diabetestalk.net

Paradoxical Intracellular Acidosis

Share on facebook

Quick and Easy Overview of Potassium Hyperkalemia Hypokalemia ( Please Read Description) This is a quick and easy overview of learning potassium. Too much potassium is hyperkalemia and low potassium is hypokalemia. If you like this video please remember to "like", "comment" and "subscribe". Thank you for watching

Md51 - Anaesthesia_mcq

MD51 [Jul01] An intravenous infusion of 8.4% sodium bicarbonate to a healthy adult maycause:A. HypotonicityB. Intracellular AcidosisC. Ionized HypercalcaemiaD.?Respiratory AlkalosisE. Rebound Metabolic AcidosisMD51b [Feb04] BicarbonateA. Complications include intracellular acidosisB. 100ml of 8.4% NaCO3 has 200 milliosmolesC.? Aug15 108. Side effect 8.4% NaHCO3 administration A. Intracellular acidosisB. Rebound metabolic acidosisC. ... Other options were easy to rule out =============================================================================================================== Brandis p38 - almost word for word (is that allowed?) 8.4% NaHCO3 is a one molar solution because the molecular weight of NaHCO3 is 84 = 84g/L = 8.4g/100mls.But each molecule of NaHCO3 dissociates into 2 particles in solution so the osmolality is double the molality. ie 2 osmoles/kg = 2000mOsm/kg = about 7 times the plasma osmolality. 100mls of the solution would then have 200 mOsm. The ECF HCO3 will cause decrease in H+ concentration. I think this then causes H+ to move out of the cells and K+ to move in. If this is true, B would also be incorrect. Don't know about C,D,E can some smart person help me? R Continue reading >>

Share on facebook

Popular Questions

  1. Christian

    I read conflicting views about whether or not the human body can create glucose out of fat. Can it?

  2. David

    Only about 5–6% of triglyceride (fat) can be converted to glucose in humans.
    This is because triglyceride is made up of one 3-carbon glycerol molecule and three 16- or 18-carbon fatty acids. The glycerol (3/51-to-57 = 5.2–5.9%) can be converted to glucose in the liver by gluconeogenesis (after conversion to dihydroxyacetone phosphate).
    The fatty acid chains, however, are oxidized to acetyl-CoA, which cannot be converted to glucose in humans. Acetyl-CoA is a source of ATP when oxidized in the tricarboxylic acid cycle, but the carbon goes to carbon dioxide. (The molecule of oxaloacetate produced in the cycle only balances the one acetyl-CoA condenses with to enter the cycle, and so cannot be tapped off to gluconeogenesis.)
    So triglyceride is a poor source of glucose in starvation, and that is not its primary function. Some Acetyl-CoA is converted to ketone bodies (acetoacetate and β-hydroxybutyrate) in starvation, which can replace part — but not all — of the brain’s requirement for glucose.
    Plants and some bacteria can convert fatty acids to glucose because they possess the glyoxylate shunt enzymes that allow two molecules of Acetyl-CoA to be converted into malate and then oxaloacetate. This is generally lacking in mammals, although it has been reported in hibernating animals (thanks to @Roland for the last piece of info).

  3. blu potatos

    To be more detailed it is the irreversibly of the reaction carried by Pyruvate dehydrogenase that makes the conversion of the fatty acid chains to glucose impossible. The fatty acids chains are converted to acetyl-CoA.
    Acetyl-CoA to be converted into pyruvate need an enzyme that can do the Pyruvate Dehydrogenase's inverse reaction (in humans there is no such enzyme). Than the pyruvete inside the mitochondria is converted into glucose(gluconeogenesis).

  4. -> Continue reading
read more
Share on facebook

What is the myocardial infarction !!

Effect Of Acidic Reperfusion On Prolongation Of Intracellular Acidosis And Myocardial Salvage

Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage Pg. Vall d Hebron 119129, Barcelona 08035 Pg. Vall d Hebron 119129, Barcelona 08035 Pg. Vall d Hebron 119129, Barcelona 08035 Pg. Vall d Hebron 119129, Barcelona 08035 Pg. Vall d Hebron 119129, Barcelona 08035 Pg. Vall d Hebron 119129, Barcelona 08035 Pg. Vall d Hebron 119129, Barcelona 08035 Corresponding author. Tel: +34 93 489 4038; fax: Cardiovascular Research, Volume 77, Issue 4, 1 March 2008, Pages 782790, Javier Inserte, Ignasi Barba, Vctor Hernando, Arancha Abelln, Marisol Ruiz-Meana, Antonio Rodrguez-Sinovas, David Garcia-Dorado; Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage, Cardiovascular Research, Volume 77, Issue 4, 1 March 2008, Pages 782790, It has been proposed that intracellular acidosis may be the basis of the cardioprotection of different interventions, including postconditioning. However, contradictory reports exist on the effects of acidic reperfusion on myocardial salvage. Here we characterized the effect of lowering the pH of the reperfusion media (pHo) on intracellular pH (pHi) and cell death. The effect of acidic per Continue reading >>

Share on facebook

Popular Questions

  1. Mindset714

    Hey All!! Happy Fourth!
    I was wondering if anyone has any advice or insights on a keto carb up day? Been seeing it a lot on some pages I follow.

    Thanks!!!

  2. JorgePasada

    Mindset714:


    I was wondering if anyone has any advice or insights on a keto carb up day?

    I've never heard that phrase before, could you explain what it means?

  3. Fiorella

    Wait. What?

    Have no clue what that is. What is the purpose of a carb up on a low carb way of eating? I don't get it.

  4. -> Continue reading
read more
Share on facebook

Vitanova Biomedical's Targeted Upconverting Nanoparticle (UCNP) Light-Activated Intracellular Acidosis (LAIA) Technology

Bicarbonate Therapy And Intracellular Acidosis.

1. Clin Sci (Lond). 1997 Dec;93(6):593-8. Bicarbonate therapy and intracellular acidosis. (1)Renal Laboratory, St Thomas' Hospital, London, U.K. 1. The correction of metabolic acidosis with sodium bicarbonate remainscontroversial. Experiments in vitro have suggested possible deleterious effectsafter alkalinization of the extracellular fluid. Disequilibrium of carbon dioxideand bicarbonate across cell membranes after alkali administration, leading to thephenomenon of 'paradoxical' intracellular acidosis, has been held responsible forsome of these adverse effects. 2. Changes in intracellular pH in suspensions ofleucocytes from healthy volunteers were monitored using a fluorescentintracellular dye. The effect in vitro of increasing extracellular pH with sodiumbicarbonate was studied at different sodium bicarbonate concentrations. Lacticacid and propionic acid were added to the extracellular buffer to mimicconditions of metabolic acidosis. 3. The addition of a large bolus of sodiumbicarbonate caused intracellular acidification as has been observed previously.The extent of the intracellular acidosis was dependent on several factors, being most evident at higher starting intracellular p Continue reading >>

Share on facebook

Popular Questions

  1. golfgal

    I was talking to someone the other day and they said that there is a medication that one of the side effects is that you smell like alcohol-like you had been drinking heavily smelling. True?? If so, what is it and what is it for.

  2. The Mystery Machine

    Maybe it was a blood sugar thing, like hypoglycemia?

  3. Goofyluver

    Tequila.
    JK. I don't really know. I'm curious, though.

  4. -> Continue reading
read more

No more pages to load

Related Articles

  • Paradoxical Acidosis

    Created by the veterinary profession for you - find out more about WikiVet Did you know you can edit or help WikiVet in other ways? Vomiting has potentially lethal effects in the monogastric animal. The effects are listed below. It is clinically important to differentiate vomiting from regurgitation , as clients can often confuse these clinical signs and the two have very different aetiologies. Fluid loss is evident as an increased PCV or haemat ...

    ketosis May 29, 2018
  • 8.4 Sodium Bicarbonate Intracellular Acidosis

    Sodium bicarbonate in the critically Ill patient with metabolic acidosis Uso de bicarbonato de sdio na acidose metablica do paciente gravemente enfermo Lactic acidosis is an acid-base imbalance frequently found in critically ill patients. It is associated with a poor prognosis. Despite the substantial body of evidence that critical levels of acidemia have several adverse effects on cell function, the use of sodium bicarbonate to treat lactic aci ...

    ketosis Apr 27, 2018
  • Paradoxical Intracellular Acidosis Definition

    Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside Kimmoun et al.; licensee BioMed Central.2015 The Erratum to this article has been published in Critical Care 2017 21:40 Lactic acidosis is a very common biological issue for shock patients. Experimental data clearly demonstrate that metabolic acidosis, including lactic acidosis, participates in the reduction of cardiac contractility and in the vascular hypo ...

    ketosis Apr 29, 2018
  • What Is Intracellular Acidosis

    Volume 49, Issue 5 , May 1996, Pages 1262-1267 Effect of sodium bicarbonate on intracellular pH under different buffering conditions Author links open overlay panel JacquesLevrautDr. Effect of sodium bicarbonate on intracellular pH under different buffering conditions. Previous in vitro studies have reported a paradoxical exacerbation of intracellular acidosis following bicarbonate therapy due to the generated CO2 entering the cytoplasm. However ...

    ketosis Jun 27, 2018
  • Sodium Bicarbonate Intracellular Acidosis

    Volume2015(2015), Article ID605830, 7 pages The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate 1Internal Medicine Department, University Hospital of Patras, 26500 Rion, Greece 2University of Patras School of Medicine, 26500 Rion, Greece 3Intensive Care Department, Brugmann University Hospital, 1030 Brussels, Belgium 4Department of Anesthesiology, Washington University School of Medicin ...

    ketosis Apr 29, 2018
  • Paradoxical Intracellular Acidosis

    Metabolic acidosis in childhood: why, when and how to treat Olberes V. B. AndradeI; Flvio O. IharaII; Eduardo J. TrosterIII IProfessor assistente, Faculdade de Cincias Mdicas, Irmandade da Santa Casa de Misericrdia de So Paulo, So Paulo, SP, Brasil. Mestre, Universidade Federal de So Paulo (UNIFESP), So Paulo, SP, Brasil. Doutor, Irmandade da Santa Casa de Misericrdia de So Paulo, So Paulo, SP, Brasil. Mdico, Centro de Terapia Intensiva Peditric ...

    ketosis Apr 26, 2018

More in ketosis