Seizure Lactic Acidosis

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View full lesson: http://ed.ted.com/lessons/how-does-an... When under anesthesia, you cant move, form memories, or hopefully feel pain. And while it might just seem like you are asleep for that time, you actually arent. Whats going on? Steven Zheng explains what we know about the science behind anesthesia. Lesson by Steven Zheng, animation by Zedem Media.

Glycolysis In Energy Metabolism During Seizures Yang H, Wu J, Guo R, Peng Y, Zheng W, Liu D, Song Z - Neural Regen Res

Studies have shown that glycolysis increases during seizures, and that the glycolytic metabolite lactic acid can be used as an energy source. However, how lactic acid provides energy for seizures and how it can participate in the termination of seizures remains unclear. We reviewed possible mechanisms of glycolysis involved in seizure onset. Results showed that lactic acid was involved in seizure onset and provided energy at early stages. As seizures progress, lactic acid reduces the pH of tissue and induces metabolic acidosis, which terminates the seizure. The specific mechanism of lactic acid-induced acidosis involves several aspects, which include lactic acid-induced inhibition of the glycolytic enzyme 6-diphosphate kinase-1, inhibition of the N-methyl-D-aspartate receptor, activation of the acid-sensitive 1A ion channel, strengthening of the receptive mechanism of the inhibitory neurotransmitter -aminobutyric acid, and changes in the intra- and extracellular environment. (1) Glycolysis increases during seizures, and the glycolytic metabolite lactic acid is used as an energy source during seizures. (2) The abnormal synchronized discharge of a large number of neurons leads to gr Continue reading >>

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  1. steverocks83

    Why no ketosis in the morning?

    I have been on Ketogenic diet for bit over a month (with a few cheat days once in a while) and monitoring the ketosis level with Ketone strips. I am very happy with my progress so far, but one thing that always puzzled me is that I never get a ketosis in the morning (at least according to ketone strip) even after a high-fat breakfast with BP coffee. It's only around noon that it starts registering the trace/low amount of ketone, and it gets stronger in the afternoon, and usually at night the strongest. Perhaps because of that, I feel a bit inert & hungry early in the morning, but less so as it gets closer to noon. Is it just me or anyone with similar experience?

  2. yoly2

    The most probable reason is that in the night the body uses most of the ketones produced since you have no food. So there is none to be spill so that the ketone strips can measure. Eating fatty acids doesn't produce ketones instanly it takes liver time to produce ketones in excess and then to arrive to the kidneys were the ketone strips can measure them.

  3. steverocks83

    Thanks yoly2, that makes sense.
    So this fat-rich breakfast I am eating doesn't really kick in until a few hours later. Are there kind of quicker acting fat food that I can eat for breakfast that would give me more energy earlier in the morning?

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What is CONGENITAL DISORDER? What does CONGENITAL DISORDER mean? CONGENITAL DISORDER meaning - CONGENITAL DISORDER definition - CONGENITAL DISORDER explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. A congenital disorder, also known as a congenital disease, deformity, birth defect, or anomaly, is a condition existing at or before birth regardless of cause. Of these disorders, those characterized by structural deformities are termed "congenital anomalies" and involve defects in a developing fetus. Birth defects vary widely in cause and symptoms. Any substance that causes birth defects is known as a teratogen. Some disorders can be detected before birth through prenatal diagnosis (screening). Birth defects may be the result of genetic or environmental factors. This includes errors of morphogenesis, infection, epigenetic modifications on a parental germline, or a chromosomal abnormality. The outcome of the disorder will depend on complex interactions between the pre-natal deficit and the post-natal environment. Animal studies indicate that the mother's (and likely the father's) diet, vitamin intake, and glucose levels prior to o

Omim Entry - # 617710 - Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures; Nemmlas

A number sign (#) is used with this entry because of evidence that mitochondrial neurodevelopmental disorder with abnormal movements and lactic acidosis and with or without seizures (NEMMLAS) is caused by homozygous or compound heterozygous mutation in the WARS2 gene ( 604733 ) on chromosome 1p12. NEMMLAS is an autosomal recessive multisystemic disorder characterized by delayed psychomotor development, intellectual disability, and abnormal motor function, including hypotonia, dystonia, ataxia, and spasticity. Patient tissues may show deficiencies in one or more of the mitochondrial oxidative phosphorylation (OXPHOS) enzymes, but this is not a constant finding (summary by Wortmann et al., 2017 ). Musante et al. (2017) reported 2 teenaged sisters, born of consanguineous Iranian parents (family 2), with delayed psychomotor development, moderate intellectual disability (IQ range, 41-46), speech impairment, and aggressive behavior. The sisters also had movement abnormalities, including muscle weakness, ataxia that became apparent in childhood, and athetosis. Brain imaging and laboratory studies were apparently not performed. They had an affected brother who died of an infectious diseas Continue reading >>

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  1. Technosmith

    Hey folks,
    As summer is on its way out I'm starting to try and get into ketosis, but the drop in carbs has now led my body temperature to drop. Feeling pretty chilly all the time. Morning temperature was 35.7!!! Fats don’t seem to heat me up, only cooked protein and vegetables seem to have this effect.
    I know my mitochondria are not functioning great, and my redox is poor.
    Any ideas on the best approach to take with this? Net carbs are very low but I doubt I'm even in ketosis at this point.

  2. Verena1028

    I aways get very hot from stuff like Beef, cod lifer, just lots of fat and protein

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Isoniazid Toxicity Litfl Life In The Fast Lane Medical Blog

isoniazid toxicity, like other hydrazines, primarily cause life-threatening seizures and lactic acidosis through depletion of vitamin B6 hydrazines like isoniazid decreased pyridoxal 5-phosphate levels (by inhibiting formation, binding and inactivating free P5P and increasing rate of P5P elimination) P5P is a cofactor in >100 enzyme reactions, including conversion of glutamate to GABA thus hydrazines cause GABA depletion resulting CNS excitation and seizures lactic acidosis results from seizures and from impaired conversion of lactate to pyruvate hepatic metabolism via acetylation or cytochrome P450 mediated hydrolysis half life varies from 1-4 hours depending on whether the patient is a fast or slow acetylator Toxicity is rapid (30 min to 2 hours) and predictable >3g (40mg/kg) seizures, metabolic acidosis, coma >10g (130 mg/kg) always lethal without treatment isoniazid levels are rarely available, and only have a potential role in retrospectively confirming the diagnosis treat seizures with benzodiazepines (high doses may be needed), escalate to barbiturates and give pyridoxine as soon as available (See below) prepare for and perform intubation in the event of prolonged seizures Continue reading >>

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  1. KetoHippy

    I want to test my blood ketones after I eat something to see if it kicks me out of ketosis. How soon after I eat the item should I test?

  2. BillJay


    I want to test my blood ketones after I eat something to see if it kicks me out of ketosis. How soon after I eat the item should I test?

    When testing blood glucose, I usually test just before (T0), 30 minutes (T30), 60 minutes (T60) and 90 minutes (T90), but ketone strips are more expensive, so I usually do T0 and T60.

  3. Tim_Scudder

    Candra, I've found that I have to wait many hours before I see a true reaction. For example, if I have a carb-refeed meal @ dinner (I do carbs like rice/sweet-potato once every few weeks), I won't see my ketones drop much until at least the next morning (and I can usually feel that I'm out of Ketosis). My theory/hypothesis (based on data like the chart below and the few times I've dropped below 0.5 ml/mol over the past year since I've measured BHB with the Precision Xtra), is that the ketones measured in your blood are the "surplus" ketones your body has not consumed - it's not what your cells are consuming but what's left over - so if your cells shift to consume glucose, this level won't drop precipitously after a carb meal. If you eat enough carbs to push your blood sugar high (assuming your body has filled it's glycogen stores), your body is going to focus on utilizing the glucose first (glucose is toxic at high levels), leaving your ketone levels somewhat unchanged, but signaling to your liver to slowly reduce ketone production. As you can see in the chart below, it slowly lowers over a few days. I've personally found that (once keto adapted) I can have a high carb meal every few weeks and regain my ketone levels the next day after skipping a meal and having a low carb lunch/dinner...hope that helps.

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    isoniazid toxicity, like other hydrazines, primarily cause life-threatening seizures and lactic acidosis through depletion of vitamin B6 hydrazines like isoniazid decreased pyridoxal 5-phosphate levels (by inhibiting formation, binding and inactivating free P5P and increasing rate of P5P elimination) P5P is a cofactor in >100 enzyme reactions, including conversion of glutamate to GABA thus hydrazines cause GABA depletion resulting CNS excitation ...

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