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Renal Tubular Acidosis Diagnosis Criteria

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For just $1/month, you can help keep these videos free! Subscribe to my Patreon at http://www.patreon.com/pwbmd Minor correction: At about 12:30, I referred to furosemide as a thiazide diuretic. It of course is not; it's a loop diuretic. Thiazide diuretics would include such drugs as hydrocholorothiazide. (Disclaimer: The medical information contained herein is intended for physician medical licensing exam review purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.)

Renal Tubular Acidosis | The Online Metabolic And Molecular Bases Of Inherited Disease | Ommbid | Mcgraw-hill Medical

Renal tubular acidosis (RTA) is a clinical syndrome characterized by hyperchloremic metabolic acidosis secondary to an abnormality in renal acidification. The acidification defect may be manifested by an inappropriately high urine pH, bicarbonaturia, and, by definition, reduced net acid excretion. Classical distal renal tubular acidosis and proximal renal tubular acidosis are frequently associated with hypokalemia. Distal renal tubular acidosis can also result from a generalized dysfunction of the distal nephron, in which case it is usually accompanied by hyperkalemia and may be associated with either hypoaldosteronism or aldosterone resistance. Proximal renal tubular acidosis may result from an isolated defect of acidification in the proximal nephron. The isolated defect in acidification could be the result of selective dysfunction of the Na+/H+ antiporter, the proximal tubule H+-ATPase or the Na+/HCO3 /CO3 = symporter. More commonly, proximal renal tubular acidosis occurs as one manifestation of a generalized defect in proximal tubule function. Patients with this generalized abnormality, the Fanconi syndrome, usually have glycosuria, aminoaciduria, citraturia, and phosphaturia. Continue reading >>

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  1. borntobethin35

    Yesterday I notice the last few seconds of urinating, I would get this tingling sensation (not really burning) in my stomach. So I went to the Dr (not the one that did the surgery but my main doctor) and she stated I have a UTI. She prescribe some antibotics that taste really nasty (since I crush them up)
    Of course the Dr checks your urine. She told me I was in Ketosis stage and I'm starving myself. I just looked at her and reminder her that I did just have VSG and basically I do eat, just not a whole lot any more. I hate to have a UTI right now but I am happyh to ketosis stage meaning I'm burning fat/calories.
    Has any one else been told they are Ketosis? If so, is this bad and how long does it last? It seems like something you want to last forever if you are burning fat, right?
    Sheka

  2. Danielle K.

    All of us should be in ketosis while in the losing stage. When you hit maintenance you start increasing your carbs and it evens out for your body. You don't want to be in ketosis forever, from a medical stand point. It could be bad for your kidneys and cause renal failure in the long run.

  3. Jennchap

    I have been in Ketosis since surgery. I bought the walgreens brand ketosticks for 10 bucks and check a few times a week. It will be 12 weeks this Thursday and Im down 45 pounds and been in Ketosis the whole time. I was in ketosis the last 3 months of my last pregnancy and never had any issues so Im not worried but sure as hell enjoying the fat burning baby cakes!

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What is renal tubular acidosis (RTA)? RTA is a type of metabolic acidosis caused by the kidneys failure to properly acidify the urine. Find more videos at http://osms.it/more. Study better with Osmosis Prime. Retain more of what youre learning, gain a deeper understanding of key concepts, and feel more prepared for your courses and exams. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways and more when you follow us on social: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Thank you to our Patreon supporters: Sumant Nanduri Omar Berrios Alex Wright Sabrina Wong Suzanne Peek Arfan Azam Mingli Fng Osmosis's Vision: Empowering the worlds caregivers with the best learning experience possible.

Renal Tubular Acidosis

Renal tubular acidosis (RTA) refers to the non-anion gap metabolic acidosis which develops due to derangement of usual metabolic processes in the kidneys. The kidneys have a critical role in maintaining stable physiologic pH and they do so through several mechanisms throughout the nephron. Proximally, filtered bicarbonate is resorbed and distally acid is excreted then buffered in the urine. If the kidneys lose the ability to carry out these functions, renal tubular acidosis results. The three major forms of renal tubular acidosis are differentiated by the specific type and location of the mechanistic defect. An understanding of the basic physiology of the handling of acid by the kidney allows one to use clinical and laboratory clues to diagnose the type of RTA. The three key renal mechanisms to handle acid are listed below with the form of RTA associated with defects at that site. Reclaiming filtered bicarbonate in the proximal tubule - proximal (type 2) renal tubular acidosis The reclamation of bicarbonate is accompanied by excretion of a proton (H+) and occurs primarily in the proximal tubule (90% of filtered bicarbonate). A decrease in proximal tubular bicarbonate resorptive ca Continue reading >>

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Popular Questions

  1. arcadia

    Hello hello there.
    So I thought about sharing a bit about my keto experience that I have just recently learned. I know for most people switching to a very low carb diet (<20g daily) there are the "keto flu" symptoms to overcome which makes keto seem not worth it: I am talking dizziness, leg cramps, headaches, weakness.
    It is because losing the water you retained you are also letting salt and electrolytes such as Magnesium and Potassium go, and those little things are basically what run the internal communication system of our body.
    I personally never experience keto flu in 2 years before today, but since I restarted keto properly last week after a bout of B/P now, possibly because the difference in carbs really is extreme (due to B/P) I went to bed and woke up with the same headache, sore muscles and zero energy levels.
    Tried what is generally recommended: drink stock.
    I made 450ml of chicken stock out of a knorr chicken cube. I suppose the real thing as in chicken broth is better but in terms of salt and electrolytes this will do as well.
    Now it's 10 minutes later and the headache has completely subsided, and I am starting to feel well rested like after a good night's sleep.
    So before throwing the towel in, try stock, you never know
    Best of luck to everyone on their journeys.

  2. Paper Clips

    thank you for sharing. i'm going to go buy some now.

  3. Gorgeousundertheskin

    Thank you so much for this advice! for the past two days I've been dizzy, having headaches and lack of energy :/ . The sad part is I have to be on this diet due to insulin resistence. Do you have any more advice for this diet?

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This is a review of the pathophysiology, diagnosis and treatment of Renal Tubular Acidosis intended for 3rd and 4th year medical students and others learning clinical medicine.

Renal Tubular Acidosis

Renal tubular acidosis (RTA) is a disease that occurs when the kidneys fail to excrete acids into the urine, which causes a person's blood to remain too acidic. Without proper treatment, chronic acidity of the blood leads to growth retardation, kidney stones, bone disease, chronic kidney disease, and possibly total kidney failure. The body's cells use chemical reactions to carry out tasks such as turning food into energy and repairing tissue. These chemical reactions generate acids. Some acid in the blood is normal, but too much acidacidosiscan disturb many bodily functions. Healthy kidneys help maintain acid-base balance by excreting acids into the urine and returning bicarbonatean alkaline, or base, substanceto the blood. This "reclaimed" bicarbonate neutralizes much of the acid that is created when food is broken down in the body. The movement of substances like bicarbonate between the blood and structures in the kidneys is called transport. One researcher has theorized that Charles Dickens may have been describing a child with RTA in the character of Tiny Tim from A Christmas Carol. Tiny Tim's small stature, malformed limbs, and periods of weakness are all possible consequence Continue reading >>

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  1. peuleu

    Hi fellow ketoers of Reddit!
    I've been doing Keto for about a month (practice what you preach, eh?) so I'm still a noobie. I've been pretty strict recording everything and keeping carbs <30g. I've noticed the changes as to where I know I've entered ketosis. I've been on (an active) vacation for a week, doing lazy keto. Think I've stayed under 30g a day in food, but might have gone over a bit with alcohol (red wine), though I don't think I've gone over 50g total. The thing I'm finding difficult to figure out is if I can tell if my body is out of ketosis or not. A lot of people here say stuff like they can eat up to 80-100g on an active day and still be in ketosis. I gather this is different for everyone, especially if you're not Keto adapted yet, but my question is: how do you KNOW you're still in ketosis when you eat that many carbs? What happens to your body and how you feel when you go over?
    TL;DR: how can you tell if your body is out of ketosis? What changes do you experience?
    Thanks!
    Edit: thanks for all the responses! To clarify: I'm not worried at all! Just curious! I'm on a vacation where I hike all day and visit vineyards. I know I'm not gonna be strict Keto at the moment. I will be when I get back. I just noticed some bodily changes, and wanted to know what people experienced when they're out of ketosis. KCKO!

  2. anbeav

    Most don't, they speculate. If they gain any water weight or feel more hungry than usual, they conclude they are not in ketosis when that's not necessarily true. I wouldn't stress it, avoid the ketosis anxiety and focus on how you feel.

  3. peuleu

    Good to know! Thanks!

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