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Renal Tubular Acidosis

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Renal Tubular Acidosis (rta)

Renal tubular acidosis (RTA)refers to anormal anion gap metabolic acidosis (also known as a hyperchloremic acidosis) caused by: decreased excretion of hydrogen ions and/or decreased reabsorption of sodium bicarbonate in the renal tubules The abnormal acid-base transport within the tubules cannot be solely explained by decreased a glomerular filtration rate (GFR) secondary to chronic kidney disease, obstructive uropathy, or some other non-specific nephropathic mechanism The precise pathophysiological mechanism underlying the disorder varies across RTA sub-types (I-IV), which are described in detail below. Normal Acid-Base Homeostasis within the Renal Tubules Acid-base handling in the renal tubule can be broken down into two stages: Proximal reabsorption of filtered bicarbonate Proximal Reabsorption of BicarbonateSoriano JR. Renal Tubular Acidosis: The Clinical Entity. JASN. 2002 The reabsorption of filtered bicarbonate in the proximal tubule depends on the activity of carbonic anhydrase and several transporters: Intracellular carbonic anhydrase (CA-II) creates carbonic acid from water and carbon dioxide, which in turn ionizes to form a hydrogen ion plus bicarbonate The newly create Continue reading >>

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Popular Questions

  1. MandyJ

    Hey everyone!
    I’ve been doing keto for roughly 4 months now and have been loving it. I’ve incorporated a 16/8 IF most days with a few 3-5 day fasts mixed in as well. I’ve been listening to a lot of podcasts that talk about fasting vs feasting, and making sure you eat enough on the feasting days. I’ve also heard these podcasts talk about really feasting and taking in enough calories in order to prevent metabolic damage. As someone who was an eternal yo-yo dieter before keto, I assume I would have some damage already. Since going keto, I’ve only lost ten pounds, though I definitely look slimmer. I’m 5’10”, plateaued at 174, and have always been a little more muscular as well. My question here is how do you guys take in enough calories, and is undereating something I should be concerned about? I’ve tried keto coffee in the morning with 1-2 tablespoons each of butter, hwc, and mct oil, and dinner will be a bun-less burger with cheese, broccoli, and sometimes bacon. If not that, then I’ll scramble some eggs with butter or bacon and melt cheese on top. My calories are always around 1100 or less, though my bmr according to online calculators is closer to 1800. The common them is to eat fat to satiety, though I feel like I’m over eating and overly stuffed at such a calorie deficit already; that is, I really only feel hungry enough for one smaller meal a day. From everything that I’ve read and listened to I’m assuming this undereating is the reason I haven’t been able to lose more than the ten pounds. If so, how do I go about fixing my metabolism in order to be able to eat more without feeling sick?

  2. MiKetoAF

    BPC or what you call “Keto coffee” can easily be 800-900 calories itself. On my feasting days I just make sure to eat lots of fat and not over do the protein. I also stick to 2 meals and avoid snacking at all costs.

  3. LizinLowell

    I hear you, it’s very confusing the advice not to undereat. BUT, as I asked this same question a dozen different ways the advice that seemed more important was not to eat if you aren’t hungry. If you are slowing your metabolism you will have more symptoms than just slowed weight loss, such as feeling cold, depressed, increased hair loss. You might have a day where your appetite knows no bounds! For me it’s always changing. The last pounds are notoriously hard to lose, but it sounds like you are doing everything right. KCKO!

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