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Metformin Antidote

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Poisoning - Hypoglycaemic Agent - Kids Health Wa (pmh Ed Guidelines)

Oral hypoglycaemic agents are used for type II diabetes mellitus (non-insulin dependent diabetes) Sulfonylurea agents increase pancreatic insulin secretion and are the most important cause of hypoglycaemic toxicity Modified-release preparations may delay onset of symptoms for up to 8-18 hours Metformin is a biguanide agent that acts by decreasing carbohydrate absorption from the gut, increasing glucose uptake in peripheral tissues in the presence of insulin, and reducing hepatic gluconeogenesis The thiazolidinedione agents act at a nuclear receptor to improve insulin sensitivity in adipose tissues, skeletal muscles and the liver. Minimal information is available regarding overdose. The sulfonylurea agents may cause prolonged and profound life-threatening hypoglycaemia after accidental paediatric ingestion or deliberate self-poisoning Large overdoses may require treatment for several days A single tablet in a toddler has the potential to cause life-threatening hypoglycaemia. The onset of hypoglycaemia may be delayed up to 18 hours after ingestion. Admission for a minimum of 12- 24 hours is indicated for blood glucose monitoring. Discharge from hospital should only occur in the dayl Continue reading >>

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Popular Questions

  1. Pistolfist

    I want to check with the community as I can't find too much information, the general consensus I can find from google is don't have sugar because sugar is a carb and carbs are anti-ketogenic, but I knew this already.
    But say hypothetically, it's a friday and I have friends round, I've had 2g of carbs in my day so far and I decide to get the tumblers out and make a couple of old fashioneds, I weigh the sugar out to be no more than 8g (of course, I don't think I need to worry about the other ingredients - whisky, angostura bitters and water), say I have two of these that's 16g of sugar. So even if the sugar is 100% carb, I'm still only on an 18g total for my day which is less than my 20g target - is this still going to kick me out of keto?
    I'm just curious because I do love an old fashioned and it's not a sweet drink despite the sugar so I don't know about the insulin response here?
    In short, even if I am below 20g of carbs, can I still not have any sugar?

  2. Pistolfist

    I've been making old fashioneds with stevia and they still taste pretty good!
    I had intended on asking a whisky/whiskey/alcohol related subreddit the question, if an old fashioned still worked with stevia (I mean, you must need like this absolute tiniest amount, right?) but I couldn't think of a decent sub to ask it, I'm only subscribed to /r/whisky and I don't imagine mentioning a cocktail would go down there. I will definitely give it a try though!

  3. RefindingMe

    It's certainly not the best idea to get your day's worth of carbs from straight up sugar, as you should try for natural vegetable sources.
    But if every now and then, you want to let loose with your buddies, it's fine as long as it's the rare exception and not the rule. That many carbs at once may throw you out of ketosis momentarily, but as long as you get back to eating properly as quickly as possible, you should be fine.
    I should point out that if you're still just starting, this will really screw up keto adaptation, so try and wait a month or two before doing this. Your gut will thank you.

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In this video i have provided simple tricks to learn Oral antidiabetic drugs

Tennessee Poison Center - 03-23-17 How Does Metformin Differ From Other Oral Hypoglycemic Drugs? - Vanderbilt Health Nashville, Tn

03-23-17 How does Metformin differ from other oral hypoglycemic drugs? 03-23-17 How does Metformin differ from other oral hypoglycemic drugs? How does Metformin differ from other oral hypoglycemic drugs? Metformin is a biguanide agent and the drug-of-choice for the treatment of newly diagnosed type-2 diabetes mellitus, making it one of the most widely prescribed medications in the world. With over half a century of clinical experience, metformin is generally recognized as safe with the most frequent adverse effects being gastrointestinal (i.e. nausea, indigestion, abdominal cramps/bloating, diarrhea). Metformin acts to reduce hepatic glucose production, reduce intestinal glucose absorption, and increase skeletal muscle glucose uptake and utilization. Because it does not affect the release of insulin or other pancreatic hormones, metformin is rarely associated with hypoglycemia. Metformin impairs mitochondrial respiration and inhibits the conversion of lactate to pyruvate. This results in both an increased production and decreased elimination of lactate with a subsequent acidosis known as metformin-associated lactic acidosis (MALA). MALA is a serious but rare complication of metfor Continue reading >>

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Popular Questions

  1. Pistolfist

    I want to check with the community as I can't find too much information, the general consensus I can find from google is don't have sugar because sugar is a carb and carbs are anti-ketogenic, but I knew this already.
    But say hypothetically, it's a friday and I have friends round, I've had 2g of carbs in my day so far and I decide to get the tumblers out and make a couple of old fashioneds, I weigh the sugar out to be no more than 8g (of course, I don't think I need to worry about the other ingredients - whisky, angostura bitters and water), say I have two of these that's 16g of sugar. So even if the sugar is 100% carb, I'm still only on an 18g total for my day which is less than my 20g target - is this still going to kick me out of keto?
    I'm just curious because I do love an old fashioned and it's not a sweet drink despite the sugar so I don't know about the insulin response here?
    In short, even if I am below 20g of carbs, can I still not have any sugar?

  2. Pistolfist

    I've been making old fashioneds with stevia and they still taste pretty good!
    I had intended on asking a whisky/whiskey/alcohol related subreddit the question, if an old fashioned still worked with stevia (I mean, you must need like this absolute tiniest amount, right?) but I couldn't think of a decent sub to ask it, I'm only subscribed to /r/whisky and I don't imagine mentioning a cocktail would go down there. I will definitely give it a try though!

  3. RefindingMe

    It's certainly not the best idea to get your day's worth of carbs from straight up sugar, as you should try for natural vegetable sources.
    But if every now and then, you want to let loose with your buddies, it's fine as long as it's the rare exception and not the rule. That many carbs at once may throw you out of ketosis momentarily, but as long as you get back to eating properly as quickly as possible, you should be fine.
    I should point out that if you're still just starting, this will really screw up keto adaptation, so try and wait a month or two before doing this. Your gut will thank you.

  4. -> Continue reading
read more
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Fatal Metformin Overdose Presenting With Progressive Hyperglycemia

Go to: CASE REPORT A 29-year-old man ingested metformin in a suicide attempt. The patient consumed the entire remaining contents of his father’s prescription metformin bottle that originally contained 100 tablets of 850 mg each. The father stated that the bottle had contained at least three-quarters of its original contents, putting the ingested dose between 64 and 85 grams. The patient also consumed ethanol, but denied any other co-ingestants. The parents discovered the overdose around 6:30 a.m., about 5 ½ hours post-ingestion, when the patient began complaining of vomiting, diarrhea, thirst, abdominal pain and bilateral leg pain. Paramedics were called, who found the patient to be agitated with a fingerstick glucose level of 180 mg/dL. The patient had a history of psychosis and depression, including prior suicide attempts by drug ingestion. He was not taking any prescribed medications, having discontinued olanzapine and sertraline several months earlier. The patient had no personal history of diabetes, despite the family history of type II diabetes in his father, who was taking no other anti-diabetic medications than metformin. The patient admitted to daily ethanol and tobacco Continue reading >>

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Popular Questions

  1. Grork

    Ketosis and Alcohol

    Simple Question: Will alcohol (and not beer or wine obviously, but straight EtOh as in vodka) boot you out of ketosis?

  2. ExNole

    Grork wrote:
    Simple Question: Will alcohol (and not beer or wine obviously, but straight EtOh as in vodka) boot you out of ketosis?

    I'm pretty sure when your metabolizing alcohol you don't burn any fat.

  3. vroom

    ExNole wrote:
    I'm pretty sure when your metabolizing alcohol you don't burn any fat.

    Yeah, I think you are right that it is preferentially consumed, but I don't think it keeps you from returning to ketosis once the alcohol is used up.

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