Ketosis Treatment In Lactating Dairy Cattle
... Cows experiencing Type I ketosis have low blood concentrations of glucose (< 2.5 mmol/L) despite high rates of gluconeogenesis and require a different treatment than those experiencing Type II ketosis with higher blood glucose concentrations and insulin resistance (Herdt, 2000). In this regard,Gordon et al. (2013)reviewed common treatments for ketosis and recommended that when ketosis occurs concurrently with hypoglycemia to treat with dextrose immediately, followed by an additional treatment, such as propylene glycol, for longer-term effects. WhenLi et al. (2012)conducted a study on ketotic cows they were able to identify cows with sub-clinical BHBA levels (mean = 1.98 ± 0.9 mmol/L) with clinical signs of ketosis due to selection of cows that were also hypoglycemic (mean glucose concentration = 2.05 ± 0.29 mmol/L). ... Continue reading >>
Subclinical Ketosis In Dairy Cows.
Abstract Subclinical ketosis is defined as a preclinical stage of ketosis. The peak prevalence of subclinical ketosis occurs during the fourth week of lactation. Herd-related factors, breed, parity, and season are other important determinants. Subclinical ketosis can be revealed by determining levels of plasma glucose, plasma NEFA and blood, and milk or urine ketone body concentration. There are theoretical and practical advantages of using milk ketone bodies. Most authors are agreed on approximate lower and upper borderlines for subclinical ketosis. The risk of an outbreak of clinical symptoms has been evaluated by some authors. Most authors have found significant negative relationships between energy balance and ketone body concentration. Some disagreement may be attributable to the fact that the diets used in different experiments can have different glucogenic potential, even if the energy content is the same. This affects the relationship between energy balance and ketone body concentration, as the ketone body level is influenced by both the energy balance and plasma glucose. Feeding silage with high butyric acid content increases the risk of subclinical ketosis. There are indications that cows with the highest milk yield directly after calving are at greatest risk for developing ketosis. Increased ketone body level secondarily reduces milk production, a decrease that has been quantified by some authors. Subclinical ketosis causes delayed reproductive functions return to normal after calving, increased intervals from calving to first and last service, and an increased frequency of ovarian cysts. The routine determination of milk acetone levels in control programs can be used to evaluate the status of individual cows, to indicate the energy feeding in early lactation Continue reading >>
Ketotic Cows: Treatment And Prognosis (proceedings)
12Next An absolute requirement for treating ketosis in cattle is to identify and treat the primary cause for the negative energy balance. Symptomatic treatment for ketosis without attacking the primary cause is doomed to failure. Propylene glycol is a routine treatment for ketosis. Only 2 oral formulations are approved for use in cattle as a treatment and the dose rate is 8 oz, q 12 h, for up to 10 days (2 other formulations labeled for use as preventive treatment). Research suggests that 296 ml once/day as on oral drench is just as effective as 887 ml once/day. Propylene glycol is absorbed from the rumen as propylene glycol, some propylene glycol is metabolized to propionate in the rumen, but most is absorbed intact and metabolized to glucose in liver. Propylene glycol increases serum [glucose], decreases serum β-OH butyrate & NEFA concentrations but only if a functional liver as propylene glycol must be metabolized. Propylene glycol is only beneficial if rumen motility to aid mixing and absorption. Glycerol (same dose rate as propylene glycol) and sodium propionate (uncertain dose rate) also reported to be of use but are both considered inferior to propylene glycol. Sodium propionate may have palatability problems. Calcium propionate has been examined, but the evidence is not convincing that it is superior to propylene glycol, even though it also has calcium. Not very soluble, and large volumes need to be administered. 500 ml of 50% Dextrose IV is also a routine treatment (one time administration of 250 g). Numerous approved products for treating ketosis in cattle. A cow uses 50-70 g glucose/hour for maintenance and 200 g glucose/hour high production, from a total blood glucose pool <40 g. Milk is 4.5% lactose, 50 kg of milk contains 2.25 kg lactose (glucose and gala Continue reading >>
What Is The Difference Between Dairy Farming And Cattle Ranching?
Dairy farming is an operation that devotes itself to the production of milk products. The stock that is bred for the production of milk in our part of the country is the Holstein. Dairy farms here in Montana are a declining breed as the move to huge corporate farms continues to dominate the market. Cattle ranching on the other hand is alive and well and run much the same as it was a hundred years ago. The production of meat for the tables of the world is the object behind cattle ranching and the primary breeds are Hereford and Angus and are often cross bred as we do here on our ranch. Cattle ranchers normally sell their spring calves to feed lots in late fall, which after fattening sell that stock to slaughter houses. The most common question I am asked is if there is a difference between Angus beef and others. My answer is that how they are fattened makes more of a difference than breed. Grass fed are the leanest and of course tougher in texture than others. My brother will not allow the steer he is going to eat touch any type of grain. My preference is 30 days on barley before slaughter. The most common feed for fattening is corn and most likely what you are eating was fattened with corn. You can thank the stupidity of subsidised ethanol for the outrageous price that you must pay for a good steak, as so much corn is used for the production of ethanol. The Walen Ranch, Lazy WF- and W connected C over bar brands. Continue reading >>
Preventive Strategies For Ketosis
Parturition and the onset of lactation challenges calcium and energy homeostasis in dairy cows predisposing them to periparturient disorders that affect health, production and reproductive performance says Carlos Risco, DVM, Dipl. ACT, University of Florida. Dairy cattle experience a negative carbohydrate balance, from -3 weeks and + 3 weeks from calving and are at risk to develop ketosis, Risco explained at the 2010 Western Veterinary Conference. Milk production, in particular, drives the high requirements for glucose because other fuels cannot substitute for lactose in milk. To counteract this, the cow mobilizes body fat and protein stores in the form of non-esterified fatty acids (NEFA) and amino acids. This promotes gluconeogenesis and occurs under the influence of low serum concentrations of insulin. Volatile fatty acids (acetate, propionate, butyrate [BHBA]) produced in the rumen are also presented to the liver as fuels. Acetate and butyrate are ketogenic, and propionate is glycogenic. The key to prevention of ketosis is to maximize dry matter intake before and after calving to prevent excessive NEFA mobilization. Preventing ketosis in the first place is key to avoid some post-partum issues. Risco outlined some preventive strategies: The transition ration. To prevent ketosis the transition ration should maximize DMI, provide adequate energy density, and minimize ketogenic precursors. Silage with a high butyric acid content should not be fed. Introduce ration changes gradually. Manage transition cows to maximize DMI, e.g., provide adequate bunk space. Avoid over-conditioning of cows in late lactation and the early dry period. Niacin (nicotinic acid) fed in transition rations at 6–12 g /d may help reduce blood ketone levels. Propylene glycol may be administered pr Continue reading >>
Ketosis In Dairy Cattle. A Review
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Research-article Ketosis In Dairy Cattle
First page preview Copyright © 1968 American Dairy Science Association. Published by Elsevier Inc. All rights reserved. View more articles Continue reading >>
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OIEGON sure tt.,. HIM .'"., OW. Coml. aad the U S. Cyan.. 1.4516),Nn Ketosis in Dairy Cows Prepared by D. E. ANDERSON and H. P. EWALT Extension Dairy Specialists, Oregon State University, Corvallis Ketosis, or acetonemia, might well be called a prob- lem of high production since prevention and control is more difficult with high milk production. Few animals are challenged to meet the metabolic demands that a high- producing dairy cow must adapt to during the early part of lactation. Common observations and experimental evidence show that cows may be in a negative balance for both protein and energy shortly after calving and for about the first 60 days of lactation. The following data on ketosis are taken from a summary of recent research published in the July 1968 issue of the Journal of Dairy Science. What Is Ketosis? Ketosis is a metabolic disorder in which something goes wrong with the normal body processes and the cow becomes sick. There are no inflammatory organisms involved and the condition is not contagious. There seems to be a situation where the cow is temporarily pro- ducing more milk and thus requiring more feed nutrients than her feed intake provides. Nature may attempt to correct this situation by using body reserves of fat. When this occurs, some intermediary products of fat metabolism, called "ketone bodies," may build up in the system. These can be detected in the milk and urine and are indications of how serious the condition may be. Ketosis may even develop in average-producing animals when the energy needs exceed the energy intake. Ketosis usually occurs more often in winter feed- ing, and three weeks after calving seems to be a very critical period for high-producing cows. Symptoms The first symptom of ketosis is a loss of appetite first for grain a Continue reading >>
Estimating The Economic Impact Of Subclinical Ketosis In Dairy Cattle Using A Dynamic Stochastic Simulation Model
Abstract The objective of this study was to estimate the economic impact of subclinical ketosis (SCK) in dairy cows. This metabolic disorder occurs in the period around calving and is associated with an increased risk of other diseases. Therefore, SCK affects farm productivity and profitability. Estimating the economic impact of SCK may make farmers more aware of this problem, and can improve their decision-making regarding interventions to reduce SCK. We developed a dynamic stochastic simulation model that enables estimating the economic impact of SCK and related diseases (i.e. mastitis, metritis, displaced abomasum, lameness and clinical ketosis) occurring during the first 30 days after calving. This model, which was applied to a typical Dutch dairy herd, groups cows according to their parity (1 to 5+), and simulates the dynamics of SCK and related diseases, and milk production per cow during one lactation. The economic impact of SCK and related diseases resulted from a reduced milk production, discarded milk, treatment costs, costs from a prolonged calving interval and removal (culling or dying) of cows. The total costs of SCK were €130 per case per year, with a range between €39 and €348 (5 to 95 percentiles). The total costs of SCK per case per year, moreover, increased from €83 per year in parity 1 to €175 in parity 3. Most cows with SCK, however, had SCK only (61%), and costs were €58 per case per year. Total costs of SCK per case per year resulted for 36% from a prolonged calving interval, 24% from reduced milk production, 19% from treatment, 14% from discarded milk and 6% from removal. Results of the sensitivity analysis showed that the disease incidence, removal risk, relations of SCK with other diseases and prices of milk resulted in a high variat Continue reading >>
What Is A Ketogenic Diet?
Alright, here’s what the ketogenic diet (often referred to as “keto”) is and the basics of how to follow it. What is the ketogenic diet? For those who don’t know the ketogenic diet is a low-carb, high fat diet (LCHF) with many health benefits. It involves drastically reducing carbohydrate intake, and replacing it with fat. The reduction in carbs puts your body into a metabolic state called ketosis. When this happens, your body becomes incredibly efficient at burning fat for energy. It also turns fat into ketones in the liver, which can supply energy for the brain. Benefits: Ketogenic diets generally cause massive reductions in blood sugar and insulin levels. This, along with the increased level of ketones provide the numerous cited health benefits. Ketogenic benefits include: Fighting diabetes Epilepsy control Alzheimer’s disease Certain cancers Cognitive performance High blood pressure control Satiety Weight/fat loss Reduced cholesterol levels The most obvious and commonly cited benefits is the decreased insulin levels. This is why fasting becomes a great solution to people’s type 2 diabetes, cushing’s disease and many other metabolic diseases. Fasting as well as the ketogenic diet increases insulin sensitivity, improves insulin resistance and allows your body to use the hormone insulin more effectively (which is important for fat loss). There are also four different classifications of the ketogenic diet. The standard ketogenic diet is accepted as reducing your carbohydrates intake to 5% carbs, with just enough protein (20%, let’s say) and the rest coming from fats. Inflammation is the root cause of so many of our ailments, which lower insulin levels decrease. Energy use: The basic principle around ketogenic diets is that our bodies first port of call f Continue reading >>
Ketosis In Cattle Symptoms And Treatments
Ketosis is a fairly common disease among adult cattle, although usually it occurs in dairy cattle.Ketosis typically occurs the first six weeks of parturition.It occurs in dairy cattle because of their inability to intake enough nutrients to meet their energy needs.This can lead to hypoglycemia which is a pathologic state produced by a lower than normal level of glucose.That in turn leads to the formation of ketone bodies from the body and fat stores. Although they are only broken down for energy to used by the heart and brain in the times of low glucose levels. Ketosis is not an immediate thing like many other illnesses, it gradually occurs. Some typical symptoms you will notice about your cattle if they have ketosis happen to be a decreased appetite,marked weight loss,decreased milk production,acetone odor of breath,nervousness, and hard, mucus covered feces. For confined cattle, usually decreased appetite is the first sign that they might have ketosis.Also if they are fed in components such as part forage, part grain, they will tend to go for the forage more than they will go for the grain.If you fed your cattle in herds, then usually you will see reduced milk production,lethargy and an somewhat “empty” appearing abdomen.When cattle are physically examined with having ketosis they may appear sightly dehydrated. Treatment for ketosis in cattle is more commonly done by IV administration of 500 ml of 50% dextrose solution. This treatment allows rapid recovery but the effects are often producing results beyond itself therefore relapses of ketosis are pretty common.Another treatment that can be used is the administration of glucocorticoids such as dexamethasone or isoflupredone acetate.You typically administer 5-20mg dose intra muscularly. This treatment often has good Continue reading >>
What Action Can Be Taken During Pre-calving To Reduce The Milk Fever In Dairy Cattle?
Good to see that you have understood the concept and need for the prevention of “milk fever” in dairy animals, prior to calving. Feeding regularly calcium through out life-time is the simplest and cheapest solution. Though the slaked lime water prepared from limestone is inorganic and hence its bio-availability is low, it is cheap and locally available and daily feeding of 20 - 50 ml of slaked lime water can do wonders. If the animal is a high yielder (above 15 litres per day) post calving, then that animal should be primed for calcium with intravenous injection four times at 15 days interval prior to calving, by a veterinarian. Please note that calcium intravenous injection is to be administered under the supervision of a veterinarian only, for it can result in heart seizure. Continue reading >>
Not to be confused with Ketoacidosis. Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides energy. Ketosis is a result of metabolizing fat to provide energy. Ketosis is a nutritional process characterised by serum concentrations of ketone bodies over 0.5 mM, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder. Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet (ketogenic diet), and deliberately induced ketosis serves as a medical intervention for various conditions, such as intractable epilepsy, and the various types of diabetes. In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is sometimes referred to as the body's "fat burning" mode. Ketosis and ketoacidosis are similar, but ketoacidosis is an acute life-threatening state requiring prompt medical intervention while ketosis can be physiological. However, there are situations (such as treatment-resistant Continue reading >>
Minimizing The Risk For Ketosis In Dairy Herds
En Español: Minimizando el Riesgo de Cetosis en el Ganado Lechero This article is part of our series of original articles on emerging featured topics. Please check here to see other articles in this series. Introduction Although most cases of ketosis occur in fresh dairy cows, feeding practices and cow health prepartum can predispose cows to experiencing ketosis after calving. Most cases of primary ketosis occur within the first 2 weeks of calving, and even most secondary ketosis (occurring after the onset of another disease) occurs within the first 30 to 60 days in milk. In general, less than 5% of the cows in a herd should experience clinical ketosis. However, some reports have indicated that the incidence of subclinical ketosis may affect 40% of cows, with the incidence rate varying widely among farms, and may be as high as 80% on individual farms. The major focus prepartum to reduce the risk for ketosis after calving is maintaining feed intake in late gestation and avoiding overconditioning cows during late lactation and the dry period. Cows should dry off and freshen at a body condition score (BCS) of 3.5. Cows with a BCS equal to or greater than 4.0 will likely have lower intake prepartum and be at higher risk for fatty liver and ketosis at and after calving. Recent work at the University of Minnesota indicates that cows with a BCS greater than 3.5 and producing over 16 lb of colostrum are at a higher risk for ketosis. Feeding programs for far-off and close-up cows should be designed to maintain intake during late gestation, i.e., minimizing the drop in intake during the last week of gestation, to reduce the risk for ketosis after calving. These prepartum diets should contain high-fiber forages and provide adequate but not excessive amounts of energy. A 20% or gr Continue reading >>
Fresh Cow Ketosis Tests Pay Back Big
A drop of blood is all that’s needed Editor’s note: This is the first of a six-part series on transition cow management that will run in 2015. When it comes to fresh cow health, an ounce of prevention can result in pounds more milk, fewer displaced abomasums (DAs) and less culling. All of it adds up to potentially thousands of dollars saved each year. And it all can be had with the use of a simple, easy-to-use blood test of cows in your fresh pen. Most dairy farmers, unless they routinely test for subclinical ketosis, are blissfully unaware of how prevalent the disease is in their herds. But work in New York and Wisconsin herds done by veterinarian researchers Jessica McArt, Cornell University, and Gary Oetzel, University of Wisconsin, suggest subclinical ketosis is challenging fresh cows through early transition. The study, done during the summer of 2010, involved 1,800 cows in four herds—two each in New York and Wisconsin. Nearly 45% of cows were subclincally ketotic during the first two weeks after calving. The good news is subclinical cows that were treated responded well, averaging 1.5 lb. more milk per day, had fewer DAs and were culled less frequently. For every 100 fresh cows tested twice between three and nine days in milk, the net economic return was roughly $1,200. What makes all this possible are easy-to-use test strips requiring just a drop of blood from the tail vein. A very small amount of blood is added to the end of the test strip and then read by a meter. The Cornell and Wisconsin vet-erinarians have found the Precision Xtra ketone meter from Abbott gives excellent results with no additional calibration needed from the human system. The meter measures whole blood beta-hydroxybutyrate (BHBA). A reading of 1.2 mmol/L or more indicates subclinical k Continue reading >>