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Nutritional Ketosis Vs Ketoacidosis

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Is The Ketogenic Diet Acidic?

One of the most common misconceptions with the ketogenic diet is that it makes the body overly acidic. While it is possible to make a ketogenic diet acidic, it is not inherently acidic and in fact may be alkaline forming. Much of this concern is rooted in our understanding of ketoacidosis, a harmful physiological condition associated with type I diabetics ( 1 ). But is a ketogenic diet acidic, or do we need to update our understanding of the metabolism? Using the ketogenic diet clinically for many years, I have become well versed with the nuances of ketone metabolism. A ketogenic diet in a healthy person is dramatically different from ketoacidosis. In fact, one might say they could be considered opposites as one is a powerful healer while the other is potentially life threatening. A ketogenic diet is one that trains the body to burn fat , instead of sugar, as its primary energy source. This happens by consuming most of your calories from fat sources, while strictly limiting the amount of carbohydrates that you consume in a given day. Once the body realizes that there has been a drop in insulin and that there is not an abundant supply of sugar to be burned as energy, it shifts its Continue reading >>

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  1. [deleted]

    I have type 1 diabetes and everytime I tell another diabetic I am on keto they tell me how ketosis is poisonius and ketons will kill me and cause my kidneys to fail or something.. I am close to finishing my first month and never felt better with my body. But I want to tell what exactly is the difference of ketosis and ketoacidosis simply to people when they ask me because I don't exactly know it too. All I know is ketosis is good and ketoacidosis is harmful and people confuse these two.

  2. anbeav

    Ketoacidosis is unregulated ketone production that occurs with inadequate insulin, nutritional ketosis is regulated ketone production which you are regulating by dosing your insulin appropriately.

  3. FrigoCoder

    During ketoacidosis you produce 10 times as much ketones as during dietary ketosis.
    Blood sugar levels that are 10 times as much as normal levels are not healthy, but this does not mean that normal glucose levels are inherently toxic.

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Ketones In Urine: All You Need To Know

Authored by Robert Iafelice , Dr. Brianna Stubbs and Nate Martins For a biohacker practicing intermittent fasting, urine ketones are a useful metric to track a state of ketosis . It's a quick and cost-effective way to indicate elevated ketone levels, which provide numerous health benefits. But for someone with uncontrolled type 1 diabetes or type 2 diabetes? Extremely high ketone levels in urine may be a sign of ketoacidosis a serious complication of diabetes which, if left untreated, can lead to coma and death. More on this outlier below. Normally, elevated ketones in urine are a good thing. In this piece, well cover what ketones in urine mean, how they get there and ways to test for ketones. But lets start with a refresher: The two predominant ketone bodies in human metabolism acetoacetate (ACAC) and beta-hydroxybutyric acid (BHB) are made in the liver from fatty acids. When glucose is not available, theyre transported by blood to other body tissues to be used as an energy source. Acetone, the third and least abundant ketone, is spontaneously formed from the breakdown of acetoacetate. Its found mostly in breath, and its contribution as an energy source is insignificant. There ar Continue reading >>

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  1. Ash Simmonds

    This topic is actually much simpler than it's made out to be, that being it is merely a question of quantity of ketone production, and is only an issue in an individual who is unable to produce insulin.
    Unfortunately this is often glossed over even in medical texts, so it's not uncommon for even doctors and nurses to misunderstand the simple yet crucial difference, not to mention nutritionists.
    In the end it's all a matter of volume. Kind of like the difference between a sip, a gulp, and drowning.
    A moderate carbohydrate diet will often result in occasional trace amounts of ketone levels in the blood, typically after a fast (first thing in the morning) or after a decent exercise session. A very low carbohydrate diet is ketogenic by nature due to both low levels of carbohydrates in circulation/storage and ingestion of high levels of fat, and will result in moderate levels of ketone bodies circulating, usually around quarter-to-half the concentration of blood glucose, but occasionally reaching or even exceeding parity.
    Proper starvation - as in complete caloric avoidance for a week or two - can result in ketone bodies up to double or even triple circulating glucose levels, but even then the body has plenty of feedback loops to maintain ketone levels that are still well within safe parameters, you'll do organ damage from other stressors before ketones become a problem. There is of course something called alcoholic ketoacidosis, but this requires extensive periods of time where near 100% of your calories are derived from ethanol.
    Point being, this has nothing to do with nutritional ketosis. If you are capable of producing insulin then there is no danger of acidosis, which is actually ridiculously elevated ketones AND glucose levels.
    Serum ketone body levels typically look like this:
    Normal diet: 0-0.1 mmol/L
    Normal diet overnight fasted: 0.1-0.5 mmol/L
    Ketogenic Diet: 0.6-3.0 mmol/L
    1-4 weeks starvation: 6-10 mmol/L
    Diabetic insulin deficiency: >20 mmol/L

  2. Ketoacidosis

    http://caloriesproper.com/?p=4192
    Quote
    Ketoacidosis
    Nutritional ketosis is a normal, physiological response to carbohydrate and energy restriction. A ketogenic diet is an effective weight loss strategy for many. Ketoacidosis, on the other hand, is a pathological condition caused by insulin deficiency. The common theme is low insulin; however, in ketoacidosis, blood glucose levels are very high. Ketone levels are elevated in both states, although are 10-20x higher in ketoacidosis (~0.5-2 vs. > 20 mM). Nutritional ketosis and ketoacidosis should not be confused with one another, and a ketogenic diet doesn't cause ketoacidosis.
    ...
    In people on a ketogenic diet, blood glucose levels are not increased. This is an important aspect differentiating nutritional ketosis from ketoacidosis.
    ...
    Ketogenic dieting is safe, and can be beneficial. Ketoacidosis is pathological, and can be fatal.

  3. Ash Simmonds

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129159/
    Quote
    Metabolic Effects of the Very-Low-Carbohydrate Diets: Misunderstood "Villains" of Human Metabolism
    ...
    Diabetic Ketoacidosis vs. Dietary Ketosis
    Diabetic patients know that the detection in their urine of the ketone bodies is a danger signal that their diabetes is poorly controlled. Indeed, in severely uncontrolled diabetes, if the ketone bodies are produced in massive supranormal quantities, they are associated with ketoacidosis.
    ...
    However, during very low carbohydrate intake, the regulated and controlled production of ketone bodies causes a harmless physiological state known as dietary ketosis.

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Prevalence Of Ketosis, Ketonuria, And Ketoacidosis During Liberal Glycemic Control In Critically Ill Patients With Diabetes: An Observational Study

Prevalence of ketosis, ketonuria, and ketoacidosis during liberal glycemic control in critically ill patients with diabetes: an observational study It is uncertain whether liberal glucose control in critically ill diabetic patients leads to increased ketone production and ketoacidosis. Therefore, we aimed to assess the prevalence of ketosis, ketonuria and ketoacidosis in critically ill diabetic patients treated in accordance with a liberal glycemic control protocol. We performed a prospective observational cohort study of 60 critically ill diabetic patients with blood and/or urine ketone bodies tested in ICU. All patients were treated according to a liberal glucose protocol targeting a blood glucose level (BGL) between 10 and 14mmol/l in a single tertiary intensive care unit in Australia. We measured quantitative bedside blood 3-beta-hydroxybutyrate (-OHB) and semi-quantitative urine ketones on ICU admission and daily during ICU stay, for a maximum of 10 consecutive days. Median blood -OHB level on admission was 0.3 (0.1, 0.8) mmol/l. Ketoacidosis was rare (3%), but some level of ketosis (-OHB 0.6mmol/l) was found in 38 patients (63%) early during their ICU stay. However, there wa Continue reading >>

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  1. [deleted]

    I have type 1 diabetes and everytime I tell another diabetic I am on keto they tell me how ketosis is poisonius and ketons will kill me and cause my kidneys to fail or something.. I am close to finishing my first month and never felt better with my body. But I want to tell what exactly is the difference of ketosis and ketoacidosis simply to people when they ask me because I don't exactly know it too. All I know is ketosis is good and ketoacidosis is harmful and people confuse these two.

  2. anbeav

    Ketoacidosis is unregulated ketone production that occurs with inadequate insulin, nutritional ketosis is regulated ketone production which you are regulating by dosing your insulin appropriately.

  3. FrigoCoder

    During ketoacidosis you produce 10 times as much ketones as during dietary ketosis.
    Blood sugar levels that are 10 times as much as normal levels are not healthy, but this does not mean that normal glucose levels are inherently toxic.

  4. -> Continue reading
read more

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