Exogenous Ketones: What They Are, Benefits Of Use And How They Work
Exogenous ketones have become a popular nutritional supplement since their introduction in 2014. Like with any new supplement, though, there tends to be a lot of misinformation that you have to sift your way through to find the reliable data. So, this article does the hard work for you and gets right to what the true benefits and drawbacks of exogenous ketones are. We also cover what forms of ketones to consider, how they function in the body, and their role in future research. What Are Ketones? Our bodies use ketones via our mitochondria to generate energy. They are an alternative fuel source to glucose. Ketones are simple compounds because of their small molecular structure and weight. Specifically, they are organic (carbon-based) compounds that contain a central carbon atom double-bonded to an oxygen atom and two carbon-containing substituents, denoted by “R” (see chemical structure below). In humans, there are 3 different ketones produced by the mitochondria of the liver. These are also often referred to as ketone bodies. The three ketones are: Acetone Acetoacetic Acid Beta-Hydroxybutyric Acid (also known Beta Hydroxybuyrate or BHB). Other chemical names include 3-hydroxybutyric acid or 3-hydroxybutyrate. BHB is not technically a ketone since it contains a reactive OH-group in place of where a double-bonded oxygen normally would be as you can see in the diagram below. Yet, BHB still functions like a ketone in the body and converts into energy much like acetoacetate and acetone. This happens via the acetoacetate and acetyl-CoA pathway. Note that acetone conversion to acetyl-CoA is not efficient due to the need to convert acetone to acetoacetate via decarboxylation. However, BHB still functions like a ketone in the body and can be converted to energy (via acetoace Continue reading >>
Is There A Dark Side Of Ketosis?
I can’t remember what appetizer she pointed to, but the woman sitting to the left of me said this so casually, and several folks at the table knew exactly what she meant, confirming what I’d long suspected: Ketogenic diets have officially gone mainstream – or recognizable at a party mainstream at least – in 2017. Let’s back up and demystify ketosis, which simply means you’re utilizing ketone bodies – more commonly called ketones – rather than glucose as your body’s primary fuel. Just like your car uses gasoline, your body needs fuel. That usually means glucose. But let’s say you’re on a very-low carbohydrate, higher-fat diet. Your body doesn’t get a lot of glucose, which primarily comes from carbohydrate and to a lesser degree protein. That means your liver’s backup glucose (glycogen) also becomes in short supply. Unlike your car, your body doesn’t just shut down. Thankfully, you have an alternative fuel source called ketones. Ketones are organic compounds your liver always makes. You’re cranking out ketones right now as you read this. During starvation or (more likely) when you restrict carbohydrate and increase fat intake, your body uses ketones as its primary fuel. In other words, when your body doesn’t receive or can’t make enough glucose, it shifts to this alternative fuel. Almost every organ can utilize ketones except for your red blood cells (which don’t have ketone-metabolizing mitochondria) and liver. Your liver, in fact, does the heavy lifting. This hardworking organ metabolizes fat into three ketone bodies: acetoacetate (ACA), beta-hydroxybutyrate (BHB), and acetone.(1) BHB is the first substrate that kicks ketosis into action. Among its benefits, BHB reduces chronic inflammation and restores healthy inflammation levels. In Continue reading >>
Exogenous Ketones: To Ketone Or Not To Ketone
My thoughts on Exogenous Ketones After being contacted (following the Youtube Q&A) by several folks – both members of Ketogains and Internet strangers, I felt compelled to write as fair and even-handed a write-up on exogenous ketone supplementation as I feel can be mustered. I condition my response by saying this – I want to deal only in evidence and hypotheses grounded in biochemistry. I admit up front that this will probably become something of a treatise on what constitutes a well-formulated ketogenic diet. I don’t have the time (or the energy) to put together a document that covers all facets of the use of exogenous ketones in sufficient depth, so what I want to do is to address the folks that I see asking me about them most often – those who have excess body fat, and are looking to lose weight. They have been told about the potential benefits to fat loss via exogenous ketones, and they want to know if the hype is real. Those of you who know me (or read my previous post here) know that I like to respond with “it depends.” So…when the question is raised, “Should I supplement with exogenous ketones?” what do you think my answer will be? Probably not! (HA, I tricked you!)…but let’s explore why. As I’m sure this is going to be hotly debated enough (as the topic is raging in numerous ketogenic groups) there isn’t any value in dealing with speculation that doesn’t have a basis in science, nor in anecdotes. The challenge in dealing with exogenous ketone supplementation is two-fold: One side of the debate has a product to sell. Anytime someone’s livelihood is tied to your purchase of their product, bias and subjective interpretation of the evidence should be considered. The evidence (either for or against) their supplemental use by average schl Continue reading >>
Of The Keto Diet?
There are many awesome benefits that come with adopting a low-carb ketogenic diet, such as weight loss, decreased cravings and even possibly reduce disease risks. With that being said, it’s also good to talk about possible ketosis side-effects when ingesting these specific ketone supplements, so you know fully what to expect when you get started on this mission. If you’ve already heard about some of the side-effects that come with this special diet and are starting to freak out, don’t panic. We’re going to break down everything you need to know when it comes to what your body will experience when using these supplements for the first time. It’s important to remember, not everyone experiences side-effects when starting a ketogenic diet and thankfully, the symptoms are all very temporary and it can pass very quickly. It varies with the individual, but just to make sure all your bases are covered, we’re going to break down each possible side effect that you could possibly experience. 1. Flu Symptoms Within the first 2-4 days of beginning this diet, a common side-effect is known as the “ketosis flu” or “induction flu” because it mimics the symptoms of the actual flu. This means you might experience: Headaches Lethargy Lack of motivation Brain fog or confusion Irritability Although these symptoms typically go away completely within a few days, they are also completely avoidable if you stay very hydrated and increase your salt intake and like always, be sure you're eating enough fat. 2. Dizzyness & Drowsiness As you start dumping water, you'll lose minerals such as salt, potassium and magnesium. Having lower levels of these minerals will make you tired, lightheaded or dizzy. You may also experience muscle cramps, headaches and skin itchiness. Fatigue Continue reading >>
Are Exogenous Ketones Right For You?
I’ve spent a lot of time lately analysing three thousand ketone vs. glucose data points trying to determine the optimal ketone and blood sugar levels for weight loss, diabetes management, athletic performance and longevity. In this article, I share my insights and learnings on the benefits, side effects and risks of endogenous and endogenous ketosis. But first, I think it’s important to understand the difference between exogenous and endogenous ketosis: Endogenous ketosis occurs when we go without food for a significant period. Our insulin levels drop, and we transition to burning body fat and ketones in our blood rise. Exogenous ketosis occurs when we drink exogenous ketones or consume a ketogenic diet. Ketones are important. As blood glucose decreases, the ketones in your blood increase to keep our energy levels stable. The chart below shows three thousand blood glucose vs ketone values measured at the same time from a range of people following a low carbohydrate or ketogenic diet. While there is generally a linear relationship between glucose and ketones, each person has a unique relationship between their blood glucose and ketone values that provide a unique insight into a particular person’s metabolic health. Hyperinsulinemia has been called as the “unifying theory of chronic disease”     . It’s beneficial to understand where you stand on the spectrum of metabolic health and insulin sensitivity. The chart below shows the typical relationship between blood glucose and blood ketone for a range of different degrees of insulin resistance/sensitivity. If your blood glucose levels are consistently high it’s likely you are not metabolising carbohydrate well. When you go without food, endogenous ketones are slow to kick in because your insulin Continue reading >>
My Big, Fat, N=1 Exogenous Ketones Supplementation Experiment (while Eating A Keto Diet)
My Big, Fat, n=1 Exogenous Ketones Supplementation Experiment (while Eating a Keto Diet) Here we go. I’ve been slightly apprehensive about sharing this latest experiment with you, because up until recently I was where I’m sure many of you are right now in my belief that exogenous ketones were a mother flippin’ ripoff. After all, all good keto kids know that ketone bodies are the RESULT of putting our bodies successfully in ketosis, so why in the hell would we want to pay to put ketones from outside ourselves into our system? Well, I got my reasons, which I’ll share with you in a bit. First, my purpose: to do an n=1 experiment in order to see if using exogenous ketones can help me lose weight while on a ketogenic diet — that is, a diet that already puts my body in ketosis. ***HUGE DISCLAIMER: I used my own hard-earned money to pay for the exogenous ketones. I was not approached by any company, and I am not doing this experiment on behalf of anybody but myself.*** Now for some background info on me: I’ve been following a keto diet for 20 months now I am approximately 75lbs overweight Aside from an initial fluid loss of 10lb, I have never lost any weight on keto Over these last 20 months I have experimented with altering my macros, intermittent fasting (IF), extended fasting, egg fasting, and meat fasting, and nothing to date has had any measurable, lasting impact on my weight I have PCOS I have low cortisol levels due to chronic Lyme disease that was finally treated in December 2016 and January 2017 I still do consider keto to be a success for me! I used it along with the protocol in the book The Mood Cure to finally get off antidepressants and anti-anxiety medication that I was previously unsuccessful in transitioning off of for 10 years (Note: Don’t ever a Continue reading >>
Exogenous Ketones Pros And Cons
What Are Exogenous Ketones? Exogenous Ketones (EK for short) are ketone supplements and by definition, a supplement is a thing added to something else in order to complete or enhance it. Think about it like building muscle, good supplements can enhance your results, but if you don’t eat right and exercise, supplements are just useless. You can’t just sit on the couch to watch TV, eat potato chips all day and drink some supplements and expect to gain muscle. A supplement is not a miracle. It’s just an addition and before you add it to your diet, you need to get the basic right first, which is dieting and exercise in the case of building muscles. The supplements are not going to lift the heavy weights for you. You do! Back to the case of EK. If you cheat on your keto diet and eat a ton of carbs, and you want to use EK as a way to feel better and less guilty about it, it’s probably not a smart choice because EK won’t do anything for you (more on this later). However, if you are eating LCHF and somehow you’re not feeling your best, EK can be helpful and we will explain more below. Our Approach We own and manage a few growing Keto Facebook groups with tens of thousands of members and we often see the exogenous ketones topic comes up. We have seen a lot of confusion and criticism as well as support from our members. Most of the complaints are normally because of the expensive price of some products, the lack of understanding about what the product is and what it does to your body or because some sellers/promoters try to bend the truth to get you buy their products or recruit you into their multi level marketing team. We recently ran a survey in our private group and asked people if they have used EK before and if it worked for them. Here’s the result: Many peopl Continue reading >>
Exogenous Ketones For Fat Burn
OVERVIEW Exogenous ketones are the newest scientific breakthrough in the world of health and wellness, making the job of achieving ketosis, the state in which the body is burning fat/ketones as fuel rather than glucose, much easier. They come in powder form and are ingested exogenously (a fancy word for outside the body). Exogenous ketones are comprised of beta-hydroxybutyrate salts, which flood your bloodstream with ketones and put the body in ketosis within 30-60 minutes. This means that you can reap all the amazing health benefits of being in ketosis in a simple and effective way (just mix the exogenous ketones with water & drink!). Research is now linking exogenous ketones to a multitude of benefits, including more efficient weight loss, athletic performance enhancement, cancer prevention, cognitive improvement, neuroprotection and anti-inflammatory properties. (See research links below.) In addition, exogenous ketones are an extremely useful tool to easily transition to the ketogenic diet. When taken daily, they can reduce carb/sugar cravings, turn on your fat burners, give you more energy, and keep "low-carb flu" at bay. So bottom line, exogenous ketones are perfect for anyone looking to improve their health and wellbeing. WHY USE THEM Reason #1 - Fat Burning Exogenous ketones for fat burn. Taking exogenous ketones will get you into ketosis quickly. Once your body is done using the exogenous ketones you ingested as fuel, then it will start looking for other places to get ketones from. And lucky for you, ketones are made from the fat stored in your body! So as your body produces more of these ketones as fuel, you end up burning fat. Reason #2 - Energy Our bodies use ketones via our mitochondria to generate energy. They are an alternative fuel source to glucose and Continue reading >>
My Experience With Exogenous Ketones: Tale And Truth
97 Comments I woke up the morning of the ceremony with butterflies in my stomach. I’d done the necessary prep. I’d abstained from carbs the past week and food the past 24 hours. I’d performed four consecutive full-body circuit workouts to deplete muscle glycogen, and undergone a liver biopsy to confirm full depletion of liver glycogen. I wasn’t taking any chances. Although I had extensive experience generating endogenous ketones and subsisting on my own body fat, exogenous ketones were another matter entirely. You don’t want to mess around with a holy sacrament without doing due diligence. Holy sacrament? Yes. According to ethnographic accounts from early Arctic explorers who encountered the sacred compound, the exogenous ketone was developed by traditional peoples of the wintry north. No one’s quite sure where it arose first—Siberia, Greenland, Alaska, Lapland. What they do know is that these societies revered the type 1 diabetic, a rare find in the pre-contact Arctic. Using an admittedly grisly and cruel process, these groups would starve the tribe’s diabetic to induce ketoacidosis, harvest the ketone-rich urine, and reduce it slowly to a ketone-rich tar over a wood fire. Tribe shamans would dissolve the tar in pine needle tea and distribute it to members exclusively before hunting trips, warfare, and any other activity requiring optimal physical and mental function to boost energy and improve performance. As Mark Twain famously quipped, “The strongest coffee I ever had was a Laplander’s piss.” So when I showed up to the small building on the edge of town on a rainy evening, I was anxious. What was I in for? The solemn countenances worn by my two guides for the day—Dr. Peter Attia, wearing dark robes and swinging a thurible loaded with burning Continue reading >>
The Keto Diet Podcast Ep. #041: Responsible Exogenous Ketone Usage
Interview with Dr. Gustin, a board certified sports physician and functional medicine practitioner, chatting about exogenous ketones – what they are, how they work, when and how to use exogenous ketones, ingredients in exogenous ketones, problems with the exogenous ketone market, and so much more. I’ll be the first to admit that I never, ever, thought in a million years that I’d be supplementing with exogenous ketones, let alone sharing them with you. But meeting many of you on the book tour, and speaking to individuals that have supplemented with ketones to compliment their ketogenic diet and help make the transition easier, I owed it to our crew to do some additional research, and here we are. Today, I interviewed the down-to-earth owner of Perfect Keto, asking him about all things exogenous ketones. From what they are, signs that you need them, signs that you don’t, the difference in products, ingredients used in exogenous ketones, whether they’re FODMAP or not, diet culture surrounding the product, accessibility issues, how exogenous ketones are digested, whether they lead to limited fat burn, and more. No stone left unturned. For podcast transcript, scroll down. SHOW NOTES + LINKS Subscribe on iTunes or your favorite podcast app Check out more from Dr. Gustin here and here TIMESTAMPS Problems with exogenous ketone supplementation (24:20) Ketone esters vs. salts (36:46) Exogenous ketone misconceptions (48:10) PARTNERS OF THE KETO DIET PODCAST The podcast is partnered with Wolfe Clinic Royal Flora, my choice in soil-based probiotics. Get 20% off your soil-based probiotics with the coupon code GUT at checkout. Thrive Market 35% savings – get an instant 35% off your favorite premium organic products. All you have to do is enter your email address, and the d Continue reading >>
My Thoughts On Exogenous Ketones
Should you supplement with exogenous ketones? What are the benefits? Which product is best? Are there people that shouldn’t use exogenous ketones? There is so much health information out there that when you want to determine whether or not something is good for you it can be challenging to know what’s what. Magic pills, super supplements and promises to a better life are yours for three payments of two hundred dollars. I do not wish to add to the aggravation, which is why I never endorsed exogenous ketones. Then, my mind was changed by many of you. Now, I can say that I’ve personally experimented with this ketogenic supplement and see that it can be helpful for some ketogenic people. Not sure what exogenous ketones are? Basically, they’re a supplement that deepens your state of ketosis by providing supplemental ketones. They can be especially helpful for kicking keto flu and assisting your body in becoming adapted. If you decide to supplement with exogenous ketones, my personal choice is Perfect Keto exogenous ketones. Why Perfect Keto? Well, to start, they are offering us an exclusive 15% off your first order of their exogenous ketones with the coupon code HEALTHFUL. So there’s something. BENEFITS TO EXOGENOUS KETONE SUPPLEMENTATION After personally trying Perfect Keto’s exogenous ketones, I see how they could be extremely useful for those dealing with things like: the keto flu, various conditions preventing certain people from going ketosis (fibromyalgia, thyroid, etc.), needing ketones for therapeutic purposes (for epilepsy, cancer, etc.), beginners on keto trying to get into ketosis for the first time, and those who need to extend a fast for medical reasons. What exogenous ketones are NOT is an absolute fix-everything supplement because not everyone need Continue reading >>
10 Best Exogenous Ketones: Weight Loss Using Ketone Supplements
The benefits of ketosis for weight loss are explosive. However, going keto is not exactly a walk in the park. The modern diet is ridiculously high carb, and many people find it difficult to make the transition. This is where exogenous ketones for weight loss could come in handy. What Are Ketones? Going Keto is especially important if you suffer from chronically high sugar levels. With the ketogenic diet, your goal is to achieve ketosis, a state where your body produces an increased number of ketones. The body uses ketones to generate energy. When you have a low carb diet, your body tends to use up stored fat as energy, instead of relying on glucose. As a result, you get to manage your sugar levels, AND burn fat. What Are Exogenous Ketones Supplements? The body naturally produces ketones. Exogenous ketones are merely in reference to ketone bodies that are ingested by taking supplements. The supplements on the market these days are usually in the form of beta-hydroxybutyrate (BHB). That’s why when you look up exogenous ketones, you’d probably end up seeing beta-hydroxybutyrate supplements, or BHB salts. Sodium and potassium are added to the formula to make the substances easier to absorb. Some supplements come with MCT oil (medium-chain triglycerides or medium-chain fatty acids. MCT are saturated fats that can be easily digested by the liver. They help boost metabolism and are used up for energy instead of being stored as fat. A diet high in fat is also beneficial for boosting testosterone levels. A Quick Look at The Best Exogenous Ketones Supplements There are many types of exogenous ketone supplements out on the market, and if you’re new to going keto, you’ll need all the help you can get to choose the best one. We did the legwork and came up with this lis Continue reading >>
The Beginner’s Guide To Exogenous Ketones
Have you been wondering what exogenous ketones are? If so, you’re not the only one. The keto-dieting world has been buzzing with information about developments on exogenous ketones for awhile now, with many brands producing exogenous ketones that are used by Keto lifestylers around the world. But the majority of Keto dieters don’t completely understand what exogenous ketones are or how they can benefit their diet (or dieting options). In this post, we’ll provide you with easy to read information about exogenous ketones. With this knowledge, you’ll be able to utilize exogenous ketones in your diet, and teach others about their value. Let’s start with the label! The Definition of Exogenous Ketones Two words: exogenous and ketones. The word exogenous describes something that is developed from external factors; something outside of the usual production. So in terms of ketones, this means that exogenous ketones are synthetic: created outside of your body by scientists and then ingested for accelerated ketosis. We assume that you already know what ketones are, but just in case, we’ll give you a brief description of this term as well. Ketones, are organic compounds produced by in your body when your system experiences starvation, or when you restrict carbohydrates and increase fats, which inhibits a starvation-like state that produces ketone bodies. These ketones are an ideal fuel source for your body and your brain. Studies have suggested that when your body is in a ketogenic state, it utilizes oxygen more efficiently in the generation of energy. In short, ketones are secret weapons for anyone looking to take their body’s fueling system to the next level! To restate the point: Exogenous Ketones are ketone supplements. They’re created outside of your body and i Continue reading >>
Top 8 Keto Supplements And 5 Functional Foods
So you’ve decided to go keto and you’ve done all of your research on which foods you’ll be eating on the keto diet. But before you do your next big grocery run, you may want to consider these keto supplements too. While supplements aren’t 100% necessary on the keto diet, certain keto supplements can maximize your results by accelerating weight and fat loss and boosting your energy levels. Some keto supplements are also helpful for reducing symptoms of the keto flu and can help make the transition to a high-fat/low-carb diet much easier, especially in the early stages when you may want to give up. In addition to keto supplements, we’ll also let you know which superfoods — or ‘functional foods’ as we call them — can also be helpful on the keto diet. These foods are concentrated in essential nutrients and can further improve how you feel on the keto diet. Let’s take a look at the most popular keto supplements and the keto-approved functional foods you may also want to try. Top 8 Keto Supplements 1. Perfect Keto Perfect Keto is a powdered drink mix and keto supplement that provides your body with exogenous ketones (whereas your body produces endogenous ketones). Taking exogenous ketones provides ketone bodies for you to burn as fuel right away, whether or not you’re in ketosis. This is why some people who aren’t following a keto diet will still take ketone supplements for energy. Being made from exogenous ketones, Perfect Keto provides the same benefits that endogenous ketones naturally offer your body: long-lasting energy, improved cognitive function, athletic performance, and mental focus, fat burning, and accelerated weight loss. To be clear, exogenous ketones aren’t a replacement for the keto diet. While exogenous ketone supplements will raise Continue reading >>
Exogenous Ketones, How The Hell Did I Get Here, And Who Are These People?
This article is about seven months in the making So if I don’t bore you, which I do my best not to (like writing 6,000 word articles on something as trivial as butt wink), then I hope you’ll hang in there long enough to get through this one. As it took me months of arguing, seeing both anecdotal results and reading a metric ass load of studies, and hearing about a hundred overwhelming testimonials to finally sit down and write this. Rewind about seven months ago to one day in the gym. I was just about to finish up my training session when this woman I sorta-kinda knew approached me. Mind out of the gutter guys…not in that way. She asked me what I thought of ketogenic diets. “Not really a big fan. Good for fat loss, but outside of that I’m not a fan.” “What if I told you I was involved with a company making exogenous ketones?” “Ok, and?” I shrugged. “Do you know much about ketones?” she asked, in a rather smart ass way. “Yes I know about ketones.” “Well” she smirked “this is a supplement you can take, pee on a stick and it shows you are using ketones for energy.” “Ok.” I said, in about the most lukewarm manner you could reply to someone with. “You don’t find that fascinating?” “Oh yes, peeing my pants over here.” I can’t remember if that’s what I said, but it was something to that effect. Either way, I wasn’t impressed nor enthralled by her information. Who the fuck cares about ketones? A few weeks later a friend of mine she was working with that was preparing for a men’s bikini competition asked me the same series of questions. Once again, my response was a lukewarm “I don’t give a shit” kind of one. “Dude, they are awesome.” he said. “How so?” I asked. “Just the focus and energy you get from them Continue reading >>