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Pathophysiology Of Type 1 Diabetes Made Easy

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Pathophysiology Of Type 1 And Type 2 Diabetes Mellitus: A 90-year Perspective

Abstract Diabetes mellitus is a complex metabolic disorder associated with an increased risk of microvascular and macrovascular disease; its main clinical characteristic is hyperglycaemia. The last century has been characterised by remarkable advances in our understanding of the mechanisms leading to hyperglycaemia. The central role of insulin in glucose metabolism regulation was clearly demonstrated during the early 1920s, when Banting, Best, Collip and Macleod successfully reduced blood glucose levels and glycosuria in a patient treated with a substance purified from bovine pancreata. Later, during the mid-1930s, clinical observations suggested a possible distinction between ‘insulin-sensitive’ and ‘insulin-insensitive’ diabetes. Only during the 1950s, when a reliable measure of circulating insulin was available, was it possible to translate these clinical observations into pathophysiological and biochemical differences, and the terms ‘insulin-dependent’ (indicating undetectable insulin levels) and ‘non-insulin-dependent’ (normal or high insulin levels) started to emerge. The next 30 years were characterised by pivotal progress in the field of immunology that were Continue reading >>

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Popular Questions

  1. jcrome04

    Hey just had a quick question. I started working out pretty hard maybe about 5 months ago, lifting lot of weight and bulking up a bit.
    I was just wondering if it was safe for a diabetic to take a protein powder type of thing, but it's not just protein. There is a lot of other stuff in it.
    Here's a link to the exact product.
    Buy Body Fortress Super Advanced Whey Protein Powder, Chocolate Online at drugstore.com
    Just being on the safe side and wondering if should take it or not, I only took it for a couple weeks, then decided to make sure..
    Thanks everyone in advance!

  2. catatonic

    I've been taking Whey Protein for a while myself, and there have been no adverse effects.
    I discussed it with my endo (and my gastro) and they said that my bloodwork had been coming back fine, so they saw no reason why I shouldn't. Besides, there's so many foods I can't eat, so the supplement helps that cause too!
    I did take a look at the label of the brand you've been taking and it sayd 6g carbs (incl 3g sugar). While that's nothing spectacular, you might want to look for something less carby? The one I take claims to have 2g carbs (incl 1 sugar) per serving.
    Of course, make sure you test a few times 1, 2, and 3 hours after you take it to see how your body's dealing with it. If all seems well, then you're good to go!

  3. viranth

    My endo said I didn't need to take protein supplements, because the insulin would make me buff.

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