diabetestalk.net

Metformin Myocardial Infarction

Share on facebook

What is the myocardial infarction !!

Metformin-associated Lactic Acidosis Presenting As Acute St-elevation Myocardial Infarction - Sciencedirect

Metformin-Associated Lactic Acidosis Presenting as Acute ST-Elevation Myocardial Infarction Metformin-associated lactic acidosis (MALA) is a rare but life-threatening adverse drug reaction of metformin, the most frequently prescribed medication for patients with type 2 diabetes mellitus. The diagnosis of MALA is difficult to make because of diverse clinical presentations that can masquerade as other critical illnesses. A 52-year-old woman presented with altered mental status, hypoglycemia, and shock. A prehospital electrocardiogram showed findings consistent with posterolateral ST-elevation myocardial infarction, and the cardiac catheterization laboratory was activated before patient arrival. On arrival to the emergency department, she was found to have severe metabolic derangements and hypothermia, and the catheterization laboratory was canceled. Aggressive supportive measures and emergent hemodialysis were instituted. A metformin concentration was sent from the ED and returned at 51g/mL (therapeutic range 12g/mL), making MALA the most likely diagnosis. She recovered after prolonged critical illness and was discharged in good condition. No alternate diagnoses were found despite e Continue reading >>

Share on facebook

Popular Questions

  1. Saraleesaralee

    Is it possible to stay on ketogenic diet for life-long?

    I have been on ketogenic diet for 2 weeks. It controls my blood sugar level really well. However I am not over weight. And I am worried about potential long term side effects of the diet. For example, high LDL level, steoporosis, auto immune disease, too much weight loss, vesicular stiffness. I was wondering if there is anyone in this forum has been on ketogenic diet for years? And do you experience any side effects from the diet?

  2. Aaron1963

    I've been on a strict ketogenic diet for 6 months, and was doing LCHF for much of the 5 months prior to that but didn't make any attempts at it being ketogenic so I may have been in and out of ketosis some during that period. I now have a blood ketone meter and remain in ketosis according to it.
    I did suffer excessive weight loss initially. I lost about 40kg (about 90 lbs.), and it ended up sending me from being very obese to being underweight. But I've always eaten very little protein, which I continued to do, plus I was doing intermittent fasting, sometimes not eating anything for days at a time. Once I stopped the intermittent fasting and concentrated on getting adequate protein, my weight went back up to my ideal weight and stabilized there. I've heard from several people that you really need to watch your protein when doing a ketogenic diet being it's easy for excess to hinder weight loss and/or increase your BG.
    I have had a few issues while doing a ketogenic diet, but not 100% sure which if any can be attributed to ketosis vs. some other factor. First off, as winter was approaching I got extremely cold all the time, especially my fingers and toes, but even my whole body was cold. I thought it might have been the caffeine I was getting as part of my ketogenic diet involves drinking lots of coffee with HWC, coconut oil, and butter. I switched to decaf and the problem pretty much went away, but I don't know if it was the caffeine, the ketosis, the massive weight loss (lack of body fat), something else, or a combination of factors.
    I've also had excessive itching and a rash. That's normal for me during the winter months, but this year it started a bit early, went longer, and was much worse than normal. I think it may very well have been my usual sensitivity to the cold dry weather, aggravated by toxins released during my rapid weight loss, and perhaps ketones being emitted through the skin. It's just recently started to clear up and the rash is gone and most of the itching.
    I got keto-breath for a week or two when I first concentrated on going keto. It was very noticeable, but disappeared after that and no issues anymore with my breath.
    This diet is very sustainable for me. I tried my whole adult life to diet to lose weight and was never successful. This time I wanted to lose weight, but my primary focus was controlling my BG, meaning reducing carbs down to a low-carb level, which caused me to gravitate naturally to a LCHF diet. For the first time I have no desire to go back to my old way of eating. I love this diet and it's completely satisfying. So I killed two birds with one stone - got my BG under control, down to non-diabetic levels, and got my weight down to ideal. Plus with the huge benefits (IMHO) of having my body use ketones rather than glucose, I'm totally sold on this way of eating for the rest of my life and have absolutely no worries about not being able to stick to my diet. I really have no strong urges for carbs anymore, and only end up going off the plan rarely due to social pressures or inadvertently eating hidden/unknown carbs.
    My LDL has gone up, but I've heard from others that usually it's benign large fluffy LDL that typically goes up when on a ketogenic diet. And my body is still adjusting. Also I've heard that LDL by itself is not a good measure of risk. So I'm not worried about it, but will keep an eye on things. I also have taken my ketogenic diet to an extreme, hitting a KR of 3.0 or higher almost everyday, and sometimes up to 4.0 or more. Not sure if eating much more fat than necessary for ketosis affected my LDL any or not. Initially my LDL dropped significantly as well as my trigs, but both increased at my last doctor's visit. I may try a more normal KR in the future while monitoring my blood ketones to verify I stay in ketosis and see if there's any difference in my BG, cholesterol, or other tests.
    I did also suffer from other typical symptoms during my keto adaptation phase. Most went away within about two weeks. But it's just been here at the 6-month mark where my BG numbers suddenly stabilized with very little change, and quite low, and overall I just feel absolutely fantastic. I feel like I'm bursting with energy and joined a gym and suddenly love running and working out whereas I hated them all my life.
    Well, I don't have years of experience with ketosis to report anything to you about that. Other than I've heard lots of other people with years of experience and not heard of anyone having any real side effects other than the things I've mentioned. However some people do find ketosis isn't for them and give up very soon. For those that feel it is working for them and stick with it, seems there's no significant side effects. But I'll let the others who've been in ketosis for longer than me speak for themselves.

  3. furball64801

    Hi and welcome to DD I know of a guy called no more carbs that was on it over 2 yrs. It is possible he is still on it, that chat site closed down but he was going strong on it.

  4. -> Continue reading
read more
Share on facebook

Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep... Missed the previous lesson? https://www.khanacademy.org/test-prep... NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/b...). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academys NCLEX-RN channel: https://www.youtube.com/channel/UCDx5... Subscribe to Khan Academy: https://www.youtube.com/subscription_...

Chronic Metformin Treatment Is Associated With Reduced Myocardial Infarct Size In Diabetic Patients With St-segment Elevation Myocardial Infarction

Chronic Metformin Treatment is Associated with Reduced Myocardial Infarct Size in Diabetic Patients with ST-segment Elevation Myocardial Infarction Lexis, C. P. H., Wieringa, W. G., Hiemstra, B., van Deursen, V. M., Lipsic, E., van der Harst, P., van Veldhuisen, D. J. & van der Horst, I. C. C. Apr-2014 In : Cardiovascular Drugs and Therapy. 28, 2, p. 163-171 9 p. Research output: Scientific - peer-review Article Lexis, C. P. H., Wieringa, W. G., Hiemstra, B., van Deursen, V. M., Lipsic, E., van der Harst, P., ... van der Horst, I. C. C. (2014). Chronic Metformin Treatment is Associated with Reduced Myocardial Infarct Size in Diabetic Patients with ST-segment Elevation Myocardial Infarction. Cardiovascular Drugs and Therapy, 28(2), 163-171. DOI: 10.1007/s10557-013-6504-7 Lexis, Chris P. H. ; Wieringa, Wouter G. ; Hiemstra, Bart ; van Deursen, Vincent M. ; Lipsic, Erik ; van der Harst, Pim ; van Veldhuisen, Dirk J. ; van der Horst, Iwan C. C./ Chronic Metformin Treatment is Associated with Reduced Myocardial Infarct Size in Diabetic Patients with ST-segment Elevation Myocardial Infarction. In: Cardiovascular Drugs and Therapy. 2014 ; Vol. 28, No. 2. pp. 163-171 Lexis, CPH, Wieringa, Continue reading >>

Share on facebook

Popular Questions

  1. Peach_Diet_Snapple

    http://authoritynutrition.com/10-benefits-of-low-carb-ketogenic-diets/
    I think this has been posted before, but I just wanted to post it and iterate how fantastic this article is. It's easy to read, clear, concise, and almost every single claim they make is immediately sourced with actual academic/scientific studies. The title makes it sound like clickbait garbage, but it's not.
    It's particularly good at addressing why low-carb won't give you a heart attack, and addressing some of the misconceptions surrounding LDL.
    Give it a read!

  2. TheJestaplero

    Hi, I'm new here. I am trying to lose 22 lbs to reach my ideal weight (185, I'm a 53 yr old male) by my birthday (3/23). I started on a low-carb diet but plateaued after losing 8 lbs., even gained a couple back. Very discouraging. I found this site last week, am limiting myself to 20g net carbs and 1600 calories a day. Two more pounds came off, just like that. So far, so good...

  3. dork_warrior

    Plateaus are common, the 8lbs was probably water weight which comes off in the first part of ketosis. I remember the first time I did keto and was really excited about 20lbs down and then fell out when I plateaued. When I got my mind back around to it and maintained the 10-20g net carbs things got so much better.
    Also, keep track of the fat. Its crucial.

  4. -> Continue reading
read more
Share on facebook

Every Girl Should Know Side Effects of Ginger and Contraindications Life Hacks Cheap DIY Easy to Make at Home. The vast majority of wellness specialists, herbalists and naturopaths agree that the use of ginger should be regulated. Even though ginger provides a wide range of benefits, using too much ginger can bring some negative side effects. Namely, in case you use large amounts of ginger on a regular basis you might witness gas, heartburn, stomach distress, nausea, bloating and few other problems. In addition, individuals dealing with gallstones, ulcers, bleeding issues, inflammatory conditions and pregnant women should stay away from ginger. Finally, people who are using blood-thinning medications should avoid ginger too. Like, Share and Subscribe Our Channel if you think these video is informative and helpful. Thank you! http://lifebuzzfeed.com/youtube http://lifebuzzfeed.com/facebook DIY,Home Remedies,Health Care,Every Girl Should Know,Easy to Make at Home,Natural Home Remedies,yt:cc=on,Girl Should Know,Side Effects of Ginger,Ginger and Contraindications,benefits of ginger,ginger benefits,ginger,do it yourself,life hacks,Make at Home,how to make,Cheap DIY,Cheap DIYs,easy DIYs,easy diy,life hack,Life Hacks Every Girl Should Know,https://goo.gl/XK0D33,rBTD4U0sh1g,ginger health benefits,ginger tea benefits,ginger root benefits,ginger juice benefits

Contraindications To The Use Of Metformin

Contraindications to the use of metformin Evidence suggests that it is time to amend the list Department of Diabetes, Gartnavel General Hospital, Glasgow G12 0YN Copyright 2003, BMJ Publishing Group Ltd This article has been cited by other articles in PMC. According to the United Kingdom prospective diabetes study, patients with type 2 diabetes randomised to intensive treatment with metformin, sulphonylurea, or insulin had similar degrees of glycaemic control and significantly reduced microvascular end points. 1 The study showed that the use of metformin in obese patients reduced cardiovascular events. The group treated with metformin had no hypoglycaemia and less weight gain. Treatment with metformin rather than diet alone produced a significant reduction in relative risk in all cause mortality (36%, P=0.011), diabetes related deaths (42%, P=0.017), any diabetes related end point (32%, P=0.0023), and myocardial infarction (39%, P=0.01). Metformin is the only oral hypoglycaemic agent proved to reduce cardiovascular risk and is now recognised as the treatment of choice in overweight patients with type 2 diabetes. Lactic acidosis associated with metformin is a rare condition with an Continue reading >>

Share on facebook

Popular Questions

  1. BobbyS

    Can insulin resistance truly be reversed?

    I'm a bit unclear on what "insulin resistance reversal" or "diabetes reversal" really means.
    I was diagnosed as prediabetic about 3 weeks ago. I got a blood meter and my first test was postprandial and showed 191.
    I have been water fasting and eating LCHF since then...except for 3 days which is where I get the following info:
    It appears that "real food carbs" (e.g. carrots, onions, etc.) have virtually no effect on me. A meal with ~ 80 grams of real food carbs moved my blood glucose from 83 to 89.
    It also appears that eating LCHF keeps my blood glucose well < 100 but a single sugar/starch/refined flour meal will spike my blood sugar anywhere from 150 to 160 (I've eaten 2 such meals is where I get this data) and it takes a couple of days for my blood sugar to drop back below 100 (at least at my "dawn phenomenon" readings).
    Is "insulin resistance reversal" truly possible or can insulin resistance only be managed as long as sugar/starch/refined is avoided like the plague?
    I know I can't go back to eating like I used to eat...but it would be nice to hope that one day I will be able to "splurge occasionally" and keep normal blood sugar numbers...

  2. qsefthuko

    You might. Some people can some people can't.

  3. qsefthuko

    Apparently LCHF causes a degree of insulin resistance or something. If you have been eating LCHF for a bit and then eat a carby meal it can and probably will raise you higher than you might expect.

  4. -> Continue reading
read more

No more pages to load

Related Articles

  • Diabetes Myocardial Infarction Pathophysiology

    Definition and etiology Acute myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Myocardial infarction occurs when myocardial ischemia, a diminished blood supply to the heart, exceeds a critical threshold and overwhelms myocardial cellular repair mechanisms designed to maintain normal operating function and homeostasis. Ischemia at this critical threshold level for an extended period results in irreversible m ...

    blood sugar May 2, 2018
  • Incidence Of Myocardial Infarction In Diabetes

    Abstract OBJECTIVE—Cardiovascular disease (CVD) is the main cause of morbidity/mortality in diabetes. We set forth to determine incidence and identify predictors (including microvascular complications and treatment) of first coronary heart disease (CHD) event in CVD-free type 2 diabetic patients. RESEARCH DESIGN AND METHODS—A cohort of 6,032 women and 5,612 men, sampled from a nationwide network of hospital-based diabetes clinics, was followe ...

    blood sugar May 1, 2018
  • Diabetes And Myocardial Infarction Risk

    , Volume 3, Issue4 , pp 164169 | Cite as Diabetes and heart failure in the post-myocardial infarction patient Diabetes mellitus, a disease which is increasing in prevalence, is a major risk factor for coronary heart disease. In patients following acute myocardial infarction, the presence of diabetes is a powerful risk factor for the development of heart failure, and this intersection of heart failure and diabetes following myocardial infarction ...

    blood sugar May 2, 2018
  • How Does Diabetes Cause Myocardial Infarction

    Abundant evidence shows that patients with type 1 diabetes or type 2 diabetes are at high risk for several cardiovascular disorders: coronary heart disease, stroke, peripheral arterial disease, cardiomyopathy, and congestive heart failure. Cardiovascular complications are now the leading causes of diabetes-related morbidity and mortality. The public health impact of cardiovascular disease (CVD) in patients with diabetes is already enormous and is ...

    blood sugar May 2, 2018
  • Metformin Myocardial Infarction

    Metformin plays role in reducing MI, heart failure risk NASHVILLE, Tenn. Even slight weight effects associated with metformin use may reduce risk for myocardial infarction and heart failure, according to a presenter here. We dont know how metformin works, but I would speculate that suppression of appetite and promotion of weight loss may play a role, John M. Miles, MD, professor of medicine at the University of Kansas in Kansas City, said during ...

    ketosis Apr 21, 2018
  • Dka Myocardial Infarction

    Objective Diabetic ketoacidosis is usually associated with type 1 diabetes; however, it is increasingly being recognized in patients with type 2 diabetes mellitus. Triggering factors usually involve infections and poor medication adherence. Other potential triggers reported are myocardial infarction, antipsychotic drug usage, malignancy and cerebrovascular accidents. No case of steroid induced diabetic ketoacidosis in a patient with type 2 diabet ...

    ketosis Dec 30, 2017

More in ketosis