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Situations In Which Ketosis May Occur

10 Signs And Symptoms That You're In Ketosis

10 Signs And Symptoms That You're In Ketosis

The ketogenic diet is a popular, effective way to lose weight and improve health. When followed correctly, this low-carb, high-fat diet will raise blood ketone levels. These provide a new fuel source for your cells, and cause most of the unique health benefits of this diet (1, 2, 3). On a ketogenic diet, your body undergoes many biological adaptions, including a reduction in insulin and increased fat breakdown. When this happens, your liver starts producing large amounts of ketones to supply energy for your brain. However, it can often be hard to know whether you're "in ketosis" or not. Here are 10 common signs and symptoms of ketosis, both positive and negative. People often report bad breath once they reach full ketosis. It's actually a common side effect. Many people on ketogenic diets and similar diets, such as the Atkins diet, report that their breath takes on a fruity smell. This is caused by elevated ketone levels. The specific culprit is acetone, a ketone that exits the body in your urine and breath (4). While this breath may be less than ideal for your social life, it can be a positive sign for your diet. Many ketogenic dieters brush their teeth several times per day, or use sugar-free gum to solve the issue. If you're using gum or other alternatives like sugar-free drinks, check the label for carbs. These may raise your blood sugar levels and reduce ketone levels. The bad breath usually goes away after some time on the diet. It is not a permanent thing. The ketone acetone is partly expelled via your breath, which can cause bad or fruity-smelling breath on a ketogenic diet. Ketogenic diets, along with normal low-carb diets, are highly effective for losing weight (5, 6). As dozens of weight loss studies have shown, you will likely experience both short- and long Continue reading >>

Fatty Acide Oxidation, Ketosis And Ketoacidosis

Fatty Acide Oxidation, Ketosis And Ketoacidosis

Sort Uptake of FA into mitochondria 1. Fatty acyl-CoA synthase fatty acid + ATP + CoA --> fatty acyl-CoA + ADP -location = outer mitochondrial membrane -fatty acyl-CoA cannot cross innner membrane of mito 2. Carnitine Palmitoyl transferase I (CPT I) Fatty acyl-coA + Carnitine --> fatty acyl-carnitine + CoA -fatty acyl-carnitine enters mito matrix through carnitine-fatty-acyl carnitine translocase 3. Carnitine Palmitoyl transferase II (CPT II) fatty acy carniitine + CoA --> fatty acyl-CoA + carnitine -carnitine returns to inter membrane space through carninitine fatty acyl carnitine translocase B-oxidation of FA's -Takes place in mitochondria -each round fatty acyl-CoA's are shortened by 2 Carbons releasing CoA -Oxidizing agents = NAD+ and FAD+ -Energy production = NADH + FADH2 = 25% of energy production, acetyl-CoA = 75% of energy production Reaction = fatty acyl coA + NAD+ + FAD+ --> fatty acyl-CoA + CoA + NADH + FADH2 Reguatlion of fatty acid oxidation 1. Insulin = ihibition, epinephrine = activation 2. Muscle cells = regulate concentration of FA transporters 3. Malonyl CoA = inhibits CPT I, inhibiting FA uptake -Note: liver acetyl-CoA carboxylase I synthesizes malonyl-coA in fed state, in muscle acetyl-CoA carboxylase II synthesizes malonyl-coA in fasting state or where there's high AMP (ATP inhibits acetyl-CoA carboxylase II) 4. PPAR-a --> increases B-oxidation by influencing transcription of enzymes involved -Note: Fibrates = a drug class that lowers triglyceride levels in blood by activating PPAR-a Diseases of FA oxidation -w/o FA oxidation in fasting state, body uses more glucose for energy production. THis glucose can only come from glycogenolysis b/c gluconeogenesis can only occur w/ the input of energy from FA oxidation. -Result = severe hypoglycemia in period Continue reading >>

Natural Ketosis Blog Archive

Natural Ketosis Blog Archive

Not only can stress influence your behaviours, but having high stress levels on a day to day basis can result in chronically elevated cortisol levels. High cortisol levels are strongly associated with weight gain and can make losing weight much more difficult. Hormones which increase your appetite can also be activated when stressed and can cause behaviours or habits to occur that involve comfort eating or emotional eating. In this blog we aim to give you some hints and tips on how best to manage these situations. Stressed? What do you do? Unfortunately it is not always possible to avoid stress altogether, with many situations requiring action so that long term stress does not occur. As everyone has a unique response to stress, you will have to find the right solution to managing it. Discover what makes you feel calm and in control by trying the following options: 1. Try changing the solution: If it is too difficult for you to avoid a stressful situation, then try to change it. Figure out what you can do so that if the problem arises again, you know how to cope with it straight away: a. Don’t bottle up your feelings - make sure you have someone to talk to, either a family member or the NK support team. This is important as your weight loss journey will be filled with lots of different emotions. b. Be more assertive - deal with problems head on, don’t avoid them. This will help you to anticipate problems in the future c. Manage your time- if you find yourself eating sweet treats due to running out of time, such as when working to a deadline, make a set-list of what you need to do and stick to this in order to manage your time. 2. Try adjusting to the stressor: If it is too difficult to change the situation, try adjusting to the stressful situation instead. This will Continue reading >>

Lipids 4

Lipids 4

Sort Lipids are included in the diet for several reasons. Lipids in the diet provide a source of the ___ ___ ___. They are often added to the diet as a concentrated source of ___. A small amount of added fat increases ___ and decreases ___ of a feed. They are required in the diet ONLY to provide ___ ____ ____. essential fatty acids energy palatability dustiness essential fatty acids There are few stated requirements for the EFA. This is a current area of research and greater detail on the requirements and roles of specific fatty acids will likely be available as more research is completed. While these amounts are small, they are critical to ____ function. body ___-___ acid (ω-3) is required, although there are few specifics on the required amount. Generally the thinking is that a ___ percentage in the diet is required than for linoleic acid. A recent publication of Nutrient Requirements of Dogs and Cats (NRC, 2006) suggests the sum of ____ (EPA, C20:5, ω-3) and ____ (DHA, C22:6, ω-3) fatty acids, included in the diet should be ___ to ___%. alpha-linolenic smaller eicosapentaenoic docosahexaenoic 0.01 0.04 Dairy cow - ___ to ___% added fat: This is usually included in early ____ to increase energy without adding more grain. It also gives the flexibility to add energy and maintain ___ levels in the diet. The fiber is needed for proper ____ function. ____ ____ is a feedstuff that is often used. ____, an escape fat source, is another example. 4-6 lactation fiber rumen whole cottonseed megalac Horse - ___ to ___% added: Fat may be added to the diet of high ___ horses. The fatty acids provide energy for ___ and spare ___ because a greater proportion of the energy used by muscle is generated from ___. Vegetable oils, such as ___ oil, ___ oil, or ___ oil are often added. 8-1 Continue reading >>

Ketosis

Ketosis

There is a lot of confusion about the term ketosis among medical professionals as well as laypeople. It is important to understand when and why nutritional ketosis occurs, and why it should not be confused with the metabolic disorder we call ketoacidosis. Ketosis is a metabolic state where the liver produces small organic molecules called ketone bodies. Most cells in the body can use ketone bodies as a source of energy. When there is a limited supply of external energy sources, such as during prolonged fasting or carbohydrate restriction, ketone bodies can provide energy for most organs. In this situation, ketosis can be regarded as a reasonable, adaptive physiologic response that is essential for life, enabling us to survive periods of famine. Nutritional ketosis should not be confused with ketoacidosis, a metabolic condition where the blood becomes acidic as a result of the accumulation of ketone bodies. Ketoacidosis can have serious consequences and may need urgent medical treatment. The most common forms are diabetic ketoacidosis and alcoholic ketoacidosis. What Is Ketosis? The human body can be regarded as a biologic machine. Machines need energy to operate. Some use gasoline, others use electricity, and some use other power resources. Glucose is the primary fuel for most cells and organs in the body. To obtain energy, cells must take up glucose from the blood. Once glucose enters the cells, a series of metabolic reactions break it down into carbon dioxide and water, releasing energy in the process. The body has an ability to store excess glucose in the form of glycogen. In this way, energy can be stored for later use. Glycogen consists of long chains of glucose molecules and is primarily found in the liver and skeletal muscle. Liver glycogen stores are used to mai Continue reading >>

What Are The Situations In Which Earthquake Occurs?

What Are The Situations In Which Earthquake Occurs?

Earthquakes are usually caused when rock underground suddenly breaks along a fault. This sudden release of energy causes the seismic waves that make the ground shake. When two blocks of rock or two plates are rubbing against each other, they stick a little. They don't just slide smoothly; the rocks catch on each other. The rocks are still pushing against each other, but not moving. After a while, the rocks break because of all the pressure that's built up. When the rocks break, the earthquake occurs. During the earthquake and afterward, the plates or blocks of rock start moving, and they continue to move until they get stuck again. The spot underground where the rock breaks is called the focus of the earthquake. The place right above the focus (on top of the ground) is called the epicenter of the earthquake. Earthquake-like seismic waves can also be caused by explosions underground. These explosions may be set off to break rock while making tunnels for roads, railroads, subways, or mines. These explosions, however, don't cause very strong seismic waves. You may not even feel them. Sometimes seismic waves occur when the roof or walls of a mine collapse. These can sometimes be felt by people near the mine. The largest underground explosions, from tests of nuclear warheads (bombs), can create seismic waves very much like large earthquakes. This fact has been exploited as a means to enforce the global nuclear test ban, because no nuclear warhead can be detonated on earth without producing such seismic waves. Continue reading >>

Ketosis: What Is Ketosis?

Ketosis: What Is Ketosis?

Ketosis is a normal metabolic process. When the body does not have enough glucose for energy, it burns stored fats instead; this results in a build-up of acids called ketones within the body. Some people encourage ketosis by following a diet called the ketogenic or low-carb diet. The aim of the diet is to try and burn unwanted fat by forcing the body to rely on fat for energy, rather than carbohydrates. Ketosis is also commonly observed in patients with diabetes, as the process can occur if the body does not have enough insulin or is not using insulin correctly. Problems associated with extreme levels of ketosis are more likely to develop in patients with type 1 diabetes compared with type 2 diabetes patients. Ketosis occurs when the body does not have sufficient access to its primary fuel source, glucose. Ketosis describes a condition where fat stores are broken down to produce energy, which also produces ketones, a type of acid. As ketone levels rise, the acidity of the blood also increases, leading to ketoacidosis, a serious condition that can prove fatal. People with type 1 diabetes are more likely to develop ketoacidosis, for which emergency medical treatment is required to avoid or treat diabetic coma. Some people follow a ketogenic (low-carb) diet to try to lose weight by forcing the body to burn fat stores. What is ketosis? In normal circumstances, the body's cells use glucose as their primary form of energy. Glucose is typically derived from dietary carbohydrates, including: sugar - such as fruits and milk or yogurt starchy foods - such as bread and pasta The body breaks these down into simple sugars. Glucose can either be used to fuel the body or be stored in the liver and muscles as glycogen. If there is not enough glucose available to meet energy demands, th Continue reading >>

Ketosis Vs Keto-adapted

Ketosis Vs Keto-adapted

As you might know already, I started a Facebook group called Ketogenic Success as a positive, success-oriented community of like-minded folks who are on their own keto journey. Well, the group is growing every day (almost 15k members as of right now), which is awesome. Because the group is growing so fast, new folks will frequently ask the same questions. There’s nothing wrong with that. Asking questions is how we all learn and grow. So I wanted to take some time to address one of the most common questions we see in the group: What’s the difference between being in ketosis and being keto-adapted? It’s easy to see why this is such a confusing topic, and it’s not made easier by the common misconceptions (and just plain errors) that seem to abound. First, let’s address the subject of ketosis. Ketosis is a situation where your body is producing ketones. There are three ketone bodies: acetone, acetoacetate, and beta-hydroxybutyrate (BHB). Ketones are produced hepatically (which is a fancy way of saying “by the liver”) as a product of breaking down fatty acids. But there’s a bit of a problem with this simple definition of ketosis. You see, your liver is constantly breaking down fatty acids, and therefore creating ketones, but it would be difficult to say that you’re in ketosis. That’s because the level of ketones isn’t high enough to be considered ketosis. So, having ketones in your body doesn’t necessarily mean you’re in ketosis. Okay. Cool. Cool, cool, cool. But, hey…so…wait a sec. Is there, like, a level of ketones that DOES mean you’re in ketosis? Well…yes. Yes, there is. Dr. Stephen Phinney is the grandmaster of ketogenic research (along with Dr. Jeff Volek), and he’s the person who coined the term “nutritional ketosis.” Before Phi Continue reading >>

Health-conscious Public Increasingly Embraces Ketogenic Diet

Health-conscious Public Increasingly Embraces Ketogenic Diet

Your body requires the metabolic flexibility to use both fat and glucose for fuel. Conventional dietary advice fails because eating a high-carb diet for a long period of time makes you unable to effectively burn fat for fuel Most people not only eat the wrong foods and too much of them, they also eat too frequently. Intermittent fasting, and longer water fasts if you’re overweight, can help you regain the ability to burn fat for fuel A ketogenic diet focuses on the three keys to achieving nutritional ketosis: minimal carbohydrates, moderate amounts of high-quality protein and high amounts of healthy fats By Dr. Mercola Your body is designed to have the metabolic flexibility to use both fat and glucose for fuel — not just one or the other. The reason conventional dietary advice has failed so miserably is because eating a high-carb diet for a long period of time results in the loss of this metabolic flexibility, making you unable to effectively burn fat for fuel. Last year, the British National Obesity Forum and the Public Health Collaboration issued a joint report based on the analysis of 43 obesity studies, warning the policy to promote a low-fat, high-carb diet is having a "disastrous impact on health."1,2,3 In conclusion, the report issued a strong recommendation to overhaul dietary guidelines to recommend a low-carb, high-fat diet instead, along with intermittent fasting or skipping meals, as chronic grazing or snacking between meals is a significant contributor to obesity. In short, most people not only eat the wrong foods and too much of them, they also eat too frequently. Lately, the ketogenic diet has become increasingly popular, and its popularity is largely driven by the sheer number of success stories. A recent article4 by CNBC, for example, notes how Sili Continue reading >>

Ketosis Fundamentals

Ketosis Fundamentals

What is ketosis? Ketosis is the physiological state where the concentration of ketone bodies in the blood is higher than normal. This is generally agreed to be at beta-hydroxybutyrate (BHB) concentrations greater than 0.5 mM. How to achieve ketosis? Ketosis occurs either as a result of increased fat oxidation, whilst fasting or following a strict ketosis diet plan (ENDOGENOUS ketosis), or after consuming a ketone supplement (EXOGENOUS ketosis). When in a state of ketosis the body can use ketones to provide a fuel for cellular respiration instead of its usual substrates: carbohydrate, fat or protein. Why does ketosis exist? Normally, the body breaks down carbohydrates, fat, and (sometimes) proteins to provide energy. When carbohydrate is consumed in the diet, some is used immediately to maintain blood glucose levels, and the rest is stored. The hormone that signals to cells to store carbohydrate is insulin. The liver stores carbohydrate as glycogen, this is broken down and released between meals to keep blood glucose levels constant. Muscles also store glycogen, when broken down this provides fuel for exercise. Most cells in the body can switch readily between using carbohydrates and fat as fuel. Fuel used depends on substrate availability, on the energy demands of the cell and other neural and hormonal signals. The brain is different as it is dependent on carbohydrates as a fuel source. This is because fats cannot easily cross the blood-brain barrier. The inability to make use of energy within fat poses a problem during periods where there is limited carbohydrate in the diet. If blood glucose levels fall to low, brain function declines. Relatively little energy is stored as carbohydrate (2,000 kCal) compared to fat (150,000 kCal). The body's store of carbohydrates runs Continue reading >>

The Ketogenic Diet Part Two: Troubleshooting

The Ketogenic Diet Part Two: Troubleshooting

Since writing about the ketogenic diet, I received a slew of inquiries on the “how-to’s,” and the process of keto-adaptation. I have also received emails from some who are having a hard time breaking into ketosis. There are numerous factors involved in the adaptation process and properly following the diet for success; however, I believe more research is needed to learn why some people become efficient fat burning machines and others struggle to keto-adapt and lose fat. I have learned a lot working with so many weight loss resistant individuals, and will attempt to bring more clarity to some of these difficult questions. Since each of our bodies is different, the diet needs to be fine-tuned to gain the greatest benefits, but there are conditions like perimenopause, hypothyroidism, and neurotoxicity that I have found will keep someone from adapting to an efficient fat burner. The complex topic remains an ongoing subject of interest for me and many of my clients, and following are some common questions I’ve been asked, as well as strategies I developed to help those who struggle to break through into fat burning machines. Some people confuse being in nutritional ketosis (NK) with diabetic ketoacidosis (DKA), which is very different. DKA is a serious condition affecting people with diabetes (mostly type 1), and occurs due to a massive shortage of insulin in the body that forces the body to burn fatty acids for energy and gives off a massive amount of the byproduct from the fat burning (ketones > than 10). The lack of insulin also leads to an increased release of glucose by the liver and dangerously high blood sugar levels, and can result in death. Conversely, NK is safe, produces normal levels of blood ketones from fat burning (.5 to 5), and can provide outstanding Continue reading >>

Ketogenic Supplements Reviews Fast & Safe Keto Products For Weight Loss

Ketogenic Supplements Reviews Fast & Safe Keto Products For Weight Loss

Ketogenic supplements are taking the world by storm and the right product can steady the balance of fats that your body needs to get your body into that state of ketosis. Those of you who have tried this form of weight loss before are probably more than aware of how hard it can be to first get your body to adapt to such a dramatic change in your daily intake of food, let alone without the help of a single exogenous ketone supplement. And the situation isn’t made any easier if you use a poor quality ketosis supplement because the wrong product may actually do you more harm than good. Bad quality ketosis supplements, have proven to lead to side-effects such as constipation and increased levels of cholesterol and triglycerides in men and women may also experience amenorrhea or other disruptions to the menstrual cycle. This is why it is really important to know what combination of compounds you are consuming, particularly while you are on this very strict diet, because the wrong balance can really mess with you in the long term. DO YOUR RESEARCH. I can't stress this point enough. This lifestyle change isn't for the faint hearted and you can't just wing it. It's a calculated exercise, which can lead to so many benefits. Check out the rest of this article so you can get up to speed, on how everything works and what powder or pill are actually out there and when you're finished go deeper and read our articles on the science behind this fascinating and our reviews on the best mix of exogenous ketone supplements out there in the market. Because without the knowledge and the right information, you'll never reach your goals and you may as well just keep eating that mash potato for dinner and club sandwich for lunch. Believe me, I stumbled onto this trend before it even blew up a Continue reading >>

Diabetic Ketosis Without Acidosis

Diabetic Ketosis Without Acidosis

Ketosis and Ketonuria Ketosis and Ketonuria may occur whenever increased amounts of fat are metabolized, carbohydrate intake is restricted, or the diet rich in fats (either “hidden” or obvious). This state can occur in the following situations: a. Metabolic conditions: Diabetes mellitus Renal glycosuria Glycogen storage disease (von Gierke’s disease) b. Dietary conditions: Starvation, fasting High-fat diets Prolonged vomiting, diarrhea Anorexia Low-carbohydrate diet Eclampsia c. Increased metabolic states caused by: Hyperthyroidism Fever Pregnancy or lactation In non-diabetic persons, ketonuria occurs frequently during acute illness, severe stress, or sternous exercise. Approximately 15% hospitalized patients have ketones in their urine even though they do not have diabetes. Children are particularly prone to developing ketonuria and ketosis. Ketonuria signals a need for caution, rather than crisis intervention, in either a diabetic or non-diabetic patient. However, this condition should not be taken lightly. In the diabetic patients, ketone bodies in the urine suggest that the diabetes is not adequately controlled and that adjustments of either the medication or diet should be made promptly. In the non-diabetic patients, ketone bodies indicate a reduced carbohydrate metabolism and excessive fat metabolism. Positive ketone urines in a children younger than 2 years of age is a critical alert. Difference between Diabetic Ketoacidosis and Diabetic ketosis or ketonuria The criteria for diagnosis of diabetic ketoacidosis (DKA) include: Blood glucose >250 mg/dl Ketonemia or ketonuria (plasma beta0hydroxybutyrate >3 mmol/l or urine ketones ≥3+) pH <7.3 or serum bicarbonate <15 mEq/L In a patient with diabetes, presence of hyperglycemia and ketosis in the absence of aci Continue reading >>

Ketosis & Acidosis

Ketosis & Acidosis

Ketosis occurs when the fat in your body does not break down completely, producing ketones. It's a condition that can occur when you go on a low-carb diet and glycogen stores in your liver are depleted. When you have too much acid in your system, you can develop acidosis. The acid build-up can take place in your kidneys or lungs for a variety of reasons. The build-up of ketones can cause an imbalance that leads to excessive acid production. Video of the Day Diabetics may be prone to ketosis or acidosis when insulin levels drop below healthy levels or when ketones build up in the body due to uncontrolled insulin levels. Ketones are the byproduct produced when the body relies primarily on fat stores for energy. While short-term ketosis can help you lose weight, ketones that continue to build up in your blood and urine are poisonous and lead to diabetic ketoacidosis, also referred to as diabetic acidosis. The condition is a more common complication of Type 1 diabetes. In addition to low insulin levels, trauma, severe infection, a heart attack or surgery can lead to diabetic ketoacidosis. Diabetic acidosis requires immediate medical attention. As insulin levels drop, your body produces blood sugar by uncontrollably burning fat. Your body turns acidic as glucose begins to appear in your urine. As your body tries to find a balance, your breathing becomes deeper and quicker, leading to a temporary balance as you blow off excess carbon dioxide. Symptoms may start with confusion, thirst, fatigue and increased urination. You may become unconscious. As acidosis progresses, you can smell acetone on your breath. Symptoms usually appear quickly, so you should seek emergency treatment. A high fat and high protein diet that's low in carbohydrates can lead to ketosis. At the same time, Continue reading >>

Ketosis Vs. Ketoacidosis: Understanding The Differences

Ketosis Vs. Ketoacidosis: Understanding The Differences

Introduction to Ketosis vs Ketoacidosis Historically, ketosis has been one of the most vaguely defined and poorly understood concepts of the last century. There are different scenarios in which are body can be in a state of ketosis (including ketoacidosis). The most basic definition of ketosis is a general increase in blood levels of ketone bodies to 0.5 mmol or above. However, the reasons for the development of ketosis, the resultant levels of blood ketones, and the associated outcomes (health versus possible death) differ drastically between different situations of ketosis. Failure to understand the differences between various incidents of ketosis has led to the common misconceptions we have today that ultimately has made educating the masses on the ketogenic diet difficult. The single most important take home from this article should be that diabetic ketoacidosis is not the same as the ketosis experienced from a ketogenic diet. Diabetic Ketoacidosis Whenever I speak about ketogenic dieting, almost inevitably I am asked the question: “But shouldn’t you be worried about going into a state of ketoacidosis?” Ketoacidosis occurs when the formation ketone bodies are uncontrolled (15-25 mmol) and acidity in the blood increases (1). It is important to understand that our body regulates blood acid concentrations tightly. We typically measure blood acidity vs. alkalinity using the pH scale. If your blood’s pH is less than 7 it is acidic, and if greater it is basic, or alkaline. Our blood is usually slightly alkaline with a pH ranging from 7.35 to 7.45. Any deviation up or down from the norm by even the smallest amount can prove fatal! The most common form of ketoacidosis to occur is known as diabetic ketoacidosis. This usually occurs in type I diabetics but can also oc Continue reading >>

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