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Respiratory Acidosis Pathophysiology

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Respiratory Acidosis

Respiratory acidosis is a medical emergency in which decreased ventilation (hypoventilation) increases the concentration of carbon dioxide in the blood and decreases the blood's pH (a condition generally called acidosis). Carbon dioxide is produced continuously as the body's cells respire, and this CO2 will accumulate rapidly if the lungs do not adequately expel it through alveolar ventilation. Alveolar hypoventilation thus leads to an increased PaCO2 (a condition called hypercapnia). The increase in PaCO2 in turn decreases the HCO3−/PaCO2 ratio and decreases pH. Terminology[edit] Acidosis refers to disorders that lower cell/tissue pH to < 7.35. Acidemia refers to an arterial pH < 7.36.[1] Types of respiratory acidosis[edit] Respiratory acidosis can be acute or chronic. In acute respiratory acidosis, the PaCO2 is elevated above the upper limit of the reference range (over 6.3 kPa or 45 mm Hg) with an accompanying acidemia (pH <7.36). In chronic respiratory acidosis, the PaCO2 is elevated above the upper limit of the reference range, with a normal blood pH (7.35 to 7.45) or near-normal pH secondary to renal compensation and an elevated serum bicarbonate (HCO3− >30 mm Hg). Causes Continue reading >>

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Popular Questions

  1. Skie

    Can You Use Ketone Sticks to "Diagnose"?

    I'm not on a low carb diet as far as I know, so having these in the urine would be a possible diabetes sign, right? Is it a safe idea to get a package and see what my results are? Or is this just a silly idea? I'm still working out arrangements to go see a doctor and get tested, but in the mean time while I figure that out with my friends, I figure something like this might be useful to get an idea of where I stand in the matter... Course I wish I could borrow a meter too, but alas... Don't know anyone who'd let me...

  2. Shanghaied Guy

    I think your blood sugars have to be extremely high before ketones would show up in your urine if you have not been on ketogenic diet (very low carb) for several days.
    You can get a free meter here: https://www.onetouchgold.com/simplestart/, but you will still need to buy the strips.
    Where do you live? If you live in Shanghai, I will buy you a cup of coffee some morning and test your BG. We diabetics are always curious about the blood sugar of other people and sometimes try to cajole our family and friends into testing their morning fasting blood sugar. If you want to disclose where you live, maybe somebody here at DD can help you out with the use of a meter.
    Tell us a bit about yourself. Do you have a family history of diabetes? How old are you? Are you overweight? Have you ever had high blood glucose on a test? What symptoms do you have that lead you to suspect diabetes?
    Be well.

  3. hannahtan

    i wouldn't dx yourself with just a ketostix... if there are sugar and ketones in the urine... it is a sign of diabetes... if ketones alone... i'm not sure... that is why i will not simply just assume i'm a diabetic based on a ketostix result...
    if you can't borrow a meter... can you just go to a pharmacy and get a simple finger bg test done? if it is high... and from the ketostix result which shows ketones as positive... please go see a doc immediately... but if bg is good...i wouldn't worry a lot... but still see a doc to get a proper diagnosis

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