Sglt2 Inhibitors Acidosis

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TORT LAW TEAM ... www.tortlawteam.com helps you to get financial compensation you deserve! This video about invokana, invokamet diabetes medicine side effects and lawsuit. If you or your loved one taken invokana, canagliflozin, diabetes medicine and faced side effect, ketoacidosis, oversee glucose, kidney failure, unsaturated fats, You may eligible to get the financial compensation. Learn More at: http://www.tortlawteam.com/ an antidiabetic drug for treatment of Type 2 diabetes. It is an individual from the new SGLT2 class of antidiabetic solution that additionally incorporates empagloflozin (Jardiance) and dapagliflozin (Farxiga). Canagliflozin is additionally sold in mix with metformin under the brand name Invokamet. invokana and Invokamet are made and advertised in the U.S. by Janssen pharmaceuticals which is a backup of Johnson and Johnson, one of the biggest pharmaceutical organizations on the planet with income of over $74 billion every year. invokana was affirmed in 2013 as the first SGLT2 (sort 2 sodium-glucose co-transporter) inhibitor. As it works uniquely in contrast to other hostile to diabetes pharmaceuticals available, it was wanted to be helpful for patients who did not react well to other drug. Sadly, numerous drugs for Type 2 diabetes have created genuine medicinal harm. The SGLT2 class rooftop solutions has been embroiled in a higher-than-ordinary advancement of diabetic ketoacidosis, an existence undermining condition. Learn More at: http://www.tortlawteam.com/ How to Dangerous of Using invokana, diabetes medicine invokana works by setting off the kidneys to discharge overabundance blood glucose through the urine. It is demonstrated for treatment of patients with Type 2 diabetes, which cant be controlled through eating regimen and activity. It is not to be endorsed to those with Type 1 diabetes or for treatment of diabetic ketoacidosis. Diabetic ketoacidosis happens when the body does not have enough insulin to oversee glucose levels. The body starts smoldering unsaturated fats, which brings about a waste item called acidic ketone bodies. These ketones are what trigger the indications of ketoacidosis. Those side effects incorporate spewing, parchedness, disarray, weakness, and stomach torment. In uncommon cases, untreated ketoacidosis can bring about trance state and even passing. While no passings have been accounted for with the utilization of invokana or Invokamet, the risk exists. Learn More at: http://www.tortlawteam.com/ About Invokana Lawsuits A conceivably deadly reaction of Invokana may prompt claims against a modest bunch of medication producers. The pharmaceutical treats Type 2 diabetes yet triggers hazardous levels of blood acids, which drove the FDA to sound an alert about the medications. Dont forget to fill the Medicine Healthcare Survey 2017 Nationwide USA at survey.tortlawteam.com Thank you and Have a nice day. www.tortlawteam.com .....................!

Severe Ketoacidosis Associated With Canagliflozin (invokana): A Safety Concern

Case Reports in Critical Care Volume 2016 (2016), Article ID 1656182, 3 pages 1Section of Pulmonary and Critical Care Medicine, Providence Hospital and Medical Center, 16001 W 9 Mile Road, Southfield, MI 48075, USA 2Department of Internal Medicine, Providence Hospital and Medical Center, 16001 W 9 Mile Road, Southfield, MI 48075, USA Academic Editor: Kurt Lenz Copyright © 2016 Alehegn Gelaye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Canagliflozin (Invokana) is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor that was first introduced in 2013 for the treatment of type 2 diabetes mellitus (DM). Though not FDA approved yet, its use in type 1 DM has been justified by the fact that its mechanism of action is independent of insulin secretion or action. However, some serious side effects, including severe anion gap metabolic acidosis and euglycemic diabetic ketoacidosis (DKA), have been reported. Prompt identification of the causal association and initiation of appropriate therapy shoul Continue reading >>

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  1. SuperBane

    The premise of the palumbo diet is high protein (about 1- 1 1/2 gram per pound), moderate fat (about 1/2 g per lb) and low low carbs (no direct sources of carbs). During this diet, the brain goes into ketosis (it uses ketone bodies for energy-- fats) and thus the energy requirements by the body can almost all be supplied by fats (which you'll be taking in plenty of). The only activity that uses carbs will be the weight workout which may use 40grams per workout. You will get these 40g indirectly through the foods you'll be eating. As a backup, the cheat meal you'll be having once per week will provide a storehouse of glycogen (glucose) in case of emergency. So, you see, very little gluconeogenesis in the liver will be occurring. If we keep cortisol low (by restricting STIMULANTS) we'll ensure that muscle is spared!
    day so you dont cheat again.T3 levels are reduced on a low carbohydrate diet, Cheat meal consumption leads to insulin production which is required for maximizing the conversion of T4 (inactive hormone) to T3 (active hormone).

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    Fiber helps burn fat! Everyone should take fiber 2x per day. Fiber actually helps increase the absorption of calcium.
    When following my dave palumbo diet plan (which includes getting your brain into ketosis), there can be NO starchy carbs eaten!
    The diet is based on the generic 1.5g pro, and about .5g fat per lb of body weight. you should have a meal every 2.5-3 hours you are awake.

  2. SuperBane

    MEAL #1
    4 whole omega-3 eggs + 7 large eggs whites (For the whole eggs, make sure to go with mostly Omega-3 eggs.)
    MEAL #2
    "Lean-Pro Meal": 6oz chicken (cooked weight) with 1 Tbs Macadamia nut oil or extra virgin olive oil, and ½ cup green beans.
    MEAL #3
    ?Pre-Workout?: 50g whey protein isolate + 2 tbs. natural peanut butter or almond butter
    MEAL #4
    ?Post-Workout?: 50g whey protein isolate + 2 tbs. natural peanut butter or almond butter
    MEAL #5
    "Fatty Protein Meal": 6oz of lean ground sirloin (cooked weight) or 7oz salmon (cooked weight), a small green salad. (No tomatoes, carrots, or red peppers) w/ ½ tablespoon of extra virgin Olive Oil.
    MEAL #6
    4 whole omega-3 eggs + 7 large eggs
    For a 200lb man:
    MEAL #1
    5 whole eggs (make sure to buy OMEGA-3 EGGS from the supermarket. They contain virtually NO saturated fat and tons of good OMEGA-3 fats); add another 4 egg whites to this (they don?t need to be the Omega-3 ones; you can use liquid egg whites)
    MEAL #2
    SHAKE: 50g Whey Protein with 1 ? tablespoon of All Natural Peanut butter (no sugar)
    MEAL #3
    "Lean Protein Meal": 8oz chicken with 1/2-cup cashew nuts (almonds, or walnuts)
    MEAL #4
    SHAKE: 50g Whey Protein with 1 ? tablespoons of All Natural Peanut butter (no sugar added)
    MEAL #5
    "Fatty Protein Meal": 8oz Salmon, Swordfish, or RED MEAT with a green salad (no tomatoes, carrots, or red peppers) with 1 tablespoon of Olive Oil or Macadamia nut oil and vinegar
    MEAL #6
    SHAKE: 50g Whey with 1 ? tablespoon all natural peanut butter or 4 whole (Omega-3) eggs and 4 extra whites
    For a 250lb+ man:
    Meal 1 6 whole Omega-3 eggs
    Meal 2 8oz chicken with 1/2 cup raw almonds
    Meal 3 50g whey with 2 tablespoons all natural peanutbutter
    Meal 4 8oz salmon with 1 cup asparagus with 1 tablespoon macadamia nut oil
    Meal 5 50 g whey with 2 tablespoon PB
    Meal 6 6 whole eggs
    Variations of the Dave Palumbo diet for certain individuals :
    120lb female
    Meal #1: 2 whole (omega-3) eggs and 6 egg-whites.
    Meal #2: 4oz chicken with 1/4 cup raw almonds.
    Meal #3: 35g whey protein with 1 tablespoon all natural peanut butter.
    Meal #4: 4oz salmon with 1 cup asparagus with 1 tablespoon macadamia nut oil.
    Meal #5: same as meal #1 or meal #3.
    100lb (lean body mass) female figure competitor
    Meal #1: 2 whole omega-3 eggs and 4 egg whites.
    Meal #2: 30g whey protein and 1 tablespoon natural peanut butter.
    Meal #3: 6oz chicken and 1oz (1/8 cup) raw almonds.
    Meal #4: same as meal #2.
    Meal #5: 4oz salmon, 2 cups of spinach leaves, 1 teaspoon virgin olive oil and vinegar.
    170lb male (153lbs LBM)
    Meal #1: 3 whole omega-3 eggs, 3 egg-whites, 3 slices fat-free turkey.
    Meal #2: 40g whey protein and 1 tablespoon olive oil.
    Meal #3: 150g skinless chicken breast and 1 tablespoon soy and 1 tablespoon mustard and 30g almonds.
    Meal #4: same as meal #2.
    Meal #5: 200g top sirloin steak and 85g raw spinach and 1 tablespoon olive oil.
    Meal #6: 2 whole omega-3 eggs, 1 can tuna.
    160 lb male
    Meal #1: 4 whole eggs, ¾ cup egg-whites, fish oil, primrose oil.
    Meal #2: 7oz chicken, ¼ cup almonds.
    Meal #3: 7oz salmon, 1 cup spinach.
    Meal #4: same as meal #2.
    Meal #5: 7oz lean ground beef, 1 cup spinach, 1 tablespoon olive oil.
    Meal #6: 3 whole eggs, 1 cup egg-whites, fish oil, primrose oil.
    185lb natty bb at 12%bf
    Meal #1: 5 whole omega-3 eggs.
    Meal #2: 7oz chicken with 1/3 cup raw almonds.
    Meal #3: 40g whey protein with 1.5 tablespoons all natural peanut butter (post-workout meal).
    Meal #4: 6oz salmon with 1 cup asparagus with 1 tablespoon macadamia nut oil.
    Meal #5: 40g whey protein with 2 tablespoons all natural peanut butter.
    Meal #6: 4 whole omega-3 eggs with 4 extra egg-whites.
    176lb natty bb at 11-12%bf
    Meal #1: 4 whole omega-3 eggs with 4 extra egg-whites.
    Meal #2: 200g chicken with 1/3 cup raw almonds.
    Meal #3: 40g whey protein with 1 tablespoon all natural peanut butter.
    Meal #4: 200g red meat or salmon with 1 cup asparagus.
    Meal #5: 40g whey protein with 1.5 tablespoons all natural peanut butter.
    Meal #6: same as meal #1.
    155lb male at 15%bf
    Meal #1: 3 whole omega-3 eggs.
    Meal #2: 5oz chicken with ¼ cup raw almonds.
    Meal #3: 30g whey isolate with 1 tablespoon all natural peanut butter.
    Meal #4: 7oz (93%) lean ground beef with 1 cup romaine lettuce (dressing: 3 teaspoons ev olive oil and 3 teaspoons balsamic vinegar) and 1 tablespoon flaxseed oil.
    Meal #5: same as meal #3.
    Meal #6: same as meal #1.
    195lb male
    Meal #1: 5 whole eggs.
    Meal #2: 8oz chicken breast and 1/3 cup almonds.
    Meal #3: 50g whey protein isolate with 1.5 tablespoon natural peanut butter.
    Meal #4: 8oz fish with 1/3 cup almonds.
    Meal #5: 55g whey protein isolate with 1.5 tablespoon natural peanut butter (post workout).
    Meal #6: same as meal #1.
    172lbs at 11%bf with protein and veggies days incorporated
    3X P-F, 2X P-V
    Meal #1: 4 whole eggs with 4 egg-whites.
    Meal #2: 6oz chicken (cooked) and 1/3 cup raw almonds.
    Meal #3: 40g whey protein and 1.5 tablespoon all natural peanut butter.
    Meal #4: 6oz red meat (cooked) with 1 cup asparagus.
    Meal #5: same as meal #3.
    Meal #6: same as meal #1.
    Meal #1: 12 egg-whites.
    Meal #2: 6oz chicken (cooked) and 1 cup asparagus.
    Meal #3: 40g whey protein with water.
    Meal #4: 6oz tuna and 1 cup asparagus.
    Meal #5: same as meal #3.
    Meal #6: same as meal #1.

  3. SuperBane

    I recommend that women take in about 8-10 g fat per meal; whereas men take in 12-17 per meal.
    And REMEMBER......... All KETOSIS means is that your BRAIN is no longer burning glucose (carbs) for energy; it's using FAT ......and because we never run out of fat, the brain has a virtually unlimited source of energy..... therefore, no low blood sugar, no hunger cravings, no mood swings, and no irritability!
    Remember, it takes 3-4 days to get into a strong ketosis where your brain is using ketone bodies (fats), instead of carbs, for energy. Be patient.
    Many times I'll switch to an alternatiing diet where one day it will be protein/fat......then another protein/vegetables (very little fat). The great thing about the body and fat is that ESSENTIAL FATTY ACIDS can be stored in the muscle for several days, up to 2 weeks......therefore, once an adequate storehouse of Essential Fats are built up, the body can be "tortured" a little and it still won't give up muscle (that's assuming you're still taking in adequate protein. Protein can't be stored).
    1oz almonds equals 6g carbs (2 of those grams are fiber) and 2oz equals 12g of carbs.
    With the beef meal (any fatty protein meal), you should have the green salad with 1 tablespoon of Olive or Mac oil INSTEAD of the nuts. Only eat the nuts with the LEAN PROTEIN MEAL (chicken, turkey, lean fish)
    The best fat sources come from the essential fatty acids-- Omega-6 and Omega-3's. Most of us get plenty of Omega-6s from cooking oils, ect..........however the Omega-3's are harder to get. I recommend WHOLE OMEGA-3 EGGS, FaTTY FISHS like SALMON and SWORDFISH and TUNA and MACKEREL, ALMONDS and WALNUTS have some OMEGA-3's (as well as OMEGA-6s). ANother great fat source is MONOUNSATURATES such as EXTRA VIRGIN OLIVE OIL and MACADAMIA NUT OIL.....they aren't essential but they are great for the metabolism (great source of energy) and they are extremely good for your heart.
    You're not getting any indirect sources of carbs (just from the 1 spoonful of PB.... you may want to have at least one 1/3cup nuts meal. Remember, Olive or Macadamia nut oil is predominantly a MONOUNSATURATED FAT (good for the heart, but not essential)........ the nuts, and fish oil have the essential fats in them. Also, with regard to FLAX SEED OIL, the OMEGA-3 Fatty Acids found in them (alpha-linolenic acid) has a very poor conversion to DHA and EPA (Essential Omega-3 intermediates) in the HUMAN........therefore, you're much better off taking in FISH OILS (that already contain DHA/EPA) than FLAX SEED OIL.
    Once fat loss slows, I always increase cardio first, then I increase the amount of fat burners (clen, cytomel, lipolyze).........After those other methods are exhausted, only then, do I play with the diet.
    Always eat BEFORE lifting........never BETWEEN lifting and cardio.
    Artificial Sweetners:
    The artificial sweetener itself (eg. aspartame, sucralose) wont cause a problem. It's what some companies complex it with. For example, EQUAL and SPLENDA combine their aspartame and sucrolose with 1g of maltodextrin........whereas, in diet drinks, they don't do that. So, diet drinks are okay, SPLENDA and EQUAL must be used in moderation (STEVIA BALANCE is fine though since they use inulin fiber instead of maltodextrin
    Forget using:
    -MCT's are a waste when you're dieting. If you're gonna use FATS for an energy source, they might as well serve a function in the body. MCTs are useless. They can only serve as a source of energy!
    -Arginine is not going to do anything. It will DO something; just not dramatic.
    CARDIO should be performed at a low intensity (under 120bpm heartrate). This will ensure that you use FAT as a fuelsource since as your heartrate increase, carbohydrates begin to become the preferred fuel of choice for the body. When on a low carb diet, you're body will break down muscle and turn that into carbs. Remember, Fat CANNOT be changed into carbs. Therefore, for bodybuilding, the rule of cardio should be LONG DURATION, LOW INTENSITY
    never do less than 20 min per session
    The BOTTOM LINE is that low intensity cardio (while you might need more of it) ensures that fat is utilized and muscle is spared (especially while on my high protein/moderate fat/low carb diet).
    Do you feel the treadmill is better for cardio, or is the bike(stationary or recumbent) just as good? As long as the intensity is LOW, it doesn't matter which piece of equipment you use. You should start at 45min/day walking (treadmill or outside). Add 10 minutes to that the second week, and 10 minutes each week after, until you reach 2 hours/day. That should do it.
    Fat burners: Start out with 40mcg per day (20mcg 2x per day) of clen 16 weeks out and 25mcg of T3 per day 14 weeks out. Increase it every 2-3 weeks as you hit plateaus. Make increases in doses of 20mcg of clen and 12.5mcg of T3. Don?t take more than 120mcg of clen and 100mcg of T3 per day.

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Obesity in America has reached a crisis point. Two out of every three Americans are overweight, one out of every three is obese. One in three are expected to have diabetes by 2050. Minorities have been even more profoundly affected. African-Americans have a 50 per cent higher prevalence of obesity and Hispanics 25 per cent higher when compared with whites. How did the situation get so out of hand? On this week's episode of Fault Lines, Josh Rushing explores the world of cheap food for Americans living at the margins. What opportunities do people have to eat healthy? Who is responsible for food deserts and processed food in American schools? Fault Lines finds food revolutions taking place and speaks with the people that are fighting back. People featured in this film: Marion Nestle, Marlene Schwartz, John Bode, Nelson Eusebio, J. Justin Wilson, Dr. Olajide Williams, Lauren Von Der Pool, Julie Paradis, Cathal Armstrong, Ed Bruske, Follow on Twitter: http://twitter.com/AJFaultLines Follow on Facebook: http://facebook.com/AJFaultLines Follow on Instagram: http://www.instagram.com/AJFaultLines See all episodes of Fault Lines: http://www.youtube.com/show/faultlines Meet the Fault Lines Team: http://aje.me/ZhfAbH

Acidosis: What Drug Is At Fault?

The sodium/glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of drugs in the armamentarium for managing diabetes. In May 2015, the US Food and Drug Administration (FDA) sent out a warning to alert the healthcare community about the potential for euglycemic ketoacidosis in patients with type 2 diabetes who are using SGLT2 inhibitors (canagliflozin, dapagliflozin, and empagliflozin).[ 1 ] Patients with type 1 diabetes using this class of medication off-label may be at even higher risk for this complication. The warning resulted from identification of 20 cases of acidosis (diabetic ketoacidosis, ketoacidosis, or ketosis) reported to the FDA Adverse Event Reporting System database between March 2013 and June 6, 2014. The risk was particularly high in patients undergoing anesthesia for minor procedures. Subsequent to this FDA warning, the results of the EMPA-REG trial were presented at the European Association for the Study of Diabetes 2015 meeting and published simultaneously in the New England Journal of Medicine.[ 2 ] This trial enrolled approximately 7000 patients with type 2 diabetes and established cardiovascular (CV) disease who were randomly assigned on a 1: Continue reading >>

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Popular Questions

  1. peuleu

    Hi fellow ketoers of Reddit!
    I've been doing Keto for about a month (practice what you preach, eh?) so I'm still a noobie. I've been pretty strict recording everything and keeping carbs <30g. I've noticed the changes as to where I know I've entered ketosis. I've been on (an active) vacation for a week, doing lazy keto. Think I've stayed under 30g a day in food, but might have gone over a bit with alcohol (red wine), though I don't think I've gone over 50g total. The thing I'm finding difficult to figure out is if I can tell if my body is out of ketosis or not. A lot of people here say stuff like they can eat up to 80-100g on an active day and still be in ketosis. I gather this is different for everyone, especially if you're not Keto adapted yet, but my question is: how do you KNOW you're still in ketosis when you eat that many carbs? What happens to your body and how you feel when you go over?
    TL;DR: how can you tell if your body is out of ketosis? What changes do you experience?
    Edit: thanks for all the responses! To clarify: I'm not worried at all! Just curious! I'm on a vacation where I hike all day and visit vineyards. I know I'm not gonna be strict Keto at the moment. I will be when I get back. I just noticed some bodily changes, and wanted to know what people experienced when they're out of ketosis. KCKO!

  2. anbeav

    Most don't, they speculate. If they gain any water weight or feel more hungry than usual, they conclude they are not in ketosis when that's not necessarily true. I wouldn't stress it, avoid the ketosis anxiety and focus on how you feel.

  3. peuleu

    Good to know! Thanks!

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Get Unlimited Access On Medscape.

You’ve become the New York Times and the Wall Street Journal of medicine. A must-read every morning. ” Continue reading >>

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  1. maple626

    I got this Champion Nutrition Protein power and it has 4 carbs scoop with 1.5 Grams of fiber and 2 grams of sugar. Is this enough sugar to kick me out of ketosis if I have like 3 shakes a day?

  2. T-Bone

    Originally Posted by maple626
    I got this Champion Nutrition Protein power and it has 4 carbs scoop with 1.5 Grams of fiber and 2 grams of sugar. Is this enough sugar to kick me out of ketosis if I have like 3 shakes a day?
    ?? No, Absolutely not!. Why would you think that?. Read up A LOT more!.

  3. WhutEvr

    What are you using for ketosis testing?

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