What Is Lactic Acidosis

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Severe Lactic Acidosis Reversed By Thiamine Within 24 Hours

Severe lactic acidosis reversed by thiamine within 24 hours 1Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria Karin Amrein: [email protected] ; Werner Ribitsch: [email protected] ; Ronald Otto: [email protected] ; Harald C Worm: [email protected] ; Rudolf E Stauber: [email protected] This article has been cited by other articles in PMC. Thiamine is a water-soluble vitamin that plays a pivotal role in carbohydrate metabolism. In acute deficiency, pyruvate accumulates and is metabolized to lactate, and chronic deficiency may cause polyneuropathy and Wernicke encephalopathy. Classic symptoms include mental status change, ophthalmoplegia, and ataxia but are present in only a few patients [ 1 ]. Critically ill patients are prone to thiamine deficiency because of preexistent malnutrition, increased consumption in high-carbohydrate nutrition, and accelerated clearance in renal replacement. In retrospective [ 2 ] and prospective [ 3 , 4 ] studies, a substantial prevalence of thiamine deficiency has been described in both adult (10% to 20%) and pediatric (28%) patients. Thiamine deficiency may become Continue reading >>

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  1. elgrayso

    > Inexpensive and Accurate Ketone Testing?

    Any good tech devices for accurate readings?
    Last year I experimented with ketosis for a month and a half, but I took daily blood readings (precision xtra) to learn what was working and what wasn't. It seemed that to do it properly I needed to "test often", as Jimmy Moore puts it.
    However it was several dollars per strip, even when getting a good deal on ebay. I think for a month of testing it was around $100!
    I read about new technologies that were coming out, such as breathalyzers and things that were growing in popularity. I would love to throw down $100 on a device and be able to use it as much as I wanted, as opposed to just for a month of strips. Are there any accurate inventions like this or are those expensive strips still basically the only option.
    PS: I tried the pee strips, they never reflected my ketosis even when my blood meter said I was highly ketogenic.

  2. GRB5111

    After investing in the Precision Xtra and paying ridiculous money for the test strips, I rarely test for ketones anymore, as I know when I'm in ketosis. Suggest you consider following Phinney and Volek's recommendations in "The Art and Science of Low Carbohydrate Living" to achieve ketosis. This is an excellent guide for how to achieve ketosis. It isn't hard, and there's really no reason to invest in expensive supplies that you'll likely not use for very long.

  3. teaser

    I used to defend ketostix, but I'm sort of drifting away from that. One study gave people fasting for weeks 7.5 grams of glucose. That knocked out their urine ketones, without at all lowering their blood ketones. The explanation given was that the glucose spared the kidneys from having to produce glucose from glutamine--that produces ammonia, and ketones would have to be spilled to keep the urine from being too alkaline.
    So you could do something that stops you from peeing ketones, without it affecting blood ketones. Or your liver could be just slightly better at gluconeogenesis than another person's--and again, your kidney doesn't have to make glucose, so again it's not producing excess ammonia, so ketones are reabsorbed instead of wasted. Or your muscles could be better at sparing glucose than somebody else's, and that puts less pressure on the kidneys to help out with glucose production...
    So breath ketones are probably more reliable.

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Lactate And Lactic Acidosis

The integrity and function of all cells depend on an adequate supply of oxygen. Severe acute illness is frequently associated with inadequate tissue perfusion and/or reduced amount of oxygen in blood (hypoxemia) leading to tissue hypoxia. If not reversed, tissue hypoxia can rapidly progress to multiorgan failure and death. For this reason a major imperative of critical care is to monitor tissue oxygenation so that timely intervention directed at restoring an adequate supply of oxygen can be implemented. Measurement of blood lactate concentration has traditionally been used to monitor tissue oxygenation, a utility based on the wisdom gleaned over 50 years ago that cells deprived of adequate oxygen produce excessive quantities of lactate. The real-time monitoring of blood lactate concentration necessary in a critical care setting was only made possible by the development of electrode-based lactate biosensors around a decade ago. These biosensors are now incorporated into modern blood gas analyzers and other point-of-care analytical instruments, allowing lactate measurement by non-laboratory staff on a drop (100 L) of blood within a minute or two. Whilst blood lactate concentration i Continue reading >>

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  1. Meggilizz

    Maybe THIS is why I'm two weeks late!! The fat burning & estrogen crap. (not PG, Dr did 2 blood tests)
    (sorry for threadjack?)

  2. TheUnrulyHound

    Evita, I have the stress thing too I am much more relieved to come back tonight and see a few others that have had similar experiences.
    Fragileknees, I REALLY want an IUD and looked into getting one last year but kinda let it slide on my list of things to do (oh yea cause you know its so fun) I really do not want more kids.
    This was evidently just an overnight phenomenon, I have not spotted all day so hopefully that will be it
    Thanks again everyone

  3. Kara

    Since nobody mentioned this: the 'period' you get on birth control is not a period. It is anaovulatory spotting--which basically means bleeding without ovulating. It's not a real period and it is not an indication that you aren't pregnant (although, since you are on BC, the chances that you would be pregnant are really, really slim). So to compare a BC cycle with a menstrual cycle is not really the same thing at all.
    Basically, when they designed the BC pill, they found out women were freaked out if they didn't have a period, so they created withdrawal bleeding. Basically, BC fakes your body out to make it seem pregnant--making the hormone levels trick your body into thinking that and therefore preventing ovulation from taking place. Then after 21 days of that, you take 7 days of sugar pills, which isn't enough time to ovulate, but enough time to drop your hormone levels and make your body bleed. So, really, having your period while on BC isn't really an indication of hormone levels.
    You can however, experience spotting while on BC midcycle. That is actually fairly common. BUT...it can also be an indication that your BC isn't working. For instance, if you took medication, such as antibiotics that interacted with your BC, you could start having midcycle spotting. Or, if you missed a few days of pills, it could make you start bleeding since the BC isn't working.
    So, it's definitely worth calling your doctor just to make sure your BC is still working. But, like I said, midcycle spotting while on BC is actually fairly common and is one of the side effects. But, the PB diet could also be changing your hormone levels. I'm not sure that would stop your BC from working, but it's worth asking about.
    Hope that helps!

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Lactic Acidosis: Symptoms, Causes, And Treatment

Lactic acidosis occurs when the body produces too much lactic acid and cannot metabolize it quickly enough. The condition can be a medical emergency. The onset of lactic acidosis might be rapid and occur within minutes or hours, or gradual, happening over a period of days. The best way to treat lactic acidosis is to find out what has caused it. Untreated lactic acidosis can result in severe and life-threatening complications. In some instances, these can escalate rapidly. It is not necessarily a medical emergency when caused by over-exercising. The prognosis for lactic acidosis will depend on its underlying cause. A blood test is used to diagnose the condition. Lactic acidosis symptoms that may indicate a medical emergency include a rapid heart rate and disorientaiton. Typically, symptoms of lactic acidosis do not stand out as distinct on their own but can be indicative of a variety of health issues. However, some symptoms known to occur in lactic acidosis indicate a medical emergency. Lactic acidosis can occur in people whose kidneys are unable to get rid of excess acid. Even when not related to just a kidney condition, some people's bodies make too much lactic acid and are unabl Continue reading >>

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  1. dunnohowtospell


  2. kickingpigeon

    I had a housemate who insisted on feeding her cat home made, vegetarian cat food. No health reason, just because she was veggie and objected to the cat eating meat. I snuck the poor thing real meat and cat food when she was out.

  3. RobotPigOverlord

    I'm a vegetarian but i would never do that to a pet. Doing that is a sign of idiocy and/or some sort of mental defectiveness.

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