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What Does Metabolic Acidosis Do To The Body?

Too Much Acid In The Body In Dogs

Too Much Acid In The Body In Dogs

Metabolic Acidosis in Dogs The lungs and kidneys help to maintain a delicate balance of acid and alkali in the blood, both normal components of a healthy blood supply. A condition of metabolic acidosis occurs when there is an increase in the levels of acid in the blood, which ultimately accumulates to abnormal levels in the body, causing various problems. This can occur due to loss of bicarbonate (alkali); acid production by increased metabolism; excess acid introduction into the body through an external source like ethylene glycol (resulting in ethylene toxicity); or by the kidney’s inability to excrete acid, which it normally does to maintain its level. Metabolic acidosis can occur in dogs of any age, size, gender, or breed. Symptoms and Types Symptoms can vary considerably, especially if your dog is concurrently suffering from other health problems like diabetes or kidney disease. The most common symptoms that you may notice in a dog that is suffering from metabolic acidosis include: Depression (especially if acidosis is severe) Confusion Causes Diagnosis You will need to give a thorough history of your dog's health, including a background history of symptoms, and possible incidents that might have precipitated this condition (such as suspected antifreeze ingestion, or use of aspirin to treat your dog). The history you provide may give your veterinarian clues as to which organs are causing secondary symptoms. Your veterinarian will then perform a thorough physical examination on your dog. For the diagnosis of metabolic acidosis, a compete blood chemical profile will be performed to check the levels of acid and alkali in the body. The next step is to find the underlying cause of the metabolic acidosis in order to treat that problem along with correcting the acid lev Continue reading >>

Metabolic Acidosis

Metabolic Acidosis

Metabolic acidosis is a condition that occurs when the body produces excessive quantities of acid or when the kidneys are not removing enough acid from the body. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low (less than 7.35) due to increased production of hydrogen ions by the body or the inability of the body to form bicarbonate (HCO3−) in the kidney. Its causes are diverse, and its consequences can be serious, including coma and death. Together with respiratory acidosis, it is one of the two general causes of acidemia. Terminology : Acidosis refers to a process that causes a low pH in blood and tissues. Acidemia refers specifically to a low pH in the blood. In most cases, acidosis occurs first for reasons explained below. Free hydrogen ions then diffuse into the blood, lowering the pH. Arterial blood gas analysis detects acidemia (pH lower than 7.35). When acidemia is present, acidosis is presumed. Signs and symptoms[edit] Symptoms are not specific, and diagnosis can be difficult unless the patient presents with clear indications for arterial blood gas sampling. Symptoms may include chest pain, palpitations, headache, altered mental status such as severe anxiety due to hypoxia, decreased visual acuity, nausea, vomiting, abdominal pain, altered appetite and weight gain, muscle weakness, bone pain, and joint pain. Those in metabolic acidosis may exhibit deep, rapid breathing called Kussmaul respirations which is classically associated with diabetic ketoacidosis. Rapid deep breaths increase the amount of carbon dioxide exhaled, thus lowering the serum carbon dioxide levels, resulting in some degree of compensation. Overcompensation via respiratory alkalosis to form an alkalemia does not occur. Extreme acidemia leads to neurological and cardia Continue reading >>

Acidosis And Alkalosis

Acidosis And Alkalosis

A list of those foods which are acidic in nature and those which are alkaline in nature can be found on the following web sites. As a general rule, vegan food, especially vegetables and greens, tend to be alkaline in nature, whereas meat and dairy products, and also oils/fats (of both plant and animal origin) tend to be acidic in nature (when digested). Most fruit is alkaline producing, although a small minority is acid producing (e.g. cranberries, blueberries, plums etc. All dried fruits are classified as acid producing, and also sweet for food combining. If you eat a snack of dried fruit instead of fresh fruit, you will be amazed at how much lower your urine pH is for the rest of the day. Grains and beans are also in general acid producing, although Millet is considered Alkaline producing. Foods containing protein are broken down into amino acids, which are of course acidic, so the more protein sources one ingests, the more acidic one's diet will be. Sprouted grains and beans are less acid producing than their unsprouted forms. Oils are of course acids by their chemical nature, be they essentil fatty acids or saturated fats. Fermented foods (e.g. raw Tempeh, Miso or fermented vegetables) are also considered alkaline producing, even though they are actually acidic (lactic acid produced during probiotic fermentation). Eating more algae/green superfoods, vegetable juicing and eating more vegetables and raw foods may indeed help to raise the body's pH, but one must also take into consideration what types of food one can tolerate and in what quantities, and also the fact that alkaline foods, especially when raw, have a large 'cold energy' component and may be more difficult to digest and may imbalance the body and contribute to ill health in some individuals, as strange a Continue reading >>

Acid-base Balance And Blood Ph

Acid-base Balance And Blood Ph

Acid-base Balance and pH Blood pH The term pH means potentials of Hydrogen. Acidity and alkalinity are expressed on the pH scale, which ranges from 0 (strongly acidic) to 14 (strongly basic, or alkaline). A pH of 7.0, in the middle of this scale, is neutral. Blood is normally slightly basic, alkaline, with a pH range of 7.35 to 7.45. To function properly, the body maintains the pH of blood close to 7.40. An important property of blood is its degree of acidity and alkalinity, and this is referred to as acid-base balance. The acidity or alkalinity of the blood is indicated on the pH scale. - The acidity level increases when the level of acidic compounds in the blood rises or when the level of alkaline compounds in the blood falls. Alkalinity levels increases with the reverse process. - The level of acidic or alkaline compounds in the body rises through increased intake, production, or decreased elimination and falls through decreased intake, production, or increased elimination. The Importance of Blood pH Blood pH and Cell Health; we live and die at a cellular level. The blood pH has a serious effect on all of the body’s systems and the body uses different mechanisms to control the blood’s acid-base balance. The blood’s acid-base balance is controlled by the body because even minor deviations from the normal range can severely affect the brain, arteries, the heart, muscles, and many organs. It can contribute to overwhelming the body leading to serious disease such as cancer. “Inflammatory disorders often increase the risk of cancer” - Merck: Risk Factors for Cancer “If the pH deviates too far in either direction, cells become poisoned by their own toxic waste and die. An imbalance pH can cause serious health problems and can lead to the progression of most deg Continue reading >>

Metabolic Acidosis - The Benefits Of Decreasing Your Body's Acidity!

Metabolic Acidosis - The Benefits Of Decreasing Your Body's Acidity!

Metabolic Acidosis - The Benefits Of Decreasing Your Body's Acidity! The body functions optimally when it is in equilibrium. When it goes out of equilibrium and becomes more acidic you will have consequences. Learn more about Metabolic Acidosis and what you can do to decrease it effects. The body functions optimally when it is in equilibrium. Cells operate best when they are within a specific pH range (this pH range varies depending on the cell type). The pH (potential of hydrogen) of the body is a measure of its acid:alkaline ratio also referred to as its acid:base ratio, which is measured on a scale of 0-14: Overall, the body functions best in a slightly alkaline state with a pH of 7.36 to 7.44. When the body becomes too acidic it is no longer in a state of balance and normal body functions are compromised. The problem is the majority of foods that compromise people's diets are acidic! For example, chicken and oatmeal, two common "fitness foods", are acidic. When the body becomes too acidic due to dietary influences it is called metabolic acidosis. In order to stabilize an acidic pH level the body must neutralize the excess dietary acid load. The two main ways the body does this is by taking calcium (and other minerals) from bones and glutamine from skeletal muscle. Both of these corrective mechanisms have negative consequences for the body. Hypercalciuria is high urine calcium levels. Bone contains the body's greatest calcium stores. Calcium is a strong base able to neutralize acids. During metabolic acidosis calcium is released from bone in an attempt to neutralize the excess acids and stabilize the body's pH level. The calcium and acids are then excreted in the urine. This calcium loss from bone leads to weak, brittle bones. Skeletal muscle contains the body's gre Continue reading >>

Metabolic Acidosis

Metabolic Acidosis

Metabolic Acidosis Definition Metabolic acidosis is a pH imbalance in which the body has accumulated too much acid and does not have enough bicarbonate to effectively neutralize the effects of the acid. Description Metabolic acidosis, as a disruption of the body's acid/base balance, can be a mild symptom brought on by a lack of insulin, a starvation diet, or a gastrointestinal disorder like vomiting and diarrhea. Metabolic acidosis can indicate a more serious problem with a major organ like the liver, heart, or kidneys. It can also be one of the first signs of drug overdose or poisoning. Causes and symptoms Metabolic acidosis occurs when the body has more acid than base in it. Chemists use the term "pH" to describe how acidic or basic a substance is. Based on a scale of 14, a pH of 7.0 is neutral. A pH below 7.0 is an acid; the lower the number, the stronger the acid. A pH above 7.0 is a base; the higher the number, the stronger the base. Blood pH is slightly basic (alkaline), with a normal range of 7.36-7.44. Acid is a natural by-product of the breakdown of fats and other processes in the body; however, in some conditions, the body does not have enough bicarbonate, an acid neutralizer, to balance the acids produced. This can occur when the body uses fats for energy instead of carbohydrates. Conditions where metabolic acidosis can occur include chronic alcoholism, malnutrition, and diabetic ketoacidosis. Consuming a diet low in carbohydrates and high in fats can also produce metabolic acidosis. The disorder may also be a symptom of another condition like kidney failure, liver failure, or severe diarrhea. The build up of lactic acid in the blood due to such conditions as heart failure, shock, or cancer, induces metabolic acidosis. Some poisonings and overdoses (aspirin, Continue reading >>

Metabolic Acidosis: Pathophysiology, Diagnosis And Management: Adverse Effects Of Metabolic Acidosis

Metabolic Acidosis: Pathophysiology, Diagnosis And Management: Adverse Effects Of Metabolic Acidosis

Recommendations for the treatment of acute metabolic acidosis Gunnerson, K. J., Saul, M., He, S. & Kellum, J. Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients. Crit. Care Med. 10, R22-R32 (2006). Eustace, J. A., Astor, B., Muntner, P M., Ikizler, T. A. & Coresh, J. Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int. 65, 1031-1040 (2004). Kraut, J. A. & Kurtz, I. Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment. Am. J. Kidney Dis. 45, 978-993 (2005). Kalantar-Zadeh, K., Mehrotra, R., Fouque, D. & Kopple, J. D. Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure. Semin. Dial. 17, 455-465 (2004). Kraut, J. A. & Kurtz, I. Controversies in the treatment of acute metabolic acidosis. NephSAP 5, 1-9 (2006). Cohen, R. M., Feldman, G. M. & Fernandez, P C. The balance of acid base and charge in health and disease. Kidney Int. 52, 287-293 (1997). Rodriguez-Soriano, J. & Vallo, A. Renal tubular acidosis. Pediatr. Nephrol. 4, 268-275 (1990). Wagner, C. A., Devuyst, O., Bourgeois, S. & Mohebbi, N. Regulated acid-base transport in the collecting duct. Pflugers Arch. 458, 137-156 (2009). Boron, W. F. Acid base transport by the renal proximal tubule. J. Am. Soc. Nephrol. 17, 2368-2382 (2006). Igarashi, T., Sekine, T. & Watanabe, H. Molecular basis of proximal renal tubular acidosis. J. Nephrol. 15, S135-S141 (2002). Sly, W. S., Sato, S. & Zhu, X. L. Evaluation of carbonic anhydrase isozymes in disorders involving osteopetrosis and/or renal tubular acidosis. Clin. Biochem. 24, 311-318 (1991). Dinour, D. et al. A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/ SLC4A4) Continue reading >>

Metabolic Acidosis: Causes, Symptoms, And Treatment

Metabolic Acidosis: Causes, Symptoms, And Treatment

The Terrible Effects of Acid Acid corrosion is a well-known fact. Acid rain can peel the paint off of a car. Acidifying ocean water bleaches and destroys coral reefs. Acid can burn a giant hole through metal. It can also burn holes, called cavities, into your teeth. I think I've made my point. Acid, regardless of where it's at, is going to hurt. And when your body is full of acid, then it's going to destroy your fragile, soft, internal organs even more quickly than it can destroy your bony teeth and chunks of thick metal. What Is Metabolic Acidosis? The condition that fills your body with proportionately too much acid is known as metabolic acidosis. Metabolic acidosis refers to a physiological state characterized by an increase in the amount of acid produced or ingested by the body, the decreased renal excretion of acid, or bicarbonate loss from the body. Metabolism is a word that refers to a set of biochemical processes within your body that produce energy and sustain life. If these processes go haywire, due to disease, then they can cause an excess production of hydrogen (H+) ions. These ions are acidic, and therefore the level of acidity in your body increases, leading to acidemia, an abnormally low pH of the blood, <7.35. The pH of the blood mimics the overall physiological state in the body. In short, a metabolic process is like a power plant producing energy. If a nuclear power plant goes haywire for any reason, then we know what the consequences will be: uncontrolled and excessive nuclear energetic reactions leading to the leakage of large amounts of radioactive material out into the environment. In our body, this radioactive material is acid (or hydrogen ions). Acidemia can also occur if the kidneys are sick and they do not excrete enough hydrogen ions out of th Continue reading >>

Metabolic Acidosis And Kidney Disease: Does Bicarbonate Therapy Slow The Progression Of Ckd?

Metabolic Acidosis And Kidney Disease: Does Bicarbonate Therapy Slow The Progression Of Ckd?

Metabolic acidosis and kidney disease: does bicarbonate therapy slow the progression of CKD? Correspondence and offprint requests to: Csaba P. Kovesdy; E-mail: [email protected] Search for other works by this author on: Nephrology Dialysis Transplantation, Volume 27, Issue 8, 1 August 2012, Pages 30563062, Csaba P. Kovesdy; Metabolic acidosis and kidney disease: does bicarbonate therapy slow the progression of CKD?, Nephrology Dialysis Transplantation, Volume 27, Issue 8, 1 August 2012, Pages 30563062, Metabolic acidosis is a common complication associated with progressive loss of kidney function. The diminishing ability of the kidneys to maintain acidbase homeostasis results in acid accumulation, leading to various complications such as impairment in nutritional status, worsened uremic bone disease and an association with increased mortality. In addition to these adverse effects which are related to acid retention, metabolic acidosis may also cause kidney damage, possibly through the stimulation of adaptive mechanisms aimed at maintaining acidbase homeostasis in the face of decreasing kidney function. Recent clinical trials have suggested that correction or prevention of metabolic acidosis by alkali administration is able to attenuate kidney damage and to slow progression of chronic kidney disease (CKD), and may hence offer an effective, safe and affordable renoprotective strategy. We review the physiology and pathophysiology of acidbase homeostasis in CKD, the mechanisms whereby metabolic acidosis may be deleterious to kidney function, and the results of clinical trials suggesting a benefit of alkali therapy, with special attention to details related to the practical implementation of the results of these trials. bicarbonate , chronic kidney disease , metabolic ac Continue reading >>

The Alkaline Way: Ten Tips For Reversing

The Alkaline Way: Ten Tips For Reversing

There's a lot of talk these days about following an "alkaline" diet as a way of restoring health and prolonging life. In principle a lot of the core ideas behind this approach make good physiological sense. Yet many people who try to follow an "alkaline lifestyle" are doing so based on observations that may be true in test tubes yet not true in physiology, in life, in reality. To make sensible lifestyle choices on this matter, it is important to understand a little bit about the chemistry and physiology of acid-base balance. All metabolic, neurohormonal, and immune system processes produce a net excess of acids. When foods induce immune reactions, additional acids are produced that lead to mineral loss in the urine, sweat and stool. Adaptive, acquired immune responses directly and indirectly generate substantial amounts of acidic products (Jaffe, R. Townsend Letter for Doctors and Patients, 2009; 316: 90-98). In people with B cell and/or T cell immune reactions and impaired buffering capacity, it is important to identify the causes of immune reactions by avoidance provocation or ex vivo lymphocyte response assays (LRA). Simply put, when cells are more alkaline, they are more tolerant, better able to detoxify, and more able to maintain a high energy potential (as indicated by an ATP:ADP ratio of 100:1). The question is how to effectively shift the cellular milieu toward greater alkalinity. To understand that, we need to consider how cells alkalinize. It is minerals such as potassium and magnesium, along with short/medium chain fats that counter this acidity and alkalinize the body. This is mission-critical for cellular health. Metabolic acidosis results when potassium and magnesium levels are too low to neutralize the normal production of acidic byproducts of metabolism Continue reading >>

Acidosis

Acidosis

For acidosis referring to acidity of the urine, see renal tubular acidosis. "Acidemia" redirects here. It is not to be confused with Academia. Acidosis is a process causing increased acidity in the blood and other body tissues (i.e., an increased hydrogen ion concentration). If not further qualified, it usually refers to acidity of the blood plasma. The term acidemia describes the state of low blood pH, while acidosis is used to describe the processes leading to these states. Nevertheless, the terms are sometimes used interchangeably. The distinction may be relevant where a patient has factors causing both acidosis and alkalosis, wherein the relative severity of both determines whether the result is a high, low, or normal pH. Acidosis is said to occur when arterial pH falls below 7.35 (except in the fetus – see below), while its counterpart (alkalosis) occurs at a pH over 7.45. Arterial blood gas analysis and other tests are required to separate the main causes. The rate of cellular metabolic activity affects and, at the same time, is affected by the pH of the body fluids. In mammals, the normal pH of arterial blood lies between 7.35 and 7.50 depending on the species (e.g., healthy human-arterial blood pH varies between 7.35 and 7.45). Blood pH values compatible with life in mammals are limited to a pH range between 6.8 and 7.8. Changes in the pH of arterial blood (and therefore the extracellular fluid) outside this range result in irreversible cell damage.[1] Signs and symptoms[edit] General symptoms of acidosis.[2] These usually accompany symptoms of another primary defect (respiratory or metabolic). Nervous system involvement may be seen with acidosis and occurs more often with respiratory acidosis than with metabolic acidosis. Signs and symptoms that may be seen i Continue reading >>

What Is Lactic Acidosis?: Signs, Symptoms, Causes And Treatment

What Is Lactic Acidosis?: Signs, Symptoms, Causes And Treatment

What is lactic acidosis? It is a condition where lactate builds up in the body which leads to extremely low pH levels in the blood. Normally, your blood is alkaline or slightly basic. Lactic acidosis occurs when your blood is much more acidic than usual. Changes in blood pH levels can adversely affect your body’s organs. Lactic acidosis is a form of metabolic acidosis characterized by excessive accumulation of acid as a result of the body failing to metabolize lactic acidosis. Metabolic acidosis is a medical state that occurs when there is reduced systemic pH because of a decrease in bicarbonate or an increase in hydrogen ion concentration. Accumulation of lactic acids happens when there is inadequate oxygen in the muscles that is required to break down the glycogen and glucose for energy. In a normal body, lactate will exit muscle cells and travel to the liver, where it will be oxidized to pyruvate, and later converted to glucose. Glucose refers to a form of sugar which is one of the main sources of energy for the body. When there is reduced oxygen in the tissue, there will be a build up of lactic acid. This medical condition usually starts in the kidneys. Lactic acidosis normally occurs when the kidneys fail to excrete excess acids from the body. As a result, lactic acid accumulates in the body faster than it is removed. This build up of lactic acid leads to a pH imbalance in the body. There are two forms of lactic acid, that is D-lactate and L-lactate. D-lactate is a form produced in bacterial metabolism and may build up in patients who have had a gastric bypass or have short gut syndrome. On the other hand, L-lactic is produced from human metabolism. Both L-lactic and D-lactic are produced from pyruvate and metabolized to pyruvate by an enzyme known as lactate deh Continue reading >>

Types Of Acidosis And Foods To Avoid- Easy Health Options

Types Of Acidosis And Foods To Avoid- Easy Health Options

Easy Health Options Home Healthy Living Full body acid: Whats eating you? You want to feel vibrant. We all do. But something is eating away at you and causing many of the ailments you potentially face, ranging from lack of energy to cancer Acidosis is when your bodys internal environment meaning all its blood, cells, tissues and organs are in an acidic state. Healthy humans are alkaline humans. An alkaline state is the opposite of an acidic state. So overcoming a chronic state of acidosis and replacing it with a natural, balanced state of alkalinity, is the way to restore health and vibrancy. To do that, you need to look at the pH of your body, the foods that go into it and the other outside factors that can tip that balance Your pH (potential of hydrogen) is a reflection of your bodys balance between its alkaline and acidic state. That pH is measured on a logarithmic scale in which 7.0 is neutral. The lower the reading on the scale the more acidic the body is and the higher the reading, above 7, the more alkaline the body. When the body maintains a high pH you feel vibrant, at ease and well. However, when the environment of the body is acidic, with a low pH reading, inflammation, pain, disease, and other unhealthful issues arise. Indeed, acidic blood can cause stroke, heart attack, atherosclerosis and high blood pressure. An acidic body can even lead to depression and obesity because of how the body is hampered in its ability to process nutrients, expel heavy metals and metabolize wastes. Diseases like cancer cannot thrive in an alkaline environment. But an acidic body does allow cancer cells to proliferate. Many other diseases, including arthritis, emphysema, and diabetes can begin, progress faster and thrive in an acidic environment. An acidic environment in the bod Continue reading >>

The Importance Of Having A Normal Body Ph

The Importance Of Having A Normal Body Ph

Reset Have you ever wondered what normal body ph is? Have you ever wondered if your body was unhealthy and had a normal body ph? Well, this article concerning normal body ph. is for you. Keep reading to learn about normal body ph and how it’s affecting you. One of the key determinants of the speed of aging and onset of degenerative diseases is the internal biochemistry and terrain of the body. Internal biochemistry is best measured and discussed in terms of the pH. pH is a measurement of the amount of acid and base. It ranges from 1 to 14, with 1 being extremely acidic, and 14 being extremely basic. A neutral state has a pH of 7. There are many environmental factors that can affect the body’s pH and it is vital for all bodily function to maintain a normal body pH. The term acidosis is and only meant to convey a shift in total body chemistry towards the acidic direction. Keep reading to learn more about normal body ph and acidosis. What is the Normal Body pH? According to the research of Dr. Enderlein, our bodies can only be healed of any chronic illness when our blood is at a normal, slightly alkaline pH. What exactly does pH mean? pH is the short form for potential hydrogen. The pH of any solution is the measure of its hydrogen-ion concentration. The higher the pH reading, the more alkaline and oxygen rich the fluid is. The lower the pH reading, the more acidic and oxygen deprived the fluid is. The pH ranges from 0 to 14, with 7.0 being neutral. The indicator above 7.0 is alkaline and below 7.0 is considered acidic. So, what is normal body ph for us? keep reading to find out if you have a normal body ph. Our blood pH has a very narrow range of around 7.35 to 7.45. If our body’s pH deviates from this range, we will be sick or have symptoms of falling sick. If our Continue reading >>

Metabolic Acidosis

Metabolic Acidosis

What is metabolic acidosis? The buildup of acid in the body due to kidney disease or kidney failure is called metabolic acidosis. When your body fluids contain too much acid, it means that your body is either not getting rid of enough acid, is making too much acid, or cannot balance the acid in your body. What causes metabolic acidosis? Healthy kidneys have many jobs. One of these jobs is to keep the right balance of acids in the body. The kidneys do this by removing acid from the body through urine. Metabolic acidosis is caused by a build-up of too many acids in the blood. This happens when your kidneys are unable to adequately remove the acid from your blood. What are the signs and symptoms? Not everyone will have signs or symptoms. However, you may experience: Long and deep breaths Fast heartbeat Headache and/or confusion Weakness Feeling very tired Vomiting and/or feeling sick to your stomach (nausea) Loss of appetite If you experience any of these, it is important to let your healthcare provider know immediately. What are the complications of metabolic acidosis if I have kidney disease or kidney failure? Increased bone loss (osteoporosis): Metabolic acidosis can lead to a loss of bone in your body. This can lead to a higher chance of fractures in important bones like your hips or backbone. Progression of kidney disease: Metabolic acidosis can make your kidney disease worse. Exactly how this happens is not clear. As acid builds up, kidney function lowers; and as kidney function lowers, acid builds up. This can lead to the progression of kidney disease. Muscle loss: Albumin is an important protein in your body that helps build and keep muscles healthy. Metabolic acidosis lowers the amount of albumin created in your body, and leads to muscle loss, or what is called Continue reading >>

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