Physiological Insulin Resistance Phinney

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What is GLYCOGEN? What does GLYCOGEN mean? GLYCOGEN meaning, definition & explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals and fungi. The polysaccharide structure represents the main storage form of glucose in the body. In humans, glycogen is made and stored primarily in the cells of the liver and the muscles hydrated with three or four parts of water. Glycogen functions as the secondary long-term energy storage, with the primary energy stores being fats held in adipose tissue. Muscle glycogen is converted into glucose by muscle cells, and liver glycogen converts to glucose for use throughout the body including the central nervous system. Glycogen is the analogue of starch, a glucose polymer that functions as energy storage in plants. It has a structure similar to amylopectin (a component of starch), but is more extensively branched and compact than starch. Both are white powders in their dry state. Glycogen is found in the form of granules in the cytosol/cytoplasm in many cell types, and plays an important role in the glucose cycle. Glycogen forms an energy reserve that can be quickly mobilized to meet a sudden need for glucose, but one that is less compact than the energy reserves of triglycerides (lipids). In the liver, glycogen can comprise from 5 to 6% of its fresh weight (100–120 g in an adult). Only the glycogen stored in the liver can be made accessible to other organs. In the muscles, glycogen is found in a low concentration (1-2% of the muscle mass). The amount of glycogen stored in the body—especially within the muscles, liver, and red blood cells—mostly depends on physical training, basal metabolic rate, and eating habits. Small amounts of glycogen are found in the kidneys, and even smaller amounts in certain glial cells in the brain and white blood cells. The uterus also stores glycogen during pregnancy to nourish the embryo.

Steve Phinney Low-carb Preserves Glycogen Better Than High Carb

I can ride continuously for three hours and go 60 miles without any hunger or food cravings or drop off in performance. And I ride as well in the last 20 miles coming home as I do going out. Steve Phinney, can you tell us who you are? Im a medical doctor and have my training in internal medicine. Early in my career developed an interest in nutrition and got a PhD in nutritional biochemistry. That was 30 odd years ago, and since then my primary interests have been in weight management, ie, obesity, exercise and the human economy of the various fats we either put in our mouths or make in our bodies. Youre a star in a Canadian documentary called My Big Fat Diet, because you helped a whole group change their eating habits to reduce insulin resistance and lose a lot of weight. youre the co-author of a book about the Atkins Diet thats been updated by you and two other clinician scientists. Partially correct. I had a bit part in My Big Fat Diet. The star is Dr. James Wortman, a Canadian physician. And yes, Im a coauthor of the updated, new Atkins book which came out last March. Youre also in the process of creating a new book thats more technical about high fat diets. Thats correct. Dr. Continue reading >>

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  1. nurseprnRN

    The hypokalemia comes when the patient gets treated with insulin, driving the glucose and K+ into the cells. The kidneys can't (and won't) move so much out through urine with the excess glucose to make for hypokalemia.

  2. Esme12

    There can be a brief period of hypoglycemia in the early stages of an elevated blood sugar (polyuria)....but by the time "ketoacidosis" sets in the Serum potassium is elevated but the cellular potassium is depleted (all that shifting that goes on)
    Diabetic ketoacidosis

  3. April2152

    So pretty much what we would observe clinically is hyperkalemia because the osmotic duiresis does not move serum potassium significantly?

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Low Carb High Fat Diet or High Carb Diet - Which Causes Insulin Resistance: https://youtu.be/NbU8RIBRvjI Diabetes: https://www.youtube.com/playlist?list... -------------------------------------------------------------------------------------- Mentioned Book - Video - Website / Shout Outs -------------------------------------------------------------------------------------- DR GREGER'S BOOK - HOW NOT TO DIE US Amazon Book How Not to Die: http://amzn.to/2g67bmK UK Amazon Book How Not to Die: http://amzn.to/2grlYwy http://nutritionfacts.org/book/ Dr Greger's YouTube Channel https://www.youtube.com/user/Nutritio... Dr Gregers website http://nutritionfacts.org/ This is for educational purposes only and no copyright infringement is intended. ===================================================== Thanx for watching this Video!! Please do SUBSCRIBE & LIKE so you can help my new channel to GROW! & share this with friends All your support means the world to me! Till next time Keep on Keepin On & Just Go Do It Already ===================================================== STATS Name: Jon Anthony Age: 45 Height: 6:3" / 191cm Starting Weight: 151.8kg / 335lbs / (BMI) 41.9 Current Weight: 111.0kg / 244lbs / (BMI) 30.6 To date Loss Weight: 40.8kg / 89.76lbs / 6 stones Goal Weight: is to lose another 20kg - 44lbs And then to see what it looks like when I get there :) 90kg / 198lbs (BMI) 24.7 KG to LBS: http://kgtolbs.net https://www.google.co.uk/search?q=kg%... =============================================== BUSINESS Inquiries: [email protected] =============================================== Michael Greger MD NGO Website: http://nutritionfacts.org Book How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease US Amazon Book How Not to Die: http://amzn.to/2g67bmK UK Amazon Book How Not to Die: http://amzn.to/2grlYwy Your purchase or the Book How Not to Die via the link above will have money go to the NGO http://nutritionfacts.org and very small affiliate commission will be sent to me. =================================================== Visualize What Losing 10kg / 22lbs Looks Like https://youtu.be/JjrsD4erTXg I have lost well over 85+ lbs to date January 23rd 2017 - 109.8kg / 241.5lbs - Went Gym January 22nd 2017 - 109.8kg / 241.5lbs - Went Gym January 21st 2017 - 110.2kg / 242.4lbs - Went Gym January 20th 2017 - 110.5kg / 243.1lbs - Went Gym January 19th 2017 - 110.8kg / 243.7lbs - Went Gym January 18th 2017 - 110.8kg / 243.7lbs - Went Gym January 17th 2017 - 110.7kg / 243.5lbs - No Gym January 16th 2017 - 110.7kg / 243.5lbs - Went Gym January 15th 2017 - 111.8kg / 244.8lbs - Went Gym January 14th 2017 - 111.3kg / 244.8lbs - No Gym January 13th 2017 - 111.9kg / 246.1lbs - Went Gym January 12th 2017 - 111.8kg / 245.9lbs - Went Gym January 11th 2017 - 112.4kg / 247.2lbs - Went Gym January 10th 2017 - 112.2kg / 246.8lbs - Went Gym

Increased Insulin Resistance With A Low Carb Diet?

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Increased Insulin Resistance with a low carb diet? Bebo321 Family member Well-Known Member @azure @Brunneria @tim2000s , I would be interested to hear your thoughts on an observation of increased insulin resistance with a very low carb/keto diet. I was discussing this topic recently with somebody with T1D (we tried a food fast together over a number of days) They noticed that coming back out of the fast, their insulin requirements had increased fairly significantly in order to manage any carb they ate (the increased requirements only lasted a few days). Interestingly, their basal had remained exactly the same throughout the fast however and blood glucose levels had remained level. This would suggest that their 'insulin resistance' hadn't actually changed at all. What we considered had perhaps happened was that the body had become so effective at burning ketones and generating its own glucose requirements (gluconeogenesis), that once carbs were re-introduced, the body was fairly 'ambivalent' to it - after all, it had everything it needed to fuel itself perfectly w Continue reading >>

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  1. roshy

    DKA- what was your experience like?

    Hi all, i haven't been here for quite a while but its nice to see some of the same friendly faces!
    So i suffered with DKA back in october and havent felt healthy ever since. The hole experience left me very shaken up and traumatised! after spending 2 days in icu and a futher 3 days in hospital with drips and a urine cathador thigs completely regressed when i finially came home!! i was afraid to eat, i was afraid to leave the house, i didnt trust the meter, i would go extrememly low and and over react! i felt like my body was completely going to fail me. I promised myself i would never let something like that happen again however things are still out of control, im not taking my insulin out of pure lazyness and its basicaly routing now that i dont take the lantus, im not recording the sugar level and i really am falling into a hole which i feel like ill never be able to climb out of!
    The DKA experience was supposed to be a wake up call for me taking control, now its just something which i barely survived and left me confused about what kind of life im capable of living.
    After having type onefor 6 years i always believed controlling and accepting that my life would need to change would get easier, but instead my health is deteriorating as well as my optimism for life, and im only 22!!
    I was wondering what other experiences people may of had with DKA please share !! did you seek
    appropriate help support or advice which you may think might help myself and others??

  2. MAYS

    Welcome to Diabetic Connect !
    First and foremost, DKA is very serious and all diabetics should know the signs and symptoms of such because although it can happen to type 1 diabetics, it also happens to type 2 diabetics.
    You must be very careful and both monitor and manage your glucose level and take your insulin when and in the necessary dosage, here is some information :
    What is diabetic ketoacidosis (DKA) ?
    Diabetic ketoacidosis (DKA) is a life-threatening condition that develops when cells in the body are unable to get the sugar (glucose) they need for energy, such as when you have diabetes and do not take enough insulin. Without insulin, the body cannot use sugar for energy. When the cells do not receive sugar, the body begins to break down fat and muscle for energy. When this happens, ketones, or fatty acids, are produced and enter the bloodstream, causing the chemical imbalance (metabolic acidosis) called diabetic ketoacidosis.
    What causes DKA ?
    Ketoacidosis can be caused by not taking enough insulin, having a severe infection or other illness, becoming severely dehydrated, or some combination of these factors. It can occur in people who have little or no insulin in their bodies (mostly people with type 1 diabetes, but it can happen with type 2 diabetes) when their blood sugar levels are high.
    What are the symptoms ?
    Your blood sugar may be quite high before you notice symptoms, which include:
    Flushed, hot, dry skin.
    Blurred vision.
    Feeling thirsty.
    Drowsiness or difficulty waking up. Young children may lack interest in their normal activities.
    Rapid, deep breathing.
    A strong, fruity breath odor.
    Loss of appetite, abdominal pain, and vomiting.
    When diabetic ketoacidosis is severe, you may have difficulty breathing, your brain may swell (cerebral edema), and there is a risk of coma and even death.

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What is INSULIN RESISTANCE? What does INSULIN RESISTANCE mean? INSULIN RESISTANCE meaning - INSULIN RESISTANCE definition - INSULIN RESISTANCE explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin. The body produces insulin when glucose starts to be released into the bloodstream from the digestion of carbohydrates in the diet. Normally this insulin response triggers glucose being taken into body cells, to be used for energy, and inhibits the body from using fat for energy. The concentration of glucose in the blood decreases as a result, staying within the normal range even when a large amount of carbohydrates is consumed. When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. This often remains undetected and can contribute to a diagnosis of type 2 diabetes or latent autoimmune diabetes of adults. Although this type of chronic insulin resistance is harmful, during acute illness it is actually a well-evolved protective mechanism. Recent investigations have revealed that insulin resistance helps to conserve the brain's glucose supply by preventing muscles from taking up excessive glucose. Insulin resistance should even be strengthened under harsh metabolic conditions such as pregnancy, during which the expanding fetal brain demands more glucose. People who develop type 2 diabetes usually pass through earlier stages of insulin resistance and prediabetes, although those often go undiagnosed. Insulin resistance is a syndrome (a set of signs and symptoms) resulting from reduced insulin action; it is also part of a larger constellation of symptoms called the metabolic syndrome. Insulin resistance may also develop in patients who have recently experienced abdominal or bariatric procedures. This acute form of insulin resistance that may result post-operatively tends to increase over the short-term with sensitivity to insulin typically returning to patients after about five days.

Ketoadaptation And Physiological Insulin Resistance

This is where the magic happens. Rat pups, fed a flaxseed oil-based ketogenic diet from weaning onward – note the drop-off in ketones after 2 weeks (Likhodii et al., 2002): Patient history: these rats have been “low carb” their whole lives. Side note: flaxseed oil is very ketogenic! (Likhodii et al., 2000): Flaxseed oil-based ketogenic diet produced higher ketones than 48h fasting; the same can’t be said for butter or lard. PUFAs in general are more ketogenic than saturated fats in humans, too (eg, Fuehrlein et al., 2004): Crisco keto (adult rats) (Rho et al., 1999): At this point, please just note the stunning consistency in the drop-off of ketones. Experiment 1 & 2 (above) are adult rats; they went through a period of high carb chow dieting, unlike experiment 3 and the rats in the first study, who were weaned onto ketogenic diets. Still same phenomenon: ~few weeks after initiation of ketogenic diet = breakpoint; ketones decline. Ketoadaptation: why do ketone levels decline? This happened in both rat studies above, Phinney 1983, and in many “n=1” practitioners. Possible explanation 1 (ketoadaptation): rat milk is kind of like a low carb diet; high in fat, but not low e Continue reading >>

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  1. Bobhes

    What is the best time of the day to check blood ketone levels? I've heard that upon rising is a bad time because the body produces glucose overnight while you sleep. I've heard others say mid afternoon and still others at night at the end of the day.

    Please unconfuse this confused keto novice. Thanks in advance!

  2. Shortstuff

    I've been testing three times a day, just out of curiosity.
    Can't keep doing it as the test strips are so expensive, but interesting to gauge things properly.

  3. MaryAnn


    I've heard that upon rising is a bad time because the body produces glucose overnight while you sleep.
    I've heard this too. But I'm doing an N=1 experiment and my blood ketone readings are higher in the AM (generally).

    Not fasting *approx 5 hrs after eating Ketones: 3.9

    Not fasting (mid afternoon) Ketones: 1.4

    Not Fasting (approx 5 hrs after eating) Ketones 2.0

    Not Fasting (approx 3.5 hrs after eating) Ketones 1.6

    Fasting Ketones 3.3

    Fasting Ketones 2.9

    Fasting but a few hours (3) after ACV Ketones 2.8

    Fasting Ketones 3.6

    Not Fasting 2.2

    Not fasting means in the afternoon and at least after 1 meal. My first reading was the highest and it was in the afternoon. These are all separate day measurements. I haven't done the test in the AM and the PM (only because of cost). Will try that next.

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