Determinants Of Plasma Potassium Levels In Diabetic Ketoacidosis.
1. Medicine (Baltimore). 1986 May;65(3):163-72. Determinants of plasma potassium levels in diabetic ketoacidosis. Adrogu HJ, Lederer ED, Suki WN, Eknoyan G. The classic proposal of intracellular K+ for extracellular H+ exchange asresponsible for the hyperkalemia of diabetic ketoacidosis (DKA) has beenquestioned because experimentally induced organic anion acidosis fails to producehyperkalemia. It has been suggested, instead, that the elevated serum [K+] of DKAmight be the result of the compromised renal function, secondary to volumedepletion, that usually accompanies DKA. However, several metabolic derangements other than volume depletion and acidosis, which are known to alter potassiummetabolism, also develop in DKA. This study of 142 admissions for DKA examinesthe possible role of alterations in plasma pH, bicarbonate, glucose (G),osmolality, blood urea nitrogen (BUN) and plasma anion gap (AG) on the levels of [K+]p on admission. Significant (p less than 0.01) correlations of [K+]p witheach of these parameters were found that could individually account for 8 to 15percent of the observed variance in the plasma potassium levels; however, theeffects of some or all of these paramete Continue reading >>