Metformin Acute Chf

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The Study of pharmaceutical addiction, prescription drug abuse opioids, Doctors over-prescribing pain medication ( Oxycodone, codeine, fentanyl, hydrocodone/acetaminophen, hydromorphone meperidine (Demerol), methadone (Dolophine, Methadose).

Prescribing Information & Medication Guides

Prescribing Information & Medication Guides Indication: NESINA (alogliptin), KAZANO (alogliptin and metformin HCl), and OSENI (alogliptin and pioglitazone) are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. NESINA, KAZANO, and OSENI are not for treatment of type 1 diabetes or diabetic ketoacidosis. Please see Important Safety Information , including boxed warnings for Congestive Heart Failure and LacticAcidosis,below. For detailed information on KAZANO, select a linkbelow. Important Safety Information for NESINA, KAZANO, andOSENI WARNING: CONGESTIVE HEART FAILUREforOSENI Thiazolidinediones, including pioglitazone, which is a component of OSENI, cause or exacerbate congestive heart failure in some patients. After initiation of OSENI, and after dose increases, monitor patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema). If heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of pioglitazone in OSENI must be considered. WARNING: CONGESTIVE HEART FAILUREforOSENI Thiazolidinediones, inc Continue reading >>

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  1. test_positive

    I am recently diagnosed Type 2 and my doctor has prescribed me metformin. I read the leaflet and it says not to have alcohol while on this medication. As I expect to be on this for life this means no more alcohol. Ever again. :thumbdown:
    I don't drink much. My wife and I have perhaps one (small) glass of wine per week. But we really enjoy it.
    Does anyone have experience of this? Should I really stop drinking completely now I'm on metformin? The leaflet says "Alcohol may increase the risk of lactic acidosis especially if you have liver problems or if you are undernourished." I do not have liver problems and am not undernourished.
    Thank you for any guidance you can provide!

  2. Grazer

    You will be fine with alcohol on metformin providing you're not a chronic heavy drinker or have existing liver disease. Lactic acidosis is EXTREMELY rare and occurs in combination with those two conditions. Metformin never stops me from enjoying my Rioja! Go and enjoy.

  3. Paul1976

    Good advice from sheepy above!..Incedently there's some good half price offers on Rioja at Tesco at the moment! :thumbup:

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Access the mini course here: http://defeatkidneydisease.com/FreeMi... Hi, my name is David. A friend of mine was diagnosed with Stage 3 Chronic Kidney Disease (CKD) recently. He was shocked - he had not felt that bad and was there for a routine check-up. He was told that there were 5 CKD stages and that all he could do is try and slow the descent down to Stage 5 - Kidney failure. I am guessing if you are watching this video then you or a loved one has had a similar experience. My personal experience with Western medicine is that it can be very useful, life saving for many. But it can take a rather narrow view to what is possible. So for my friends sake, I went out to find the truth for myself. I learned about the CKD stages which I tell you about in the video. But in the course of my searches I came across Duncan, a second generation naturopath who was leading the world in the natural healing of kidneys. He has many patients who have reversed their Kidney disease, moving from Stage 3 to Stage 2 as an example. Knowing how severe the lower CKD stages are I asked Duncan if he would put together a course I could provide people like you and me who are looking to heal kidney disease. He

Medical Xpress: Metformin Tied To Better Clinical Outcomes In Ckd, Chf, Cld

Metformin tied to better clinical outcomes in CKD, CHF, CLD (HealthDay)For patients with chronic kidney disease (CKD), congestive heart failure (CHF), or chronic liver disease (CLD) with hepatic impairment, metformin use is associated with improvements in clinical outcomes, according to a review published online Jan. 3 in the Annals of Internal Medicine. Matthew J. Crowley, M.D., from the Durham Veterans Affairs Medical Center and Duke University School of Medicine in North Carolina, and colleagues synthesized data addressing outcomes of metformin use in patients with type 2 diabetes and moderate to severe CKD, CHF, or CLD with hepatic impairment. Data were included from studies that compared diabetes regimens that included metformin with those that did not, and reported all-cause mortality, major adverse cardiovascular events, and other outcomes of interest. The researchers found that metformin use correlated with reduced all-cause mortality in patients with CKD, CHF, or CLD with hepatic involvement on the basis of quantitative and qualitative syntheses involving 17 observational studies. In patients with CKD or CHF, metformin use correlated with fewer heart failure readmissions. Continue reading >>

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  1. Fwatuheard

    Sorry if this question has been asked a million times, but the search didn't get me what I was looking for.
    I've been on a TKD for 2 days now, and I'm not quite sure if I'm doing all of this correctly. I can't really monitor my diet down to the calorie due to my job, but I'm using common knowledge to steer clear of carbs (bread, rice, beans, fruit, etc, etc). I'm estimating that I've been consuming around 40-50 carbs a day with the bulk of it coming from my post-workout shake.
    From you keto pros out there, do you think I can achieve ketosis with my current carb intake, or should I restrict carbs even further? I'm starting to feel like I should restrict carbs totally save for my carb up day at the end of the week ala the CKD.
    All I all I got the basics down, but I think I need a little more guidance. Any help would be much appreciated.

  2. timmymayes

    I was into ketosis within 3 days...but i did a 3 day fast to get into it. I think it can take up to 10 days depending....I think thats the duration of induction on atkins.

  3. �STFU!ˇN�LIFT!

    how the HELL do you not eat for 3 days ?
    one day even omg

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http://diabetestruth247.com While many people are becoming aware of the prevalence of diabetes in the United States, many people still do not know the diabetes risk factors that put them at risk of developing the disease. Knowing the diabetes risk factors can greatly help you reduce your risk of diabetes. If you have any of the risk factors, taking active steps to change your diet and lifestyle can greatly help you lower your chances of developing type II diabetes.

Cardiovascular Risk Associated With Acarbose Versus Metformin As The First-line Treatment In Patients With Type 2 Diabetes: A Nationwide Cohort Study

Cardiovascular Risk Associated With Acarbose Versus Metformin as the First-Line Treatment in Patients With Type 2 Diabetes: A Nationwide Cohort Study Institute of Preventive Medicine (C-H.C., S-T.C., L-M.C., M-S.L.), College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine (C-H.C., L-M.C.), Taipei, Taiwan; Department of Medicine (C-H.C., Y-C.C., J-W.L., L-M.C.), College of Medicine, National Taiwan University, Taipei, Taiwan; Search for other works by this author on: Graduate Institute of Medical Genomics and Proteomics (Y-C.C.), National Taiwan University, Taipei, Taiwan; National Taiwan University Hospital, Taipei, Taiwan; Department of Medicine (C-H.C., Y-C.C., J-W.L., L-M.C.), College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine (Y-C.C.), National Taiwan University Hospital, Hsin Chu Branch, HsinChu, Taiwan; Search for other works by this author on: Department of Medicine (C-H.C., Y-C.C., J-W.L., L-M.C.), College of Medicine, National Taiwan University, Taipei, Taiwan; Cardiovascular Center (J-W.L.), National Taiwan University Hospital, Yun-Lin Branch, Dou-Liou City, Yun-Lin County, Taiwan Continue reading >>

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  1. sharperhawk

    Chris Masterjohn explains the Arctic variant of CPT-1a deficiency. In an environment that forced humans living there to eat a high fat diet, evolution weighed the benefits and the risks of constant ketosis against each other.

  2. Neckhammer

    Yeah, I remember when this came out (not the video, but the gene mutation information) a few years back. I think that the point many made at the time was that the inuit have the capacity to burn FAT for energy at high rates due to this without having to survive indefinitely in deep ketosis. The selective pressures are obviously directly related to this region, so perhaps even the temperature and light/dark cycle played a role in selection. At the levels of fat they consume they would be in deep ketosis without this mutation. Deep ketosis is associated with a high degree of appetite suppression, which might be an issue in such an environment that requires high caloric intake to survive.
    I don't see the need for permanent deep ketosis aside from treatment. Episodic and sporatic? Of course. I'm on more of a gluconeogenic diet these days if I have to call it anything. Sure I'm in mild ketosis most the time, but I have plenty of protein about for when its needed!
    Edit: I just searched MDA and it seems mark recently posted on this:
    "Yet in the Inuit and other Arctic populations, these mutations are incredibly common. What’s going on here? Why was it preserved in the Inuit, let alone selected for?
    First of all, the gene variant doesn’t seem to be deleterious in adult Inuit. A number of studies have shown that Inuit with the mutation tend to have less body fat and better blood lipids, though the mutation is still dangerous in kids and babies.
    The mutation also makes it easier for carriers to burn free fatty acids in mitochondria. This is a good thing for a population like the Inuit on a traditional diet, because they’re swimming in free fatty acids and they aren’t able to produce ketones or eat enough carbohydrates for energy. Free fatty acids are everywhere. If you can use them more efficiently, you’ve got a great, reliable source of energy on demand.
    Without a mutation like this one, the Inuit would likely be in permanent, deep ketosis. That can be hugely therapeutic in the right context. Ketones can prevent and treat epilepsy, for example. But what if there is a problem with long-term ketosis? Given the high-fat nature of their diet, this mutation is the only thing standing between a traditionally-eating Inuit and chronic, unavoidable ketosis. The rise of this mutation may have been a way to stave off that possibility.
    In a roundabout way, ketone adaptation is a way for anyone not carrying the anti-ketotic genetic marker common among Inuit to obtain Inuit-type metabolism. Long term ketone adaptation leads to an increased ability of skeletal muscle to directly oxidize free fatty acids for energy; the Inuit with the mutation do that already."

  3. OnTheBayou

    I recall a discussion on FTA a couple of years ago about the discovery, IIRC, that marine mammals have a surprising amount of carbohydrates in the skin. The amount was sufficient to theoretically move their diet from ketogenic to low carb.

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