What Is Intracellular Acidosis

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http://brs.li/BRSMagnesium Did you know that magnesium is the element that essentially makes reefing possible? Magnesium is used by corals for metabolic function to stay healthy and grow. However, since it's not largely or quickly consumed, it's pretty easy to maintain with infrequent additions of a supplement like magnesium chloride, or even just water changes. So, what's the magnesium doing in your tank? Let's back up a bit. If you caught our last two videos, you know that the corals in your tank are pulling both calcium and alkalinity (which we'll refer to as carbonate) from the surrounding water to support its overall health and growth. The problem is that the calcium and carbonate ions also have quite the affinity for each other, and will join in the tank to form calcium carbonate crystals. You might see the results of this as a white buildup on on your heaters and pumps, or even tiny particles settling in your sand bed. Here's where the magnesium comes in! The magnesium ions in the tank prevent the calcium carbonate crystals from growing by incorporating itself into the growing calcium carbonate crystal, which makes it unattractive to additional calcium and carbonate ions. Th

Species-specific Differences In Thermal Tolerance May Define Susceptibility To Intracellular Acidosis In Reef Corals.

Species-specific differences in thermal tolerance may define susceptibility to intracellular acidosis in reef corals. Gibbin, E. M.Putnam, H. M.Gates, R. D.Nitschke, M. R.Davy, S. K. It is widely acknowledged that temperature stress affects an organism's sensitivity to ocean acidification and vice versa, yet it is not clear how the two are mechanistically linked. Here, we induced thermal stress in two coral species with differing bleaching susceptibilities to measure how a reduction in photosynthetic performance impacts intracellular pH (pH(i)) regulation in the symbiotic dinoflagellates (Symbiodinium sp.) and their host coral cells. Our hypothesis was that thermally induced photosynthetic dysfunction in the symbiont would prevent the efficient removal of additional CO2, lowering its buffering capacity and thus increasing the host cell's susceptibility to intracellular acidosis. To test this, we exposed Pocillopora damicornis (a thermally sensitive coral) and Montipora capitata (a thermally resilient coral) to four different temperature treatments (23.8, 25.5, 28 and 31 A degrees C) for 1 week. We then isolated intact symbiotic coral endodermal cells, placed them in a live-cell ch Continue reading >>

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  1. Saraleesaralee

    Is it possible to stay on ketogenic diet for life-long?

    I have been on ketogenic diet for 2 weeks. It controls my blood sugar level really well. However I am not over weight. And I am worried about potential long term side effects of the diet. For example, high LDL level, steoporosis, auto immune disease, too much weight loss, vesicular stiffness. I was wondering if there is anyone in this forum has been on ketogenic diet for years? And do you experience any side effects from the diet?

  2. Aaron1963

    I've been on a strict ketogenic diet for 6 months, and was doing LCHF for much of the 5 months prior to that but didn't make any attempts at it being ketogenic so I may have been in and out of ketosis some during that period. I now have a blood ketone meter and remain in ketosis according to it.
    I did suffer excessive weight loss initially. I lost about 40kg (about 90 lbs.), and it ended up sending me from being very obese to being underweight. But I've always eaten very little protein, which I continued to do, plus I was doing intermittent fasting, sometimes not eating anything for days at a time. Once I stopped the intermittent fasting and concentrated on getting adequate protein, my weight went back up to my ideal weight and stabilized there. I've heard from several people that you really need to watch your protein when doing a ketogenic diet being it's easy for excess to hinder weight loss and/or increase your BG.
    I have had a few issues while doing a ketogenic diet, but not 100% sure which if any can be attributed to ketosis vs. some other factor. First off, as winter was approaching I got extremely cold all the time, especially my fingers and toes, but even my whole body was cold. I thought it might have been the caffeine I was getting as part of my ketogenic diet involves drinking lots of coffee with HWC, coconut oil, and butter. I switched to decaf and the problem pretty much went away, but I don't know if it was the caffeine, the ketosis, the massive weight loss (lack of body fat), something else, or a combination of factors.
    I've also had excessive itching and a rash. That's normal for me during the winter months, but this year it started a bit early, went longer, and was much worse than normal. I think it may very well have been my usual sensitivity to the cold dry weather, aggravated by toxins released during my rapid weight loss, and perhaps ketones being emitted through the skin. It's just recently started to clear up and the rash is gone and most of the itching.
    I got keto-breath for a week or two when I first concentrated on going keto. It was very noticeable, but disappeared after that and no issues anymore with my breath.
    This diet is very sustainable for me. I tried my whole adult life to diet to lose weight and was never successful. This time I wanted to lose weight, but my primary focus was controlling my BG, meaning reducing carbs down to a low-carb level, which caused me to gravitate naturally to a LCHF diet. For the first time I have no desire to go back to my old way of eating. I love this diet and it's completely satisfying. So I killed two birds with one stone - got my BG under control, down to non-diabetic levels, and got my weight down to ideal. Plus with the huge benefits (IMHO) of having my body use ketones rather than glucose, I'm totally sold on this way of eating for the rest of my life and have absolutely no worries about not being able to stick to my diet. I really have no strong urges for carbs anymore, and only end up going off the plan rarely due to social pressures or inadvertently eating hidden/unknown carbs.
    My LDL has gone up, but I've heard from others that usually it's benign large fluffy LDL that typically goes up when on a ketogenic diet. And my body is still adjusting. Also I've heard that LDL by itself is not a good measure of risk. So I'm not worried about it, but will keep an eye on things. I also have taken my ketogenic diet to an extreme, hitting a KR of 3.0 or higher almost everyday, and sometimes up to 4.0 or more. Not sure if eating much more fat than necessary for ketosis affected my LDL any or not. Initially my LDL dropped significantly as well as my trigs, but both increased at my last doctor's visit. I may try a more normal KR in the future while monitoring my blood ketones to verify I stay in ketosis and see if there's any difference in my BG, cholesterol, or other tests.
    I did also suffer from other typical symptoms during my keto adaptation phase. Most went away within about two weeks. But it's just been here at the 6-month mark where my BG numbers suddenly stabilized with very little change, and quite low, and overall I just feel absolutely fantastic. I feel like I'm bursting with energy and joined a gym and suddenly love running and working out whereas I hated them all my life.
    Well, I don't have years of experience with ketosis to report anything to you about that. Other than I've heard lots of other people with years of experience and not heard of anyone having any real side effects other than the things I've mentioned. However some people do find ketosis isn't for them and give up very soon. For those that feel it is working for them and stick with it, seems there's no significant side effects. But I'll let the others who've been in ketosis for longer than me speak for themselves.

  3. furball64801

    Hi and welcome to DD I know of a guy called no more carbs that was on it over 2 yrs. It is possible he is still on it, that chat site closed down but he was going strong on it.

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Royal Society Croonian Lecture given by Professor Frances Ashcroft FRS on 29 May 2013 Whether you eat a whole box of chocolates or fast for the day, the pancreatic beta-cells ensure that your blood glucose level remains relatively constant by regulating the release of insulin from the pancreatic beta-cells. Diabetes results when insulin release is inadequate and blood glucose levels chronically rise. This lecture will describe how a membrane protein pore known as the ATP-sensitive potassium (KATP) channel plays a vitally important role in regulating insulin secretion and show how mutations in KATP channel genes can cause neonatal diabetes, a rare genetic form of diabetes that develops soon after birth, and occasionally also developmental problems. It will also reveal how an understanding of KATP channel function has led to a new therapy for patients with neonatal diabetes. Frances Ashcroft is Professor of Physiology at the Department of Physiology, Anatomy and Genetics, University of Oxford. Professor Ashcroft's research focuses on ion channels and their role in insulin secretion. She was awarded the Croonian Lecture for outstanding work on the link between glucose metabolism and i

Direct Activation Of Cloned Katp Channels By Intracellular Acidosis*

From the Department of Biology, Georgia State University, Atlanta, Georgia 30302-4010 ATP-sensitive K+(KATP) channels may be regulated by protons in addition to ATP, phospholipids, and other nucleotides. Such regulation allows a control of cellular excitability in conditions when pH is low but ATP concentration is normal. However, whether the KATP changes its activity with pH alterations remains uncertain. In this study we showed that the reconstituted KATP was strongly activated during hypercapnia and intracellular acidosis using whole-cell recordings. Further characterizations in excised patches indicated that channel activity increased with a moderate drop in intracellular pH and decreased with strong acidification. The channel activation was produced by a direct action of protons on the Kir6 subunit and relied on a histidine residue that is conserved in all KATP. The inhibition appeared to be a result of channel rundown and was not seen in whole-cell recordings. The biphasic response may explain the contradictory pH sensitivity observed in cell-endogenous KATP in excised patches. Site-specific mutations of two residues showed that pH and ATP sensitivities were independent of e Continue reading >>

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  1. Mimi

    We've been seeing trace to low ketones since yesterday morning with Amanda - as low as .1 up to 1.3 on the ketone meter. BG has been okay, a few lows that came up with carbs. She wasn't able to keep anything down yesterday and I was thinking they were more starvation ketones. However, today she ate small amounts of food which I was able to cover and give extra insulin but we can't seem to get rid of the ketones completely. Just checked her and BG is 7.2, ketones 0.1.
    What do I need to do at this point?

  2. Lee

    We always have .1 on our ketone meter, even .2...this is nothing and counts as negative for ketones!
    According to the Abbot USer Guide:
    Blood ?-Ketone is expected to
    be lower than 0.6 mmol/L.3
    Blood ?-Ketone may be higher
    when a person is ill, is fasting,
    exercises vigorously, or if
    blood glucose levels are
    not controlled.

  3. ashley_lynden

    When we were dealing with Sloan's ketones a few weeks ago, the endo told us that it could take up to a week before the ketones were totally out of his body. It didn't take a week, but it was several days of low ketones before they were finally into the 0.2 or 0.3 range. Also, sometimes they would look like they were going down, just to rebound again despite nothing changing.

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Light-Activated Intracellular Acidosis killing cancer cells

Intracellular Acidosis: Can It Delay The Inevitable?

Citation:Moseley, Richard H. (1990)."Intracellular acidosis: Can it delay the inevitable?." Hepatology 11(4): 707-708. Continue reading >>

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  1. munkeesmama

    A little back history. I have always gained a ton in my pregnancies 50+ lbs. I've always started off at a "normal" pre-pregnancy weight, and the weight gain is gradual but consistent from the time I get a positive test. I've also in general had no real issue getitng back to pre-pregnancy weight within a few months.
    Well, this pregnancy I started off as overweight. I am 5'4" and weighed 204. When I found out I was pregnant, I cut WAY back on my soda intake (now i have just a few a week instead of like 6-8 cans a DAY), we also cut out ALOT of fast food and really only eat out once a week or so. I will be 18 weeks tomorrow and have lost a total of 14 lbs. At my last midwife appt. I had Ketones in my urine. (I know some of you don't believe in pee sticks during pregnancy, but that's another post of mine to make). Anyways, my midwife said that with the weight loss and the ketones in my urine that I'm burning too much fat and the ketones can be toxic to the baby and I NEED to gain weight and not spill ketones.
    I'm not really sure how to fix this though. I really think the weightloss is from ditching the soda, and eating better. I'm not dieting, I don't watch my calories, in fact, I'm not really excercising besides walking to the mailbox down the road, shopping, and running after my 3 kids. I am eating smaller more frequent meals, and nothing sounds good, but I wouldn't say i'm not eating enough.
    So, if I were your client, what would you have me do? Should I be worried? Or, could this be normal for somebody who was so overweight to begin with?

  2. dewi

    As a trained CB educator I would encourage you to seek guidance from a nutritionist. Especially since you feel you're eating a balanced diet (not just proteins), you need more guidance than the statement to "gain weight".
    It is not so easy for a very overweight women who is now eating healthier wholesome food to "gain weight" in pregnancy.
    Your calorie intake is probably now "normal" and that is making you loose weight as it should.
    An alternative if you cannot afford to see a nutritionist is to use a Weight Watchers meetings, they will give you the "pregnancy diet". It is great program. It's a 100% balanced nutrition and so much food to eat while you continue to loose or maintain your weight.
    This is a great supportive web site .

  3. munkeesmama

    I should also mention, that my midwife seems to be really "in the know" about nutrition and gave me some suggestions on food, how much protein, veggies, fruits, carbs, etc. I should be eating etc. I guess my question is moreso, is this normal for somebody who is overweight, and now eating better? How dangerous are the ketones to the baby? Is there a way to hep with the ketone issue besides "just gaining weight"?

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