Metformin-associated Lactic Acidosis Following Intentional Overdose Successfully Treated With Tris-hydroxymethyl Aminomethane And Renal Replacement Therapy
Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy Ngan Lam ,1,2 Gurbir Sekhon ,3and Andrew A. House 1,3 1Division of Nephrology, Department of Medicine, Western University, London, ON, Canada N6A 3K7 2London Health Sciences Centre, Kidney Clinical Research Unit, Victoria Hospital, Westminster Tower 800 Commissioners Road East, London, ON, Canada N6A 4G5 3Department of Medicine, Western University, London, ON, Canada N6A 3K7 Received 19 February 2012; Accepted 6 May 2012 Academic Editors: Y.Fujigaki, D.Packham, A.Papagianni, and H.Schiffl Copyright 2012 Ngan Lam et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A 43-year-old woman was brought to the hospital with severe metabolic acidosis (pH 6.56, bicarbonate 3 mmol/L, and lactate 18.4 mmol/L) and a serum creatinine of 162 mol/L with a serum potassium of 7.8 mmol/L. A delayed diagnosis of metformin-associated lactic acidosis was made, and she was treated wi
Share your health issues with the doctor and find their solutions. Learn to live a healthy life. Listen us live at Radiokantipur.ekantipur.com . Produced in this radio show, easy to listen to conversational style, our shows ... the world of health and medicine to help you understand every day health issues. Specialist and mainstream audiences alike rely on the Health Report to bring clarity to health and medical issues from social, scientific and political points of view. This radio program empowers you, providing crucial information ... regarding health issues and their solutions. Since the start of present day human services, drug and dentistry have existed as partitioned social insurance areas. The foundational partition started a century back, and social insurance strategy has generally strengthened it. While this partition seemed to work well for a long time, critical changes in medicinal services have happened and this division is currently outdated and may in reality be destructive. This counterfeit division of care into hierarchical storehouses overlooks the way that the mouth is a piece of the body. The emanant comprehension of how oral wellbeing influences general wellbeing, and the other way around, recommends that continuation of this division prompts deficient, off base, wasteful and insufficient treatment of both restorative and dental maladies. We are entering a period of responsibility and need to concentrate on oral and craniofacial wellbeing and in addition its association with foundational wellbeing, research and instruction. This will guarantee the most astounding nature of tend to the patients and the groups. Developing proof backings the need to incorporate medicinal and dental patient care and information. Not very many associations in Nepal are situated to address this issue and medicinal and dental practices keep on remaining storehouse ed in conveying social insurance. Concentrate ought to be on creating wellbeing data innovation foundation to share the patient data consistently crosswise over restorative and dental suppliers. This not just advances conveyance of viable and amazing consideration yet additionally practical medicinal services. Rising confirmation demonstrates a connection between poor oral hygience, cardiovascular infection and other interminable ailmentsthe regular connection is irritation. Periodontal illness is caused by microorganisms. At the point when your gums are excited, microscopic organisms from the mouth are getting into the circulatory system. There have been confirm based logical discoveries worth featuring. The nearness of periodontal malady might be related with heart assaults, respiratory sickness, diabetes, preterm births, erectile brokenness and osteoporosis. There are connects between human papillomavirus and oral diseases. Periodontal ailment can execute something beyond your grin. Nepal's social insurance arrangements the norm approach of keeping up partitioned medicinal and dental care conveyance frameworks should be reexamined. We have to create medicinal dental model of care to encourage cross-disciplinary care wherein essential care professionals participate in oral wellbeing screening and dental suppliers perform fundamental history and physical appraisal, with triage to fitting consideration; and following of consistence and results. There are significant difficulties ahead for Nepal's social insurance framework. For this reconciliation to happen, there are imperative conditions that should be met. These incorporate characterizing a center arrangement of dental care administrations denied regions in the nation to advance adaptability for forte care administrations. Center needs ought to incorporate access to dental watch over hindered populace by coordinating therapeutic and dental care to enhance general wellbeing. The emphasis ought to be on counteractive action through between proficient training and joint efforts. Essential care doctors and medical attendants ought to take part in the early intercession on the significance of keeping up great oral wellbeing. Telemedicine, tolerant gateway, online networking and versatile advancements can be utilized as a part of overseeing oral-fundamental ailments. In particular, prepare up and coming era of restorative and dental suppliers, instructors, and scientists in the new integrative model. Innovation and digitalisation are truly changing dental and therapeutic care on the planet. The patients know. Therefore, access to the most recent data, best practices and skill is more essential than any other time in recent memory. Despite the fact that innovation and the market are continually changing, there is one thing which dependably continues as beforethe human worry for wellbeing. Like us at: https://www.facebook.com/kantipurradio Follow us at: https://twitter.com/kantipurfm961
Metformin Overdose: An Unusual Cause Of Severe Metabolic Acidosis Singh Y, Joshi Sc, Tayal I, Sharma N - Chrismed J Health Res
Metformin is commonly used in the treatment of type 2 diabetes mellitus (DM). Severe lactic acidosis is a rare side effect of this drug. We present a 45-year-old man who deliberately took 30 g of metformin, presumably with suicidal intent. He had not eaten the previous night and presented with altered sensorium and recurrent seizures. He had profound metabolic acidosis at presentation with a pH of 7.06 and a low blood sugar of 44 mgs/dl. The patient was admitted in intensive care unit (ICU) with the suspicion of metformin-associated lactic acidosis. He developed irreversible renal failure, neurological deterioration and anemia. Despite of daily intensive hemodialysis and other supportive measures the patient expired 14 days later. Metformin overdose with renal failure and severe lactic acidosis have high mortality; hence, urgent medical consultation and treatment can be life saving in these patients. Keywords:Anemia, diabetes mellitus, metformin, metabolic acidosis, renal failure Singh Y, Joshi SC, Tayal I, Sharma N. Metformin overdose: An unusual cause of severe metabolic acidosis. CHRISMED J Health Res 2015;2:166-8 Singh Y, Joshi SC, Tayal I, Sharma N. Metformin overdose: An unu
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Fatal Metformin Overdose: Case Report And Postmortem Biochemistry Contribution
Abstract Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Lactic acidosis from metformin overdose is a rare complication of metformin therapy and occurs infrequently with therapeutic use. Fatal cases, both accidental and intentional, are extremely rare in clinical practice. Metformin is eliminated by the kidneys, and impaired renal function can result in an increased plasma concentration of the drug. In this report, we describe an autopsy case involving a 70-year-old woman suffering from diabetes mellitus and impaired renal function who received metformin treatment. Metformin concentrations in the peripheral blood collected during hospitalization and femoral blood collected during autopsy were 42 and 47.3 µg/ml, respectively. Lactic acidosis (29.10 mmol/l) was objectified during hospitalization. Furthermore, postmortem biochemistry allowed ketoacidosis to be diagnosed (blood β-hydroxybutyrate, 10,500 µmol/l). Death was attributed to lactic acidosis due to metformin intoxication. Increased plasma concentrations of the drug were attributed to severely impaired renal function. The case emphasizes the usefulness of performing exhaustiv
, Volume 128, Issue3 , pp 483492 | Cite as Fatal metformin overdose: case report and postmortem biochemistry contribution Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Lactic acidosis from metformin overdose is a rare complication of metformin therapy and occurs infrequently with therapeutic use. Fatal cases, both accidental and intentional, are extremely rare in clinical practice. Metformin is ...
Diabetic ketoacidosis is a serious condition that can occur as a complication of diabetes. People with diabetic ketoacidosis (DKA) have high blood sugar levels and a build-up of chemicals called ketones in the body that makes the blood more acidic than usual. Diabetic ketoacidosis can develop when there isn’t enough insulin in the body for it to use sugars for energy, so it starts to use fat as a fuel instead. When fat is broken down to make en ...
With type 2 diabetes (also called type 2 diabetes mellitus), if you don’t work hard to keep your blood glucose level under control, there are short- and long-term complications to contend with. However, by watching the amount and types of food you eat (your meal plan), exercising, and taking any necessary medications, you may be able to prevent these complications. And even if you have some of the long-term, more serious complications discussed ...
Tweet Taking too much insulin can lead to hypoglycemia. This can become particularly serious if your insulin dose was significantly more than it should have been. If you are worried that you have overdosed on insulin, take ample fast-acting carbohydrate immediately and seek advice from your health team, or the out-of-hours service at your local hospital, if applicable. Symptoms of an insulin overdose The list of symptoms below are symptoms of hyp ...
By and large, individuals who take after veggie lover diets weigh less and have and bring down dangers for coronary illness and a few sorts of growth. These potential advantages are more probable when you settle on nutritious decisions, for example, picking supplement thick nourishments, including entire grains, organic products, vegetables, vegetables and solid fats. Additionally, restrict your admission of sugar-sweetened sustenances and refres ...
Others have already mentioned that type 1 diabetes is because the body does not produce insulin. In fact, the body’s immune system thinks the beta cells producing insulin are alien cells. Hence, it attacks and kills them. Until science figures out how to fix/fool the immune system into letting the beta cells live, type 1 diabetics have to take insulin to control blood sugar levels. Given that, what can one do to maintain “normal” blood suga ...