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What Are The Side Effects If You Stop Taking Metformin?

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Effects Of Withdrawal From Metformin On The Development Of Diabetes In The Diabetes Prevention Program

Go to: Abstract OBJECTIVE— In the Diabetes Prevention Program (DPP), metformin significantly reduced the risk of diabetes in individuals with impaired glucose tolerance. Diabetes status was assessed by oral glucose tolerance tests (OGTTs) performed while participants were still taking metformin or placebo. To determine whether the observed benefit was a transient pharmacological effect or more sustained, we performed a repeat OGTT after a short “washout” period during which medications (metformin or placebo) were withheld. RESEARCH DESIGN AND METHODS— All participants assigned to medication who had not developed diabetes at the end of the DPP were asked to have a repeat OGTT after discontinuing the study medication for 1–2 weeks. The predesignated outcome was the odds of diabetes in metformin versus placebo comparisons during the trial and washout combined. RESULTS— There were 1,274 participants who participated in the washout study and 529 who did not because they had already developed diabetes. Before the washout, the odds of diabetes in the metformin group was lower than that in the placebo group (odds ratio 0.66, 95% CI 0.54–0.82, P < 0.001). After the washout, di Continue reading >>

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Popular Questions

  1. AMeyer05

    I'm somewhat confused by your doctors reasoning? I had a stillborn at 22w in February. We are currently 14w pregnant again and my high risk doctor told me that at 16w I will start progesterone shots and that I have to do them every week until 36w. He said they are not recommended until week 16? It was always my understanding that early miscarriages were due to issues in the pregnancy and that nothing could be done if you were having one? They even told me this when they deemed my first pregnancy a "threatened miscarriage" at 17w. I would seek a second opinion personally. I would be concerned about being taken off of progesterone as well! Best of luck momma :)

  2. sesame16

    Thanks for getting back to me. I'm sorry to hear about your loss.
    My understanding from my doctor is that at 12 weeks the placenta takes over as it should be producing enough progesterone that the suppositories are redundant...

    I have heard of other moms starting progesterone later on for other reasons (much like you) so I find it very confusing.

  3. petrap14

    I have had 2 miscarriages because of low progesterone. I will be 12 wks this coming Thursday and last Friday my dr said I could stop taking the progesterone at 12 wks bc the placenta has taken over. She also said I could have some spotting. Hope this helps.

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