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Sglt2 Inhibitors For Type 1 Diabetes

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Dr. Tom Elliott from BCDiabetes discusses the value of SGLT2 inhibitors for people with diabetes in BC and the fact pharmacare does not cover this class of medication. Sign our petition at https://www.change.org/p/bcpharmacare...

Sglt2 Inhibitor Tested In Type 1 Diabetes

SGLT2 Inhibitor Tested in Type 1 Diabetes The oral sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin had acceptable short-term tolerability when given as an adjunct to insulin in patients with type 1 diabetes, with expected increases in urinary glucose excretion seen with this class of drugs. Although hypoglycemia was common, patients assigned to the study drug had reductions in 24-hour daily average blood glucose levels, glycemic variability, and mean percent change in total daily insulin dose, according to study results published in Diabetes Care.. Dapagliflozin, which is currently approved as an adjunct to diet and exercise in adults with type 2 diabetes, reduces glycemic levels by inhibiting the reabsorption of renal glucose independently of insulin. The efficacy of dapagliflozin and other SGLT2 inhibitors in patients with type 2 diabetes suggests that this oral therapeutic may provide a new option for patients with type 1 diabetes as well, according to researchers led by Robert R. Henry, MD, of San Diego Healthcare System. The researchers designed this pilot study as a proof-of-concept study to test the safety and tolerability of dapagliflozin in this patient pop Continue reading >>

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  1. Comment

    Source(s): Reverse Any Diabetes Easily - http://DiabetesGoFar.com/?hJON

  2. Jacqueline

    You need to see an endocrinologist as soon as possible. You may very well have an unusual disease. Autoimmune diseases can do all sorts of weird things like you describe. Ketones can get high if someone eats a lot of meat without any vegetables. But this does not sound like your problem. Eat more vegetables, especially sweet potatoes, eat no candy or sugar crap, eat less meat.

  3. Dave

    Shocking New Diabetes Research Revealed : http://Help.DiabetesGoGo.com

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What is POINT-OF-CARE TESTING? What does POINT-OF-CARE TESTING mean? POINT-OF-CARE TESTING meaning - POINT-OF-CARE TESTING definition - POINT-OF-CARE TESTING explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Point-of-care testing (POCT), or bedside testing is defined as medical diagnostic testing at or near the point of care—that is, at the time and place of patient care. This contrasts with the historical pattern in which testing was wholly or mostly confined to the medical laboratory, which entailed sending off specimens away from the point of care and then waiting hours or days to learn the results, during which time care must continue without the desired information. Point-of-care tests are simple medical tests that can be performed at the bedside. In many cases the simplicity was not achievable until technology developed not only to make a test possible at all but then also to mask its complexity. For example, various kinds of urine test strips have been available for decades, but portable ultrasonography did not reach the stage o

Researchers Testing Sglt2 Drugs For Type 1 Use

Researchers Testing SGLT2 Drugs for Type 1 Use The popular Type 2 medication is already being used off-label as an add-on to insulin therapy. Pharma companies are testing whether drugs designed for combatting Type 2 diabetes can be used to also treat Type 1 diabetes. The latest attempt involves a class of of oral antidiabetics called SGLT2 inhibitors, first cleared by the Food and Drug Administration on March 29, 2013. There have been roughly 100 clinical trials involving SGLT2 drugs logged at the National Institutes of Health since researchers first began evaluating canagliflozin. All but two have involved individuals with Type 2 diabetes or those who dont have diabetes. Recently, there have been studies undertaken to evaluate SGLT2 drugs as an add-on to insulin therapy; the following trials involve people with Type 1 diabetes: The drug company Janssen initiated an SGLT2 trial in May 2014 in the U.S. and Canada. 232 participants were enrolled to investigate whether 100 mg and 300 mg canagliflozin doses with insulin would help better control blood sugar levels than insulin alone. Phase II of this trial was completed in June 2015, and the study process came under some criticism, bu Continue reading >>

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  1. softail925

    So Ive been eating keto for 10 months. I have lost approx' 14 pounds. I dont keep exact track of my macros, but am very conscientious of them and follow this woe. I have used the keto urine strips and they have shown me in ketosis. But Ive also read after awhile those strips arent accurate for a few reasons. Sooooo, my question is this: How does one know they are still in ketosis? (I have my own thoughts on this, but just want to read urs, as well)

  2. Mark_Bousquet

    You want to throw away those Ketostix, they are highly unreliable. Especially after you become fat adapted
    and your body starts utilizing the ketones more efficiently.
    Personally, I use both the blood test strips and the Ketonix breath acetone analyzer.
    Blood ketones (bOHB) over 0.5 mmol/L will indicate you are in nutritional ketosis. These strips are expensive in the U.S. Google "Canadian pharmacy blood ketone strips" or "Australian pharmacy blood ketone strips" to find less expensive strips.

    The Ketonix is a reusable breath analyzer that tests for acetone. The maker of this found that the level of acetone is not correlated with blood ketones, however it will give you a ballpark idea of whether or not you are in ketosis or not.

  3. softail925

    Thank you! I am also looking for how to know ur in ketosis w/out any of the tests? (If possible)

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Sglt2 Inhibitor Has Some Utility In Type 1 Diabetes

SGLT2 Inhibitor Has Some Utility in Type 1 Diabetes But canagliflozin use increases risk for ketoacidosis by Parker Brown Parker Brown, Staff Writer, MedPage Today Note that this randomized trial of canagliflozin found an elevated risk of DKA in treatment arms at various doses, but no DKA events in those receiving placebo. Note that the SGLT-2 inhibitor class has been associated with DKA in other studies as well. Canagliflozin (Ivokana), an SGLT-2 inhibitor for patients with type 2 diabetes, increased risk of ketoacidosis when used in patients with type 1 diabetes. The drug was associated with a serious case of diabetic ketoacidosis (DKA) in five of 117 patients on 100 mg/day of the drug and in seven of 117 on 300 mg/day in an 18-week trial funded by Janssen, which markets the drug. None of the 117 patients in the placebo group had DKA, reported Anne Peters, MD , at the University of Southern California, and colleagues in Diabetes Care . After 18 weeks, the incidence of any ketone-related adverse event was 5.1% (n=6) in the 100-mg group and 9.4% (n=11) in the 300-mg group. "Because of the potentially life-threatening nature of DKA in patients with type 1 diabetes, further developm Continue reading >>

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  1. Duckfeet

    Had a midwife appointment yesterday & as you do supplied a urine sample & when she tested it she there was ketones present. I read up on ketones in urine during pregnancy today & it's not good. Now I feel really guilty. I haven't purposely beeen dieting or not eating properly but before I was pregnant I never had a massive appetite & since being pregnant my appetite has took a big nose dive because of nausa. But now I can't stop crying because I feel like I've harmed my unborn baby.
    All I can do is start snacking through out the day so my body doesn't think I'm starving myself.
    Sorry for moaning. Thanks for listening.

  2. Nat_Apple

    The only thing I know about ketones is tht I want them
    Present in urine wen im on atkins. I know as soon as I eat carbs they dwindle mayb thts it hun? Get some toast down ya. Sorry if this is useless but Im sure ur not doing anything to harm ur baby hun xx

  3. Kalyke

    Firstly, don't worry! Easier said than done I know, but baby will be fine.
    I had hyperemesis all the way through my pregnancy with my daughter, the sickness was so bad by the time I had my daughter I weighed two stone less than I had at my booking in appointment. I had ketones in my urine all the way through and DD (dear daughter) is now a very happy and healthy two year old.
    It could be due to dehydration, you not keeping down enough carbs, etc. Baby will for the most part take when it needs from the fat reserves you have stored (and which build up over pregnancy) and/or what you are keeping down. The main concern would be for you and making sure that you drink enough fluid to stay hydrated and eat enough to keep you healthy.
    I've found that this time round eating/drinking little and often seems to be making things so much better.

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