Metformin Contraindications Scr

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Metformin 500 mg review is here! If you want to know about Metformin how it works and Metformin side effects and also lots of other answers of questions related to metformin is given in this video.


Postmarketing cases of Metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of Metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (>5 mmol/Liter), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio; and Metformin plasma levels generally >5 mcg/mL (see PRECAUTIONS). Risk factors for Metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g. carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage Metformin-associated lactic acidosis in these high risk groups are provided (see DOSAGE AND ADMINISTRATION, CONTRAINDICATIONS, and PRECAUTIONS). If Metformin-associated lactic aci Continue reading >>

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  1. doghead

    For the last couple weeks I have been doing my best to stay under 50g daily. With a few weekend 20% exceptions, I have been fairly successful, and I feel great!
    My goal is to be in the single digit body fat range, and once I am there I will bump up the carb intake (more veggies, right now I eat meat + fat almost exclusively) for maintenance.
    My question is this - Has anyone noticed some HORRIBLE body odor? In particularly the more private regions?
    I noticed this a while ago. It comes and goes, but when its bad, its really bad. Is this just toxins exiting my body? Will it eventually go away? I have been reading many people's stories on how they don't smell, and have dropped deodorant use all together. I would really like to try this approach, just not sure how much longer until it happens.

  2. Pantera

    [TMI alert - scroll down at your own risk]
    I've been told the seeds' taste is different in a non-pleasant way. If I get fruit (pineapple in particular) it gets better.

  3. AuH2Ogirl

    Yes, doghead - when I am dropping fat my face breaks out and I have a tendency not to smell so good. It'll pass.

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What is ADRENAL INSUFFICIENCY? What does ADRENAL INSUFFICIENCY mean? ADRENAL INSUFFICIENCY meaning - ADRENAL INSUFFICIENCY definition - ADRENAL INSUFFICIENCY explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol; but may also include impaired production of aldosterone (a mineralocorticoid), which regulates sodium conservation, potassium secretion, and water retention. Craving for salt or salty foods due to the urinary losses of sodium is common. Addison's disease and congenital adrenal hyperplasia can manifest as adrenal insufficiency. If not treated, adrenal insufficiency may result in severe abdominal pains, vomiting, profound muscle weakness and fatigue, depression, extremely low blood pressure (hypotension), weight loss, kidney failure, changes in mood and personality, and shock (adrenal crisis). An adrenal crisis often occurs if the body is subjected to stress, such as an accident, injury, surgery, or severe infection; death may quickly follow. Adrenal insufficiency can also occur when the hypothalamus or the pituitary gland does not make adequate amounts of the hormones that assist in regulating adrenal function. This is called secondary or tertiary adrenal insufficiency and is caused by lack of production of ACTH in the pituitary or lack of CRH in the hypothalamus, respectively. There are three major types of adrenal insufficiency. Primary adrenal insufficiency is due to impairment of the adrenal glands. 80% are due to an autoimmune disease called Addison's disease or autoimmune adrenalitis. One subtype is called idiopathic, meaning of unknown cause. Other cases are due to congenital adrenal hyperplasia or an adenoma (tumor) of the adrenal gland. Secondary adrenal insufficiency is caused by impairment of the pituitary gland or hypothalamus. Its principal causes include pituitary adenoma (which can suppress production of adrenocorticotropic hormone (ACTH) and lead to adrenal deficiency unless the endogenous hormones are replaced); and Sheehan's syndrome, which is associated with impairment of only the pituitary gland. Tertiary adrenal insufficiency is due to hypothalamic disease and a decrease in the release of corticotropin releasing hormone (CRH). Causes can include brain tumors and sudden withdrawal from long-term exogenous steroid use (which is the most common cause overall). Signs and symptoms include: hypoglycemia, dehydration, weight loss, and disorientation. Additional signs and symptoms include weakness, tiredness, dizziness, low blood pressure that falls further when standing (orthostatic hypotension), cardiovascular collapse, muscle aches, nausea, vomiting, and diarrhea. These problems may develop gradually and insidiously. Addison's disease can present with tanning of the skin that may be patchy or even all over the body. Characteristic sites of tanning are skin creases (e.g. of the hands) and the inside of the cheek (buccal mucosa). Goitre and vitiligo may also be present. Causes of acute adrenal insufficiency are mainly Waterhouse-Friderichsen syndrome, sudden withdrawal of long-term corticosteroid therapy, and stress in patients with underlying chronic adrenal insufficiency. The latter is termed critical illnessrelated corticosteroid insufficiency. For chronic adrenal insufficiency, the major contributors are autoimmune adrenalitis (Addison's Disease), tuberculosis, AIDS, and metastatic disease. Minor causes of chronic adrenal insufficiency are systemic amyloidosis, fungal infections, hemochromatosis, and sarcoidosis. Autoimmune adrenalitis may be part of Type 2 autoimmune polyglandular syndrome, which can include type 1 diabetes, hyperthyroidism, and autoimmune thyroid disease (also known as autoimmune thyroiditis, Hashimoto's thyroiditis, and Hashimoto's disease). Hypogonadism and pernicious anemia may also present with this syndrome. Adrenoleukodystrophy can also cause adrenal insufficiency. Adrenal insufficiency can also result when a patient has a craniopharyngioma, which is a histologically benign tumor that can damage the pituitary gland and so cause the adrenal glands not to function. This would be an example of secondary adrenal insufficiency syndrome.....

Use Of Metformin In The Setting Of Mild-to-moderate Renal Insufficiency

Go to: HISTORICAL PERSPECTIVE Despite these proven benefits, metformin remains contraindicated in a large segment of the type 2 diabetic population, largely because of concerns over the rare adverse effect of lactic acidosis. For these reasons, the drug has been restricted to individuals with normal creatinine levels as a surrogate for renal competence. Other contraindications (e.g., any significant hypoxemia, alcoholism, cirrhosis, a recent radiocontrast study) also increase the risk for or the consequences of lactic acidosis, but these are not the topic of this review. Metformin belongs to the biguanide drug class (previous members include phenformin and buformin), developed for lowering glucose in the 1950s. Initial enthusiasm for biguanides was tempered over the next two decades by the growing recognition of their risk of lactic acidosis. A marked reduction in biguanide use occurred in the mid-1970s because phenformin, extensively adopted in clinical practice, was implicated in a number of fatal cases of this severe metabolic decompensation (17). The association with lactic acidosis eventually led to its withdrawal from the market. Importantly, lactic acidosis with phenformin s Continue reading >>

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  1. testudoaubreii

    Oh man this is great info. I went full keto a few years ago, but have long since lost sight of the wagon I fell off of since then. My wife and I are ... considering (dithering/procrastinating/enjoying ice cream) it again now.
    Anyway, I never got past a vague light purple before, and wondered if I was somehow doing it wrong. This is really good info. Thanks!


    I'd say that if you get any change at all in color, you're in ketosis . If it goes very dark, it more then likely speaks to your level of hydration ( Lack thereof ).

  3. xpnerd

    I concur - I have never seen dark purple but I'm drinking 3 to 4 litres a day. It's always a light purple and I'm doing just fine. I use them maybe once every few weeks just to see. I certainly do not use them every day and I got solid advice from the beginning not to as it affects the mental state of weight loss. Stick to your macros and Keto On. The rest will take care of itself.

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Want a chronic kidney disease stage 3 diet? Try this for a chronic kidney disease stage 3 diet click here http://kidney.diethere.net/kidney-dis... - the best diet for kidney disease Read the testimonials from other followers of the kidney diet secrets. These are all extracts from testimonials that people who have used the Kidney diet to drastically change their lives and regained health; The Kidney Diet Secrets Guide Book was easy enough for an active guy like me to follow. It took sometime, but I managed to do it. No more kidney stones for 3 years. I know it will never come back once you really beat the root cause. This book taught me to get rid of kidney stones right from the roots. I was diagnosed with acute renal failure 7 months ago. I thought it was the end for me as the doctor's tone of voice implied. I did my research, and came across your guide. That was one of the best days in my life....being a business consultant, I had to travel a lot by land and by air...I thought I would never be able to follow the Kidney Diet Secrets guide but I was wrong. 11 months after, I'm still easily eating kidney-healthy diet and it never took control of my life. Thanks again! My family and I used to be very frustrated because the doctors wouldn't give us enough information for my father who has kidney failure for 3 years. 'eat a low protein diet' is never enough. How low is low? etc. This book solved everything about that. Now my father does not experience fatigue and is as happy as ever. Thanks!" I had chronic kidney disease (CKD) for 6 years before I got a hold of this book. Few weeks later after I had my regularly scheduled laboratory test for kidney function, my doctor was amazed my kidneys were progressing. It continues until today after all these months. I really am thankful to have come across this amazing guide. Easily the Best book in Kidney Disease anywhere. And the recipes included are simply the best! I had to endure having high blood pressure since I was 40, diagnosed with acute renal failure a few months later and I was advised to get ready for dialysis by my doctor. After having through your book and following your advise, It's been 1 year and 5 months I still haven't undergone dialysis. I owe it to you and your diet method Rachelle. Thank you. My Doctor Was Amazed...I promised to give you a testimonial if it worked for me. And surely enough.. it did!...the doctor was amazed how my creatinine got back to normal range pretty quickly. Everything is laid out in an easy and understandable manner. Not a single medical jargon! I definitely recommend the book to anyone with chronic kidney disease - even if you only get a couple of tips from it, they have got to be the tips that will save you from dialysis or a transplant! Glad I found your guide! "Its a Must for Kidney Patients..." This book, in my opinion, is a must for kidney patients. It wasn't easy at first, but I'm very much used to it now. Well written and easy to understand, it gave me a much better understanding of CKD and what I need to do to live a longer and healthier life. Dialysis is not something I want to experience. For those seeking information on Kidney Disease and how to best deal with it, the biggest frustration is the lack of good information available. The author explains why not much has been done about educating the public with kidney disease. A lot of good information I haven't found anywhere up until today! "GFR Shoot up in a few weeks!" The book spells out how diet and restricting certain foods can stop and even reverse kidney disease. I had a blood test done and found that my GFR was only 26 - Stage 4 Kidney Disease - that was a huge shock to me since it went from above 60 down to 26 in five months! That was a huge motivator for me to do try out the Kidney Diet Secrets and it worked! You need to check out the Kidney Diet for yourself and you can do it RISK FREE. Find out information on kidney diet, kidney diet secrets, diet kidney disease, kidney disease diet, diet for kidney disease, chronic kidney disease diet, polycystic kidney disease diet, kidney disease diet plan, chronic kidney disease treatment, diet for chronic kidney disease, stage 3 kidney disease diet, low protein diet kidney disease, low protein diet for kidney disease, kidney disease diet restrictions, diets for kidney disease, kidney disease diets, diet for stage 3 kidney disease, diet for polycystic kidney disease, chronic kidney disease stage 3 diet, chronic kidney disease diet plan, stage 4 kidney disease diet, kidney disease diet recipes, diet and kidney disease, diabetic kidney disease diet, best diet for kidney disease, how to treat chronic kidney disease, diet plan for kidney disease, diet for people with kidney disease, diet for kidney disease patients, just go to http://kidney.diethere.net or dietkidneydisease to see videos:, http://youtu.be/pzA1GuZASI8, http://youtu.be/uvIpUcWH2tE, http://youtu.be/bN08Utq_6aM

Changes In Metformin Use In Chronic Kidney Disease

Go to: Fear of LA Metformin is chemically similar to phenformin, but has a different mechanism of action. Although the fear of LA remains, no absolute definitive causal relationship has been proven beyond doubt. Many reported cases of metformin-associated LA (MALA) did not measure metformin levels, whereas in others levels were not high, suggesting ‘metformin coincident lactic acidosis’ [9]. In 1998, Misbin et al. reported that after starting to use metformin, rates of LA in the USA were no different from prior to the approval of metformin [10]. Many reported cases of LA had multiple risk factors besides renal failure. Since DM2 is a risk factor, it is thought that many such cases may have been just from DM2. The putative risk factors for LA described in the literature include old age, decreased cardiac output, respiratory failure or hypoxic conditions, ethanol intoxication, fasting and decreased hepatic function. In a nested case–control analysis that included 50 048 patients, six patients were identified with active use of metformin and LA. Out of those, five patients had sepsis and signs of end-organ damage, suggesting that LA most frequently occurs in acutely worsening cl Continue reading >>

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  1. GaresTaylan

    My first 2 weeks on Keto.

    Hey everyone. Just finished my carb up after the 2nd week of keto. The first week, I lost 4.7lbs (which I figured a lot of was water weight). I came down with a cold my 3rd day in, so exercise was rather limited.
    I have not strayed from my diet a single time. I have been at a -700 calorie deficit; 1 gallon of water or slightly less per day; and I have been very strict at staying around 65/30/5. I use fitday to track everything, and I weigh and measure *everything.*
    On my 2nd week, I lost a whopping .4lbs. By default, at a deficit, shouldnt I have lost at LEAST another 1lb? Something doesnt seem right. Now, I will admit, I normally weigh on Sunday but since I would be carbing up I weighed Friday night before I started my carb up.
    -Fats/proteins include: Sausage, bacon, pepperoni, cheese, steak, chicken, almonds, natural pb, hot dogs (minimal), ranch dressing
    -Carbs include: Cheese, natural pb, almonds, broc****, green beans, bell pepper, romaine lettuce
    During my 2nd week, I had 3 weight training days (Mon/Weds/Fri) and 3 cardio days (Sun/Tues/Fri). On Thurs and Friday, I did weights and cardio both. Saturday was my rest day since I figured I would feel bad.
    Can anyone see what I am doing wrong? I will admit, I could have had a few more veggies in there per day. I would average about 1-1.5 cups of veggies per day. My carbs have never been over 25g and usually around 15-20g. Is it a fluke because I weighed in so late in the day? I tested myself twice with ketostix, and I had traces each time.

  2. anabolicangel

    From a diet standpoint, you might still be holding onto some water since some of the foods you have listed contain a lot of sodium (hot dogs, cheese, pepperoni, bacon, sausage, etc), and if these make up the majority of your daily intake that could possibly cause some water retention... thus, making you look like you're holding onto weight.
    Also, sometimes peanut butter can be a problem for people on keto... there have been those that said when they drop it altogether, weight loss begins again.
    More importantly, you should pay more attention to your measurements/mirror/clothes to see your progress. The scale may not show a loss for weeks but you'll be losing fat and thus, your measurements will go down, you'll see more definition, and your clothes will fit better.
    You're only two weeks in... don't get hung up on it unless it continues to be a problem and the indicators mentioned above aren't yielding positive results.
    Good luck!

  3. rbdwarf

    The late weighing is almost definitely a factor. Try to weigh yourself in the morning after you hit the bathroom but before breakfast - that will give you the truest indication. If you weigh yourself at the end of the day you have a variable amount of food and water in your system.

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