In the opening segment of this AJMC Peer ExchangeTM, moderator Dennis P. Scanlon, PhD, discusses results of the EMPA-REG OUTCOME trial that demonstrated treatment effectiveness in both diabetes and cardiovascular mortality.
Empa-reg Outcome - Wiki Journal Club
Among patients with T2DM at high risk for CV events, does daily empagliflozin 10 or 25 mg reduce CV mortality, nonfatal MI, or nonfatal strokes when compared to placebo? In this industry-sponsored trial, empagliflozin reduced the rate of CV events and slowed the progression of kidney disease among patients with T2DM and high CV risk. Excess mortality in T2DM is largely related to an increased incidence of CV disease.  In the 1998 UKPDS 34 study, metformin was associated with reduced all-cause mortality. The 2005 PROactive study not only failed to demonstrate a reduction in all-cause mortality with pioglitazone; the drug was associated with excess HF hospitalizations.  Subsequent studies of newer agents, including the DPP-4 inhibitor sitagliptin ( TECOS , 2015  ) and the GLP-1 inhibitor lixisenatide ( ELIXA , 2015  ), have also been unable to demonstrate a significant improvement in cardiovascular outcomes among selected patients with T2DM. Empagliflozin is a glucose-lowering agent that inhibits the renal sodium glucose cotransporter-2 (SGLT-2 inhibitor) which confers several advantages including weight loss, reduction in blood pressure, and a low risk of hypoglycemia.
TORT LAW TEAM ... www.tortlawteam.com helps you to get financial compensation you deserve! This video about invokana, invokamet diabetes medicine side effects and lawsuit. If you or your loved one taken invokana, canagliflozin, diabetes medicine and faced side effect, ketoacidosis, oversee glucose, kidney failure, unsaturated fats, You may eligible to get the financial compensation. Learn More at: http://www.tortlawteam.com/ an antidiabetic drug for treatment of Type 2 diabetes. It is an individual from the new SGLT2 class of antidiabetic solution that additionally incorporates empagloflozin (Jardiance) and dapagliflozin (Farxiga). Canagliflozin is additionally sold in mix with metformin under the brand name Invokamet. invokana and Invokamet are made and advertised in the U.S. by Janssen pharmaceuticals which is a backup of Johnson and Johnson, one of the biggest pharmaceutical organizations on the planet with income of over $74 billion every year. invokana was affirmed in 2013 as the first SGLT2 (sort 2 sodium-glucose co-transporter) inhibitor. As it works uniquely in contrast to other hostile to diabetes pharmaceuticals available, it was wanted to be helpful for patients who did not react well to other drug. Sadly, numerous drugs for Type 2 diabetes have created genuine medicinal harm. The SGLT2 class rooftop solutions has been embroiled in a higher-than-ordinary advancement of diabetic ketoacidosis, an existence undermining condition. Learn More at: http://www.tortlawteam.com/ How to Dangerous of Using invokana, diabetes medicine invokana works by setting off the kidneys to discharge overabundance blood glucose through the urine. It is demonstrated for treatment of patients with Type 2 diabetes, which cant be controlled through eating regimen and activity. It is not to be endorsed to those with Type 1 diabetes or for treatment of diabetic ketoacidosis. Diabetic ketoacidosis happens when the body does not have enough insulin to oversee glucose levels. The body starts smoldering unsaturated fats, which brings about a waste item called acidic ketone bodies. These ketones are what trigger the indications of ketoacidosis. Those side effects incorporate spewing, parchedness, disarray, weakness, and stomach torment. In uncommon cases, untreated ketoacidosis can bring about trance state and even passing. While no passings have been accounted for with the utilization of invokana or Invokamet, the risk exists. Learn More at: http://www.tortlawteam.com/ About Invokana Lawsuits A conceivably deadly reaction of Invokana may prompt claims against a modest bunch of medication producers. The pharmaceutical treats Type 2 diabetes yet triggers hazardous levels of blood acids, which drove the FDA to sound an alert about the medications. Dont forget to fill the Medicine Healthcare Survey 2017 Nationwide USA at survey.tortlawteam.com Thank you and Have a nice day. www.tortlawteam.com .....................!
Side Effects Blog: Jardiance, Invokana, And Farxiga Double Risk Of Diabetic Ketoacidosis
Tom Lamb A lawyer helping people in drug injury lawsuits and asbestos-mesothelioma claims Side Effects Blog: Jardiance, Invokana, And Farxiga Double Risk Of Diabetic Ketoacidosis The June 8, 2017 edition ofThe New England Journal of Medicine(NEJM) has a To the Editor letter, titled Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor, which is likely causing some concerns among doctors and type 2 diabetes (T2D) patients. It is about the safety of Jardiance, Invokana, Farxiga, and other diabetes medicines in the SGLT2 inhibitor class of diabetes drugs. A June 7, 2017MedPage Todayarticle, Study Warns of Diabetic Ketoacidosis With SGLT2 Inhibitors in T2D, provides a summary and some commentary about the recent medical study which is described in this June 2017 NEJM letter to the editor: The newest class of drugs for treating type 2 diabetes carries a greater risk for diabetic ketoacidosis compared to other classes of drugs, a new study suggests. Newly initiated use of an SGLT2 inhibitor was associated with a roughly twofold greater risk of diabetic ketoacidosis versus new initiation of a DPP4 inhibitor (HR 2.2, 95% CI 1.4 to 3.6), according to Michael Fralick, MD, of
Invokana works differently from other type II diabetes drugs. Instead of helping the body metabolize glucose, Invokana inhibits SGLT2 ("sodium glucose co-transporter 2") which reabsorbs sugar into the bloodstream through the kidneys. This overworks the kidneys to extricate glucose out of the body through the urine. By constricting blood vessels in the legs and creating blood volume loss, there is an increased risk of foot, toe, and leg amputations. An FDA black box warning was issued on May 16, 2017 informing the public about this risk and requiring labeling on every Invokana pill bottle as well as on Janssen's website. If you or a loved one sustained a foot, toe, or leg amputation while taking Invokana, contact the Invokana Claim center at www.InvokanaClaim.org or call us toll free (855) DRUG HURT Frekhtman & Associates 212.222.1111
Jardiance, Invokana, Farxiga, And The Other Sglt2 Inhibitors Might Double The Risk Of Diabetic Ketoacidosis (dka) - Drug Injury Watch
Jardiance, Invokana, Farxiga, And The Other SGLT2 Inhibitors Might Double The Risk Of Diabetic Ketoacidosis (DKA) Study Compared Newly Initiated Use Of SGLT2 Inhibitor To New Initiation Of Another Class Of Diabetes Drugs To Assess The DKA Side Effect (Posted by Tom Lamb at DrugInjuryWatch.com ) All of these newer diabetes medicines are part of the Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors class of drugs: Invokamet XR (canagliflozin and metformin extended-release) Xigduo XR (dapagliflozin and metformin extended-release) Synjardy (empagliflozin and metformin hydrochloride) Synjardy XR (empagliflozin and metformin hydrochloride) The SGLT2 inhibitor class of diabetes drugs is approved by the FDA for treatment of type 2 diabetes (T2D). A "To the Editor" letter in the June 8, 2017 edition of The New England Journal of Medicine (NEJM), titled " Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor ",is likely causing some concerns among doctors and patients about the safety of Jardiance, Invokana, Farxiga, and the other SGLT2 inhibitors. From the start of that letter we get some introductory information about this drug-safety concern raised for these newer diabete
Report Compiles Data on Diabetic Ketoacidosis With SGLT2 Inhibitors While rare, diabetic ketoacidosis occurs overwhelmingly in patients taking SGLT2 inhibitors with type 2 diabetes, according to the analysis from 3 North Carolina medical schools. A data analysis in Diabetes Care finds that diabetic ketoacidosis (DKA) in patients taking sodium glucose co-transporter-2 (SGLT2) inhibitors occurs most often among patients taking the drug for type 2 ...
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The Case At Hand Recently, the U.S. Food and Drug Administration (FDA) issued a Drug Safety Communication that warns of an increased risk of diabetic ketoacidosis (DKA) with uncharacteristically mild to moderate glucose elevations (euglycemic DKA [euDKA]) associated with the use of all the approved sodium–glucose cotransporter 2 (SGLT2) inhibitors (1). This Communication was based on 20 clinical cases requiring hospitalization captured between ...
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Key points for the trauma anesthesiologist The diagnosis of lactic acidosis is best made by the serum lactate level. Anion gap and decline in the serum HCO3 levels, although suggestive of lactic acidosis are non-specific and can be causedby other acid-base disorders. Cardiogenic or hypovolemic shock, advanced heart failure, sepsis, and severe trauma account for the majority of lactic acidosis. Treatment consists of restoring tissue perfusion wit ...
Landmark blood pressure study, published by NEJM, confirms benefits of lower blood pressure Suzanne Oparil, M.D., and Cora Lewis, M.D.Final results from the landmark SPRINT study, published online today in the New England Journal of Medicine , confirm that treating adults 50 years and older with high blood pressure but without diabetes or prior stroke to a systolic blood pressure of 120 reduces the risk of cardiovascular disease and can save liv ...