Nutritional Ketosis Vs Ketoacidosis

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Dear Mark: Ketosis

Dear Mark, What are ketones? How does ketosis play into the Primal Blueprint? Did our bodies evolve to run on ketones? If not, why do they exist? Ketones, to put it briefly, are compounds created by the body when it burns fat stores for energy. When you consume a diet very low in carbohydrates, the body responds to the significantly lowered levels of blood sugar by flipping the switch to another power source. The body converts fatty acids in the liver to ketones. Ketones, then, become the main energy source as long as blood sugar levels remain low. Recently, researchers have discovered more about the unique mechanisms behind this energy “switch.” It turns out a specific liver hormone, FGF21, is essential for the oxidation of the liver’s fatty acids. Furthermore, animals who were fed a ketogenic diet over time showed “increased expression of genes in fatty acid oxidation pathways and reduction in lipid synthesis pathways.” In other words, their bodies adapted metabolically and genetically to the diet. Ketosis was crucial to our evolution. Given the relatively minor role of carbohydrate-rich foods (even the consumption of many tubers is thought to have come later with the a Continue reading >>

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  1. Ash Simmonds

    This topic is actually much simpler than it's made out to be, that being it is merely a question of quantity of ketone production, and is only an issue in an individual who is unable to produce insulin.
    Unfortunately this is often glossed over even in medical texts, so it's not uncommon for even doctors and nurses to misunderstand the simple yet crucial difference, not to mention nutritionists.
    In the end it's all a matter of volume. Kind of like the difference between a sip, a gulp, and drowning.
    A moderate carbohydrate diet will often result in occasional trace amounts of ketone levels in the blood, typically after a fast (first thing in the morning) or after a decent exercise session. A very low carbohydrate diet is ketogenic by nature due to both low levels of carbohydrates in circulation/storage and ingestion of high levels of fat, and will result in moderate levels of ketone bodies circulating, usually around quarter-to-half the concentration of blood glucose, but occasionally reaching or even exceeding parity.
    Proper starvation - as in complete caloric avoidance for a week or two - can result in ketone bodies up to double or even triple circulating glucose levels, but even then the body has plenty of feedback loops to maintain ketone levels that are still well within safe parameters, you'll do organ damage from other stressors before ketones become a problem. There is of course something called alcoholic ketoacidosis, but this requires extensive periods of time where near 100% of your calories are derived from ethanol.
    Point being, this has nothing to do with nutritional ketosis. If you are capable of producing insulin then there is no danger of acidosis, which is actually ridiculously elevated ketones AND glucose levels.
    Serum ketone body levels typically look like this:
    Normal diet: 0-0.1 mmol/L
    Normal diet overnight fasted: 0.1-0.5 mmol/L
    Ketogenic Diet: 0.6-3.0 mmol/L
    1-4 weeks starvation: 6-10 mmol/L
    Diabetic insulin deficiency: >20 mmol/L

  2. Ketoacidosis

    Nutritional ketosis is a normal, physiological response to carbohydrate and energy restriction. A ketogenic diet is an effective weight loss strategy for many. Ketoacidosis, on the other hand, is a pathological condition caused by insulin deficiency. The common theme is low insulin; however, in ketoacidosis, blood glucose levels are very high. Ketone levels are elevated in both states, although are 10-20x higher in ketoacidosis (~0.5-2 vs. > 20 mM). Nutritional ketosis and ketoacidosis should not be confused with one another, and a ketogenic diet doesn't cause ketoacidosis.
    In people on a ketogenic diet, blood glucose levels are not increased. This is an important aspect differentiating nutritional ketosis from ketoacidosis.
    Ketogenic dieting is safe, and can be beneficial. Ketoacidosis is pathological, and can be fatal.

  3. Ash Simmonds

    Metabolic Effects of the Very-Low-Carbohydrate Diets: Misunderstood "Villains" of Human Metabolism
    Diabetic Ketoacidosis vs. Dietary Ketosis
    Diabetic patients know that the detection in their urine of the ketone bodies is a danger signal that their diabetes is poorly controlled. Indeed, in severely uncontrolled diabetes, if the ketone bodies are produced in massive supranormal quantities, they are associated with ketoacidosis.
    However, during very low carbohydrate intake, the regulated and controlled production of ketone bodies causes a harmless physiological state known as dietary ketosis.

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Understanding Ketosis Vs Ketoacidosis

Ketosis is a state in which the body starts burning fat for energy due to lack of new glucose in the diet. Althugh ketosis is commonly seen in individuals participating in a low-carb diet, it is also seen in people suffering from a lack of insulin as well as prolonged periods of fasting or starvation. Carbohydrates provide the body with glucose. The pancreas secretes a hormone called insulin that works with the glucose in the bloodstream to provide energy to the body's organs and cells. When the glucose supply is exhausted, it begins to break down stored fat to meet its energy needs for normal functioning. The accumulation of ketone molecules in the blood make it extremely acidic. This irritates the kidneys, which flush out ketones through urine. Ketosis gets its name from the ketones that are produced in the process of breaking down the fat. In a healthy person, the amount of fat that is burned and ketones that are produced is tightly controlled, causing no harmful side effects. Dietary ketosis seen in those participating in low-carbohydrate diets can be quite helpful in losing weight, as fat is burned in the entire process to gain energy. As ketosis is usually a diet-induced proc Continue reading >>

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  1. [deleted]

    I have type 1 diabetes and everytime I tell another diabetic I am on keto they tell me how ketosis is poisonius and ketons will kill me and cause my kidneys to fail or something.. I am close to finishing my first month and never felt better with my body. But I want to tell what exactly is the difference of ketosis and ketoacidosis simply to people when they ask me because I don't exactly know it too. All I know is ketosis is good and ketoacidosis is harmful and people confuse these two.

  2. anbeav

    Ketoacidosis is unregulated ketone production that occurs with inadequate insulin, nutritional ketosis is regulated ketone production which you are regulating by dosing your insulin appropriately.

  3. FrigoCoder

    During ketoacidosis you produce 10 times as much ketones as during dietary ketosis.
    Blood sugar levels that are 10 times as much as normal levels are not healthy, but this does not mean that normal glucose levels are inherently toxic.

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The Paleo Diet is not only the healthiest diet a human can eat, but it can even reverse type 2 diabetes! Chrystyne Olivieri, NP, interviews her patient, Mr. Kevin Cooney, as he discusses how the Paleo lifestyle has changed his life. Want to learn how to live a healthier, longer, and more natural life life? Learn about the Paleo Diet and much more at www.YourPaleoPractitioner.com!

The Paleo Guide To Ketosis

Ketosis is a word that gets tossed around a lot within the Paleo community – to some, it’s a magical weight-loss formula, to others, it’s a way of life, and to others it’s just asking for adrenal fatigue. But understanding what ketosis really is (not just what it does), and the physical causes and consequences of a fat-fueled metabolism can help you make an informed decision about the best diet for your particular lifestyle, ketogenic or not. Ketosis is essentially a metabolic state in which the body primarily relies on fat for energy. Biologically, the human body is a very adaptable machine that can run on a variety of different fuels, but on a carb-heavy Western diet, the primary source of energy is glucose. If glucose is available, the body will use it first, since it’s the quickest to metabolize. So on the standard American diet, your metabolism will be primarily geared towards burning carbohydrates (glucose) for fuel. In ketosis, it’s just the opposite: the body primarily relies on ketones, rather than glucose. To understand how this works, it’s important to understand that some organs in the body (especially the brain) require a base amount of glucose to keep fu Continue reading >>

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  1. Kalisiin

    Ketosis Versus Ketoacidosis

    Since much discussion has come up lately concerning Dr. Fung, Intermittent Fasting, and ketosis…I thought it would be timely to share this article I found explaining the difference between ketosis and ketoacidosis.
    New diabetics and even a few old hands seem to sometimes confuse these two things…even some doctors do!!
    Ketosis is safe, ketoacidosis can be a life-threatening condition. I might add that DKA, diabetic ketoacidosis happens much more frequently in Type 1 rather than Type 2 diabetics. Usually, you also need to have high BG readings to develop ketoacidosis, as I understand it.
    Anyway, my clinical knowledge is limited, and I certainly am not qualified to give medical advice, so I will just present the article as is.

  2. Gabby

    This really does help explain things a good bit. Once again, when we try to get things into any extreme, we end up out of balance.

  3. kidsclubkryse

    I tried to do ketosis because a friend mines father does it and it's work wonders, but it's very restrictive most things I can leave behind but I really really like oatmeal!! I'm still looking into it and I do find it promising lol!

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