Preventing Cerebral Edema In Dka

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Why does diabetic ketoacidosis cause cerebral edema - Find out more explanation for : 'Why does diabetic ketoacidosis cause cerebral edema' only from this channel. Information Source: google

Increased Activity Of Inflammasomes As Osmosensors As Cause Of Cerebral Edema In Diabetic Ketoacidosis

Increased activity of inflammasomes as osmosensors as cause of cerebral edema in diabetic ketoacidosis Diabetic ketoacidosis (DKA) related cerebral edema (CE) is associated with a high mortality and rate of neurodisability and neurocognitive difficulties. In 54% of children with DKA there is subclinical evidence of CE on MRI studies. It is known that DKA is accompanied by a systemic inflammatory response characterized by elevated cytokine levels including interleukin-1 (IL-1) and interleukin-6. IL-1 has been linked to the pathogenesis of CE. Inflammasomes like nucleotide binding domain and leucine-rich repeat containing proteins 3 (NRLP3) are multiprotein complexes generating the active form of IL-1 in response to high glucose levels. The resulting hypothesis is that increased activity of inflammasomes as osmosensors is the cause of CE in diabetic ketoacidosis. Confirmation of the hypothesis could be achieved by correlation of IL-1 and NRLP3 levels and expression with degree of subclinical CE on MRI imaging and peripheral blood glial fibrillary acidic protein levels (a marker of brain injury). If confirmed future randomized controlled trials could use NRLP3 inhibitors and IL-1 ant Continue reading >>

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  1. aceclipse

    So, I've been ketoing for over a month now and it's been going pretty great. However, I am still a bit confused/unclear on a certain aspect. When it comes to getting "kicked out" of keto, what exactly triggers that? It's it simply having too many carbs, causing your body to temporarily switch back over to carb energy? I keep seeing a lot of..."debate" in regards to substances that cause a raise/spike in blood sugar. Does the spike in blood sugar contribute to getting out of ketosis or would it be more an insulin related thing? I'm asking because I rely on Monster Ultra "0 carb" energy drinks and do indulge occasionally in low carb dark chocolate with maltitol, and wanted to see if that would affect my ketosis. Any input or advice would be appreciated!

  2. DownhillYardSale

    There are 2 responses to this.
    Ketosis as defined by 0.2 mmol/L of beta-hydroxybutyrate or greater in the blood.
    Ketosis as defined by the state of burning primarily fat via beta-oxidation for energy requirements.
    In order for both thresholds to be crossed one must simply take in enough carbohydrates to increase insulin to the point that glucose becomes the primary fuel source.
    The spike in bloods sugar increases insulin because that intense amount of carbohydrates needs to be dealt with pronto - too much sugar in our blood is detrimental to our health.
    I'm asking because I rely on Monster Ultra "0 carb" energy drinks and do indulge occasionally in low carb dark chocolate with maltitol, and wanted to see if that would affect my ketosis.
    Sugar alcohols do not affect ketosis that I am aware of. Your low-carb dark chocolate? Depends how many carbs you eat in one sitting but it's doubtful this will kick you out although your body may temporarily need to switch to burning off the sugar.
    Either way I wouldn't worry about it.

  3. [deleted]

    Glucose in the liver. Liver produces ketones when the there is no glucose. A certain amount of carbs gets absorbed by your muscles before hitting the liver so you can have a few. Sometimes bodybuilders will eat a lot of carbs before a work out and remain in ketosis.

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Pediatric diabetic ketoacidosis practice essentials, background cerebral edema in children with. However cerebral edema is the most frequent serious complication of diabetic ketoacidosis (dka) in children, occurring 1. 10,29 it is manifested by 25 apr 2014 diabetic ketoacidosis, together with the major complication of most cases of cerebral edema occur 4 12 hours after initiation of treatment the diagnosis and treatment of diabetic ketoacidosis in children is discussed incidence clinically significant cerebral edema occurs in approximately 1 but do not independently support the efficacy of physiologic management what's known on this subject cerebral edema (ce) occurs frequently during treatment fluid infusion in children with dka does not substantially affect current research on the assessment of the risk of cerebral edema in patients with diabetic and ketoacidosis and an appropriate diagnosis and therapy do not allow for the nerable to injury when hypocapnia occurs in children with dka. Probably occurs in most cases during or even before treatment. Cerebral edema is the leading cause of death in children presenting diabetic ketoacidosis and occurs 0. Diabetic emergencies diabetic

What Are The Diagnostic Criteria For Cerebral Edema In Diabetic Ketoacidosis (dka)?

What are the diagnostic criteria for cerebral edema in diabetic ketoacidosis (DKA)? Muir et al have identified diagnostic criteria for cerebral edema that include abnormal response to pain, decorticate and decerebrate posturing, cranial nerve palsies, abnormal central nervous system respiratory patterns, fluctuating level of consciousness, sustained heart rate deceleration, incontinence, and more nonspecific criteria such as vomiting, headache, lethargy, and elevated diastolic blood pressure. [ 27 ] Cerebral edema begins with mental status changes and is believed to be due partially to idiogenic osmoles, which have stabilized brain cells from shrinking while the diabetic ketoacidosis was developing. Glaser NS, Marcin JP, Wootton-Gorges SL, et al. Correlation of clinical and biochemical findings with diabetic ketoacidosis-related cerebral edema in children using magnetic resonance diffusion-weighted imaging. J Pediatr. 2008 Jun 25. [Medline] . Umpierrez GE, Jones S, Smiley D, et al. Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial. Diabetes Care. 2009 Jul. 32(7):1164-9. [Medline] . [Full Text] . Herrington W Continue reading >>

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  1. JAMES

    A carbonyl group refers to the oxygen double bonded to a carbon. A ketone is a type of carbonyl group. The easiest way to tell if it is a ketone is if it is in the middle of the molecule. If it is, then it is a ketone. If the carbonyl is at the terminus of a molecule, then it is a aldehyde.

  2. Simon Moore


    Carbonyl is a type of functional group. Ketones are a class of organic compounds that contain this functional group.
    Carbonyl is the functional group -C=O
    In simple terms, ketones are a class of organic compound that contain a carbonyl group between two other alkyl groups. For example








    O (Acetone)

    They can be derived from the oxidation of secondary alcohols.

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Part of our series on hyponatraemia - where we tackle the causes of low sodium using a systematic approach. This video series is best watched from the start. Hyponatramia EXPLAINED: https://youtu.be/3QunAw5l0w8 Pseudohyponatraemia: https://www.youtube.com/watch?v=laQRt... True Hyponatraemia: https://www.youtube.com/watch?v=1krkd... Primary Polydipsia: https://www.youtube.com/watch?v=p05lj... Urine Osmolality vs Serum Osmolality: https://www.youtube.com/watch?v=0KUCw... Adrenal Insufficiency: https://www.youtube.com/watch?v=YZBpg... Fluid Assessment: https://www.youtube.com/watch?v=QOjzN... Hypovolaemia: https://www.youtube.com/watch?v=hq8u_... Oedematous Conditions: https://www.youtube.com/watch?v=9Rb3T... SIADH: https://www.youtube.com/watch?v=xS7m1... You only need five pieces of information to make a diagnosis! They are: 1. Serum sodium 2. Serum osmolality 3. Urine osmolality 4. Urine sodium 5. An assessment of the patient's fluid balance Causes include: Pseudohyponatraemia Primary polydipsia Adrenal insufficiency Hypovolaemia Oedematous States SIADH And take it from there! Hope you enjoy these videos - leave us some feedback and tell us what you'd like to see us cover next! REF

Preventing A Drop In Effective Plasma Osmolality To Minimize The Likelihood Of Cerebral Edema During Treatment Of Children With Diabetic Ketoacidosis - Sciencedirect

Volume 150, Issue 5 , May 2007, Pages 467-473 Preventing a Drop in Effective Plasma Osmolality to Minimize the Likelihood of Cerebral Edema During Treatment of Children with Diabetic Ketoacidosis Author links open overlay panel Ewout J.HoornMD Get rights and content To test whether a drop in effective plasma osmolality (PEff osm; 2 plasma sodium [PNa] + plasma glucose concentrations) during therapy for diabetic ketoacidosis (DKA) is associated with an increased risk of cerebral edema (CE), and whether the development of hypernatremia to prevent a drop in the PEff osm is dangerous. This study is a retrospective comparison of a CE group (n = 12) and non-CE groups with hypernatremia (n = 44) and without hypernatremia (n = 13). The development of CE (at 6.8 1.5 hours) was associated with a drop in PEff osm from 304 5 to 290 5 mOsm/kg (P < .001). Control patients did not show this drop in PEff osm at 4 hours (1 2 and 2 2 vs 9 2 mOsm/kg; P < .01), because of a larger rise in PNa and/or a smaller drop in plasma glucose. During this period, the CE group received more near-isotonic fluids (69 9 vs 35 2 and 27 3 mL/kg; P < .001). The CE group had a higher mortality (3/12 vs 0/57; P = .003), Continue reading >>

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  1. nattty3

    Thanks janielm9 I am pleased, just to let u know I went out on saturday and I had three vodkas with soda water and I dnt think it made much difference to my weight loss! Didn't drink as much as I normallly would tho as I had the diet in mind! And felt better the next day haha let me know how your weigh in goes! Good luck for the weekend! Xxx

  2. soundgirl64

    Hi all, its taken me ages to find this forum topic again, its not that easy to find things on this website-well i find that anyway.
    I have lost 4 lbs in first week even though i went out to dinner on Friday at a friends house and had some wine.
    Wondered how you are all doing as its all gone a bit quiet, maybe youve had the same problem as me finding it.
    I am fighting off a cold just now so just having root ginger and hot water as all the remedies are full of sugar , (horror)!
    Ive got 12 pounds to go, hope I can keep this up, finding recipes is quite hard and I made a special journey to a chemis t listed on this site as a stockist when I got there they had not much at all. I wanted some snack bars which Ive run out of and they had none ;(
    Ah well will have to get creative.

  3. AimeeB25

    Hi Soundgirl! If you have problems finding any of the conversations just go to your dashboard and any forum that you have posted in should be down on the left had side!
    Im struggling! I just cant seem to fight my sweet tooth. The first week went great but the second wasnt so good at all :( I am on the final day of my second week and Im literally terrified to get on the scales tomoro morning as I know I havent lost anything.
    Im really lucky though, the pharmacy where I get my products have a great range but Im going to have to reasses the situation after tomorrow and see if the money is worth it all. At the very least I am eating really really well, probably better than I have ever eaten so thats a huge plus. I havent touched bread, pasta, rice, noodles etc in 2weeks so, i dunno, maybe I just need to give it some more time? hmmm!
    Have you looked at any of the recipes on here Soundgirl? Some of them are really great. Also dont forget we are allowed muller light yoghurts and atkins bars (indulge for a snack and the other one-cant remember the name, as a meal replacement) they are available in boots-at least thats where I get them.
    I have 12 pounds left to lose too....I have a feeling it'll be a slow slog though haha!!
    What are you having for meals? x x

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