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Pathophysiology Of Metabolic Acidosis

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Metabolic Acidosis

What is metabolic acidosis? The buildup of acid in the body due to kidney disease or kidney failure is called metabolic acidosis. When your body fluids contain too much acid, it means that your body is either not getting rid of enough acid, is making too much acid, or cannot balance the acid in your body. What causes metabolic acidosis? Healthy kidneys have many jobs. One of these jobs is to keep the right balance of acids in the body. The kidneys do this by removing acid from the body through urine. Metabolic acidosis is caused by a build-up of too many acids in the blood. This happens when your kidneys are unable to adequately remove the acid from your blood. What are the signs and symptoms? Not everyone will have signs or symptoms. However, you may experience: Long and deep breaths Fast heartbeat Headache and/or confusion Weakness Feeling very tired Vomiting and/or feeling sick to your stomach (nausea) Loss of appetite If you experience any of these, it is important to let your healthcare provider know immediately. What are the complications of metabolic acidosis if I have kidney disease or kidney failure? Increased bone loss (osteoporosis): Metabolic acidosis can lead to a loss Continue reading >>

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Popular Questions

  1. ILoveTrance

    No appetite, less sleep, bouncing off the walls, and what I found most interesting is that my music preference changes. I listen to faster, more upbeat music when I can feel that I'm deep in ketosis. Interesting.
    That aside, I've been doing this since January 1st and lost 40lbs, with not much exercise. I'm at the weight I want to be now, but still sticking with keto. I like it.

  2. Targash

    As someone who is actually on stimulants I don't really find this to be true.

  3. mkaito

    As someone deep in ketosis, I don't find it to be true either. You feel hyper for a few days when your body goes into ketone overdrive after taking out the carbs, but it evens out. I'm just fine now.

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A Comprehensive Review Of Metabolic Acidosis

A comprehensive review of metabolic acidosis Summarized from Kraut J, Madias N. Metabolic acidosis: pathophysiology diagnosis and management. Nat Rev Nephrol 2010; 6: 274-85 Arterial blood gas analysis is used to assess and monitor patient acid-base status. Disturbance of acid-base balance is classified to one of four main types depending on the pH, pCO2(a) and bicarbonate results generated during blood gas analysis; the four types are respiratory acidosis, respiratory alkalosis, metabolic acidosis and metabolic alkalosis. A recent review article focuses on one of these disturbances, metabolic acidosis, which is characterized by primary decrease in bicarbonate and compensatory decrease in pCO2(a). pH may be either reduced (if compensation is incomplete) or normal (if compensation is complete). This wide-ranging, comprehensive review includes discussion of epidemiology, pathophysiology, clinical consequences and management of metabolic acidosis. The authors distinguish acute metabolic acidosis (lasting hours/days) from the much less common, chronic metabolic acidosis, which can last for years. Acute metabolic acidosis is a common feature of serious illness; a study quoted in the re Continue reading >>

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  1. W. Prins

    On the initial stages of a ketogenic diet you typically keep your carb intake per day ideally less than 25g. Eating one serving of kamut therefore nearly doubles that budget all by itself, so it’s not surprising that it might interfere or disrupt ketosis.

  2. Stephen Thomas

    Hi,
    Kamut is high in carbohydrates and subtraction of its fibre content (which is essentially what the ‘net carbs’ means) does not negate its high carbohydrate contents effect on the body that much.
    To be in ketosis you need to have around 30g of carbohydrates per day (or less but some people can stay in ketosis at higher levels)
    So let’s assume you’re in the average range of needed 30g of carbohydrates to stay in ketosis. Kamut has 70g for one 100g serving. It’s simply too high in carbs for most people.

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  3. John Limansky

    Great question. In general the idea of net carbs is a farce. Net carbs are calculated taking total carbohydrate content and subtracting the fiber portion to come up with a net carb total. Unfortunately, the net carb is usually underestimating real carb intake and thus kicking you out of ketosis. It’s important to understand how the food you are consuming is impacting your body specifically. Some can tolerate 20-gm or 50 gm or 100 gm before being kicked out of ketosis, while others who are quite insulin/leptin resistant will need to significantly reduce their carbohydrate intake to achieve real ketosis. My advice would be to avoid grains in general if trying to maintain ketosis. Hope that helps!

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Metabolic Acidosis In Emergency Medicine

Author: Antonia Quinn, DO; Chief Editor: Romesh Khardori, MD, PhD, FACP more... Metabolic acidosis is a clinical disturbance characterized by an increase in plasma acidity. Metabolic acidosis should be considered a sign of an underlying disease process. Identification of this underlying condition is essential to initiate appropriate therapy. This article discusses the differential diagnosis of metabolic acidosis and presents a scheme for identifying the underlying cause of acidosis by using laboratory tests that are available in the emergency department. Clinical strategies for treating metabolic acidosis are also reviewed. There are 3 approaches to understanding acid/base balance: A qualitative approach using the Henderson/Hasselbalch equation, a semiqualitative approach with base excess, and the Strong Ion Theory. The 3 theories are reviewed below. Henderson-Hasselbalch approach to acid/base physiology The Henderson-Hasselbalch equation describes the relationship between blood pH and the components of the H2 CO3 buffering system. This qualitative description of acid/base physiology allows the metabolic component to be separated from the respiratory components of acid/base balanc Continue reading >>

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Popular Questions

  1. wlsuser9

    I do a lot of reading about low carb/kenogenic diets, and typically I see people are in ketosis and losing weight between 20-60 net grams of carbs a day. I began my "low carb" (not low enough for some people) with a goal of <100 net grams a day, and I've lost about 2 lbs a week. My current calorie goal is 1200 because that's just what was recommended when I first joined myfitnesspal, and I really eat between 1100-1800 net calories, depending on my exercise and how many low carb snacks I decide to eat. I used ketostrips when I first started my diet, I had small to trace amounts detected and I was losing weight. I haven't used a test strip in a few weeks, but I've been keeping my carbs consistently lower than when I first started, anyway. I am on the cross country team at my college, so exercise is a necessity for me. I used to just eat whatever I wanted around 1200 calories a day, and would lose weight, but I couldn't stick to it and never got results like I have been eating a reduced carb amount.
    To anyone else who eats reduced carbs and exercises around 40 min a day 6 days a week, how many carbs do you eat to lose weight? Heck, even if you don't exercise, please let me know.
    I am probably going to buy more test strips to make sure I'm doing it right, but sometimes I think I might be eating too many carbs, and I just lose weight because of the amount of calories I eat. I just don't know! I hope to find somebody who can eat as many carbs as I do and still be burning fat!

  2. Carnivor0us

    I don't work out everyday, and when I do, it's just vigorous walking. I aim for as close to zero as possible, with no more than 75g in any one day. It's almost always way less than that. Also, a ketogenic diet isn't just low carb, it's also high-fat. If you can do at least 50% of calories from fat, that would help out any ketosis.
    On a personal note, I'd encourage you to not get too caught up focusing on the strips. I was like that for a long time and it frustrated me more than it helped (although it did help a bit).

  3. albertabeefy

    As a diabetic who controls my glucose with diet, I eat a ketogenic diet of 65-70% of my calories from fat, 25-30% from protein and a maximum 5% from carbohydrate. I will occasionally have more carbohydrate on days where I'm doing considerable exercise - such as a 100km bike ride, a 5 hour mountain hike, etc.
    I ONLY have more carbohydrate IF I'm burning it while exercising. IE: I'll eat it within 30-45 minutes prior to exercise.
    To GET ketogenic I did 2 weeks of 20-30g a day. That, combined with exercise, got me into ketosis in a few days, actually. I slowly added more carbohydrate into my diet - but found 5% on normal days was my threshold for good glycemic control. (On high-exercise days I can eat up to 10% with no issues.)
    The amount (in grams) of carb you have that keeps you in ketosis will obviously vary depending on your caloric intake.
    I normally eat up to 3,000 calories a day - as such 40g daily is about 5%. On a 5,000+ calorie day (not uncommon for me when doing endurance exercise) I may eat 120g or more...
    My daughter recently started a ketogenic diet for weight-loss. She doesn't really count calories, just eats reasonably, and keeps her carbohydrate intake about 20g a day. She lost 20lbs in the first 3 weeks.

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