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In the opening segment of this AJMC Peer ExchangeTM, moderator Dennis P. Scanlon, PhD, discusses results of the EMPA-REG OUTCOME trial that demonstrated treatment effectiveness in both diabetes and cardiovascular mortality.

Empa-reg Outcome - Wiki Journal Club

Among patients with T2DM at high risk for CV events, does daily empagliflozin 10 or 25 mg reduce CV mortality, nonfatal MI, or nonfatal strokes when compared to placebo? In this industry-sponsored trial, empagliflozin reduced the rate of CV events and slowed the progression of kidney disease among patients with T2DM and high CV risk. Excess mortality in T2DM is largely related to an increased incidence of CV disease. [1] In the 1998 UKPDS 34 study, metformin was associated with reduced all-cause mortality. The 2005 PROactive study not only failed to demonstrate a reduction in all-cause mortality with pioglitazone; the drug was associated with excess HF hospitalizations. [2] Subsequent studies of newer agents, including the DPP-4 inhibitor sitagliptin ( TECOS , 2015 [3] ) and the GLP-1 inhibitor lixisenatide ( ELIXA , 2015 [4] ), have also been unable to demonstrate a significant improvement in cardiovascular outcomes among selected patients with T2DM. Empagliflozin is a glucose-lowering agent that inhibits the renal sodium glucose cotransporter-2 (SGLT-2 inhibitor) which confers several advantages including weight loss, reduction in blood pressure, and a low risk of hypoglycemia. Continue reading >>

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Popular Questions

  1. Gaash

    The BIG QUESTION: Do Calories Matter in Keto?

    This has probably been answered numerous times but never definitively, at least as long as I have been reading the boards. Does anyone know if, when in KETO, do total calories consumed matter for weightloss or not.
    There are numerous arguments that KETO diet works, in part, because cutting out carbs ends up making people eat less calories than they need for maintenance; however, the are other arguments that in the state of Ketosis, your body is buring fat for energy (most likely at an inefficient pace, but even if not), so as long as you eat less FAT calories than your body needs, any extra calories don't matter, and they are just excreted (i guess)
    Others still say that it doesn't matter at all, that you can eat 8000 calories a day if you are in ketosis and you will still lose weight.
    So, whats the truth?

  2. johnnyironboard

    Yes they matter. Debit maint. calories 10% and you will see a tremendous amount of fat loss. You can eat maint while in keto and believe it or not still lose weight. When I am cutting, I debit 10% during the week and then carb up on the weekend with about 100 to 1000 calories over maint-depending on where I'm at. During "normal" times I eat maint. every day and do low carb M-F and carb up on the weekend.

  3. camo1131

    What kinda question is that??? Since when is there a confusion about this? People continue to amaze me.......

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TORT LAW TEAM ... www.tortlawteam.com helps you to get financial compensation you deserve! This video about invokana, invokamet diabetes medicine side effects and lawsuit. If you or your loved one taken invokana, canagliflozin, diabetes medicine and faced side effect, ketoacidosis, oversee glucose, kidney failure, unsaturated fats, You may eligible to get the financial compensation. Learn More at: http://www.tortlawteam.com/ an antidiabetic drug for treatment of Type 2 diabetes. It is an individual from the new SGLT2 class of antidiabetic solution that additionally incorporates empagloflozin (Jardiance) and dapagliflozin (Farxiga). Canagliflozin is additionally sold in mix with metformin under the brand name Invokamet. invokana and Invokamet are made and advertised in the U.S. by Janssen pharmaceuticals which is a backup of Johnson and Johnson, one of the biggest pharmaceutical organizations on the planet with income of over $74 billion every year. invokana was affirmed in 2013 as the first SGLT2 (sort 2 sodium-glucose co-transporter) inhibitor. As it works uniquely in contrast to other hostile to diabetes pharmaceuticals available, it was wanted to be helpful for patients who did not react well to other drug. Sadly, numerous drugs for Type 2 diabetes have created genuine medicinal harm. The SGLT2 class rooftop solutions has been embroiled in a higher-than-ordinary advancement of diabetic ketoacidosis, an existence undermining condition. Learn More at: http://www.tortlawteam.com/ How to Dangerous of Using invokana, diabetes medicine invokana works by setting off the kidneys to discharge overabundance blood glucose through the urine. It is demonstrated for treatment of patients with Type 2 diabetes, which cant be controlled through eating regimen and activity. It is not to be endorsed to those with Type 1 diabetes or for treatment of diabetic ketoacidosis. Diabetic ketoacidosis happens when the body does not have enough insulin to oversee glucose levels. The body starts smoldering unsaturated fats, which brings about a waste item called acidic ketone bodies. These ketones are what trigger the indications of ketoacidosis. Those side effects incorporate spewing, parchedness, disarray, weakness, and stomach torment. In uncommon cases, untreated ketoacidosis can bring about trance state and even passing. While no passings have been accounted for with the utilization of invokana or Invokamet, the risk exists. Learn More at: http://www.tortlawteam.com/ About Invokana Lawsuits A conceivably deadly reaction of Invokana may prompt claims against a modest bunch of medication producers. The pharmaceutical treats Type 2 diabetes yet triggers hazardous levels of blood acids, which drove the FDA to sound an alert about the medications. Dont forget to fill the Medicine Healthcare Survey 2017 Nationwide USA at survey.tortlawteam.com Thank you and Have a nice day. www.tortlawteam.com .....................!

Side Effects Blog: Jardiance, Invokana, And Farxiga Double Risk Of Diabetic Ketoacidosis

Tom Lamb A lawyer helping people in drug injury lawsuits and asbestos-mesothelioma claims Side Effects Blog: Jardiance, Invokana, And Farxiga Double Risk Of Diabetic Ketoacidosis The June 8, 2017 edition ofThe New England Journal of Medicine(NEJM) has a To the Editor letter, titled Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor, which is likely causing some concerns among doctors and type 2 diabetes (T2D) patients. It is about the safety of Jardiance, Invokana, Farxiga, and other diabetes medicines in the SGLT2 inhibitor class of diabetes drugs. A June 7, 2017MedPage Todayarticle, Study Warns of Diabetic Ketoacidosis With SGLT2 Inhibitors in T2D, provides a summary and some commentary about the recent medical study which is described in this June 2017 NEJM letter to the editor: The newest class of drugs for treating type 2 diabetes carries a greater risk for diabetic ketoacidosis compared to other classes of drugs, a new study suggests. Newly initiated use of an SGLT2 inhibitor was associated with a roughly twofold greater risk of diabetic ketoacidosis versus new initiation of a DPP4 inhibitor (HR 2.2, 95% CI 1.4 to 3.6), according to Michael Fralick, MD, of Continue reading >>

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Popular Questions

  1. sassiebritches

    Second time I pee'd on my ketone test strips and they are 1 step above low ;0( I am not eating a whole lot of carbs here....like no more than 40g....why am I not going into ketosis this time.....guess I am gonna have to just buckle down even more?
    How long did it take for your body to go into ketosis and what was your carb intake when you were in ketosis....I am just curious.
    Also, I know that there are alot of people who do not agree with low carb eating. I have done my research and prefer to hear from people who are also eating this way. Thank you.

  2. Mimigurken

    It's just an indicator, not a tool. As long as it turns you're fine. I started at under 20 gr/ day and when I slowly added carbs it turned the same color with 70 gr/ day 3 months later. Please remember to take your supplements every day.

  3. angebean

    Pardon my ignorance. What are Ketone strips?

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Invokana works differently from other type II diabetes drugs. Instead of helping the body metabolize glucose, Invokana inhibits SGLT2 ("sodium glucose co-transporter 2") which reabsorbs sugar into the bloodstream through the kidneys. This overworks the kidneys to extricate glucose out of the body through the urine. By constricting blood vessels in the legs and creating blood volume loss, there is an increased risk of foot, toe, and leg amputations. An FDA black box warning was issued on May 16, 2017 informing the public about this risk and requiring labeling on every Invokana pill bottle as well as on Janssen's website. If you or a loved one sustained a foot, toe, or leg amputation while taking Invokana, contact the Invokana Claim center at www.InvokanaClaim.org or call us toll free (855) DRUG HURT Frekhtman & Associates 212.222.1111

Jardiance, Invokana, Farxiga, And The Other Sglt2 Inhibitors Might Double The Risk Of Diabetic Ketoacidosis (dka) - Drug Injury Watch

Jardiance, Invokana, Farxiga, And The Other SGLT2 Inhibitors Might Double The Risk Of Diabetic Ketoacidosis (DKA) Study Compared Newly Initiated Use Of SGLT2 Inhibitor To New Initiation Of Another Class Of Diabetes Drugs To Assess The DKA Side Effect (Posted by Tom Lamb at DrugInjuryWatch.com ) All of these newer diabetes medicines are part of the Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors class of drugs: Invokamet XR (canagliflozin and metformin extended-release) Xigduo XR (dapagliflozin and metformin extended-release) Synjardy (empagliflozin and metformin hydrochloride) Synjardy XR (empagliflozin and metformin hydrochloride) The SGLT2 inhibitor class of diabetes drugs is approved by the FDA for treatment of type 2 diabetes (T2D). A "To the Editor" letter in the June 8, 2017 edition of The New England Journal of Medicine (NEJM), titled " Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor ",is likely causing some concerns among doctors and patients about the safety of Jardiance, Invokana, Farxiga, and the other SGLT2 inhibitors. From the start of that letter we get some introductory information about this drug-safety concern raised for these newer diabete Continue reading >>

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Popular Questions

  1. Melissa_Carver

    Hi all! I’m new here and to ketosis, 10 days in and feeling great!
    So I was listening to the 2 Keto Dudes episode on sweeteners and they were talking about how one sweetener or the other would “knock them out of ketosis.” How do you know when you’ve been knocked out of ketosis? Is it a blood sugar thing? Or are you using a ketone tester (blood/breath/urine strip) to verify?
    (Note: I’m T1D, 25 years now, diagnosed as a kid. I just started wearing my CGM again today to try to level off the blood sugars and adjust my basal rate in my insulin pump as needed. If I can tell by blood sugar if I’m knocked out of ketosis that would perfect and so easy for me!)

    Thanks in advance everyone!

  2. Ernest

    Most likely from experimentation to test tolerance.
    I did a protein tolerance experiment and I’d test my ketone readings, using the Precision Xtra, a few times after eating a large amount of protein .
    I bet one could do the same experiment with sweeteners.

  3. Rian

    There are a few sure ways to know if you are in ketosis. In my opinion the most reliable and easiest way is to acquire a blood ketone test meter. Many people here like the Abbott Precision Xtra. The strips to test ketones are a few bucks each but if you try eBay you can usually get them a little cheaper. You will have to do a fair amount of testing in the beginning to see what foods do what to your ketone levels but after awhile you’ll become familiar with the do’s and don’t and will only need to test or occasion.

    Testing for ketones isn’t a requirement but it is nice to know what’s going on without resorting to guessing.

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