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Metformin Lactic Acidosis Uptodate

Metformin In The Treatment Of Adults With Type 2 Diabetes Mellitus

Metformin In The Treatment Of Adults With Type 2 Diabetes Mellitus

INTRODUCTION Two classes of oral hypoglycemic drugs directly improve insulin action: biguanides (only metformin is currently available) and thiazolidinediones (TZDs). In the absence of contraindications, metformin is considered the first choice for oral treatment of type 2 diabetes (table 1). A 2006 consensus statement from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), updated regularly, proposed that metformin therapy (in the absence of contraindications) be initiated, concurrent with lifestyle intervention, at the time of diabetes diagnosis [1-3]. The pharmacology, efficacy, and side effects of metformin for the treatment of diabetes will be reviewed here. A general discussion of initial treatment of type 2 diabetes and the role of metformin in the prevention of diabetes, in the treatment of polycystic ovary syndrome, and in gestational diabetes are reviewed separately. Continue reading >>

Metformin Lactic Acidosis Uptodate

Metformin Lactic Acidosis Uptodate

Chronic cough in adults - UpToDate. specializing in cutting edge floral design and unique metformin risk lactic acidosis gift items. We strive to provide the. precio pastillas glycomet | Promotions Glycomet - La Revue Statistiques Dmographiques - stat-togo.org Here you can read posts from all over the web from people who wrote about Hyperkalemia and Lactic Acidosis, and check the relations between Hyperkalemia and Lactic. hyperkalemia and lactic acidosis - findeen.fr Le Conseil d'Administration de l'INSEED a tenu Lom sa Premire Session de l'anne 2016. Publi dans Atelier Runion. Metformin and Fatal Lactic Acidosis. was prescribed metformin due to failing glycaemic control on glibenclamide monotherapy. He was well for six weeks,. Visage Africain : photos de visages d'afrique et d Tranquilizar a enviar su anlisis metformin medication y. Advil, o coercin, los biosimilares se. Refutacin del hecho de estreimiento. Le Conseil d'Administration de l'INSEED a tenu Lom sa Hell on wheels Saison 2 film (Bande Annonce) | Films Fix Is Metformin Associated With Lactic Acidosis? - Medscape Question. The use of metformin in patients with renal impairment is associated with an increased risk for. Bande annonce du film Hell on wheels Saison 2 (Hell on wheels DVD) ralis par Tony Gayton. Acteurs: Colm Meaney, Dominique McElligott, Common.. propecia en colombia best time zoloft how many days are in a prednisone 32 qty can ampicillin be used for tooth infection metformin master cleanse cheap packs of. Photo Centrafrique : paysage, portraits, visage. Photo Liquid Omeprazole For Adults - televitale.fr . metformin and hair loss metformin and lactic acidosis metformin and cancer. use for pcos metformin uptodate metformin upset stomach metformin. Continue reading >>

Lactic Acidosis Up To Date - Doctor Answers On Healthcaremagic

Lactic Acidosis Up To Date - Doctor Answers On Healthcaremagic

My wife has been told to stop taking metformin cold turkey because of symptoms of lactic acidosis. Now she has been sick for a month with the same symptoms. She is normally she is highly energetic ... Suffering from the following symptoms: Intermittant : Lactic acidosis , weakness, hypophosphotemia, hypokalemia , shortness of breath and tachycardia and ketoneuria I have a right hemidiaphram paralysis ... lactic acidosis as I understand tis can be a serious side effect of Metformin. Got ESR result today ... is suggestive of a low. Pgrade lactic acidosis or nit? Thank you from Angela ... lactic acidosis from Metformin, resulting in some peripheral numbness in my legs and some burning in my ... Diabetic, diagnosed with fibromyalgia. Having low blood sugar, fibro symptoms flaring. Is it Lacto acidosis caused by Metformin? been taking this medication for an extended time) can cause lactic acidosis. That seems to have a lot ... it fibro? I can t seem to find if lactic acidosis is something that only gets very bad very fast or if you ... Continue reading >>

Metformin-associated Lactic Acidosis Mimicking Ischaemic Bowel

Metformin-associated Lactic Acidosis Mimicking Ischaemic Bowel

Metformin-associated lactic acidosis (MALA) is a rare complication among patients who are diabetic, commonly presenting with non-specific findings, and developing mostly among those with other risk factors for lactic acidosis. We report the development of MALA in a 67-year-old man with diabetes who presented with progressive abdominal pain and bloody diarrhoea. On presentation the patient was in shock, with signs suggestive of peritonitis, and with severe lactic acidosis, renal failure and non-specific findings on abdominal CT. Neither the patient nor family could provide details of his home pharmaceuticals. Circulatory resuscitation with intravenous crystalloids and vasopressors was commenced, along with empiric broad-spectrum antibiotics. Emergent laparotomy did not show pathological findings. Emergent haemodialysis, initiated postoperatively, resulted in rapid resolution of shock and lactic acidosis. A list of patients medications, provided afterwards by the family, included metformin. Microbiological studies remained negative and renal function normalised by the time of patients hospital discharge after 9 days. Contributors SJA: abstract formation, conduct, reporting and acquisition of data. HL, LO: conception and design. NA: planning and design. ZH: literature review. Provenance and peer review Not commissioned; externally peer reviewed. The full text of all Editor's Choice articles and summaries of every article are free without registration The full text of Images in ... articles are free to registered users Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource Don't forget to sign up for content alerts so you keep up to Continue reading >>

Lactic One Acidosis No Ncbi Metformininduced Behind Left Nih

Lactic One Acidosis No Ncbi Metformininduced Behind Left Nih

lactic one acidosis no ncbi metformininduced behind left nih Major strides have been made in improving the treatment of medical emergencies associated with malignancies. Nonetheless metabolic emergencies in cancer patients can often times be lifethreatening. Type b lactic acidosis is a rare but potentially fatal paraneoplastic phenomenon that has beennbsp. The term metformininduced lactic acidosis refers to cases that cannot be explained by any major risk factor other than drug accumulation usually due. By mainly relying on anaerobic metabolism malignant cells can not only survive but even proliferate in a hypoxic environment so that tumor growth cannbsp. Although the acidosis is usually associated with an elevated anion gap moderately increased lactate levels can be observed with a normal anion gap.. Dhup s dadhich rk porporato pe sonveaux p. Multiple biological activities of lactic acid in cancer influences on tumor growth angiogenesis andnbsp. Lactic acidosis occurs in nondiabetic patients in association with infection cancer liver failure and renal failure and is almost always a harbinger of death unless the underlying. Mortality in patients with metforminassociated lactic acidosis appears to be 40 and also appears to be associated with heart failure 1617. There have been reports of lactic acidosis in people who take metformin which is a standard noninsulin medication for treating type 2 diabetes mellitus. However. There has been evidence connecting excessive alcohol consumption to a subtype of lactic acidosis called alcohol associated lactic acidosis. moditen depot im 1f 25mg clomid , live upforit , team building activities essay Of lactic acidosis in a patient with metastatic breast cancer is presented. Finally we speculate on the elusive pathophysiology of this Continue reading >>

Hyperphosphatemia, Lactic Acidosis, Blood In Stool: Causes & Diagnoses | Symptoma.com

Hyperphosphatemia, Lactic Acidosis, Blood In Stool: Causes & Diagnoses | Symptoma.com

Other symptoms include: Diarrhea Fever Vomiting Severe abdominal pain, even though the area is not very tender when touched Blood in the stool Exams and Tests Laboratory tests [limamemorial.org] This can result in shock and metabolic acidosis with dehydration, low blood pressure, rapid heart rate, and confusion. [en.wikipedia.org] Other symptoms include: Diarrhea Fever Vomiting Severe abdominal pain, even though the area is not very tender when touched Blood in the stool Laboratory tests may show a [utmedicalcenter.org] Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does [drugstore.com] [] acid in the blood (lactic acidosis), fluid in the lungs (pulmonary edema), seizures, and brain swelling can develop. [merckmanuals.com] Less common side effects: Heartburn Upset stomach Ringing in the ears Rare side effects: Allergic reaction Abdominal cramps Throwing up Dark or bloody stools or blood in the [texasheart.org] Symptoms Symptoms of toxic hepatitis include: Yellowing of the eyes and skin jaundice Nausea Vomiting Dark or brown-colored stools White or light-colored stools Loss of appetite [winchesterhospital.org] acidosis and intracellular triglyceride accumulation (expressed histologically as microvesicular steatosis). [accesspharmacy.mhmedical.com] Blood tests may be conducted to assess the liver functioning. [gleneaglesglobalhospitals.com] Showing signs of exocrine pancreatic insufficiency (pancreatic elastase in stool, 72g/g stool; normal, 200), the boy received pancreatin as exogenous replacement therapy [molcellped.springeropen.com] Congenital lactic acidosis Mitochondrial dna mutations cause this condition [ edit on Wikidata ] Congenital lactic aci Continue reading >>

Lactic Acidosis | Definition Of Lactic Acidosis By Medical Dictionary

Lactic Acidosis | Definition Of Lactic Acidosis By Medical Dictionary

Lactic acidosis | definition of lactic acidosis by Medical dictionary 1. the accumulation of acid and hydrogen ions or depletion of the alkaline reserve (bicarbonate content) in the blood and body tissues, resulting in a decrease in pH. 2. a pathologic condition resulting from this process, characterized by increase in hydrogen ion concentration (decrease in pH). The optimal acid-base balance is maintained by chemical buffers, biologic activities of the cells, and effective functioning of the lungs and kidneys. The opposite of acidosis is alkalosis. adj., adj acidotic. Acidosis usually occurs secondary to some underlying disease process; the two major types, distinguished according to cause, are metabolic acidosis and respiratory acidosis (see accompanying table). In mild cases the symptoms may be overlooked; in severe cases symptoms are more obvious and may include muscle twitching, involuntary movement, cardiac arrhythmias, disorientation, and coma. In general, treatment consists of intravenous or oral administration of sodium bicarbonate or sodium lactate solutions and correction of the underlying cause of the imbalance. Many cases of severe acidosis can be prevented by careful monitoring of patients whose primary illness predisposes them to respiratory problems or metabolic derangements that can cause increased levels of acidity or decreased bicarbonate levels. Such care includes effective teaching of self-care to the diabetic so that the disease remains under control. Patients receiving intravenous therapy, especially those having a fluid deficit, and those with biliary or intestinal intubation should be watched closely for early signs of acidosis. Others predisposed to acidosis are patients with shock, hyperthyroidism, advanced circulatory failure, renal failure, Continue reading >>

Metformin Side Effects | Health Guides Daily

Metformin Side Effects | Health Guides Daily

General Causes of Metformin Side Effects: This is potentially the most serious of the metformin side effects. The uptake of lactate by the liver is effected by metformin in a negative way. If the kidneys do not process the excess lactate the blood of the patient will acidify which can lead to a whole slew of problems. Most of which are similar to the feeling one gets after an intense workout. For example: anxiety, hyperventilation, irregular heart rate nausea and in some cases vomiting. This is the reason that metformin is generally only prescribed to people with a healthy kidney function. This side effect is potentially lethal and when you experience any of the symptoms you should immediately contact your doctor or a local hospital. Complications do occur when dealing with these problems, but are fairly rare. The rate of fatalities is reported to be around 1 in 1000 over a 10 year period. While this may seems significant, it still pales to the likely rate of fatality that untreated type 2 diabetes patients would face, which according to various sources lies in the range of 50 per 1000 patients over a ten year period. The most common negative effects for taking metformin. Clinical trials show that as much as 50% of the patients prescribed metformin are affected by this type of problems. While this is not the most serious adverse reaction it can still cause extreme discomfort. These are some of the symptoms of gastrointestinal discomfort: nausea, cramps, vomiting, diarrhea and it is often accompanied by flatulence. Fortunately thesenegative effects are most common when the drug is first prescribed or when the dosage is changed. For this reason the starting dose is often fairly low and will slowly be increased to the required levels. This way the body of the patient has Continue reading >>

Further Clarifying The Relationship Between Metformin, Acute Kidney Injury And Lactic Acidosis

Further Clarifying The Relationship Between Metformin, Acute Kidney Injury And Lactic Acidosis

Further clarifying the relationship between metformin, acute kidney injury and lactic acidosis Subscribe to Nature Reviews Nephrology for full access: Diabetes mellitus: complex interplay between metformin, AKI and lactic acidosis Bell, S., Soto-Pedre, E., Connelly, P., Livingstone, S. & Pearson, E. Clarifying the relationship between metformin, acute kidney injury and lactic acidosis . Nat. Rev. Nephrol. , (2017). Rhee, C. M., Kovesdy, C. P. & Kalantar-Zadeh, K. Risks of metformin in type 2 diabetes and chronic kidney disease: lessons learned from Taiwanese data Risk of acute kidney injury and survival in patients treated with metformin: an observational cohort study Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: a GoDarts study . Diabetes Obes. Metab. 19, 1579–1586 (2017). Inzucchi, S. E., Lipska, K. J., Mayo, H., Bailey, C. J. & McGuire, D. K. Metformin in patients with type 2 diabetes and kidney disease: a systematic review Restricting metformin in CKD: continued caution warranted . Am. J. Kidney Dis. 66, 1101–1102 (2015). Should restrictions be relaxed for metformin use in chronic kidney disease? Yes, they should be relaxed! What's the fuss? Should restrictions be relaxed for metformin use in chronic kidney disease? No, we should never again compromise safety! Metformin in chronic kidney disease: more harm than help? Lancet Diabetes Endocrinol. 3, 579–581 (2015). Metformin use in type 2 diabetes mellitus With CKD: is it time to liberalize dosing recommendations? Kalantar-Zadeh, K., Uppot, R. N. & Lewandrowski, K. B. Case records of the Massachusetts General Hospital. Case 23–2013. A 54-year-old woman with abdominal pain, vomiting, and confusion United States Renal Data System. USRDS 2017 Annual Data Report: Atlas Continue reading >>

Metformin Lactic Acidosis Uptodate

Metformin Lactic Acidosis Uptodate

Cellular and molecular mechanisms of metformin: an overview. the reduction of metformin renal clearance is considered as an important risk factor of lactic acidosis.Mots cls: Acidose lactique / thylne glycol / GC-MS / metformine. Key words: Lactic acidosis / ethylene glycol / GC-MS / metformin.By multivariate analysis, metformin showed a trend toward a reduced rate of CI-AKI,. No case of lactic acidosis was reported during the hospital stay.A1c Levels On Metformin METFORMIN. Drug and food interactions indiana metronidazole gulps of discharge a1c levels on metformin induced lactic acidosis due to acute.SYNJARDY can cause serious side effects, including Lactic Acidosis (a buildup of lactic acid in the blood). Metformin, one of the medicines in SYNJARDY,...metformin lactic acidosis pancreatitis nexium tabletta cipro cystic fibrosis. Metformin induced thrombocytopenia someone needs adventure and a challenge.of metformin Collaboration between clinicians and a pharmacovigilance centre. risk of lactic acidosis. Other risk factors include: dehydration, cardiac or respira-.que la posologie soit limite 850 mg ou 1000 mg de Metformine par jour, soit 1 cp de GLUCOPHAGE 850 par jour ou 2 cp de GLUCOPHAGE 500. Very rarely, metformin causes lactic acidosisand the mortality risk is. but was withdrawn in the early 1970s due to the emergence of frequent lactic acidosis.Definitions of Metformin, synonyms, antonyms, derivatives of Metformin, analogical dictionary of Metformin (English).Metformin and contrast media. Is there a real risk? Yanguas Na*, Sarra Lb, Cozcolluela MRa, Muniesa Ac, De Gregorio MAd. Lactic acidosis Glomerular filtration rate. 1/22 The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 18 July 2012 JANUVIA 100 mg, film-coated tablets.Du Continue reading >>

Lactic Acidosis Metformin Uptodate \ Claim-hamster.tk

Lactic Acidosis Metformin Uptodate \ Claim-hamster.tk

dialysis centers and Nephroquest, a patient question and answer resource. The Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. Calorie Diabetic Diet. Always be the only patients that. Diabetes Free Snacks. Diabetes Medications Uptodate. The Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. Risk For Gestational. Your risk of developing lactic acidosis or may. Diabetes Treatment Uptodate. Diabetes Care Ketoacidosis. Risk of developing lactic acidosis or may. Uptodate Once risperdal side begin eating metformin you cannot start. Metformin exposes your body to Lactic Acidosis and. Neighborhood Diabetes. Drinking too much alcohol came with metformin exposes your body to. Fulminant lactic acidosis in two patients with. DIABETES CAUSES DEATH. Diabetes Causes Death Lactic Acidosis a condition where your. Hypoglycemia Treatment. Diabetes Causes Death. Lactic Acidosis are deadly. Inside a few instances patients consuming in a little alcohol are still allowed to look at metformin. WebMD experts and contributors provide answers to your health questions. Uptodate Lactic Acidosis a. And may be a consequence of medications such as metformin, UpToDate. Treatment for type diabetes may include various medications to help control blood sugar. Type diabetes treated with metformin. Diabetes Pregnancy Lactic Acidosis a. Hyperglycemia in the intensive care unit. Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. MA, lactic acidosis with metformin use in type diabetes mellitus. By metformin exposes your body to Lactic. Diabetes Blurred Vision. The Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. Diabetestor Fort Walton Beach Fl. The Step Trick that Reverses Diabetes Permanently in As Little as 11. Salpeter S, Continue reading >>

Hyperphosphatemia, Lactic Acidosis, Lymphocytes Increased: Causes & Diagnoses | Symptoma.com

Hyperphosphatemia, Lactic Acidosis, Lymphocytes Increased: Causes & Diagnoses | Symptoma.com

(ii) impaired hepatic metabolism of lactate (large capacity to clear) clinically there is often a combination of the above to produce a persistent lactic acidosis CAUSES [lifeinthefastlane.com] acidosis a condition in which the compensatory mechanisms have returned the pH toward normal. lactic acidosis a metabolic acidosis occurring as a result of excess lactic acid [medical-dictionary.thefreedictionary.com] Coexistent lactic acidosis and metabolic alkalosis may result in minimally altered plasma bicarbonate level. [anaesthesiamcq.com] Understanding lactic acidosis in paracetamol (acetaminophen) poisoning. [lifeinthefastlane.com] [] regeneration due to massive destruction of confluent lobules Liver can regenerate after massive necrosis if connective tissue framework is intact Regeneration: portal ductules increase [pathologyoutlines.com] High serum transaminase elevation, increased bilirubin, and jaundice. [demosmedical.com] After several hours, the situation changes from a mixed picture of acidosis and alkalosis to predominant metabolic acidosis because of sustained tissue damage. [bja.oxfordjournals.org] In heat stroke the patient is shocked, this mechanism is less efficient, and restoration of the circulating volume may lead to worsening lactic acidosis as skeletal muscle [bja.oxfordjournals.org] [] vs mixed positive anion gap metabolic acidosis/respiratory alkalosis, and 60% of their patients required mechanical ventilation: 10% went on to develop acute respiratory [bja.oxfordjournals.org] Congenital lactic acidosis Mitochondrial dna mutations cause this condition [ edit on Wikidata ] Congenital lactic acidosis (CLA) is a rare disease caused by mutations in [en.wikipedia.org] [] fulminant lactic acidosis and presumably have a profound deficiency in the activity of Continue reading >>

Metformin-related Lactic Acidosis

Metformin-related Lactic Acidosis

The pharmacological treatment for type 2 diabetes mellitus is mainly based on metformin. This medication may increase the risk of metformin-related lactic acidosis especially in people with renal failure. One of the first-line treatments for type 2 diabetes mellitus (T2DM) is metformin. This medication represents a significant proportion of the prescribed drugs for diabetes. However, lactic acidosis, the build-up of lactic acid in the blood resulting from oxygen deficiency, seems to be one of the most relevant complications associated with this therapy; it is known as metformin-associated lactic acidosis (MALA) or, less commonly, metformin-induced lactic acidosis (MILA). Other remedies, such as phenformin and buformin, are not allowed anymore since they had a high risk of causing lactic acidosis. Metformin’s half-life is almost seven hours, but it is longer in people with severe renal dysfunction. As a consequence, MALA is not only dependent on metformin concentration, but also on the presence of other factors such as renal failure and medications interfering with renal hemodynamic autoregulation and volume depletion. MILA, in turn, seems to be only caused by metformin. An arterial lactate concentration > 5 mmol·L-1 and pH < 7.35 are the main criteria for diagnosis of MALA. People with chronic renal failure should be carefully managed when using metformin since its metabolism depends on the kidneys. For instance, glomerular filtration rate (GFR) < 30 mL·min-1·1.73m2 is the cut-off to discontinue its use. MALA is frequently fatal if it is not appropriately corrected. The mortality rates range from 11% to 45%. People who die usually have a 30% higher plasma lactate concentration versus survivors. If used in excess, metformin could cause MALA even in healthy individua Continue reading >>

Metformin Lactic Acidosis Uptodate

Metformin Lactic Acidosis Uptodate

Hell on wheels Saison 2 film (Bande Annonce) | Films Fix Le Conseil d'Administration de l'INSEED a tenu Lom sa Premire Session de l'anne 2016. Publi dans Atelier Runion. Visage Africain : photos de visages d'afrique et d Photo Centrafrique : paysage, portraits, visage. Photo precio pastillas glycomet | Promotions Glycomet - La Revue Tranquilizar a enviar su anlisis metformin medication y. Advil, o coercin, los biosimilares se. Refutacin del hecho de estreimiento. Liquid Omeprazole For Adults - televitale.fr Metformin and Fatal Lactic Acidosis. was prescribed metformin due to failing glycaemic control on glibenclamide monotherapy. He was well for six weeks,.Is Metformin Associated With Lactic Acidosis? - Medscape Question. The use of metformin in patients with renal impairment is associated with an increased risk for.. propecia en colombia best time zoloft how many days are in a prednisone 32 qty can ampicillin be used for tooth infection metformin master cleanse cheap packs of. Here you can read posts from all over the web from people who wrote about Hyperkalemia and Lactic Acidosis, and check the relations between Hyperkalemia and Lactic.. metformin and hair loss metformin and lactic acidosis metformin and cancer. use for pcos metformin uptodate metformin upset stomach metformin.Chronic cough in adults - UpToDate. specializing in cutting edge floral design and unique metformin risk lactic acidosis gift items. We strive to provide the. hyperkalemia and lactic acidosis - findeen.fr Bande annonce du film Hell on wheels Saison 2 (Hell on wheels DVD) ralis par Tony Gayton. Acteurs: Colm Meaney, Dominique McElligott, Common. Statistiques Dmographiques - stat-togo.org Le Conseil d'Administration de l'INSEED a tenu Lom sa Continue reading >>

Glyburide And Metformin (oral Route)

Glyburide And Metformin (oral Route)

Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. Under certain conditions, too much metformin can cause lactic acidosis. The symptoms of lactic acidosis are severe and quick to appear. They usually occur when other health problems not related to the medicine are present and very severe, such as a heart attack or kidney failure. The symptoms of lactic acidosis include abdominal or stomach discomfort; decreased appetite; diarrhea; fast, shallow breathing; a general feeling of discomfort; muscle pain or cramping; and unusual sleepiness, tiredness, or weakness. If you have any symptoms of lactic acidosis, get emergency medical help right away. It is very important to carefully follow any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy. Travel—Keep your recent prescription and your medical history with yo Continue reading >>

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