Jci -effects Of Dichloroacetate In The Treatment Of Hypoxic Lactic Acidosis In Dogs.
Effects of dichloroacetate in the treatment of hypoxic lactic acidosis in dogs. Find articles by Arieff, A. in: JCI | PubMed | Google Scholar First published September 1, 1985- More info Published in Volume 76, Issue 3 (September 1, 1985) J Clin Invest.1985;76(3):919923.doi:10.1172/JCI112090. Copyright 1985, The American Society for Clinical Investigation. The metabolic and systemic effects of dichloroacetate (DCA) in the treatment of hypoxic lactic acidosis were evaluated in the dog and compared with the infusion of equal quantities of volume and sodium. Hypoxic lactic acidosis was induced by ventilating dogs with an hypoxic gas mixture of 8% oxygen and 92% nitrogen, resulting in arterial PO2 of less than 30 mmHg, pH below 7.20, bicarbonate less than 15 mM, and lactate greater than 7 mM. After, the development of hypoxic lactic acidosis dogs were treated for 60 min with either DCA as sodium salt or NaCl at equal infusions of volume and sodium. Dogs treated with DCA showed a significant increase of arterial blood pH and bicarbonate, and steady levels of lactate, whereas NaCl resulted in further declines of blood pH and bicarbonate, and rising blood lactate levels. Overall lactate Continue reading >>