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What Is Anion Gap Metabolic Acidosis?

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Metabolic Acidosis; Gap Positive

Metabolic acidosis is defined by low serum pH (less than 7.35-7.45) and low serum bicarbonate. It occurs by one of three major mechanisms: 1. Increased endogenous acid (i.e., lactic acidosis, diabetic ketoacidosis). 2. Decreased renal acid excretion (i.e., renal failure). In determining the underlying etiology for a metabolic acidosis, the serum anion gap must be calculated by subtracting the major measured anions (chloride and bicarbonate) from the major measured cation (sodium). If the result is greater than 12 meq/L (which is the normal value for most laboratories), the acidosis is said to be an anion gap acidosis. The expected anion gap should is lower in hypoalbuminemia and should be corrected - for each decrease of 1gm/dl in albumin, the normal anion gap should be decreased by approximately 2.5 meq/L. A. What is the differential diagnosis for this problem? Anion gap acidosis can be the result from: 1. A fall in unmeasured cations (as seen in hypomagnesemia or hypocalcemia). The most common reasons for a rise in anions are ingestions, lactic acidosis, ketoacidosis and renal failure. Ingestions of multiple different toxins can result in unmeasured anions causing a metabolic ga Continue reading >>

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Popular Questions

  1. LipstickLady

    My teeth look awesome because I brush 10-15 times a day. Listerine breath strips don't touch it. Neither gum nor mints help. I don't even want to be in public.
    Nothing is worse than catching a whiff of my own breath and wondering what died and then realizing it's my innards slowly rotting and wafting out of my mouth.
    How long does this rotting corpse smell last and what can I do?

  2. Bufflehead

    I don't know how long it lasts but I hear you. I'm glad I'm not seeing anyone right now because the only creature alive who could want to kiss me (and does) is my dog.

  3. Matthew

    Ketosis breath is typically "sweet" smelling.....similar to juicy fruit gum, oddly enough. If you truly have ketosis breath....eat some carbs, you really shouldn't be in ketosis if you're getting 20g of carbs a day. This isn't the Atkins diet we're doing here.
    However....I see you're recently sleeved and your body is going to be in upheaval..."Cleaning house" so to speak...it's common to have a bit more bacteria living in the oral region than usual causing some rank breath. Try a tongue brush and attempt to get waaaay back on your tongue without gagging yourself....you'd be amazed by how much gunk can live back there....also, a good mouthwash swish and gargle will help. This too shall pass...hang in there and best of luck.

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