Starvation Ketoacidosis Pdf

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Jci -liver And Kidney Metabolism During Prolonged Starvation

Liver and kidney metabolism during prolonged starvation Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215 Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115 Peter Bent Brigham Hospital, Boston, Massachusetts 02115 Joslin Diabetes Foundation, Inc., Boston, Massachusetts 02215 Find articles by Owen, O. in: JCI | PubMed | Google Scholar Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215 Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115 Peter Bent Brigham Hospital, Boston, Massachusetts 02115 Joslin Diabetes Foundation, Inc., Boston, Massachusetts 02215 Find articles by Felig, P. in: JCI | PubMed | Google Scholar Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215 Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusett Continue reading >>

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  1. Jason Homan

    What is Ketoacidosis?

    Only add:
    Diabetic ketoacidosis (DKA) is one consequence of untreated diabetes mellitus (chronic high blood sugar, or hyperglycemia), and is linked to an impaired glucose cycle.
    Diabetic Ketoacidosis is a complication of diabetes in which the animal becomes very ill. Symptoms of this condition, in addition to the symptoms observed with diabetes mellitus, include: dehydration, weakness, vomiting, rapid respiratory rate, and sometimes the breath takes on an odor of nail polish remover. This is an emergency and often requires many days of hospitalization to treat. This condition often requires another inciting cause in addition to diabetes. Examples of conditions that can cause diabetic ketoacidosis in a diabetic animal include: stress, infection, inflammation, estrus (heat), steroids, congestive heart failure and kidney failure.
    The condition is definitely treatable, and need not shorten the animal's life span or life quality. In type-2 cats, prompt effective treatment can even lead to diabetic remission, in which the cat no longer needs injected insulin. Untreated, the condition leads to blindness in dogs, increasingly weak legs in cats, and eventually malnutrition, ketoacidosis and/or dehydration, and death.
    I just did a quick check on ketoacidosis and they had a very nice presentation. You might want to check out this site: http://diabetes.healthcentersonline.com/
    Jason Homan

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    What Is Ketoacidosis. - What is Ketoacidosis Reference.com/What is Ketoacidosis What is Ketoacidosis. Find Easy-to-Read Related Content. Thousands Of Articles - Explore Answers At Reference.com Now!
    Ketoacidosis is a state of methabolic acidosis due to high blood concentration of substances called ketonic bodies. It is a common complication of Diabetes mellitus,in wich the body cretes these ketonic bodies as a result of excesive fat removal to provide an alternative energy source( the liver is the main organ for the synthesis), since glucose can´t be incorporated because cells ( specially muscle, neurons, liver, white blood cells)need insuline to do that. this condition takes time to develop, and in the end it can become life threatening, for the ketonic bodies lower the blood ph and increase seruum osmolarity, both of these dangerous for organs, specially the brain, kidneys, heart. When a person or animal goes in to diabetic ketoacidosis, it must be hospitalized inmediately and stabilized with careful fluidtherapy and insuline treatment. The type of insuline used is crystaline regular( bovine)

  3. Comment

    Ketoacidosis is when the body has an insufficient supply of insulin it
    cannot metabolize carbohydrates. Because of this inability to
    metabolize carbohydrates, the muscles become starved for glucose needed
    to provide the energy for work. In order to get that needed energy, the
    muscle breaks down fat. Fat, when metabolized produces the by-products
    called Ketones, which are normally excreted in the urine. If the body
    is unable to clear the ketones through the kidneys, they build to toxic
    levels and eventually lead to ketoacidosis.
    At the same time the body is producing ketones, it is not using glucose.
    The kidneys, through the production of urine, must remove both. The
    higher the ketones and unused glucose levels, the more urine must be
    produced and the body will become dehydrated.

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Euglycemic Diabetic Ketoacidosis: A Review

Euglycemic Diabetic Ketoacidosis: A Review Author(s): Anar Modi , Department of Endocrinology, Diabetes & Metabolism, Cooper University Hospital, Camden, New Jersey, United States Abhinav Agrawal* , Department of Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, New Jersey, United States Farah Morgan . Department of Endocrinology, Diabetes & Metabolism, Cooper University Hospital, Camden, New Jersey, United States Introduction: Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes.It is characterised by the triad of hyperglycemia (blood sugar >250 mg/dl), metabolic acidosis(arterial pH <7.3 and serum bicarbonate <18 mEq/L) and ketosis. Rarely these patients can present withblood glucose (BG) levels of less than 200 mg/dl, which is defined as euglycemic DKA. The possibleetiology of euglycemic DKA includes the recent use of insulin, decreased caloric intake, heavy alcoholconsumption, chronic liver disease and glycogen storage disorders. DKA in pregnancy has also beenreported to present with euglycemia. The recent use of sodium glucose cotransporter 2 (SGLT2) inhibitorshas shed light on another possible mechanism of euglycemic DKA. Clinicia Continue reading >>

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Popular Questions

  1. Injecto

    I can't seem to find anything that backs this up. I know that high BG will damage them over time (duh!!), but what about ketones?

  2. fgummett

    Ketone bodies are water-soluble compounds that are produced as by-products when fatty acids are broken down for energy. They are a vital source of energy during fasting -- such as overnight.
    The brain gets its energy from ketone bodies when insufficient glucose is available. In the event of low blood glucose, most other tissues have additional energy sources besides ketone bodies (such as fatty acids), but the brain does not.
    Remember that when you are not fasting, the body can use Amino Acids (from dietary Protein) to synthesize Glucose (Gluconeogenesis).
    Any production of Ketones is called ketogenesis, and this is necessary in small amounts. When even larger amounts of ketone bodies accumulate such that the blood's pH is lowered to dangerously acidic levels, this state is called ketoacidosis. This happens in untreated Type I diabetes (DKA).
    In short, the human body has evolved over the millennia to burn either Glucose or Fatty Acids -- think of these as the short-term fuel and longer-term reserve, respectively.
    So if it is normal to burn Fatty Acids and produce Ketones why would they be harmful unless they accumulate to dangerous levels? Yes I know... we always get the "dangerous levels" lecture but consider that BG can be toxic at high enough levels... that does not mean it is bad for us at any level


    can we get the production of ketones correct??
    The primary cause of ketogenesis in the body is.....
    gluconeogenesis from dietary protein, when there is insufficient dietary glucose to fill the body needs, aka the ketogenic diet.
    The process of gluconeogenesis utilises a key component of the citric acid cycle (oxaloacetate), which blocks the oxidation of Acetyl CoA. Fatty acid (and glucose oxidation) require their conversion to Acetyl CoA. It is Acetyl CoA which is converted to ketone bodies and this process occurs pretty exclusively in the liver (also happens in the kidney)
    Normally oxidation of fatty acids does NOT produce ketone bodies, even during fasting overnight, as usually there are more than sufficient stores of glycogen.
    - starvation is an entirely different matter. Fasting for longer than a day or so can be sufficient for ketogenesis to start.
    Astrocytes in the brain can produce ketone bodies in response to hypoglycemia, but this will not provide adequate protection in the event of hypoglycemia caused by insulin overdose.
    The simple reason why ketogenesis as caused by a ketogenic diet is probably safe is because ketones only transiently rise in response to food, and the levels sustained should not be sufficient to disturb the body's buffer system.
    if however you spent long periods without food, or lacking insulin then that is a very different matter.
    I can't find anything definitive about ketones and kidney function - the only thing of note is an association with kidney stones for children on ketogenic diets to control epilepsy - but this could be due to the components of the diet (high protein) rather than ketones. There are no long term safety studies on ketogenic diets, but they are though to be safe (probably).
    Those on this forum on low carbohydrate diets 50g to 120g of carbs probably do not experience ketogenesis to any significant degree. Significant ketogenesis only occurs at <30g.

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Severe Ketoacidosis Secondary To Starvation In A Frutarian Patient

El presente trabajo es el primer caso descrito de un paciente que sufre de Frugitarismo Trastorno de con- ducta alimentaria de reciente aparicin que ingresa en la UVI por cetoacidosis grave. La alimentacin es estric- tamente slo de frutas. Esta alteracin del compor- tamiento alimentario nos lleva a desarrollar una ketoaci- dosis severa con secundaria a la desnutricin. Palabras clave: Frugitarismo. Cetoacidosis severa. The present paper presents the firts clinical case of a patient suffering from Frutarianism a new Eating dis- order and severe Ketoacidosis. The life-style feed strict- ly only on fruits (not even other vegetables, since plant death is necessary previous consumption).This behav- ioural alteration frequently leads to starvation and the subsequent Ketoacidosis due to starvation. Key words: Frutarianism. Severe Ketoacidosis. Starva- Diabetic ketoacidois is a common cause of metabolic acidosis observed in daily clinical practice. Thus, in the context of a metabolic acidosis involving elevated os- molarity and anion gap, a diagnosis of ketoacidosis due to starvation should be considered in differential diag- nosis1,2. Metabolic acidosis related to starvation is usu- ally Continue reading >>

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Popular Questions

  1. Kristy

    Hi everybody! So I've been eating paleo for about a year and BP for about half a year. I started to to BP intermittent fasting and continued for about 3 months. Although I made sure to eat enough during the eating window and put enough fat in my coffee, I ended up loosing my period and not getting it back for 3 months. Thought it might be the IF so I started having breakfast (eggs and BPC) for a month and did get my period. However, that was two months ago and I haven't gotten my period again. I'm really confused and would like some ideas as to why this is happening.
    I'm 17, 5'5, 125lb.
    This is a typical day:
    Breakfast: two eggs, "Skinny BPC": 1 tbsp butter, 1tbsp mct, small bit of veg.
    Lunch: 3oz beef/lamb/fish/eggs. Butter/coconut oil/mct, 2 cups veg, avocado, olives
    Dinner: like 4 cups of veg, butter/coconut oil/mct.
    In between meals/dessert/on-the-go food: 1 oz macadamia nuts, Lindt 90, coconut flakes
    I eat about 3/4 cups of starch every 2-3 days or so.
    Any help would be greatly appreciated!

  2. Meghan0825

    This one is easy.... not enough carbs! Women need more carbs... check out Jason Seib's work, Stephanie at Paleo for Women... Go Kaleo... IFing and low carb ketosis is not good for most females

  3. Marielle

    Here's another opinion. I think you need to go consult a medical professional to find out what is going on with you hormonally. It might not be connected to your diet. Just don't let the doc try to put you on birth control pills (say "thank you" when they hand you the prescription, then don't fill it).
    I don't think ketosis is necessarily bad for women. I think long term ketosis can have some effects on many people, especially women with our touchier systems, and that's why you'll hear to recommendation to come out of ketosis approximately weekly with a "re-feed".
    I personally think your protein is too low for someone your age, especially if you are really active. Why not add some meat or fish for dinner?
    Good luck to you

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