Being Fat Adapted Versus "in Ketosis" (pt.1/3)
UPDATE!! (9/20/2017) I have a new post that explains how and why the body produces ketones, It will help you understand much better the difference between burning fat and having a fat-based metabolism, versus being "in ketosis." It's very long, but I think it's worth reading if you'd really like to understand this -- and if you want to stop freaking out about your ketone levels. (If you click over to that post and want to read only the section that explains the difference between ketosis and running on fat, scroll way down to where it says Ketogenesis: How and Why Do We Make Ketones? Also: Fat Adaptation versus Ketosis.) Happy reading! If I never hear or read those six words, in that order, ever again, I’ll be one happy individual. Based on what I come across on low-carb forums, blogs, and videos, there is a lot of confusion about the correct use of urine ketone test strips (which I’ll sometimes refer to as ketostix, since “ketone test strips” is a mouthful, even when you’re only reading). So allow me to ‘splain a little bit about how to interpret these things, and what role they should play—if any—in your low-carb life. First and foremost is the most important thing you will read in today’s post. (And it is so important that I will likely repeat it in all the posts to follow in this little series. Plus, you can tell it’s important because it’s red, bold, in italics, and all caps, hehheh.) You can be in ketosis and not lose body fat, and you can lose body fat without being in ketosis. Here is an exhaustive, comprehensive list of everything urine ketone test strips tell you: There is acetoacetate in your urine. That’s it. Nothing more. Nada más. Game over. Finito. The fat lady has sung, and Elvis has left the building. Your worth as a human being Continue reading >>
Comparing The Urine Ketone Strip Test And The Handheld Ketone Meter To Diagnose Ketosis In Early Lactation Dairy Cows1
Introduction Ketosis is a common metabolic disease in fresh dairy cows. Clinical and subclinical ketosis (SCK) can cause reduced milk yield, decreased milk protein, reduced reproductive capacity, and increased risk of displaced abomasum. Subclinical ketosis may be present in 30%–50% of early lactation cows in some herds (Divers and Peek 2008). Subclinical ketosis in dairy cattle is defined as an excess level of circulating ketone bodies in the absence of the clinical signs of ketosis (Andersson 1988). Ketosis occurs in early lactation because of the drop in blood glucose levels, which leads to a high degree of fatty acids mobilization in the form of nonesterified fatty acids (NEFA). The NEFA are then oxidized by the liver, leading to ketone body production, namely acetone, acetoacetate, and ß-Hydroxybutyrate (BHBA). Treatment for clinical ketosis or SCK is aimed at restoring glucose levels by administration of glucose i.v., glucocorticoids i.v., and propylene glycol orally or combinations. Usually, diagnosing ketosis is performed by measuring acetoacetate or BHBA levels in the blood, urine, or milk samples. The threshold for BHBA levels in the blood or urine samples to classify cows as having SCK ranges from ≥ 1.0 millimoles/liter (Ospina et al. 2010) to ≥ 1.4 mmol/L (Duffield et al. 2009), with most using ≥ 1.2 mmol/L (McArt et al. 2011; Oetzel 2004). Cows are classified as having clinical ketosis if BHBA concentration is ≥ 3.0 mmol/L (McArt et al. 2011; Oetzel 2004). Converting the BHBA measurement from mmol/L to mg/dL is done by multiplying the measurement in mmol/L by 10 (10.4 to be precise; American Medical Association 2004). Measuring BHBA in serum or plasma is considered the gold standard diagnostic test for subclinical ketosis, because this method has Continue reading >>
Is There A Dark Side Of Ketosis?
I can’t remember what appetizer she pointed to, but the woman sitting to the left of me said this so casually, and several folks at the table knew exactly what she meant, confirming what I’d long suspected: Ketogenic diets have officially gone mainstream – or recognizable at a party mainstream at least – in 2017. Let’s back up and demystify ketosis, which simply means you’re utilizing ketone bodies – more commonly called ketones – rather than glucose as your body’s primary fuel. Just like your car uses gasoline, your body needs fuel. That usually means glucose. But let’s say you’re on a very-low carbohydrate, higher-fat diet. Your body doesn’t get a lot of glucose, which primarily comes from carbohydrate and to a lesser degree protein. That means your liver’s backup glucose (glycogen) also becomes in short supply. Unlike your car, your body doesn’t just shut down. Thankfully, you have an alternative fuel source called ketones. Ketones are organic compounds your liver always makes. You’re cranking out ketones right now as you read this. During starvation or (more likely) when you restrict carbohydrate and increase fat intake, your body uses ketones as its primary fuel. In other words, when your body doesn’t receive or can’t make enough glucose, it shifts to this alternative fuel. Almost every organ can utilize ketones except for your red blood cells (which don’t have ketone-metabolizing mitochondria) and liver. Your liver, in fact, does the heavy lifting. This hardworking organ metabolizes fat into three ketone bodies: acetoacetate (ACA), beta-hydroxybutyrate (BHB), and acetone.(1) BHB is the first substrate that kicks ketosis into action. Among its benefits, BHB reduces chronic inflammation and restores healthy inflammation levels. In Continue reading >>
Is Ketosis Dangerous?
Duck Dodgers October 14, 2014 Peter, An article by Per Wikholm was published in this month’s LCHF Magasinet, where Per demonstrates that the Inuit could not have been in ketosis given that the scientific literature is abundantly clear, over and over again, that the Inuit consumed too much protein, and more importantly, Per debunks Stefansson’s claims for high fat with writing from his own books—Stef admitted in the pemmican recipes that Arctic caribou was too lean to make pemmican that supported ketosis. The most popular LCHF bloggers in Sweden, Andreas Eenfeldt/Diet Doctor and Annika Dahlquist have reluctantly agreed with Per’s findings—admitting that the Inuit were likely not ketogenic from their diet. I’ve put together a comprehensive review of the scientific literature regarding the Inuit, encompassing over two dozen studies, spanning 150 years, with references from explorers, including Stefansson. In the comments section of that post, Per gives a brief overview of how he was able to prove Stefansson’s observations on high fat intake were flawed. The post is a review of all the available literature that I could find (over two dozen studies). But, the literature certainly does not in any way support ketosis from the Inuit diet due to such high protein consumption. As Per (and Stefansson) points out, the caribou is too lean and as the many quotes show, the Inuit were saving their blubber and fat for the long dark Winter to power their oil lamps and heat their igloos. Again and again, we see that in the literature, as even Stefansson admits this. As far as glycogen is concerned, their glycogen intake is probably not worth scrutinizing given the well-documented high protein consumption in every published study. It really is besides the point. But, interest Continue reading >>
Ketosis: Symptoms, Signs & More
Every cell in your body needs energy to survive. Most of the time, you create energy from the sugar (glucose) in your bloodstream. Insulin helps regulate glucose levels in the blood and stimulate the absorption of glucose by the cells in your body. If you don’t have enough glucose or insufficient insulin to get the job done, your body will break down fat instead for energy. This supply of fat is an alternative energy source that keeps you from starvation. When you break down fat, you produce a compound called a ketone body. This process is called ketosis. Insulin is required by your cells in order to use the glucose in your blood, but ketones do not require insulin. The ketones that don’t get used for energy pass through your kidneys and out through your urine. Ketosis is most likely to occur in people who have diabetes, a condition in which the body produces little or no insulin. Ketosis and Ketoacidosis: What You Need To Know Ketosis simply means that your body is producing ketone bodies. You’re burning fat instead of glucose. Ketosis isn’t necessarily harmful to your health. If you don’t have diabetes and you maintain a healthy diet, it’s unlikely to be a problem. While ketosis itself isn’t particularly dangerous, it’s definitely something to keep an eye on, especially if you have diabetes. Ketosis can be a precursor to ketoacidosis, also known as diabetic ketoacidosis. Ketoacidosis is a condition in which you have both high glucose and high ketone levels. Having ketoacidosis results in your blood becoming too acidic. It’s more common for those with type 1 diabetes rather than type 2. Once symptoms of ketoacidosis begin, they can escalate very quickly. Symptoms include: breath that smells fruity or like nail polish or nail polish remover rapid breat Continue reading >>
Ketosis & Ketone Test Strips
Discuss this article! By Doreen EVERYTHING YOU'VE EVER WANTED TO KNOW ABOUT KETOSIS ... 1. What are ketones? 2. How will ketosis help me to lose weight? 3. But, isn't ketosis dangerous? 4. How do the ketone test strips work, and where do I get them? 5. I'm following Induction strictly; why won't my strips turn purple? 6. Will I lose weight faster if the strips show dark purple all the time? 7. Does caffeine affect ketosis? 8. Will drinking alcohol affect ketosis? What are ketones? Ketones are a normal and efficient source of fuel and energy for the human body. They are produced by the liver from fatty acids, which result from the breakdown of body fat in response to the absence of glucose/sugar. In a ketogenic diet, such as Atkins ... or diets used for treating epilepsy in children, the tiny amounts of glucose required for some select functions can be met by consuming a minimum amount of carbs - or can be manufactured in the liver from PROTEIN. When your body is producing ketones, and using them for fuel, this is called "ketosis". How will ketosis help me to lose weight? Most reducing diets restrict calorie intake, so you lose weight but some of that is fat and some of it is lean muscle tissue as well. Less muscle means slowed metabolism, which makes losing weight more difficult and gaining it back all too easy. Ketosis will help you to lose FAT. Being in ketosis means that your body's primary source of energy is fat (in the form of ketones). When you consume adequate protein as well, there's no need for the body to break down its muscle tissue. Ketosis also tends to accelerate fat loss --- once the liver converts fat to ketones, it can't be converted back to fat, and so is excreted. But, isn't ketosis dangerous? Being in ketosis by following a low carbohydrate diet is Continue reading >>
Why Is Ketosis Is Important For Our Bodies
A lot of people are confused by the term "ketosis." You may read that it is a "dangerous state" for the body, and it does sound abnormal to be "in ketosis." But ketosis merely means that our bodies are using fat for energy. How Ketones Are Made in Our Bodies Ketones (also called ketone bodies) are molecules generated during fat metabolism, whether they are from the fat in the guacamole you just ate or fat you were carrying around your middle. When our bodies are breaking down fat for energy, most of it gets converted more or less directly to ATP. (Remember high school biology? This is the "energy molecule.") But ketones are also produced as part of the process. When people eat less carbohydrate, their bodies turn to fat for energy, so it makes sense that more ketones are generated. Some of those ketones (acetoacetate and ß-hydroxybutyrate) are used for energy; the heart muscle and kidneys, for example, prefer ketones to glucose. Most cells, including the brain cells, are able to use ketones for at least part of their energy. But there is one type of ketone molecule, called acetone, that cannot be used and is excreted as waste, mostly in the urine and breath (sometimes causing a distinct breath odor). If enough acetone is in your urine, it can be detected using a dipstick commonly called by the brand name Ketostix (though there are other brands, they are still often called Ketostix). Even though everyone is generating ketones continuously, this detection in the urine is what is commonly called "ketosis." (Less commonly but more accurately blood ketones can also be measured). The higher the concentration of ketones in the urine, the more purple the sticks will turn. The Atkins Diet, in particular, advises people to monitor ketosis as an indication of fat burning. Other r Continue reading >>
Fellow Low-carbs, How Yellow Is Your Urine?
I'm in Ketosis constantly and I notice that my urine, especially in the morning, is SUPER deep yellow. Like multivitamin-runoff yellow. I hydrate myself at the watering hole (my kitchen) in the morning. I try to sip water or ginger tea throughout the day. Since ketosis is obviously dehydrating (lose all that water weight), I replace lost water by drinking regular filtered water with a pinch of sea salt (my own version of Gatorade) or coconut water. But for the most part, when in ketosis, my pee never really gets as watered down as when I'm not in glycolysis. Continue reading >>
Idiots' Guide to The Biochemistry and Management of Ketosis Ketosis is a disease of dry cows that shows up in fresh cows. Fundamentally, we have a situation where the cow is mobilizing body fat (condition) faster than the liver is able to metabolize it. In order for the liver to normally metabolize that fat, glucose is required. If glucose availability is limited due to inadequate substrate (mostly propionate from the diet) or glucose production via gluconeogenesis is inadequate or impaired, then ketosis can result because of the inability to convert the fat to energy. Loss/mobilization of body fat is a normal part of the onset of lactation. As the rate of fat mobilization rises, circulating NEFA levels begin to rise. If these fatty acids reach the liver and begin to accumulate in significant amounts, the liver switches away from TCA towards ketogenesis in an attempt to provide more energy and eliminate the fat buildup. Ketogenesis produces the ketone bodies, acetoacetate and beta-hydroxybutyrate. Some ketone production is normal in all periparturient cows, so diagnosis is made on clinical history, physical examination, and the presence of significant ketones in milk or urine. Presence of ketones in milk or urine is inadequate, in and or itself, to make the diagnosis of clinical ketosis. Feed intake, or lack thereof, is a critical component in the onset of ketosis. In all cows, dry matter intake begins to decline approximately one month prior to calving, although many people will not notice this decline until several days prior to calving. as feed intake declines and galactopoeisis begins, body fats are mobilized, resulting in an increase in circulationg NEFA levels. NEFAs themselves are mild appetite suppressants, so they continue to hamper feed intake. NEFAs are also Continue reading >>
The Signs Of Ketosis On Atkins Diets
The Atkins diet, first published in 1972 and reinvented 20 years later, has helped countless people lose weight, but isn't without controversy. The diet severely limits your intake of carbohydrates -- found in sugar, bread, pasta, most fruits, starchy vegetables and many processed snacks -- to encourage your body to lose fat. Often, this pushes you into a state of ketosis, a process that occurs when you burn fat for fuel. Video of the Day Ketosis isn't inherently harmful, but in some cases can lead to a build up of the ketone bodies, causing dehydration and changes in your blood chemistry. Though a blood test is the most accurate way to determine if you're in ketosis, certain other physical changes provide clues that you're in this state. Ketosis and the Atkins Diet Your body usually uses glucose, derived from carbohydrates, for energy -- particularly to fuel the brain. Ketones are produced when you're short on carbohydrates and must burn fat for fuel. When you produce ketones for energy, you are in ketosis. Phase One, or the "Induction Phase," of Atkins will likely cause you to produce ketones. During these first two weeks, you consume no more than 20 grams of carbohydrates per day. This represents a significant restriction in carbohydrates -- the Institute of Medicine recommends you eat 45 to 65 percent of your daily calories from carbs, or 225 to 325 grams daily on a standard 2,000-calorie diet. To meet your low-carb limit, the Atkins diet has you subsist primarily on meats, fish, poultry, eggs, oils, some cheese and watery, fibrous vegetables with few carbohydrates, such as lettuce and cucumbers. Breath and Urine Signs of Ketosis Ketones are burned for energy, but also breathed out through the lungs and excreted in the urine. As a result, your breath takes on a frui Continue reading >>
Ketosis And The Hcg Diet
Ketosis The HCG diet is a ketogenic diet, meaning that it brings the body into a state where it burns fat in order to supply its energy needs. Ketones are used by the muscles, the brain and other parts of the body as energy, and they are derived from fat when fat is metabolized. When carbohydrate levels are low, the body must break down fat stores to provide sufficient energy. Carbohydrates are converted the most easily into energy by the body, and when we eat excess carbohydrates they are stored as fat. When dietary carbohydrate levels are low, such as with the HCG diet or low carb diets like the Atkins diet, fat is metabolized for energy. When the body is in ketosis it is constantly burning fat for energy and any diet with a net consumption of less than 100 grams of carbohydrates per day is considered to be ketogenic. The HCG diet usually results in a metabolic state of ketosis The HCG diet has about 60 to 80 grams of carbohydrates per day on average, and as a result it causes the body to enter into a state of ketosis. Ketosis will begin during the first week of the HCG diet, and you can test for ketosis by using urine strips that can be purchased at a local pharmacy. The strips test for ketones in the urine, but testing for ketosis is not necessary as a part of the diet. The strips also show the quantity of ketones in the urine, but the level of ketones in the urine are not considered to be a good indicator of the level of ketosis, so this can mostly be ignored unless otherwise advised by a medical professional. Ketosis is not harmful for the body Some people think that ketosis is somehow dangerous or bad for the body because of some misconceptions about ketogenic diets. The truth is that ketogenic diets have been used for several decades without major medical proble Continue reading >>
Is There A Best Way To Monitor Ketosis?
Ketosis is underrecognized on most farms and is associated with several clinical diseases, lost milk, breeding problems, and greater risk of early culling. You should test cows for ketosis for three main reasons: 1. It helps you diagnose and treat clinically sick cows. 2. You can monitor and identify changes in transition cow performance earlier. 3. You can establish the basis for herd investigations. Herd investigation and diagnosing and treating of sick cows are good reasons for testing and can be considered reactive approaches . . . you identify a problem and employ a ketone testing strategy as a diagnostic tool. Monitoring herd performance is a proactive approach. The idea is to track herd data over time so you can identify herd problems earlier than you might have using a reactive approach. Ketone tests Excess ketone production occurs in the liver in response to excess fat mobilization. The circulating ketones are acetone, acetoacetate, and beta-hydroxybutyrate (BHBA). They are found in all body fluids including urine, blood, and milk. The predominant ketone in cows is BHBA. The gold standard for ketone testing is considered to be laboratory measurement of BHBA. However, taking a blood sample, shipping it to a lab, and then waiting for the results is costly and inconvenient. Fortunately, there are cowside tests for milk, urine, and blood tests. Milk tests. Milk ketone tests such as Ketocheck measure acetone and acetoacetate. These tests are very insensitive, but, when they are positive, they almost always are correct. Unfortunately, their poor sensitivity makes them essentially useless in ketone testing programs. The only useful milk ketone test is the Keto-Test. This test measures milk beta-hydroxybutyrate and is very easy to use. In a monitoring program, a cow th Continue reading >>
Breath Acetone Is A Reliable Indicator Of Ketosis In Adults Consuming Ketogenic Meals1,2,3
Abstract Background: Ketogenic diets are used therapeutically to treat intractable seizures. Clinically, it appears that the maintenance of ketosis is crucial to the efficacy of the diet in ameliorating seizures. To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed. Objective: The objective was to determine which index, breath acetone or urinary acetoacetate, is more strongly related to the plasma ketones acetoacetate and β-hydroxybutyrate. Design: After fasting overnight for 12 h, 12 healthy adults consumed 4 ketogenic meals over 12 h. Blood, breath, and urine samples were collected hourly. Blood was analyzed for plasma acetoacetate and β-hydroxybutyrate, breath for acetone, and urine for acetoacetate. Results: By the end of the 12-h dietary treatment, plasma acetoacetate, plasma β-hydroxybutyrate, and breath acetone had increased 3.5-fold, whereas urinary acetoacetate increased 13-fold when measured enzymatically and 25-fold when measured with urinary ketone dipsticks. Plasma acetoacetate was best predicted by breath acetone (R2 = 0.70, P < 0.0001). Plasma β-hydroxybutyrate was equally predicted by breath acetone and urinary acetoacetate (R2 = 0.54, P = 0.0040). Conclusions: Breath acetone is as good a predictor of ketosis as is urinary acetoacetate. Breath acetone analysis is noninvasive and can be performed frequently with minimal discomfort to patients. As an indicator of ketosis in epilepsy patients consuming a ketogenic diet, breath acetone may be useful for understanding the mechanism of the diet, elucidating the importance of ketosis in seizure protection, and ultimately, enhancing the efficacy of the diet by improving patient monitoring. I Continue reading >>
Urine Ketones - Meanings And False Positives
Professional Reference articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use. You may find the Urine Ketones article more useful, or one of our other health articles. Description Ketones are produced normally by the liver as part of fatty acid metabolism. In normal states these ketones will be completely metabolised so that very few, if any at all, will appear in the urine. If for any reason the body cannot get enough glucose for energy it will switch to using body fats, resulting in an increase in ketone production making them detectable in the blood and urine. How to test for ketones The urine test for ketones is performed using test strips available on prescription. Strips dedicated to ketone testing in the UK include: GlucoRx KetoRx Sticks 2GK® Ketostix® Mission® Ketone Testing should be performed according to manufacturers' instructions. The sample should be fresh and uncontaminated. Usually the result will be expressed as negative or positive (graded 1 to 4). Ketonuria is different from ketonaemia (ie presence of ketones in the blood) and often ketonuria does not indicate clinically significant ketonaemia. Depending on the testing strips used, urine testing for ketones either has an excellent sensitivity with a low specificity, or a poor sensitivity with a good specificity. However, this should be viewed in the context of uncertainty of the biochemical level of significant ketosis. Interpretation of results Normally only small amounts of ketones are excreted daily in the urine (3-15 mg). High or increased values may be found in: Poorly controlled diabetes. Starvation: Prolonged vomiting. Rapid weight loss. Frequent strenuous exercise. Poisoning (eg, with isop Continue reading >>
3 Best Ways To Measure Ketones For Your Ketogenic Diet (review & Buyers Guide)
How do you get accurate readings of ketones? Which methods actually work? These are common questions I going to help you with in this article. Anyone interested in using the latest nutritional research to improve their health has likely heard of a ketogenic diet. Ketogenic diets are a simple way to get your metabolism to prioritize the consumption of fatty acids, also known as ketones, when at rest or exercising. While there is a wide body of research that confirms the benefits of this type of nutritional plan, for the average user at home – one big question remains. How can you measure ketone levels to ensure your body is reaching a perfect state of ketosis? Without an accurate method of ketosis measurement, you will never achieve an optimized LCHF or ketogenic diet. However, it has not always been easy to measure your level of ketosis at home. At least this concern is now a thing of the past, because there are many ways to measure ketone levels easily and accurately in the comfort of your own home. Find out the very best method to test your level of nutritional ketosis that strikes the perfect balance of ease, price and quality. Before getting too deep into the different methods for measuring ketosis, it is important to first look at exactly why measuring them is so important and to clarify some of the more complex scientific terms. Ketone Testing Terminology If you have decided to try a ketogenic diet to achieve nutritional ketosis, then finding an accurate way to measure your ketone levels is important. You need to be able to maintain yourself in the optimal zone where fat is used as energy rather than glucose. Too little ketone and you will not see any positive effects. But higher levels give no real benefit and could indicate a serious problem with your diet. Li Continue reading >>
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