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Metabolic Acidosis Caused By Adrenaline

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If your friends acted like your pets, you might not keep them around. Bananas for president- https://www.youtube.com/watch?v=R4xXo... Facebook - http://facebook.com/fatawesome Episode 2 - https://www.youtube.com/watch?v=4fsSA... Outtakes - https://www.youtube.com/watch?v=7S6ww... Episode 3 - https://www.youtube.com/watch?v=iTYI7... Featured on Huffington Post: If Your Friends Acted like Your Pets. Seen on: The Today Show, CBS News, Forbes, The Boston Globe, Collegehumor, Ebaums, Cheezburger, The Boston Herald, and TastefullyOffensive Descriptions: If humans acted like cats and dogs, Why Dogs are Better than Cats, Cats versus Dogs, Cat Lovers and Dog Lovers, If humans acted like pets, cat people and dog people, cat people vs dog people, cat-people versus dog-people, humans acting like pets Cat- Jimmy Craig Dog- Justin Parker Filmed in Billerica, Massachusetts / Boston, Massachusetts Theme Song by Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/b...

The Strange Tale Of Muscle Lactate: When The Villain Becomes Your Friend

Follow all of ScienceDaily's latest research news and top science headlines ! The Strange Tale Of Muscle Lactate: When The Villain Becomes Your Friend Scientists add to the growing literature leading to a more complete understanding of the physiological role of lactic acid production in muscle. In an article published in The Journal of Physiology, Frank de Paoli and colleagues, working at the University of Aarhus in Denmark, add to the growing literature leading to a more complete understanding of the physiological role of lactic acid production in muscle. In the late 19th century, fermentation chemists realized that juice left to ferment without adequate oxygen resulted in acid products. Then, in the early 20th century, when physiologists stimulated isolated frog muscles to contract until exhaustion, they found that the tissues had accumulated high amounts of lactic acid. Since then, the idea that lactic acid accumulation causes muscle fatigue has persisted. But did early scientists fail to address the various issues adequately and interpret the results appropriately? Did they fail to ask the essential question? "Why does nature make lactic acid?", and did they in effect put one Continue reading >>

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Popular Questions

  1. dolby

    WalMart's ReliOn Ultima Reliable?

    I bought WalMart's ReliOn Ultima BG monitor since their strips are among the cheapest. (I have a prescription for Freestyle Lite, but can't get enough strips to test as much as I want.)
    They're both manufactured by Abbott Labs, but ReliOn's lancet device is big and unwieldy. If you're trying to draw blood from either hand, you should be able to hold and fire with one hand. It also slips away sometimes because it's circular (not rectangular).
    The strips are all individually packaged. So in order not to kill any time, you have to remove the strips from the package, then insert them half way to the monitor, then stab your finger, then draw blood, ensure you have enough blood or milk to get some more. Too many steps are involved here. If you stab and then try to remove the strip from the package, you risk having your blood smudged. It's too easy to botch the process and waste strips.
    I've graduated to using Freestyle Lite's lancet device with ReliOn. The strips, however, require more blood than Freestyle's simple black & white strips. You can actually see the blood travelling through the strip to its destination. However, the distance is too long and this often requires milking and oozing blood from the prick. When not enough blood comes out, you have to stab yourself elsewhere. I noticed that if you botch a stab and have to draw blood from another location, the reading frequently will be faulty and unusally low (like 34, 41, 57).
    One other thing: the numbers sometimes seem wildly off. I don't have Freestyle's strips to confirm these numbers. But do people find ReliOn to be Reliable? Dr. Bernstein's office only recommends Accucheck's Aviva. Do people find Aviva to be more accurate than Freestyle Lite or Relion Ultima?

  2. drewgolden

    Originally Posted by dolby
    One other thing: the numbers sometimes seem wildly off. I don't have Freestyle's strips to confirm these numbers. But do people find ReliOn to be Reliable? Dr. Bernstein's office only recommends Accucheck's Aviva. Do people find Aviva to be more accurate than Freestyle Lite or Relion Ultima? Yes, I have found the Relion Ultima to be VERY accurate. It is Abbot's BEST meter technology - and if you live in the UK you get the same great meter with 1/2 the blood required.
    The Freestyle Lite is my personal favorite - only because of the night light / test stip run way light - and code free strips. The Ultima requires coding - sticking the wand in with each pack of strips. And I did not like all of the waste the foil wrappers creates.
    -but- The ultima is more consistent than the Freestyle lite - shocking.
    I have tested all of the Accucheck meters and have found them to have the widest variability in testing. Plus the LARGEST test strips. I know there are a lot of people in the UK in love with it - it's just not got my heart.
    drew

  3. HarleyGuy

    I think the Multiclix(Accuchek) lancet device is the best for me. Really painless for the most part. You can buy it for $20 or so, but I just contacted Roche and asked for one and they gladly sent one. Of course, they now have given me one and I will have to buy the drum of lancets to use it. Smart move on their part.

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This goes into detail about the kind of test you can expect to take for your pre-op for any kind of weight loss surgery. Be sure to visit our blog at http://bypassprincess.com

Epinephrine-induced Lactic Acidosis Following Cardiopulmonary Bypass

Objective To determine if lactic acidosis occurring after cardiopulmonary bypass could be attributed to the metabolic or other effects of epinephrine administration. Setting Postsurgical cardiothoracic intensive therapy unit. Patients Thirty-six adult patients, without acidosis, requiring vasoconstrictors for the management of hypotension after cardiopulmonary bypass. Interventions Randomized administration of either epinephrine or norepinephrine by infusion. Measurements and Main Results Hemodynamic and metabolic data were collected before commencement of vasoconstrictor therapy (time 0) and then 1 hr (time 1), 6 to 10 hrs (time 2), and 22 to 30 hrs (time 3) later. Six of the 19 patients who received epinephrine developed lactic acidosis. None of the 17 patients receiving norepinephrine developed lactic acidosis. In the epinephrine group, but not in the norepinephrine group, lactate concentration increased significantly at times 1 and 2 (p = .01), while pH and base excess decreased (p Continue reading >>

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  1. <7%

    Do Ketogenic Diets Slow Metabolism?

    I have had insomnia for close to two decades and amazingly, very few things helped as much as a keto diet. At first, I thought this was odd but later I read about many other people who had better sleep while on KETO. Also, I read somewhwere -may be on Lyle's board- that KETO diets slow down the metabolism via reduction in T3 and T4 secretion and this is one of the reasons they help you preserve muscle mass. So is this true? Do they actually decrease T3 and T4 levels? If not, what is the better sleep attributable to?
    Sub7

  2. Eileen

    I don't think keto diets slow metabolism any more than other diets, and probably less, since it preserves muscle better, which works to keep up the metabolism.
    I've also found I sleep better in keto, and wake constantly when I'm doing a carb-up. I think it's just the effect of the insulin spikes and dips that wake me up when I eat carbs, rather than something special about keto.

  3. leenmeen

    Eileen, you might be interested in this: beneficial effect of keto diet on the sleep disorder narcolepsy has been reported in the medical literature:
    ---
    Husain AM, et al. Diet therapy for narcolepsy. Neurology, 22 June 2004; 62 (12): 2300-2302
    Abstract�
    The effects of a low-carbohydrate, ketogenic diet (LCKD) on sleepiness and other narcolepsy symptoms were studied. Nine patients with narcolepsy were asked to adhere to the Atkins� diet plan, and their symptoms were assessed using the Narcolepsy Symptom Status Questionnaire (NSSQ). The NSSQ�Total score decreased by 18% from 161.9 to 133.5 (p = 0.0019) over 8 weeks. Patients with narcolepsy experienced modest improvements in daytime sleepiness on an LCKD.
    Narcolepsy is a syndrome characterized by excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, and hypnagogic hallucinations. However, despite optimal pharmacologic management, daytime sleepiness persists in many patients. The effect of diet on the sleep�wake cycle in narcolepsy has not been studied in detail. We examined the effect of a low-carbohydrate, ketogenic diet (LCKD) on daytime sleepiness in patients with narcolepsy already on optimal doses of stimulant medications.
    Methods.
    Patients were recruited from the narcolepsy clinic at the Veterans Affairs Medical Center, Durham, NC. Inclusion criteria consisted of a diagnosis of narcolepsy with continued daytime sleepiness despite optimal stimulant therapy. Narcolepsy was defined as the presence of EDS with either unequivocal cataplexy or presence of at least two sleep-onset REM periods on a Multiple Sleep Latency Test (MSLT). 1 Additionally, patients had to have a body mass index (BMI) of at least 20 kg/m2 and agree to modify their diet per instructions. Patients were excluded if they were pregnant or nursing or had a serious medical condition.
    Diet instructions for the LCKD were derived from a popular lay press book, Dr. Atkins� New Diet Revolution. 2 Patients were instructed to restrict carbohydrate intake to <20 g/day. They were advised to take a standard multivitamin and drink copious fluids daily. Follow-up group visits occurred every other week for 8 weeks. Patients were instructed not to change their stimulant medication dosage.
    Sleepiness was measured at baseline and weeks 2, 4, and 8 using three validated self-administered scales: the Narcolepsy Symptoms Severity Questionnaire (NSSQ), the Epworth Sleepiness Scale (ESS), and the Stanford Sleepiness Scale (SSS). 3,4 Adherence to the diet intervention was measured by self-report and urinary ketones. Patients self-monitored urine ketone levels with dipsticks at the same time daily using the following semiquantitative scale: 0 = none, 1 = trace (up to 5 mg/dL), 2 = small (5 to 40 mg/dL), 3 = moderate (40 to 80 mg/dL), 4 = large-80 (80 to 160 mg/dL), 5 = large-160 (>160 mg/dL). The mean level of urine ketones for each week was calculated for each patient. Weight and vital signs were measured at each visit. A fasting lipid profile and routine serum chemistries were obtained at baseline and study termination.
    Linear mixed-effects models, with a random intercept and time (i.e., week) as a fixed effect, were used to analyze the effect of the diet on sleepiness symptoms as measured by the NSSQ, ESS, and SSS. Paired t-tests, or Wilcoxon signed-rank tests where appropriate, were used to compare baseline to week 8 vital and laboratory measurements for the eight participants who completed the study. A p value of <=0.05 was considered significant. Analyses were performed using SAS Statistical Software (version 8.02; SAS Institute, Cary, NC).
    Results.
    Nine patients were recruited for the study. The mean � SD age was 47.6 � 10.9 years; eight were men, seven were African American, two were Caucasian. The mean body weight at baseline was 100.9 � 19.8 kg, and the mean BMI was 32.8 � 6.9 kg/m2. One subject dropped out after 4 weeks owing to inability to adhere to the diet.
    Significant improvements were seen on the NSSQ�Total score and the following subscales: Sleepiness, Sleep Attacks, and Sleep Paralysis (table;figure 1). The Total score on the NSSQ decreased by 18% from 161.9 at baseline to 133.5 at week 8 (p = 0.0019). In addition, the Sleepiness Subscale score decreased by 22% from 51.0 to 39.6 (p = 0.017), the Sleep Attacks Subscale score decreased by 13% from 46.0 to 40.0 (p = 0.016), and the Sleep Paralysis Subscale score decreased by 24% from 21.1 to 16.0 (p = 0.015). The ESS and SSS did not change significantly over the 8-week duration of the study.
    Graphic
    Table Predicted scores* on sleep questionnaires
    Graphic
    Figure 1. Predicted mean scores of Narcolepsy Symptom Status Questionnaire (NSSQ) subscales by linear mixed-effects model. Diamonds = Sleepiness; squares = Sleep Attacks; triangles = Cataplexy; x�s = Sleep Paralysis; circles = Vivid Dreams.
    The mean number of days since the previous visit that participants were not adherent to the diet increased from 0.3 � 0.5 day at week 2 to 1.3 � 1.3 days at week 8. The mean urine ketone levels by self-testing increased from 0 at baseline to 2.8 � 0.6 at week 1, peaked at 3.7 � 0.9 at week 2, and declined gradually to a plateau at 2.8 � 1.1 at week 8 (figure 2). Over the 8 weeks, body weight decreased from 99.3 � 20.7 kg at baseline to 92.2 � 19.8 kg (p < 0.0001). No adverse changes were noted in blood pressure, serum lipid profiles, or serum chemistry tests.
    Graphic
    Figure 2. Mean (SE) urine ketone levels for each week (n = 9 for weeks 0 to 4, n = 8 for weeks 5 to 8). Urine ketone scale: 0 = none, 1 = trace (up to 5 mg/dL), 2 = small (5 to 40 mg/dL), 3 = moderate (40 to 80 mg/dL), 4 = large-80 (80 to 160 mg/dL); 5 = large-160 (>160 mg/dL).
    There were no serious adverse events reported during this study. Four patients (44%) had transient side effects (headache, leg cramps, irritability, and difficulty with concentration); however, none was severe enough to prompt discontinuation of the study or the diet. No patient reported a worsening of daytime sleepiness.
    Discussion.
    EDS is often debilitating for patients with narcolepsy. Many patients continue to experience daytime sleepiness despite the optimal use of stimulant medications. Another treatment commonly recommended to narcolepsy patients is dietary modification, even though its effect has not been studied prospectively.
    In the current study, dietary modification resulted in significant improvements of narcolepsy symptoms as measured by the NSSQ. The NSSQ�Total score decreased by 18% after 8 weeks of treatment, whereas the Sleepiness Subscale score decreased by 22%, Sleep Attacks Subscale by 13%, and Sleep Paralysis Subscale by 24%.
    Serum ketones are one potential mechanism for the observed effect on narcolepsy symptoms, although the pathway involved has not been identified. Urinary ketones were highest in the first 2 weeks and then decreased somewhat to plateau at week 8. A similar pattern of ketonuria with this diet has been noted previously. 5 The most likely reason for the gradual decline in urine ketones is that subjects increased their carbohydrate intake. Alternatively, it is possible that the body adjusts physiologically to reduced carbohydrate intake.
    Another intriguing mechanism to consider involves the role of orexin (hypocretin). Patients with narcolepsy have been shown to have impaired orexin signaling. 6 Hypoglycemia tends to activate orexin-containing neurons. 7 It is possible that the LCKD, by inducing relative hypoglycemia (blood glucose lower than baseline), increases the activation of orexin-containing neurons, which in turn improves daytime sleepiness.
    Dietary effects on sleep and fatigue have been evaluated in other situations. In one study, volunteers without a sleep disorder who consumed a high-carbohydrate, low-fat diet spent less time in slow wave sleep than those who consumed either a balanced or a low-carbohydrate, high-fat diet. 8 In a review of occupational sleep and fatigue, the authors noted that simple carbohydrates produce a transient increase in alertness, followed by a decrease in alertness after a few hours. 9 These studies support the view that diet influences sleep and that carbohydrates may exacerbate sleepiness in certain individuals.
    One possible limitation of this study was the method used to measure daytime sleepiness. The gold standard for measuring the degree of daytime sleepiness is the MSLT. This test was not employed for this study because of the considerable cost and time required for its use. It can be argued that daytime alertness may have improved because of decreases in body weight. As this variable was not controlled in this study, it remains a possibility, although benefits were noted by patients early in the study before substantial weight loss occurred. Though this study suggests that dietary therapy may improve daytime sleepiness, a randomized trial with a comparison intervention is needed to determine if weight loss or other factors contributed to the observed improvements in sleepiness symptoms.

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Mild Metabolic Acidosis Impairs The -adrenergic Response In Isolated Human Failing Myocardium

Mild metabolic acidosis impairs the -adrenergic response in isolated human failing myocardium Schotola et al.; licensee BioMed Central Ltd.2012 Pronounced extracellular acidosis reduces both cardiac contractility and the -adrenergic response. In the past, this was shown in some studies using animal models. However, few data exist regarding how the human end-stage failing myocardium, in which compensatory mechanisms are exhausted, reacts to acute mild metabolic acidosis. The aim of this study was to investigate the effect of mild metabolic acidosis on contractility and the -adrenergic response of isolated trabeculae from human end-stage failing hearts. Intact isometrically twitching trabeculae isolated from patients with end-stage heart failure were exposed to mild metabolic acidosis (pH 7.20). Trabeculae were stimulated at increasing frequencies and finally exposed to increasing concentrations of isoproterenol (0 to 1 10-6 M). A mild metabolic acidosis caused a depression in twitch-force amplitude of 26% (12.1 1.9 to 9.0 1.5 mN/mm2; n = 12; P < 0.01) as compared with pH 7.40. Force-frequency relation measurements yielded no further significant differences of twitch force. At the m Continue reading >>

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  1. serrelind

    > Does sugar alcohol kick you out of ketosis?

    Welcome to the Active Low-Carber Forums
    Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

  2. Dustin

    It doesn't effect my ketosis.

  3. Paradox

    i think (and others may correct me if i'm wrong) that sugar alcohol is like regular alcohol in that even though it doesn't prevent weight loss, it slows it, because while it is available in your body, your body will burn it for fuel instead of your fat stores. but don't take that as gospel (its not as if i'm Nat or something! *wink*)

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