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Metformin Contraindications

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Metformin For Weight Loss, Side Effects, Contraindications

Nearly more than 35% of American adults are obese which means every one-third of American is obese or overweight. According to statistics, it shows that the annual medical cost for persons who are obese is $1,429 higher than that of the persons with normal body weight. Metformin, sold under various brand names like Glumetza , Glucophage, Fortamet is a drug of group Biguanides. It is an oral hypo-glycemic drug introduced in late 50s. It is used as first line of treatment in diabetes mellitus type 2 as well as in pre-diabetic condition. But recent studies has shown that it also helps non-diabetics persons in weight loss. Obesity or overweight is a condition when the weight of a person is greater that of which is considered as healthy for a given height. You might be wondering whether your weight is normal or not? Well let me explain you the simple way to find. It is calculated by using BMI (Body Mass Index). If a persons BMI is between 25 to 29.9 then the person is over weight and the person with BMI higher than 30 is considered as obese. Since obesity has been linked with a lot of new world diseases like different heart diseases and stroke, diabetes, gall diseases, hypertension and Continue reading >>

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  1. Kingleonidas

    Metformin and DKA>>

    Just wondering, I have read that taking metformin without food can lead to dka, or does this usually pertain to people who eat absolutely nothing or very little all day?
    I am going to start my 850mg three times a day at about 4-5am, 9-10am, then again at the end of the day when I go to bed.
    Has anyone had a problem with metformin and dka?
    Thanks.

  2. MarkM

    no, metformin won't cause dka. its main action is to inhibit glycogenolysis. only insufficient insulin will cause dka. metformin can cause lactic acidosis, but it is not the same thing as ketoacidosis (dka).

  3. Ken S

    Studies have also shown that the risk of getting lactic acidosis with or without taking metformin is about the same. This is an extremely rare affliction that only really seems to affect patients with serious preexisting health problems. It's really not an issue to be concerned about.
    As for DKA, metformin is contradicted in cases where patients are experiencing symptoms of DKA, and therefore it may be surmised that it may worsen this condition, although it does not seem to cause it.

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Maladaptive: Do We Avoid Metformin Unnecessarily?

MALAdaptive: Do We Avoid Metformin Unnecessarily? From the Departments of Family Medicine and Clinical Pharmacy, West Virginia University, Charleston. Corresponding author: Chris M. Terpening, PhD, PharmD, BCACP Departments of Family Medicine and Clinical Pharmacy, West Virginia University, 3110 MacCorkle Ave SE, Charleston, WV 25304 (E-mail: cterpening{at}hsc.wvu.edu). Convention holds that the use of metformin is contraindicated in many patients secondary to concerns about lactic acidosis. However, current evidence suggests that metformin-associated lactic acidosis is at most idiosyncratic. Awareness of the current evidence should permit broader use of this valuable medication. Treatment of type 2 diabetes is one of the most common challenges encountered by the family physician. The percentage of people diagnosed with diabetes in the United States has risen from <1% in the 1950s to 7% in 2010. 1 In response to this increase, the pharmaceutical industry has developed a wide array of treatment options, with 29 individual agents, not including combinations, currently approved and marketed in the United States to help control blood glucose levels. Of all these agents, the one drug t Continue reading >>

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Popular Questions

  1. Kingleonidas

    Metformin and DKA>>

    Just wondering, I have read that taking metformin without food can lead to dka, or does this usually pertain to people who eat absolutely nothing or very little all day?
    I am going to start my 850mg three times a day at about 4-5am, 9-10am, then again at the end of the day when I go to bed.
    Has anyone had a problem with metformin and dka?
    Thanks.

  2. MarkM

    no, metformin won't cause dka. its main action is to inhibit glycogenolysis. only insufficient insulin will cause dka. metformin can cause lactic acidosis, but it is not the same thing as ketoacidosis (dka).

  3. Ken S

    Studies have also shown that the risk of getting lactic acidosis with or without taking metformin is about the same. This is an extremely rare affliction that only really seems to affect patients with serious preexisting health problems. It's really not an issue to be concerned about.
    As for DKA, metformin is contradicted in cases where patients are experiencing symptoms of DKA, and therefore it may be surmised that it may worsen this condition, although it does not seem to cause it.

  4. -> Continue reading
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Metformin, Diabetes Mellitus, Adverse effects of metformin, How does metformin work, Mechanism of action of metformin, Indications of metformin, Contraindications of metformin, Blood Glucose, Hypoglycemia, Side Effects of metformin Adverse effects of metformin, Oral hypoglycemic Drugs, Metformin and lactic Acidosis, Type II diabetes mellitus, NIDDM, Non insulin dependent diabetes mellitus, Uses of Metformin. About Me: Dr. Sumit Verma MD, DNB , with more than 15 years of experience in clinical medicine / clinical research / pharmacovigilance domain I have co-authored a book titled "Fundamentals of Pharmacovigilance" (http://www.amazon.in/Fundamentals-Pha...) https://www.linkedin.com/in/dr-sumit-... Disclaimer: Medicine is an ever-changing science. The information presented in the video or on this channel is of a general informational nature and should not be considered as specific to the needs of a particular individual or organisation or entity. Please consult your doctor, medical specialist or your health care professional for all matters related to health. The video does not contain all the information about any drug. Any information presented in the video or on this channel does

Metformin May Be Effective In Previous Contraindications

Metformin May Be Effective in Previous Contraindications A recent review of current outcome data regarding metformin, a first-line drug for type 2 diabetes mellitus in the United States since the mid-1990s, has prompted new assessment of the drugs association with reduced mortality rates in patients with chronic kidney disease (CKD), congestive heart failure (CHF), and chronic liver disease (CLD). Concerns about lactic acidosis have limited the use of metformin in patients with CKD, CHF, and CLD. But, a safety announcement from the US Food and Drug Administration (FDA) in April 2016 allowed it to be used to treat certain patients with reduced kidney function. The review, published in the February 2017 issue of Annals of Internal Medicine , supported the FDAs decision and encouraged additional clinical trials to examine the effectiveness of the drug in the setting of previously contraindicated conditions. The review was supported by the US Veterans Affairs Administration in conjunction with the Durham Center for Health Services Research and Development in Primary Care. The systematic review examined existing studies, all-cause mortality, and major cardiovascular events in patients Continue reading >>

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Popular Questions

  1. Kingleonidas

    Metformin and DKA>>

    Just wondering, I have read that taking metformin without food can lead to dka, or does this usually pertain to people who eat absolutely nothing or very little all day?
    I am going to start my 850mg three times a day at about 4-5am, 9-10am, then again at the end of the day when I go to bed.
    Has anyone had a problem with metformin and dka?
    Thanks.

  2. MarkM

    no, metformin won't cause dka. its main action is to inhibit glycogenolysis. only insufficient insulin will cause dka. metformin can cause lactic acidosis, but it is not the same thing as ketoacidosis (dka).

  3. Ken S

    Studies have also shown that the risk of getting lactic acidosis with or without taking metformin is about the same. This is an extremely rare affliction that only really seems to affect patients with serious preexisting health problems. It's really not an issue to be concerned about.
    As for DKA, metformin is contradicted in cases where patients are experiencing symptoms of DKA, and therefore it may be surmised that it may worsen this condition, although it does not seem to cause it.

  4. -> Continue reading
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