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Lactic Acidosis Ncbi

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Lactic Acidosis Induced By Metformin: Incidence, Management And Prevention.

Abstract Lactic acidosis associated with metformin treatment is a rare but important adverse event, and unravelling the problem is critical. First, this potential event still influences treatment strategies in type 2 diabetes mellitus, particularly in the many patients at risk of kidney failure, in those presenting contraindications to metformin and in the elderly. Second, the relationship between metformin and lactic acidosis is complex, since use of the drug may be causal, co-responsible or coincidental. The present review is divided into three parts, dealing with the incidence, management and prevention of lactic acidosis occurring during metformin treatment. In terms of incidence, the objective of this article is to counter the conventional view of the link between metformin and lactic acidosis, according to which metformin-associated lactic acidosis is rare but is still associated with a high rate of mortality. In fact, the direct metformin-related mortality is close to zero and metformin may even be protective in cases of very severe lactic acidosis unrelated to the drug. Metformin has also inherited a negative class effect, since the early biguanide, phenformin, was associat Continue reading >>

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Popular Questions

  1. Jennifer72

    Breathalyzer ($13) for testing breath ketones

    Turns out these things really do work. I have a $13 Greenwon breathalyzer I just bought off Amazon and its readout jives with the Ketonix I have along with my Precision Xtra blood ketone meter.
    Here's a link with more details of the comparison I did -- it's a response to the thread I read where I got this whole idea :
    https://www.ketogenicforums.com/t/te...3?u=jennifer72
    Note: make sure to quickly breath out, into the breathalyzer, all the air in your lungs to where you are straining to exhale that last bit -- all in the short time it allows you. Don't take a deep breath before exhaling into the meter, just breath normally as if you were reading a book -- the highest concentration of acetone is at the tail of the breath anyways.
    Link to the meter I got -- it's $13 after the discount is applied in the cart:
    https://www.amazon.com/gp/product/B00J21HL64

  2. CalgaryDiabetic

    Sounds like a worthwhile product.

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