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Metformin Antidote

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Oral Hypoglycemic Agent Toxicitytreatment & Management

Oral Hypoglycemic Agent ToxicityTreatment & Management Author: David Tran, MD; Chief Editor: Timothy E Corden, MD more... The main goal in oral hypoglycemic agent exposure is supportive care, which includes airway, breathing, and circulation. Intravenous administration of glucose rapidly resolves the effects of hypoglycemia. Its onset is quicker than oral administration of sugar, and it is safer in patients with a depressed mental status who should not take anything by mouth for fear of aspiration. Glucagon is helpful and can be administered intravenously, intramuscularly, or subcutaneously. Glucagon is particularly useful in the intramuscular mode when intravenous access cannot be obtained immediately. Generally, all symptomatic patients who present with hypoglycemia need admission to the hospital in a monitored setting. Patients who remain asymptomatic and who do not develop hypoglycemia in the first 8-12 hours may be discharged safely home. However, the data from one study suggest that because accidental ingestion of sulfonylurea results in delayed and often prolonged hypoglycemia, admission for at least 16 hours is recommended, with frequent glucose monitoring. [ 17 ] At minim Continue reading >>

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Popular Questions

  1. Maverik

    I have been on a keto diet for about a week and a half and Monday I came down with a bad cold. So my question is, do I need more carbs to heal quicker or will it matter. Common sense would tell me to increase the carbs and resume the diet when I am well. Any docs or med students out there that can help??

  2. Hacker

    Don't know Mavs, so I'll bump for you.

  3. MPJBR

    My personal experience is that if you get a cold while on a Keto diet, you won't get over it until you resume a more balanced diet. I am a big fan of the ketogenic diets, but they really wear down your resistance and immune system.

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https://www.store.hormonesynergy.com/... https://www.store.hormonesynergy.com/... https://www.store.hormonesynergy.com/... S-Acetyl Glutathione is an acetylated form of glutathione. This form is well-absorbed and more stable throughout the digestive tract than other forms on the market. Use of stomach acid-resistant capsules, further protect stability. Laboratory data showed that S-acetyl glutathione increased intracellular glutathione and had a positive effect on many oxidative stress biomarkers.* For additional information about S-Acetyl Glutathione, NAC and other detoxification products please click here: https://www.store.hormonesynergy.com/...

A Comparison Between The Effects Of Metformin And N -acetyl Cysteine (nac) On Some Metabolic And Endocrine Characteristics Of Women With Polycystic Ovary Syndrome

Full Terms & Conditions of access and use can be found at Download by: [Kashanian Maryam] Date: 25 December 2015, At: 00:26 ISSN: 0951-3590 (Print) 1473-0766 (Online) Journal homepage: A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with Forough Javanmanesh, Maryam Kashanian, Maryam Rahimi & Narges To cite this article: Forough Javanmanesh, Maryam Kashanian, Maryam Rahimi & Narges Sheikhansari (2015): A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with polycystic ovary syndrome, Gynecological Endocrinology, DOI: 10.3109/09513590.2015.1115974 To link to this article: Department of Obstetrics & Gynecology, Firoozgar Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran, & Gynecology, Akbarabadi Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran, and Medicine, University of Southampton, Southampton, UK Objective: To compare N-acetyl cysteine (NAC) and metformin on polycystic ovary syndrome Method: Study was performed as a randomized double-blind clinical trial on women with diagnosis of Continue reading >>

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Popular Questions

  1. KetoHippy

    I want to test my blood ketones after I eat something to see if it kicks me out of ketosis. How soon after I eat the item should I test?

  2. BillJay

    candrak:


    I want to test my blood ketones after I eat something to see if it kicks me out of ketosis. How soon after I eat the item should I test?

    When testing blood glucose, I usually test just before (T0), 30 minutes (T30), 60 minutes (T60) and 90 minutes (T90), but ketone strips are more expensive, so I usually do T0 and T60.

  3. Tim_Scudder

    Candra, I've found that I have to wait many hours before I see a true reaction. For example, if I have a carb-refeed meal @ dinner (I do carbs like rice/sweet-potato once every few weeks), I won't see my ketones drop much until at least the next morning (and I can usually feel that I'm out of Ketosis). My theory/hypothesis (based on data like the chart below and the few times I've dropped below 0.5 ml/mol over the past year since I've measured BHB with the Precision Xtra), is that the ketones measured in your blood are the "surplus" ketones your body has not consumed - it's not what your cells are consuming but what's left over - so if your cells shift to consume glucose, this level won't drop precipitously after a carb meal. If you eat enough carbs to push your blood sugar high (assuming your body has filled it's glycogen stores), your body is going to focus on utilizing the glucose first (glucose is toxic at high levels), leaving your ketone levels somewhat unchanged, but signaling to your liver to slowly reduce ketone production. As you can see in the chart below, it slowly lowers over a few days. I've personally found that (once keto adapted) I can have a high carb meal every few weeks and regain my ketone levels the next day after skipping a meal and having a low carb lunch/dinner...hope that helps.

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Session 6 - Case Study Diabetes Complication ( Dr/ Heba Mady )

Metformin-related Acidosis In A Woman While Performing Haj: A Conservative Approach Ansari Rs, Mady Af, Qutub Ho, Althomaly E, Alzayer Za, Moulana Aa - Saudi J Kidney Dis Transpl

Metformin is a biguanide that enhances the release of glucose from the liver and the insulin effect on peripheral tissues thus decreasing the blood glucose. The most serious sideeffect of metformin is lactic acidosis due to inhibition of hepatic gluconeogenesis and/or reduction of conversion of lactic acid, pyruvic acid or alanine to glucose. The yearly incidence of lactic acidosis in previous reports was less than five episodes in every 100,000 treated individuals. Still, there is no particular antidote for metformin-induced lactic acidosis and its treatment mainly involves the correction of acidemia. [1] Considerable efficacy has been observed in the use of hemodialysis to treat the metformin-induced lactic acidosis. Hemodialysis application is currently recommended in patients with severe metabolic acidosis (pH < 7.1) and renal failure. It has been shown that plasma metformin concentrations are only slightly increased when the estimated glomerular filtration rate is 30 mL/ min/1.73 m2. [2] We present a case of successful management of metformin-associated metabolic acidosis, treated simply with intravenous sodium bicarbonate and aggressive hydration and intensive monitoring. Ou Continue reading >>

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  1. BieraK

    Introduction (The introduction can be skipped and go immediately to the question)
    As we know ketogenic diet has positive effects on the body, among them a higher mental energy due to consumption of ketonic bodies from brain, increased axon growth, and has excellent effects on autophagy process, and can even produce mitochondrial biogenesis and mitophagy.
    As I understand for doing a correct and "normal" ketogenic diet you first need to eliminate all glycogen reserves, For doing this it requires a fasting of two days and then begin to consume a diet high in fat, followed by protein and 20 grams of carbs (this is the standard ketogenic diet, not the paleo diet. Paleo diet is confused by some people as the ketogenic diet).
    However a Keto diet is a bit hard to do, and in the long term it is the possibility of slowly starting to lose muscle, that was what happened to me when I made a ketogenic diet, it worked perfectly, the smell of my body changed, I had a lot of energy, but I started to lose muscle and over time it became very boring.
    Questions
    So my question is this: Is it possible to induce a ketosis state for only 24 hours, in order to enter in ketosis once or twice a week?. With this in the following days you could do a normal diet or build muscle with protein and some carbs
    I usually practice intermittent fasting, I skip breakfast and sometimes I eat when it is only 6 o'clock in the afternoon, so the other option is this:
    It is possible to stay in ketosis for 16 hour in a intermitten fasting protocol, like the 16:8?
    Basically I want the mitophagy, mitobiogenesis and brain energy effects from ketosis in a window and controlled time. This way I can generate muscle the following days of the week and "at the same time" produce autophagy and mitophagy states from ketosis.
    Possible ideas
    I'm thinking in bulletproof coffe as an option, It is possible to induce a ketogenic state with a bulletproof coffe first thing in the morning with adding some supplements or drugs, like metformin, quercetin, cinnamon?

  2. Spicyramyun

    If you are doing intermittent fasting in the days prior to it could be possible to go through a bit of the ketogenic induction period with a planned ketogenic day. How fast do you normally take to get into ketosis? I imagine with proper meal planning you could pull this off. If you were having muscle loss I believe there are some ways around that. Ketogains on Red had quite a few who were successfully building muscle during their keto and lifting programs.

  3. BieraK

    Yes I've heard of Ketogains in reddit, however still looks a bit difficult, if Leangains [1] is difficult due to the lifestyle in the city, with work, studies, etc... Ketogains looks more difficult.
    Ketosis needs 24 - 48 hours of fasting. My intermittent fasting protocol is a flexible 16:8, there are 16 hours of no eating and a eating window of 8 hours, however it could be donde in a more flexible way for example 14:10.
    My regular fasting is, wake up, coffe with green tea cup, and then some supplements like Grape Seed, Andrographis Paniculata, Methylene blue... Vitamin b3, curcumin, quercetin. I try not to take vitamin 3 close to meals.
    Varies slightly, but usually 1) Andrographis, 2) Grape seed and 3) a dose of 10 mg of methylene blue have been my supplements for the last 5 months. Usually I eat when it's 3 o'clock, sometimes an earlier type 2 pm, on the best days I try to eat at 6 o'clock.
    On some occasions I consume 400 mg of Metformin in the morning along with methylene blue and the other supplements. No problem with dizziness or anything like that, just very hungry that disappears with the passing of the morning.
    [1]Leangains: 16:8 intermittent fasting, with workout on an empty stomach the protein and carb consumption after the workout, with a 8 hours window for eating
    Edited by BieraK, 17 December 2016 - 11:34 PM.

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