this new process, or once the process stops. The most common signs are tiredness, weakness, headache, constant feeling of thirst, metallic taste in the mouth and bad breath, nausea, dizziness and problems with sleeping. Causes of ketosis In the greatest majortity of the cases, ketosis is a result of inadequate diet, or more precisely, it is a result of low-carb diet. Very frequently, people who want to lose some weight experience the symptoms of ketosis, because if they introduce a low-carb diet, sooner or later their body Continue reading >>

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  1. NewdestinyX

    Is moderate Ketosis too much?

    Hey gang,
    For dieting reasons I've recently started an Atkins styled approach. It's modified in that I sorta blend Phase 1 and 2(which adds nuts and more dairy) with a little bit of 'potatoes' (from Phase 3). No grains at all no fruit juices at all. I stay under 30g of carbs a day without fail. In the first 5 days I'm down 6.5 lbs -- after having been on an extended plateau for 6 months caused by taking too much basal insulin AND by still allowing myself some grains in the form of Sugar Free treats from different companies.
    So this modified Atkins is working. Cool!. BUT I picked up Ketosis sticks the other day to verify whether or not I'm in full Ketosis (not to be confused with Ketoacidosis which is VERY bad for diabetics). I had heard on several forums that it's good to get yourself so the read out is between 'trace' to 'low' and that means you're where Atkins wants you for fat burning. But I was surprised to not that I'm in the MODERATE zone for sure -- with the color coding and at the 15 second mark after passing thru urine stream. Even on a very 'liberal' Atkins program that is not following it to a tee... I've achieved and agressive ketosis. That explains the nearly 1 pound of weight loss a day so far..
    My question is -- is 'moderate' on the read too TOO MUCH ketosis. Should I add back some carbs to slow that down? Am I endangering myself at all for the dreaded 'ketoacidosis' by being at this level of ketosis?
    Thanks for your input!

  2. jwags

    I think you are confusing ketoacidosis which is caused by very high bgs and dehydration, usually in Type 1's but can happen in Type 2's ( rarely). Usually bgs are quite high . When you are on a ketogenic diet you start to use fat for fuel ( energy). That is why you lose weight. Bein on a ketogenic diet does not lead to ketoacidosis. Go to Jenny's Low Carb Blog, she discusses all aspects of very low carb diet and what to expect
    www.phlaunt.com/lowcarb/

  3. furball64801

    When I was Atkins I never was concerned with it, felt the best in my life if only I have the determination again, you never know I might wake up and say this is the day.

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