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Lactic Acidosis Ncbi

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Dichloroacetate In The Treatment Of Lactic Acidosis.

1. Ann Intern Med. 1988 Jan;108(1):58-63. Dichloroacetate in the treatment of lactic acidosis. Stacpoole PW(1), Lorenz AC, Thomas RG, Harman EM. (1)Department of Medicine, University of Florida, Gainesville. An open, prospective evaluation of the effects of dichloroacetate on morbidityand survival time was done in 29 pediatric and adult patients with lacticacidosis. Dichloroacetate was administered intravenously over 30 minutes as two50 mg/kg body weight doses separated by 2 hours. Five patients underwentretreatment with two additional drug doses and were considered new cases whenanalyzing for treatment response. Survival, however, was determined from the timeof initial entry into the study. Patients were considered to respond to treatmentif arterial lactate concentration decreased at least 20% from the pretreatmentlevel within 6 hours of beginning the first dichloroacetate infusion. Using this criterion, 26 cases responded to therapy with dichloroacetate. For all cases,patients' mean arterial lactate concentration decreased 52% (P = 0.0009),arterial bicarbonate concentration increased 35% (P = 0.0003), and arterial pHincreased (P = 0.024) to normal, defined as the range 7.35 to 7 Continue reading >>

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  1. AbbaZabba

    OK So I was trying to learn more about Ketosis and came across a forum where a guy claimed you could reach ketosis in just 24hours of water fasting. I really wish I could start it right now but I already had a cliff bar today so I may not start this until this weekend but here is what you do.
    - The day before you want to start your water fast you eat only fruit, so that is the only carbs and glucose in your system. He says to preferably eat it for 2-3 days in advance.
    - On Day 1 of the fast you drink 8oz of orange juice and then you walk for 2-3 hours or around 5-6.5 miles. He claims this will burn all of your carb reserves and go directly into ketosis by the next morning.
    - After the first day you do not exercise and just continue on to the normal water only fast.
    I need a weekend day to be able to walk around for 3 continuos hours & a few days planning so I think I am going to try and start fruit fasting tomorrow or Thursday and then start the fast Saturday. I really want to get into Ketosis for awhile because I have plenty of fat to burn. I am also a highly toxic person and I know this so it would be nice to really flush stuff out.
    If anyone wants to trade kik names & join me this weekend hit me up!
    Here is the link where I found this stuff: http://www.stevepavl...s-24-hours.html

  2. Caliico

    Sounds a little complicated? You will reach ketosis within 24-48h by simply water fasting.

  3. xoxomelodie

    Yeah it's not a big secret. It's very easy after a day of fasting. Heck the hours of walking sound terrible to me. Maybe 30 mns of running or on the elliptical while fasting. Also, depending on how long you're planning on water fasting, you will barely be able to do anything and you will lose all muscle mass. Plus fasting/juicing does not make you detoxify.
    I mean, don't get me wrong. I've done this before successfully so you will shed weight but better have the facts. And if you ever feel you're getting too weak, just remember just some protein and fat can go a long way in strengthening your resolve and it will not ruin the diet.

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Lactate Versus Non-lactate Metabolic Acidosis: A Retrospective Outcome Evaluation Of Critically Ill Patients

Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients 1Assistant Professor, VCURES (Virginia Commonwealth University Reanimation Engineering Shock Center) Laboratory, Departments of Anesthesiology/Critical Care and Emergency Medicine, Medical College of Virginia/Virginia Commonwealth University, 1200 East Broad Street, Richmond, VA, 23298, USA 2Director, Clinical Research Informatics Service, University of Pittsburgh, 450 Scaife Hall, 200 Lothrop St. Pittsburgh, PA, 15213, USA 3Research Assistant, Department of Biostatistics, University of Pittsburgh, Graduate School of Public Health, Crabtree Hall, Pittsburgh, PA, 15213, USA 4Professor, CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute illness) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 608, Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA 1Assistant Professor, VCURES (Virginia Commonwealth University Reanimation Engineering Shock Center) Laboratory, Departments of Anesthesiology/Critical Care and Emergency Medicine, Medical College of Virginia/Virginia Commonwealth University, 1200 East Broad Street, Richmond, Continue reading >>

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Popular Questions

  1. Flavorbaby13

    So I've got the keto eating down! I've already lost over 97 pounds! I'm currently 147.6 pounds, 5'5.5" and I'm eating at 1,000 calories a day and staying under 20g if net carbs. I usually am around 85-100 g of protein a day, but I have this stubborn belly fat I'm trying to get rid of! What's your best advice to get rid of it? Currently I am not doing any exercise, besides my 10,000+ steps at work a day. Does any have maybe a beginners Ab workout to get rid of this tummy?!?!?

  2. Maurodamia

    It's simply not possible to target fat loss. It goes when it goes, mid section being typically the last thing to go if you hang in there and go all the way.

  3. lessthanjoey

    Keep losing fat. I find intermittent fasting to help, but nothing targets.

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[metabolic Acidosis].

G Ital Nefrol. 2016 Nov-Dec;33(6). pii: gin/33.6.1. Regolisti G , Fani F , Antoniotti R , Castellano G , Cremaschi E , Greco P , Parenti E , Morabito S , Sabatino A , Fiaccadori E . Metabolic acidosis is frequently observed in clinical practice, especially among critically ill patients and/or in the course of renal failure. Complex mechanisms are involved, in most cases identifiable by medical history, pathophysiology-based diagnostic reasoning and measure of some key acid-base parameters that are easily available or calculable. On this basis the bedside differential diagnosis of metabolic acidosis should be started from the identification of the two main subtypes of metabolic acidosis: the high anion gap metabolic acidosis and the normal anion gap (or hyperchloremic) metabolic acidosis. Metabolic acidosis, especially in its acute forms with elevated anion gap such as is the case of lactic acidosis, diabetic and acute intoxications, may significantly affect metabolic body homeostasis and patients hemodynamic status, setting the stage for true medical emergencies. The therapeutic approach should be first aimed at early correction of concurrent clinical problems (e.g. fluids and hem Continue reading >>

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Popular Questions

  1. zerogs

    Reintroducing carbs after keto

    I've seen that the biggest problem people talk about when they come off a keto diet and add carbs back into their diet is that they have a lot of rapid fat gain, as well as water weight. But it seems that in a lot of cases they were going from a cut on keto to bulking, so they increased their calories at the same time as adding carbs back in. Then the recommendations were to slowly add carbs in, anywhere from 20-50g per week, usually pre or postworkout first.
    If a person were to add carbs back in without the slow incrementation, wouldn't it be possible to do so without the fat gain as long as calories were still kept in a deficit? I'd still expect there to be water weight gained, but wouldn't that still avoid gaining fat? Would it help even more to increase cardio and to add something like ALA to the higher carb meals and slowly taper that off?

  2. lth

    Originally Posted by zerogs
    I've seen that the biggest problem people talk about when they come off a keto diet and add carbs back into their diet is that they have a lot of rapid fat gain, as well as water weight. But it seems that in a lot of cases they were going from a cut on keto to bulking, so they increased their calories at the same time as adding carbs back in. Then the recommendations were to slowly add carbs in, anywhere from 20-50g per week, usually pre or postworkout first.
    If a person were to add carbs back in without the slow incrementation, wouldn't it be possible to do so without the fat gain as long as calories were still kept in a deficit? I'd still expect there to be water weight gained, but wouldn't that still avoid gaining fat? Would it help even more to increase cardio and to add something like ALA to the higher carb meals and slowly taper that off?

    Most of the time they freak out too. Usually on keto you always have that dry and lean appearance; carbs pull water into the muscle and underneath the skin and people mistake that for fat gain, when you've been on keto for a while your body will pull in as much of the carbs as it can until it adjusts. So, maybe start out at 100g and work your way up.

  3. biggabriel

    Originally Posted by lth
    Most of the time they freak out too. Usually on keto you always have that dry and lean appearance; carbs pull water into the muscle and underneath the skin and people mistake that for fat gain, when you've been on keto for a while your body will pull in as much of the carbs as it can until it adjusts. So, maybe start out at 100g and work your way up.

    Good advise. The first 2 weeks at elast will all be water. Your face will blow up like a watermelon if you don't go easy. Thats a big reason why I don't advocate a total keto diet, even for comps.
    Make sure all the cabs you have are complex carbs too. No sugars, or you'll be getting wicked insulin spikes that will just put you to sleep.

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