Dichloroacetate In The Treatment Of Lactic Acidosis.
1. Ann Intern Med. 1988 Jan;108(1):58-63. Dichloroacetate in the treatment of lactic acidosis. Stacpoole PW(1), Lorenz AC, Thomas RG, Harman EM. (1)Department of Medicine, University of Florida, Gainesville. An open, prospective evaluation of the effects of dichloroacetate on morbidityand survival time was done in 29 pediatric and adult patients with lacticacidosis. Dichloroacetate was administered intravenously over 30 minutes as two50 mg/kg body weight doses separated by 2 hours. Five patients underwentretreatment with two additional drug doses and were considered new cases whenanalyzing for treatment response. Survival, however, was determined from the timeof initial entry into the study. Patients were considered to respond to treatmentif arterial lactate concentration decreased at least 20% from the pretreatmentlevel within 6 hours of beginning the first dichloroacetate infusion. Using this criterion, 26 cases responded to therapy with dichloroacetate. For all cases,patients' mean arterial lactate concentration decreased 52% (P = 0.0009),arterial bicarbonate concentration increased 35% (P = 0.0003), and arterial pHincreased (P = 0.024) to normal, defined as the range 7.35 to 7 Continue reading >>