Toxic Acidosis

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Author: Elizabeth Walter, MD. Mayo Clinic Emergency Medicine Residency Program

Salicylate Toxicity: Practice Essentials, Etiology And Pathophysiology, Epidemiology

Salicylates are ubiquitous agents found in hundreds of over-the-counter (OTC) medications and in numerous prescription drugs, making salicylate toxicity an important cause of morbidity and mortality. [ 1 , 2 , 3 , 4 ] Salicylates are used as analgesic agents for the treatment of mild to moderate pain. Aspirin is used as an antipyretic and as an anti-inflammatory agent for the treatment of soft tissue and joint inflammation and vasculitides such as acute rheumatic fever and Kawasaki disease. Aspirin is also used to treat acute coronary syndrome. Low-dose aspirin helps to prevent thrombosis. Acetylsalicylic acid is colorless or white in crystalline, powder, or granular form. The chemical is odorless and is soluble in water. Salicylate is available for ingestion as tablets, capsules, and liquids. Salicylate is also available for topical application, in creams or lotions. Salicylate ingestion continues to be a common cause of poisoning in children and adolescents. The prevalence of aspirin-containing analgesic products makes these agents, found in virtually every household, common sources of unintentional and suicidal ingestion. However, the incidence of salicylate poisoning in childr Continue reading >>

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  1. GreyhoundGuru

    So, prior to starting my weight loss journey, I was always warm. I kept the heat set to about 65 degrees all day, and then down to 60 degrees at night.
    Since I've been on the weight loss program (about 4 1/2 weeks), I notice that I am always getting cold and hiking up the thermostat.
    I keep my calorie intake at least 1200 a day, plus I'm trying to work out at least an hour a day. I drink about ten to twelve 8oz glasses of water a day. Over the previous 3 1/2 weeks, I've lost 7lbs (hopefully more this week when I weigh in on Wednesday).
    I'm just wondering if this is normal.
    You'd think with the extra activity, I would be warmer than I was before.
    Just makes me scratch my head and go "huh?"
    Any ideas?

  2. elsinora

    Totally normal! What you describe is EXACtLY what happens to me when I start losing weight. Eventually you acclimatise x

  3. TuscanySun

    Ever since i dropped 125#, I'm freaking freezing all the time and its been 2 years since I started the weight loss...havent gotten used to it yet!

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This is a video that I've been meaning to make for a while. I think the idea of converting one drug to another is a pretty cool concept. About a year ago, I made a series where I chemically converted Aspirin to Tylenol (aka acetaminophen, paracetamol, or APAP). The original series was spread out over several videos and was over 90 minutes long. It has a lot more detail, but it was a much bigger commitment to watch. ------------------------------------------ Nile Red Shop: https://nile.red Patreon: https://goo.gl/3h353G Facebook: https://goo.gl/uyxvJV Twitter: https://goo.gl/uCmnV4 Personal Instagram: https://goo.gl/EdBq4b

Metabolic Acidosis Due To Paracetamol (acetaminophen)

Summarized from McGregor A, Laight N, Nolan S. Paracetamol and high anion gap metabolic acidosis. J Intensive Care Society 2012; 13: 54-56 Armenian P, Gerona R, Blanc P et al. 5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use. J Emerg Med 2012; 43: 54-57 Metabolic acidosis is a common metabolic disturbance among the acutely/critically ill that has many possible causes. The condition is diagnosed by arterial blood gas analysis which reveals primary reduction in pH and bicarbonate, followed by secondary (compensatory) reduction in pCO2. Abnormal accumulation of endogenous organic acids is one broad mechanism that gives rise to metabolic acidosis, which is differentiated from other mechanisms by being associated with high anion gap. The most common endogenous organic acid metabolic acidosis are: lactic acidosis (accumulation of lactic acid) and ketoacidosis (accumulation of ketoacids). Rarer causes of high anion gap metabolic acidosis due to organic acid accumulation are those that result from ingestion of a toxic substance whose metabolism involves production of an organic acid. For example, the toxicity of ethylene glycol is due in par Continue reading >>

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  1. BobbyS

    Can insulin resistance truly be reversed?

    I'm a bit unclear on what "insulin resistance reversal" or "diabetes reversal" really means.
    I was diagnosed as prediabetic about 3 weeks ago. I got a blood meter and my first test was postprandial and showed 191.
    I have been water fasting and eating LCHF since then...except for 3 days which is where I get the following info:
    It appears that "real food carbs" (e.g. carrots, onions, etc.) have virtually no effect on me. A meal with ~ 80 grams of real food carbs moved my blood glucose from 83 to 89.
    It also appears that eating LCHF keeps my blood glucose well < 100 but a single sugar/starch/refined flour meal will spike my blood sugar anywhere from 150 to 160 (I've eaten 2 such meals is where I get this data) and it takes a couple of days for my blood sugar to drop back below 100 (at least at my "dawn phenomenon" readings).
    Is "insulin resistance reversal" truly possible or can insulin resistance only be managed as long as sugar/starch/refined is avoided like the plague?
    I know I can't go back to eating like I used to eat...but it would be nice to hope that one day I will be able to "splurge occasionally" and keep normal blood sugar numbers...

  2. qsefthuko

    You might. Some people can some people can't.

  3. qsefthuko

    Apparently LCHF causes a degree of insulin resistance or something. If you have been eating LCHF for a bit and then eat a carby meal it can and probably will raise you higher than you might expect.

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Quickest Way to Flush Your BODY CLEAN of TOXINS. Help PREVENTS CANCER & REMOVE TOXIN from LIVER, COLON. On any given day, you may be exposed to any number of the 80,000-plus industrial chemicals in use today. Another 1,000 chemicals or so are introduced every year, according to Brenda Watson, a certified nutritional consultant and author of The Detox Strategy. These toxic substances lurk everywherein the air, water, household cleaners, perfumes, food and childrens toys. While the process of detox has its critics, natural health professionals extol its benefits for helping your body to expel toxins. Step 1 Reduce the amount of toxins you take in on a daily basis. Its self-defeating to do a detox if youre still taking in a significant amount of toxins, points out Peter Bennett, a naturopathic doctor and author of The Purification Plan. Switch to organic foods and beverages and drink filtered or distilled water. Avoid using products that contain toxins, such as household cleaners, inorganic cosmetics and perfumes, and avoid exposure to cigarette smoke or other airborne chemicals. Step 2 Eat about 30 to 40 grams of fiber daily. As Ann Louise Gittleman puts it in her book The Fast Track One-Day Detox Diet, "The colon is the garbage dump in your system, but fiber acts as a garbage truck hauling away the toxic waste." Organic vegetables, fruits and whole grains are good sources. Step 3 Drink a glass of cranberry juice combined with orange juice daily. Both juices are loaded with antioxidants that fight free radicals. Cranberry juice also enables the liver to break down fat more efficiently and contains a key ingredient, arbutin, which acts as a diuretic and draws out toxins to be excreted, according to Gittleman. Step 4 Drink at least eight 8 oz. glasses of purified water each day to increase kidney activity and speed up the removal of toxins. Water will also prevent constipation from your increased fiber intake. Step 5 Exercise for at least 30 minutes every day. When you dont exercise, the lymphatic systemwhich keeps your immune system working at peak conditionbecomes stagnant, causing waste to spill over into your body, Bennett explains. Exercise also increases sweating, which also effectively removes toxins. Step 6 Treat yourself to a full-body rub down with an organic sea salt scrub. According to Bennett, salts have detoxifying qualities and increase perspiration. They also exfoliate your skin to remove dead skin cells and dirt that may be blocking pores on your skin, another powerful detoxification organ in your body. Things You'll Need Dietary fiber Cranberry juice Orange juice Purified water Sea salt scrub Air purifier Tips Practice meditation or deep breathing for at least 15 minutes a day during your detox, which can be stressful. Also, it can help to offset detox side effects such as hunger pangs, according to Gittleman. Turn on an air purifier to eliminate airborne toxins in your home. Warnings If you have a disease or medical condition, consult your doctor before attempting a detoxification treatment.

Metabolic Acidosis Due To Drugs And Toxins Acidosis due to Drugs and Toxins Metabolic Acidosis due to Drugs and Toxins Several drugs and toxins have been implicated as direct or indirect causes of a high-anion gap metabolic acidosis (HAGMA). A consideration of these drugs needs to be included in an differential diagnosis of a HAGMA. The three most common ones to consider are methanol, ethylene glycol and salicylates. Other toxins which can cause acidosis are isopropyl alcohol and butoxyethanol. Toluene also causes an acidosis and the anion gap may be normal or elevated. * Initially no acid-base disorder due to long latent period while methanol is metabolised * Later, typically develop a high anion gap metabolic acidosis -due to formic acid * May also develop a respiratory acidosis secondary to CNS depression (with depression of respiratory centre and/or airway obstruction) * May occasionally present with normal anion gap acidosis if smaller ingestion * If patient is an alcoholic, there may other types of acidosis present as well (eg alcoholic ketoacidosis, starvation ketoacidosis, lactic acidosis, respiratory acidosis due aspiration, respiratory alkalosis due chronic liver disease.) Principles of Treatmen Continue reading >>

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  1. ably65

    My body is FINALLY releasing weight and I am so so glad but I have a question...
    Over the last few days I have been noticing that I have really bad body odor. It is all over my body. I keep showering, using deodorant (obviously) and using perfume so I hope it isn't too noticeable to other people. I have NEVER had a problem with this before.
    Then, two days ago, I noticed a strong cigarette smell that seemed to be coming off of me. I smoked for years but haven't touched a cigarette in 2 years so I thought I was imagining it. Then, last night, I had the "taste" of having smoked in my mouth. This is really strange. Have any former smokers experienced anything like this? Could nicotine be stored in my fat cells?
    Come to think of it, I have also been very jittery and having trouble sleeping and that is what used to happen if I smoked in the evening.
    I know this sounds crazy but I swear I am of sound mind.

  2. nxd10

    I have read that fat stores toxins and that when you metabolize it they are released. It could be that. No idea of the veracity of that, but it is plausible.
    My son has a serious problem with body odor even though he bathes daily. Part of it can be caused by the particular strains of bacteria growing on your skin. If you with your armpits with white vinegar or lime juice it helps tremendously. Solved his problem completely.
    IMO, perfume makes you smell worse. It doesn't cover up anything.

  3. gingerveg

    My instincts tell me this is excellent news for you. After reading your post I realized this happened to me too. It was years ago after quitting smoking and getting healthy. I think your body is detoxing and that is definitely hopeful news.
    By far the very best deodorant I have ever used is coconut oil (something like this: http://www.walmart.com/ip/Spectrum-Naturals-Organic-Coconut-Oil-14-fl-oz/10535750) mixed with baking soda. That's it, mix it in a little bowl until it is a creamy consistency and you can use this stuff all over your (exterior) body . My husband (who is a sweaty person) also swears by it. You can cover the mixture with plastic wrap to save (or put it in a little jar maybe even a roll on stick [never tried that]) and this stuff stays good for years. Not only is this the good stuff, but you also get the added benefit of no added aluminum (or anything) so it's likely much healthier for you than the store bought brands. Congrats on your detox and good luck!
    ETA: Just wanted to add that coconut oil turns liquid when heated so that is just something to think about when you are storing/using it.

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