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Metabolic Acidosis Caused By Adrenaline

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Anion gap usmle - anion gap metabolic acidosis normal anion gap metabolic acidosis

What Is Metabolic Acidosis?

Metabolic acidosis happens when the chemical balance of acids and bases in your blood gets thrown off. Your body: Is making too much acid Isn't getting rid of enough acid Doesn't have enough base to offset a normal amount of acid When any of these happen, chemical reactions and processes in your body don't work right. Although severe episodes can be life-threatening, sometimes metabolic acidosis is a mild condition. You can treat it, but how depends on what's causing it. Causes of Metabolic Acidosis Different things can set up an acid-base imbalance in your blood. Ketoacidosis. When you have diabetes and don't get enough insulin and get dehydrated, your body burns fat instead of carbs as fuel, and that makes ketones. Lots of ketones in your blood turn it acidic. People who drink a lot of alcohol for a long time and don't eat enough also build up ketones. It can happen when you aren't eating at all, too. Lactic acidosis. The cells in your body make lactic acid when they don't have a lot of oxygen to use. This acid can build up, too. It might happen when you're exercising intensely. Big drops in blood pressure, heart failure, cardiac arrest, and an overwhelming infection can also cau Continue reading >>

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  1. Liza20

    I have always been big but in 2006 I went up to 130kg by 2009 my body was very stressed
    My doctor and dietitian said that I had the signs of prediabetes even if my blood sugar was normal
    I lost 30kg then gained 10 back by last year.
    Been LCHF since jan and down 14kg
    My blood sugar is 4.8 so my doctor says I'm not prediabetic
    but I got some ketone sticks and if I eat sugar then I go out of ketosis
    Also if I eat sweets etc then I get very tired and dizzy or headache
    the next morning my joints are sore and the soles of my feet are swollen and sore
    am I prediabetic or maybe pushed my body too far and now have a sensitivity to sugar?
    Is there a difference?
    Thank you

  2. Alison Campbell

    Hi @Liza20 was the 4.8 a HBA1C test? I think anyone diabetic or not will get out of ketosis if they eat sugar.Is there any reason why you don't want to stick with LCHF
    I think if you are in ketosis you need to gently come out as your body will not be able to cope with huge changes so quickly and you will feel rough. A bit like keto flu in reverse
    If your doctor says you are not prediabetic anymore then you have greatly reduced the risk of type 2 at this time but keep an eye on any weight gain and make sure you have lab blood tests at least annually.

  3. Totto

    4.8 is a perfectly normal blood sugar level. Have you tested after a fall off the low carb wagon?
    Many non-diabetics on LCHF have similar experiences to yours, feeling very ill after eating carbs, both sugar and starch.
    Well done on your weight loss!

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Epinephrine-induced Lactic Acidosis Following Cardiopulmonary Bypass

Objective To determine if lactic acidosis occurring after cardiopulmonary bypass could be attributed to the metabolic or other effects of epinephrine administration. Setting Postsurgical cardiothoracic intensive therapy unit. Patients Thirty-six adult patients, without acidosis, requiring vasoconstrictors for the management of hypotension after cardiopulmonary bypass. Interventions Randomized administration of either epinephrine or norepinephrine by infusion. Measurements and Main Results Hemodynamic and metabolic data were collected before commencement of vasoconstrictor therapy (time 0) and then 1 hr (time 1), 6 to 10 hrs (time 2), and 22 to 30 hrs (time 3) later. Six of the 19 patients who received epinephrine developed lactic acidosis. None of the 17 patients receiving norepinephrine developed lactic acidosis. In the epinephrine group, but not in the norepinephrine group, lactate concentration increased significantly at times 1 and 2 (p = .01), while pH and base excess decreased (p Continue reading >>

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  1. AlexBest96

    Hi guys! Could someone answer how does acetoacetate change the pH? I mean, if it is released in ionized form (COO-) how can it change the pH of blood? I cant understand, where does it get protonized? Sorry for my English

  2. Dr. Stalker

    Ketone bodies can contribute to blood pH changes. Specifically, they acidify the blood by donating protons. In organic chemistry/biochemistry you'll learn that a substance doesn't necessarily need to have a -COOH to have acidic properties. It just so happens the hydrogen in the -COOH is very acidic and there's many reasons why. Without diving into all of those, the H in -OH can sometimes be acidic.
    To answer your question specifically about ketones, look at the carboxyl group. If we look at the carbons attached to the carbon that is double bonded to the oxygen, we have an opportunity for resonance. If we deprotonate the carbon adjacent to the carbon in the ketone functional group, those electrons can form a double bond to the carbon and push the one of the double bonds onto the oxygen leading to resonance stability.
    I unfortunately couldn't find a better image than this one (ignore the fact that this has two ketone functional groups)

  3. AlexBest96

    Dr. Stalker, so ketones are not protonized in mitochondria and get in blood in COOH form? they change the pH in ionized form by the mechanism, which you explain?

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The Strange Tale Of Muscle Lactate: When The Villain Becomes Your Friend

Follow all of ScienceDaily's latest research news and top science headlines ! The Strange Tale Of Muscle Lactate: When The Villain Becomes Your Friend Scientists add to the growing literature leading to a more complete understanding of the physiological role of lactic acid production in muscle. In an article published in The Journal of Physiology, Frank de Paoli and colleagues, working at the University of Aarhus in Denmark, add to the growing literature leading to a more complete understanding of the physiological role of lactic acid production in muscle. In the late 19th century, fermentation chemists realized that juice left to ferment without adequate oxygen resulted in acid products. Then, in the early 20th century, when physiologists stimulated isolated frog muscles to contract until exhaustion, they found that the tissues had accumulated high amounts of lactic acid. Since then, the idea that lactic acid accumulation causes muscle fatigue has persisted. But did early scientists fail to address the various issues adequately and interpret the results appropriately? Did they fail to ask the essential question? "Why does nature make lactic acid?", and did they in effect put one Continue reading >>

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Popular Questions

  1. simonsaysnono

    If you can, please give the examples of kinds of fruits (berries) and what would be a good amount per day. My friend has just started keto and is wondering if she has to give up fruits at all.

  2. scira

    yes, but you need to treat it like candy, because on keto that's essentially what it is.

  3. simonsaysnono

    yeah, just sometimes people eat too much candy :)

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