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What Are The Symptoms Of Renal Tubular Acidosis?

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Renal Tubular Acidosis (rta)

By L. Aimee Hechanova, MD, Assistant Professor of Medicine, Texas Tech University; Attending Nephrologist, University Medical Center (See also Introduction to Disorders of Kidney Tubules .) In renal tubular acidosis, the kidney tubules malfunction, resulting in excess levels of acid in the blood. The tubules of the kidneys that remove acid from the blood are damaged when a person takes certain drugs or has another disorder that affects the kidneys. Often muscle weakness and diminished reflexes occur when the disorder has been present for a long time. Blood tests show high acid levels and a disturbance of the body's acid-base balance. Some people drink a solution of baking soda every day to neutralize the acid. To function normally, body acids and alkali (such as bicarbonate) must be balanced. Normally, the breakdown of food produces acids that circulate in the blood. The kidneys remove acids from the blood and excrete them in the urine. This function is predominantly carried out by the kidney tubules . In renal tubular acidosis, the kidney tubules malfunction in one of two ways that tend to increase acids in the blood ( metabolic acidosis ): Too little of the acids the body produc Continue reading >>

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Popular Questions

  1. AnnieC

    Keto insomnia?

    I've been doing this for 5 days now and I had a lot of trouble sleeping unlike before where I had no trouble falling asleep. Have any of you experienced this?

  2. maresf16

    Yea when I was "adjusting" I kept getting massive headaches and feverish. I woke up every two hours if I was sleeping reasonably well, and sometimes I just drifted in and out of consciousness by the minutes. It's passed now, but I don't remember it taking 5 days.

  3. AnnieC

    Originally Posted by maresf16
    Yea when I was "adjusting" I kept getting massive headaches and feverish. I woke up every two hours if I was sleeping reasonably well, and sometimes I just drifted in and out of consciousness by the minutes. It's passed now, but I don't remember it taking 5 days.

    How long have you been doing it?
    Maybe it takes longer for me because my metabolism is more screwed up eheh. I've been a mega-sugar addict all my life. This is a HUGE change for me. At least, I don't feel as sluggish now as I did on day 3 so that's pretty good!

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What is renal tubular acidosis (RTA)? RTA is a type of metabolic acidosis caused by the kidneys failure to properly acidify the urine. Find more videos at http://osms.it/more. Study better with Osmosis Prime. Retain more of what youre learning, gain a deeper understanding of key concepts, and feel more prepared for your courses and exams. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways and more when you follow us on social: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Thank you to our Patreon supporters: Sumant Nanduri Omar Berrios Alex Wright Sabrina Wong Suzanne Peek Arfan Azam Mingli Fng Osmosis's Vision: Empowering the worlds caregivers with the best learning experience possible.

Renal Tubular Acidosis In Children - Symptoms & Treatment

Does your child complain of intense pain when he is urinating? Does he exhibit any obvious growth impairments? If you nodded along anxiously, you might want to consult the doctor, as he may be suffering from renal tubular acidosis or RTA. In the meanwhile, read our post below to learn more about Renal Tubular Acidosis symptoms, causes, types and treatments in children. What Is Renal Tubular Acidosis? Renal tubular acidosis or RTA is a disorder in which kidneys are unable to extract excess acid from the blood. The acids are flushed from the body through the urine. Any problem with the task makes the blood acidic and causes health problems (1). It is important for children with RTA to receive prompt treatment for the same. Any delay in treatment may cause poor growth in the child along with other kidney disorders (2). [ Read: Kidney Stones In Children ] All body functions utilize chemical reactions for various tasks. These chemical reactions produce acid. With RTA, acidosis (excessive acid) becomes the norm. Kidneys remove acids in the urine. They also bring bicarbonate (a base) back into the blood. This is the way kidneys maintain a perfect balance of acid and base in the body (3). Continue reading >>

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  1. teamzissous

    I made a post a little while back about having consistent bladder and or kidney pains whenever I was in ketosis. It took a while to correlate the pain with low carb (originally thought I may have a hernia, even a doctor thought so and ordered a CT scan, found nothing and gave up on me)
    One redditor (THANK YOU SoftwareMaven) suggested an acidic urine pH. After charting my pain and testing my urine with rapid response urinalysis strips I found that my urine was much too acidic, and it correlated with the pain.
    Apparently ketones tend to make your urine more acidic and you HAVE to balance out your protein/meat intake with alkalizing vegetables (fruits really help too) I've been following the PRAL food lists in order to help keep my urine more alkaline.
    It was also suggested that I try adding some baking soda (sodium bicarbonate) to some water if I was eating a particularly acidic forming meal, and IT WORKS!
    There are also some supplementary benefits of baking soda according to examine.com, it has the same benefits of supplementing with beta alanine (reduces muscle burn when taken 60-90 min before a workout) They also note that a study has shown it has no significant effect on your blood pressure, good to know.
    note: I make a point to drink a TON of water, but it is not sufficient to balance out my urine pH.
    TL;DR Thank you SoftwareMaven! Ketosis can make your urine too acidic causing kidney/bladder pain. Eat more alkalizing vegetables (and/or fruit). Also drinking baking soda and water with your acidic forming meal can also keep your pee balanced.

  2. emag

    It's interesting that acidic foods like lemon juice, orange juice, tomatoes, and vinegar all exert a base effect...

  3. happee

    What about coffee? It's pretty acidic, would it exert a base effect as well?

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Genetic Causes And Mechanisms Of Distal Renal Tubular Acidosis

Genetic causes and mechanisms of distal renal tubular acidosis Northwestern University Feinberg School of Medicine Correspondence and offprint requests to: Daniel Batlle; E-mail: [email protected] Search for other works by this author on: Northwestern University Feinberg School of Medicine Nephrology Dialysis Transplantation, Volume 27, Issue 10, 1 October 2012, Pages 36913704, Daniel Batlle, Syed K. Haque; Genetic causes and mechanisms of distal renal tubular acidosis, Nephrology Dialysis Transplantation, Volume 27, Issue 10, 1 October 2012, Pages 36913704, The primary or hereditary forms of distal renal tubular acidosis (dRTA) have received increased attention because of advances in the understanding of the molecular mechanism, whereby mutations in the main proteins involved in acidbase transport result in impaired acid excretion. Dysfunction of intercalated cells in the collecting tubules accounts for all the known genetic causes of dRTA. These cells secrete protons into the tubular lumen through H+-ATPases functionally coupled to the basolateral anion exchanger 1 (AE1). The substrate for both transporters is provided by the catalytic activity of the cytosolic carbonic Continue reading >>

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  1. blurfocus

    Your first, best, and cheapest option is not to use them.
    Ketostix do not measure what many people expect that they do.
    Ketostix only measure excess levels of acetoacetate, which is not the type of ketones that correlate with nutritional ketosis.
    Ketostix may show negative ketones when your blood ketones are high and then may show positive ketones when your blood ketones are low.
    Misinterpretation of what they show is one of the most common unnecessary causes of keto anxiety and wasted time. You can be perfectly successful on a ketogenic or low-carb diet without ever measuring ketones.
    Many people are already overwhelmed with learning about keto diets. Adding another layer of unnecessary complexity doesn't help the matter. Often, people are most successful on keto when they treat it as a lifestyle and not a diet. Obsessively measuring ketones can be at odds with attempting to live a keto lifestyle.
    If you decide to use Ketostix anyway, please be kind to those who answer questions here by not submitting a question that begins with I know that Ketostix are unreliable, but ...
    If you consume few enough carbohydrates and avoid excessive intake of protein, you can trust that your liver will be producing ketones within a single day. That is how human metabolism works.
    If you consume too many carbs, you will be kicked out of ketosis temporarily. However, if you once again restrict carbs, you will go right back into ketosis within 24 hours. This is because the liver can store only 100 grams of glycogen. If you restrict carbs, the liver will run out of glycogen within a day and begin burning fat instead. The liver produces ketones as a side effect of burning fat.
    As an example of how Ketostix can be misleading, it is possible to eat a high-carbohydrate meal followed by a positive Ketostix result. You may think that you cheated the system, but you didn't. It takes time for excess ketones to appear in urine. Ketostix are showing you what happened in the past before you cheated.
    If you have the time and really want to know why Ketostix will not tell you much, read pages 164 and 165 of The Art and Science of Low Carbohydrate Living by Volek and Phinney. This is the section headed by Ketones: To Measure or Not.
    If you do not have this book, read this summary:
    http://ketopia.com/why-you-need-to-stop-worrying-about-the-color-of-your-ketostix/
    Ketostix were designed to help diabetics avoid ketoacidosis which is a dangerous condition involving very high blood sugar and very high serum ketones. If you have near normal blood sugar and serum ketone levels consistent with nutritional ketosis, you don't need to worry about this.
    Ketostix only measure excess levels of acetoacetate, which is not the type of ketones that correlate with nutritional ketosis.
    The ketones that correlate with nutritional ketosis are known as beta-hydroxybutyrate. This type can be measured only with a blood ketone meter.
    There is a built-in time lag. Ketostix are measuring what has happened in the past since it takes a while for the kidneys to produce urine.
    Exercise can influence how many excess ketones are excreted.
    You can be in nutritional ketosis even when Ketostix show no excess acetoacetate. In the keto-adapted state, very little acetoacetate ketones will be excreted in urine even though blood ketones may be high.
    Note that it takes a period of four to six weeks of being in ketosis every day in order to become keto-adapted. Someone who is keto-adapted has adapted to using fat as the primary fuel for muscles and various organs. The keto-adapted brain uses ketones in place of glucose for most of its energy needs. When keto-adapted, most acetoacetate is not excreted. Instead, muscles convert it to beta-hydroxybutyrate and return it to the blood for use by the brain.
    If after all of this, you still want to use Ketostix because you bought them and cannot bring yourself to throw them away or because they are comforting in some way, here is how they may be useful.
    When you are first starting a low-carb or keto diet and transitioning into ketosis from a moderate to high-carb diet, Ketostix will confirm that your body has in fact done what biology says that it must do. It will show that your liver has begun producing ketones.
    Once you are a few days into the diet, you can give them away to a keto newbie or toss them. Note that Ketostix will eventually expire, especially if you keep them in a moist environment like a bathroom.
    If you have a medical condition that makes monitoring blood ketone levels necessary or if you are a numbers geek with spending money, you may be interested in purchasing a ketone blood meter and test strips for measuring beta hydroxybutyrate in your blood. The test strips cost somewhere between $2 and $5 per strip.
    There are a few meters to choose from.
    Precision Xtra - https://www.abbottdiabetescare.com/products/patient/pxtra-overview.html
    Nova Max Plus - http://www.novacares.com/nova-max-plus/
    CardioChek Home - http://www.healthchecksystems.com/CardioChek.cfm#home
    Most use one of the first two listed (Precision Xtra or Nova Max Plus). Some say that the Precision Xtra is the more accurate of the two. I've found that readings from these two track fairly closely with each other. The Nova Max Plus has cheaper test strips.
    To detect nutritional ketosis, look for a reading between 0.5 and 5.0 mmol / liter. Some experts recommend aiming for a level of 1.0 to 5.0 mmol / liter.
    Another option is the Ketonix Sport breath meter. This meter measures acetate in the breath. It does not require test strips.
    Acetate forms when acetoacetate spontaneously breaks down to acetate. According to Volek and Phinney (page 165 of The Art and Science of Low Carbohydrate Living), it should be linearly correlated with blood ketones. In practice, it is not as accurate as the blood meters in part because it is difficult to breathe in the same way every time you test.
    Ketonix Sport (order direct from Sweden) - https://www.ketonix.com/index.php/product/sport
    Again, remember that you can be perfectly successful on a ketogenic or low-carb diet without ever measuring ketones whether in urine, blood, or breath.
    In the final analysis, ketone concentrations are what they are. Chasing ketone concentrations often becomes as unnecessary and distracting as Ketostix. Unless you are treating epilepsy, cancer, or other medical condition, the concentration of ketones do not matter too much. You can achieve weight loss and a sense of well-being even with lower levels of ketones.
    Focus on how you feel, not on the number. Use ketone meters for interest and experimentation, but don't let the results stress you out.
    tl;dr never, unless you have read and understood this post, yet still want to use them anyway
    [If anyone has any suggestions for improving this post or correcting misinformation, let me know. I'll correct this and re-post it once in a while]

  2. anbeav

    Hallelujah!!
    tl;dr never
    If you want to do it for experimentation, go for it but please spare the rest of us the unnecessary ketosis anxiety
    edits: In addition to false negatives, ketostix commonly show false positives as in when people eat a high carb meal and think they cheated biology. Also I might remove the bit about using ketostix to monitor keto-adaptation, just asking for more posts about the issue. Also I might emphasize that people seem to already be overwhelmed with keto when starting and adding another layer of unnecessary complexity doesn't help the matter. People always talk about lifestyle, live a lifestyle and IMO living a lifestyle certainly shouldn't have to include measuring. Lastly, ketone concentrations are what they are. If you want to measure with a blood or breath meter, they are what they are and chasing ketone concentrations often becomes as unnecessary as ketostix. Unless someone has a medical condition for which a particular concentration is required for management, focus on how you feel not the number. Use the meter for interest and experimentation, but don't let it stress you out.

  3. blurfocus

    Thanks. I have incorporated your feedback.

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