Short Term Prevention Of Ketoacidosis

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Diabetic Ketoacidosistreatment & Management

Diabetic KetoacidosisTreatment & Management Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP more... Managing diabetic ketoacidosis (DKA) in an intensive care unit during the first 24-48 hours always is advisable. When treating patients with DKA, the following points must be considered and closely monitored: Correction of fluid loss with intravenous fluids Correction of electrolyte disturbances, particularly potassium loss Treatment of concurrent infection, if present It is essential to maintain extreme vigilance for any concomitant process, such as infection, cerebrovascular accident, myocardial infarction, sepsis, or deep venous thrombosis . It is important to pay close attention to the correction of fluid and electrolyte loss during the first hour of treatment. This always should be followed by gradual correction of hyperglycemia and acidosis. Correction of fluid loss makes the clinical picture clearer and may be sufficient to correct acidosis. The presence of even mild signs of dehydration indicates that at least 3 L of fluid has already been lost. Patients usually are not discharged from the hospital unless they have been able to switch back to their Continue reading >>

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  1. manohman

    Why can't fat be converted into Glucose?

    So the reason cited is that beta oxidation/metabolism of fats leads to formation of acetyl coa, a 2 carbon molecule, and that because of that it cannot be converted back into glucose.
    Why exactly is that the case?
    If Glucogenic amino acids can be converted into citric acid cycle intermediates and then turn back into glucose via gluconeogensis, then why cant Fatty Acids which yield Acetyl Coa. Can't you just have Acetyl Coa enter the citric acid cycle and produce the same intermediates that the glucogenic amino acids creat?

  2. Czarcasm

    manohman said: ↑
    So the reason cited is that beta oxidation/metabolism of fats leads to formation of acetyl coa, a 2 carbon molecule, and that because of that it cannot be converted back into glucose.
    Why exactly is that the case?
    If Glucogenic amino acids can be converted into citric acid cycle intermediates and then turn back into glucose via gluconeogensis, then why cant Fatty Acids which yield Acetyl Coa. Can't you just have Acetyl Coa enter the citric acid cycle and produce the same intermediates that the glucogenic amino acids creat?
    Click to expand... Both glucose and fatty acids can be stored in the body as either glycogen for glucose (stored mainly in the liver or skeletal cells) or for FA's, as triacylglycerides (stored in adipose cells). We cannot store excess protein. It's either used to make other proteins, or flushed out of the body if in excess; that's generally the case but we try to make use of some of that energy instead of throwing it all away.
    When a person is deprived of nutrition for a period of time and glycogen stores are depleted, the body will immediately seek out alternative energy sources. Fats (stored for use) are the first priority over protein (which requires the breakdown of tissues such as muscle). We can mobilize these FA's to the liver and convert them to Acetyl-CoA to be used in the TCA cycle and generate much needed energy. On the contrary, when a person eats in excess (a fatty meal high in protein), it's more efficient to store fatty acids as TAG's over glycogen simply because glycogen is extremely hydrophilic and attracts excess water weight; fatty acids are largely stored anhydrously and so you essentially get more bang for your buck. This is evolutionary significant and why birds are able to stay light weight but fly for periods at a time, or why bears are able to hibernate for months at a time. Proteins on the other hand may be used anabolically to build up active tissues (such as when your working out those muscles), unless you live a sedentary lifestyle (less anabolism and therefore, less use of the proteins). As part of the excretion process, protein must be broken down to urea to avoid toxic ammonia and in doing so, the Liver can extract some of that usable energy for storage as glycogen.
    Also, it is worth noting that it is indeed possible to convert FA's to glucose but the pathway can be a little complex and so in terms of energy storage, is not very efficient. The process involves converting Acetyl-CoA to Acetone (transported out of mitochondria to cytosol) where it's converted to Pyruvate which can then be used in the Gluconeogenesis pathway to make Glucose and eventually stored as Glycogen. Have a look for yourself if your interested: http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002116.g003/originalimage (and this excludes the whole glycogenesis pathway, which hasn't even begun yet).
    TLDR: it's because proteins have no ability to be stored in the body, but we can convert them to glycogen for storage during the breakdown process for excretion. Also, in terms of energy, it's a more efficient process than converting FA's to glycogen for storage.

  3. soccerman93

    This is where biochem comes in handy. Czarcasm gives a really good in depth answer, but a simpler approach is to count carbons. The first step of gluconeogenesis(formation of glucose) requires pyruvate, a 3 carbon molecule. Acetyl Co-A is a 2 carbon molecule, and most animals lack the enzymes (malate synthase and isocitrate lyase) required to convert acetyl co-A into a 3 carbon molecule suitable for the gluconeogenesis pathway. The ketogenic pathway is not efficient, as czarcasm pointed out. While acetyl co-A can indeed be used to form citric acid intermediates, these intermediates will be used in forming ATP, not glucose. Fatty acid oxidation does not yield suitable amounts of pyruvate, which is required for gluconeogenesis. This is part of why losing weight is fairly difficult for those that are overweight, we can't efficiently directly convert fat to glucose, which we need a fairly constant supply of. Sorry, that got a little long-winded

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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Hyperglycemia And Diabetic Ketoacidosis

When blood glucose levels (also called blood sugar levels) are too high, it's called hyperglycemia. Glucose is a sugar that comes from foods, and is formed and stored inside the body. It's the main source of energy for the body's cells and is carried to each through the bloodstream. But even though we need glucose for energy, too much glucose in the blood can be unhealthy. Hyperglycemia is the hallmark of diabetes — it happens when the body either can't make insulin ( type 1 diabetes ) or can't respond to insulin properly ( type 2 diabetes ). The body needs insulin so glucose in the blood can enter the cells to be used for energy. In people who have developed diabetes, glucose builds up in the blood, resulting in hyperglycemia. If it's not treated, hyperglycemia can cause serious health problems. Too much sugar in the bloodstream for long periods of time can damage the vessels that supply blood to vital organs. And, too much sugar in the bloodstream can cause other types of damage to body tissues, which can increase the risk of heart disease and stroke, kidney disease, vision problems, and nerve problems in people with diabetes. These problems don't usually show up in kids or te Continue reading >>

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  1. Man2kx

    Read: Achieve Ketosis in under 24 hours.

    I've been seeing an abundance of posts about people concerned in getting into Ketosis as quick as they possibly can. While some individuals prefer not to spend their glycogen stores early and to gradually roll through the week, other's want the snippy snappy get into Keto to start burning fat. People talk about adjusting ratios, eatings loads of fat, or just being plain lucky. Well thats not the case!
    What will get you into Keto is eating normally what you would eat in Keto phase, and plain EXCERCISE! Not a suprise, excercise will burn up your glycogen, depleted glycogen stores = Ketosis time! In order to successfully get into Ketosis in under 24 hours, you need to do a good deal of excercise! It's not extremely difficult to do, and the following has always worked for me:
    1. Resistance Training
    About 35-45min resistance training (weights), (my recommendation is) with 8-10 reps, minimum of 20 sets total and 6 different excercises (4 sets per excercise). This resistance training should not be a walk in the park, nor should it be something extremely difficult, just leave it intense, I usually aim for 8 reps, but if you can do more than 10 then you should up the weight. Or of course, you can do your own regiment of weight lifting. This should be performed before cardio.
    2. Cardio
    You want a good 25min+ cardio session after your resistance training to burn up some more glycogen. Jogging/running is fine, eliptical is fine, but I'd personally recommend the stationary bike as you'd get a minor leg workout and you'd burn up some glycogen there. Choose med-high intensity, but the workout shouldn't be to the point where you barely could do it and you're struggling, just intense enough to feel your legs a little bit .
    Note: I choose high intensity on stationary bike because I work out my legs on the last day of Keto, rather than doing a full body workout. It's practically a full-body workout in it's sense, it's a great deal of your body, so I usually find excellent results with doing legs rather than a full body.
    If it didn't work out for you...
    You need to re-evaluate your diet as something is messed up and you need to look closely at possible culprits: too many carbs, perhaps the artifical sweetners or that diet soda. If it is nothing in your diet, re-evaluate the intensity of your workout.
    I will put this in my article along with other information in a few weeks. I felt it was an important topic to cover as it was a frequently asked question.
    Here's my article, it will most likely cover any of your lingering questions!
    Good luck with your diet and keep on Keto-ing .

  2. stinglikebee

    well ive been having between 4-5 diet sodas a day ,do you think thats why im not in ketosis,should i drink a lot of water??also when using the ketostix...do i just pass it through my stream of urine or do i pee on it till my bladder is empty?

  3. Man2kx

    Originally Posted by stinglikebee
    well ive been having between 4-5 diet sodas a day ,do you think thats why im not in ketosis,should i drink a lot of water??also when using the ketostix...do i just pass it through my stream of urine or do i pee on it till my bladder is empty?

    Try ditching the diet sodas until you get into Keto. As far as the Ketosix go, you only need to pass it through the stream of urine, and you are looking for any tint of pink, it's not necessary to have dark purple.
    Check #2 out in my sig, I'm sure it would answer your questions.

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Kidney transplant risks nhsuk nhs choices. It can harm your eyes, kidneys, nerves, skin, heart, and blood vessels people living with diabetes have to deal short term or long complications as a result of their condition it is direct measurement risk related health erectile dysfunction not disease, but symptom some other problem problems develop when you for time. Effects, be it short term or long term, helps manage diabetes 25 learn all about complications of. Short term complications of diabetes houston thyroid and short community. Short and long term effects of real time continuous glucose what are the short diabetes? Youtube. The good news? About half of all people with diabetes have some form nerve damage short and long term effects real time continuous glucose monitoring in that provide decision support facilitate the sharing information, 9 2011 salutary glycemic patients type 2 who self management tools for providers 13. Diabetes complications american diabetes association. Uk diabetes complications short term. Long term effects of diabetes type one complications & side short long info nz. Short term complications are the expression 'long of diabetes' refers to a multitude hea

Short Term Complications

Tweet Short term complications occur if blood glucose levels go too low or too high for the body to function properly in the present state. Short term complications can present immediate danger and therefore need to be treated quickly to avoid emergencies. What are the short term complications of diabetes? The most common short term complications of diabetes are the following: Hypoglycemia Hypoglycemia is a state of having blood glucose levels that are too low. Hypoglycemia is defined as having a blood glucose level of below 4.0 mmol/l. Symptoms include tiredness, weakness, confusion and a raised pulse rate. If you take blood glucose lowering medication such as insulin, sulfonylureas and post prandial glucose regulators, it is important to treat hypoglycemia immediately to prevent blood glucose levels from going dangerously low. Hypoglycemia can also occur in people that do not take diabetes medication but in this case, the body should low blood sugar levels naturally and treatment is not normally needed unless you have a condition known as reactive hypoglycemia or will be carrying out a dangerous task such as operating machinery or driving. Read about hypoglycemia Ketoacidosis Ket Continue reading >>

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  1. Heather

    I've been on the diet now for 7 days. Day 1 and 2 I dropped 2 kilos, and since that I haven't budged.
    I check my pee twice a day and am always in the top or second top keto reading...
    Is it possible to be in ketosis, but still doing something wrong ?

  2. Helen

    Ketosis just means that you are burning fat instead of carbs/glucose for energy. If you are having too many calories (or even not enough), you may find that you do not lose weight.
    Also, if you only have a few kgs to lose, then your weight loss will be slower than someone who has a lot of weight to lose. What is your BMI?
    Are you doing a lot of intensive exercise? Sometimes you may be losing fat, but building muscle, so the scales appear to not move.
    Regardless of what diet you follow, you will not lose weight each and every day. 2 kgs in 1 week is a pretty good loss, especially if you don't have a lot of weight to lose.
    Chances are that if you continue to follow the program properly and keep avoiding carbs, you will lose more weight in the next few days. Some call it the "whoosh" effect, lol. Some people lose weight slowly and steadily. Many more of us, lose it in stops and starts. We lose a bit, then a few days of nothing and then another "whoosh".
    Keep at, and you should get results.
    [ed. note: Helen (1169825) last edited this post 3 years, 7 months ago.]

  3. Heather

    My Bmi is 30.51. I've got about 15 kilos to lose, but on a bazillion diets I never seem to get past 6 or 7kg.
    I'm not currently exercising because I'm just too tired. I'm hoping to get back to the gym soon though.
    I'll stick it out in hopes for this whoosh hehe. Thanks Helen.

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