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Metformin Overdose Fatal

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Metformin Overdose: An Unusual Cause Of Severe Metabolic Acidosis Singh Y, Joshi Sc, Tayal I, Sharma N - Chrismed J Health Res

Metformin is commonly used in the treatment of type 2 diabetes mellitus (DM). Severe lactic acidosis is a rare side effect of this drug. We present a 45-year-old man who deliberately took 30 g of metformin, presumably with suicidal intent. He had not eaten the previous night and presented with altered sensorium and recurrent seizures. He had profound metabolic acidosis at presentation with a pH of 7.06 and a low blood sugar of 44 mgs/dl. The patient was admitted in intensive care unit (ICU) with the suspicion of metformin-associated lactic acidosis. He developed irreversible renal failure, neurological deterioration and anemia. Despite of daily intensive hemodialysis and other supportive measures the patient expired 14 days later. Metformin overdose with renal failure and severe lactic acidosis have high mortality; hence, urgent medical consultation and treatment can be life saving in these patients. Keywords:Anemia, diabetes mellitus, metformin, metabolic acidosis, renal failure Singh Y, Joshi SC, Tayal I, Sharma N. Metformin overdose: An unusual cause of severe metabolic acidosis. CHRISMED J Health Res 2015;2:166-8 Singh Y, Joshi SC, Tayal I, Sharma N. Metformin overdose: An unu Continue reading >>

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Popular Questions

  1. Inkey-2008

    My wife and I have been low carbing for over month.
    I use keto sticks and have been in ketosis since the end of the first week.
    I was using MFP to monitor what we are eating And it says we should be losing weight,
    I have weighed out food etc used the bar code scanner which is good. But the weight will not move. (
    We have eggs bacon mushrooms cooked in butter.
    lunch is salad with fish or ham with mayo and coleslaw
    dinner tonight was 2 small pork belly slices grilled, mix veg stir fry.
    coffee with double cream
    fruit berries in sugar free jelly with double cream.
    Our only direct carbs are from milk.
    most days carbs are below 20
    We are thinking of cutting back the protien by going veggie at lunch and dinner a couple of days a week.
    Andy

  2. carol anne

    Inkey-2008 said: ↑
    My wife and I have been low carbing for over month.
    I use keto sticks and have been in ketosis since the end of the first week.
    I was using MFP to monitor what we are eating And it says we should be losing weight,
    I have weighed out food etc used the bar code scanner which is good. But the weight will not move. (
    We have eggs bacon mushrooms cooked in butter.
    lunch is salad with fish or ham with mayo and coleslaw
    dinner tonight was 2 small pork belly slices grilled, mix veg stir fry.
    coffee with double cream
    fruit berries in sugar free jelly with double cream.
    Our only direct carbs are from milk.
    most days carbs are below 20
    We are thinking of cutting back the protien by going veggie at lunch and dinner a couple of days a week.
    Andy
    Click to expand... All the fats in your diet are calories so how can you lose weight is cream butter belly pork lean meat olive oil skimmed milk is better

  3. Robbity

    carol anne said: ↑
    All the fats in your diet are calories so how can you lose weight is cream butter belly pork lean meat olive oil skimmed milk is better
    @carol anne - you need to read up on low carb high fat diets - plenty of people on this forum are losing weight this way, and it's an excellent diet for diabetics, because it also helps reduce high blood glucose levels. It's carbohydrates not fat that are the problem, and skimmed milk is full of carbohydrates, so isn't appropriate for this type of diet.
    @Inkey-2008 :
    It's possible to in ketosis and not lose weight - it's not of itself a weight loss diet - you still do need to take care of total calories. I know because I'm currently in this same position!
    Check with one of the keto specific nutritional calculators, e.g. http://www.phlaunt.com/diabetes/DietMakeupCalc.php or http://www.ruled.me/keto-calculator/, and see how they compare with what MFP is telling you. Jenny Ruhl's mini book advertised on the phlaunt calculator page may also be helpful.
    Maybe ditch the milk too for lactose free or something like Alpro unsweetened almond milk, and check carefully for hidden sugars in the mayo and coleslaw if they're not homemade.
    Robbity

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