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What Are The Signs Of Lactic Acidosis With Metformin?

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Please *LIKE || COMMENT | | SHARE | | SUBSCRIBE* to support this channel. For more info visit http://www.DiseasesAndTreatment.com/ ============================================================= Lactic Acidosis ,MELAS Syndrome, what, is, causes, symptoms, diagnosis, treatment, complications, prevention , cure, risk factors, outlook, prognosis, remedies, surgery, causes of Lactic Acidosis, symptoms of Lactic Acidosis, treatment of Lactic Acidosis, diagnosis of Lactic Acidosis, Lactic Acidosis symptoms, Lactic Acidosis treatment, Lactic Acidosis causes,

Lactic Acidosis: Symptoms, Causes, And Treatment

Lactic acidosis occurs when the body produces too much lactic acid and cannot metabolize it quickly enough. The condition can be a medical emergency. The onset of lactic acidosis might be rapid and occur within minutes or hours, or gradual, happening over a period of days. The best way to treat lactic acidosis is to find out what has caused it. Untreated lactic acidosis can result in severe and life-threatening complications. In some instances, these can escalate rapidly. It is not necessarily a medical emergency when caused by over-exercising. The prognosis for lactic acidosis will depend on its underlying cause. A blood test is used to diagnose the condition. Lactic acidosis symptoms that may indicate a medical emergency include a rapid heart rate and disorientaiton. Typically, symptoms of lactic acidosis do not stand out as distinct on their own but can be indicative of a variety of health issues. However, some symptoms known to occur in lactic acidosis indicate a medical emergency. Lactic acidosis can occur in people whose kidneys are unable to get rid of excess acid. Even when not related to just a kidney condition, some people's bodies make too much lactic acid and are unabl Continue reading >>

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  1. 2blessed4stress

    metformin and lactic acidosis

    I am hoping that I can get some guidance from the members here. There are many of you that have a wealth of information on diabetes and things related so please bear with me. I went to the doctor yesterday and finally asked her for metformin er and was all set to try it out. Then I read the paper that came with it from the pharmacy. The warning about lactic acidosis stopped me in my tracks. Now I am afraid to take it. I searched the posts her a DD about lactic acidosis and I also found that some members said it caused them to be really fatigued. Another member posted that she had trouble with exercise because it caused leg cramps. I feel so overwhelmed now. I really wanted to try it out I believe it could help me but I don't want to put my life at risk to try it. I looked up lactic acidosis and I was reading about the bloods ph and acid in your blood. I have a problem with uric acid in my blood but I believe that is not related to lactic acidosis. I have had a problem with kidney infections and a lot of crystals in my urine and kidney stones the past year, but I believe my kidney function is ok. Does metformin cause lactic acidosis very often? Are the symptoms of lactic acidosis easy enough to pick up on so it can be caught early. I am sorry I am such a worry wart. Thank you in advance for any guidance/reassurance from you.

  2. furball64801

    All I can tell you is that millions upon millions take met with 0 issues. You are reading the absolute worst side affects. Have you see tv commericails on meds that is any meds. They say could cause heart attack, fatigue, even death no kidding. I been on met and so has my diabetic family and 0 issues other than a tad of diahrea. To me its extemely rare many here are on met me a very very long time on it. What am I saying to me its about the best D med out there other than exercise its free. It is just my opion for what its worth, I know others might have other ideas and of course its is there opinion also. Some take b-12 if they get fatigued on met, I do not get that way, all I can say is to me its as safe as can be.

  3. coravh

    Every drug has potential side effects. Some more common than others. I'm not sure of the exact specifics, but I believe that for a side effect to be listed, it needs to happen in 1% of the people that take it.
    My husband has been on met with no side effects other than a little bit of tummy trouble. I have a dozen local diabetic friends (through volunteer work) that are also on it, and have no side effects. I do have one friend who reacts to everything and has no issues with it. I think i've only seen people with this issue a couple of times after about 15 years online haunting a variety of message boards.
    Take for example my warfarin. It can cause bleeding. Even a baby aspirin can cause this. And it does happen to some people. But the vast majority of folks don't have issues.
    Do you have some history of lactic acidosis? Or is this simply general anxiety over something new?
    All meds are a cost benefit analysis. Do you want to try the drug to alleviate a serious issue ( like high blood sugar) or do you decide to refuse it on the basis of a rare side effect and maybe get into trouble due to glucose issues? Why not try it? Discuss with your phamacist what to look for if you are worried. But basically it is a safe, effective drug.
    Cora

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Metformin-induced Lactic Acidosis: No One Left Behind

Metformin-induced lactic acidosis: no one left behind 1Centro Nazionale di Informazione Tossicologica - Centro Antiveleni, IRCCS Fondazione Salvatore Maugeri, Via S. Maugeri 10, 27100 Pavia, Italy 2Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universit degli Studi di Milano, Via F.sco Sforza 35, 20122 Milano, Italy This article has been cited by other articles in PMC. Metformin is a safe drug when correctly used in properly selected patients. In real life, however, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug removal, mainly achieved by renal replacement therapy. Despite dramatic clinical presentation, the prognosis of metformin-induced lactic acidosis is usually surprisingly good. In the previous issue of Critical Care, Friesecke and colleagues demonstrate that the survival rate of patients with severe lactic acidosis due to metformin accumulation can be strikingly higher than expected based on the in Continue reading >>

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  1. MAYS

    Metformin Induced Lactic Acidosis! ... It can happen to anyone!

    How many questions do you ask your doctor, pharmacist or medical team concerning your nedications?
    How much in the way of research do you do on your own pertaining to medications and treatment that has been prescribed, or administered unto you?
    Let's talk about the diabetes medication, "Metformin" and a serious complication that it can cause called " Lactic Acidosis" in some people.
    What is Metformin induced Lactic Acidosis?
    http://diabetes.emedtv.com/metformin/metformi...
    Diabetic Connect family member "granniesophie" sent me this message, which I am sharing with everyone here (with her permission) concerning "Metformin and Lactic Acidosis" from a very personal perspective, her very own words!
    " I have to sit on my hands everytime a Metformin discussion comes up! I have just been diagnosed, after 4 months of tests and pain and losing 20 pounds for no reason and 2 different doctors not having a clue until just a few days ago, with Lactic Acidosis, caused by Metformin. This is a very rare side effect wihich only affects 5% of users. I'd been on it for over 6 years now, and it just came up in June. It can be fatal if not caught in time. It has also done damage to my kidneys, which the doctors hope can be reversed.
    The FDA says this is not a side effect, and studies are out on it, but there is a black box warning on it that it can cause Lactic Acidosis in some people. I have to report it to the FDA.
    This is a dangerous drug, and I may never be 100 percent-
    I have just begun taking Lantus, since the doctor no longer wants me on any oral meds until we can assess the damage that the Met may have caused long term.
    I am one sick human and I have other meds that have been causing issues now as well, related or not. So I am being juggled on all my meds in hopes that there is no long term damage.
    Whether this gets mentioned in discussions or not (and I am not going to) people should be aware that the Gold Standard of Diabetes treatment has some darn nasty thorns."
    Sonya
    ——————————
    If you have any questions, or concerns about Metformin and Lactic Acidosis talk to your doctor or pharmacist, if you have any questions that you would like to ask "Sonya" personally concerning this you can contact her here:
    http://www.diabeticconnect.com/users/85827-gr...

  2. Mamawiggles

    Metformin can aggravate breathing. Stupid D.O. Put my dad on it! Endocrinologist took him off immediately. You see. He has copd. Put him on Lantus.

  3. Jimbo6217

    I've only been taking the drug for a week but I've already developed hives head to toe and painfully swelled hands and feet. The only kidney proems I've had are stones .

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Is Metformin Associated With Lactic Acidosis?

Is Metformin Associated With Lactic Acidosis? The use of metformin in patients with renal impairment is associated with an increased risk for lactic acidosis. Why is this and what is the mechanism? Are sulfonylureas associated with lactic acidosis? Adjunct Faculty, Albany College of Pharmacy, Albany, New York; Clinical Pharmacy Specialist, VA Medical Center, Bath, New York Metformin is one of most commonly prescribed medications for the treatment of type 2 diabetes mellitus. Metformin exerts its activity by increasing peripheral glucose uptake and utilization, and decreasing hepatic gluconeogenesis. By decreasing pyruvate dehydrogenase activity and mitochondrial reducing agent transport, metformin enhances anaerobic metabolism and increased production of tricarboxylic acid cycle precursors. Inhibition of pyruvate dehydrogenase subsequently decreases the channeling of these precursors into aerobic metabolism and causes increased metabolism of pyruvate to lactate and ultimately lactic acid production.[ 1 ] In a patient with normal renal function, the excess lactic acid is simply cleared through the kidneys. However, in a patient with renal impairment, both metformin and lactic acid Continue reading >>

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Popular Questions

  1. MAYS

    Metformin Induced Lactic Acidosis! ... It can happen to anyone!

    How many questions do you ask your doctor, pharmacist or medical team concerning your nedications?
    How much in the way of research do you do on your own pertaining to medications and treatment that has been prescribed, or administered unto you?
    Let's talk about the diabetes medication, "Metformin" and a serious complication that it can cause called " Lactic Acidosis" in some people.
    What is Metformin induced Lactic Acidosis?
    http://diabetes.emedtv.com/metformin/metformi...
    Diabetic Connect family member "granniesophie" sent me this message, which I am sharing with everyone here (with her permission) concerning "Metformin and Lactic Acidosis" from a very personal perspective, her very own words!
    " I have to sit on my hands everytime a Metformin discussion comes up! I have just been diagnosed, after 4 months of tests and pain and losing 20 pounds for no reason and 2 different doctors not having a clue until just a few days ago, with Lactic Acidosis, caused by Metformin. This is a very rare side effect wihich only affects 5% of users. I'd been on it for over 6 years now, and it just came up in June. It can be fatal if not caught in time. It has also done damage to my kidneys, which the doctors hope can be reversed.
    The FDA says this is not a side effect, and studies are out on it, but there is a black box warning on it that it can cause Lactic Acidosis in some people. I have to report it to the FDA.
    This is a dangerous drug, and I may never be 100 percent-
    I have just begun taking Lantus, since the doctor no longer wants me on any oral meds until we can assess the damage that the Met may have caused long term.
    I am one sick human and I have other meds that have been causing issues now as well, related or not. So I am being juggled on all my meds in hopes that there is no long term damage.
    Whether this gets mentioned in discussions or not (and I am not going to) people should be aware that the Gold Standard of Diabetes treatment has some darn nasty thorns."
    Sonya
    ——————————
    If you have any questions, or concerns about Metformin and Lactic Acidosis talk to your doctor or pharmacist, if you have any questions that you would like to ask "Sonya" personally concerning this you can contact her here:
    http://www.diabeticconnect.com/users/85827-gr...

  2. Mamawiggles

    Metformin can aggravate breathing. Stupid D.O. Put my dad on it! Endocrinologist took him off immediately. You see. He has copd. Put him on Lantus.

  3. Jimbo6217

    I've only been taking the drug for a week but I've already developed hives head to toe and painfully swelled hands and feet. The only kidney proems I've had are stones .

  4. -> Continue reading
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