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Lactic Acidosis Causes

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https://www.facebook.com/drinkhealthy... - Do you want to learn how to get rid of lactic acid as an athlete, and start recovering quicker with more energy? Learn how to reduce lactic acid symptoms and increase your performance. Getting rid of lactic acid may be easier than you have imagined. Many professional athletes know the importance of eliminating lactic acid so they can recover quicker and perform at an optimal level. Start flushing out that lactic acid today! Many people suffer from lactic acidosis symptoms and are rigorously searching for a lactic acid treatment. More and more athletes are searching for solutions on how to get rid of lactic acid. In this video you will learn what a professional football player from the Seattle Seahawks is using to eliminate lactic acid after his workouts, practices, and NFL games. Learn how to make lactic acid a symptom of the past. Begin your journey to faster recovery today. See what the pro's are using to reduce lactic acid, recover quicker, and have more energy. Uncertain of what lactic is? Here is the definition https://en.wikipedia.org/wiki/Lactic_... Contact me for more information on getting rid of lactic acid FB: http://www.faceboo

Lactic Acidosis: Background, Etiology, Epidemiology

Author: Kyle J Gunnerson, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM more... In basic terms, lactic acid is the normal endpoint of the anaerobic breakdown of glucose in the tissues. The lactate exits the cells and is transported to the liver, where it is oxidized back to pyruvate and ultimately converted to glucose via the Cori cycle. In the setting of decreased tissue oxygenation, lactic acid is produced as the anaerobic cycle is utilized for energy production. With a persistent oxygen debt and overwhelming of the body's buffering abilities (whether from chronic dysfunction or excessive production), lactic acidosis ensues. [ 1 , 2 ] (See Etiology.) Lactic acid exists in 2 optical isomeric forms, L-lactate and D-lactate. L-lactate is the most commonly measured level, as it is the only form produced in human metabolism. Its excess represents increased anaerobic metabolism due to tissue hypoperfusion. (See Workup.) D-lactate is a byproduct of bacterial metabolism and may accumulate in patients with short-gut syndrome or in those with a history of gastric bypass or small-bowel resection. [ 3 ] By the turn of the 20th century, many physicians recognized that patien Continue reading >>

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  1. LWYZYKOWSKI

    I find that testing at night my sticks are much darker. I also read in ATkins to test later in the day. Often in the AM the sticks are the lightest for me.
    However, I dont understand how my sticks are turning, butI dont seem to be losing very fast. It might be just water retention.. I hope!

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  2. XANADUREALM

    Gigi, thanks for the valuable info on Ketosis.
    Everyone should consider several things before giving up drinking the water. First, test first thing in the morning before eating or drinking anything. Second, give up all artificial sweetners or things with them it it. If you are still not in ketosis after a few days, then look at what carbs you have been consuming. Maybe you are one of those people who are very carb sensitive. Try a couple of day with meat, eggs and green veggies.
    As the article says make sure your sticks are fresh.
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  3. GIGIX068

    I was under the understanding that the ketostix will not measure accurately when we drink a lot of water. Your urine is too diluted to get a good result. I test in the morning.
    Here is a copy and paste with a lot more information than you asked for--but it might be helpful. After I read it I understood that because of the volume of water I drink that it is not registering but I am still in ketosis.
    What are ketones?
    Ketones are a normal and efficient source of fuel and energy for the human body. They are produced by the liver from fatty acids, which result from the breakdown of body fat in response to the absence of glucose/sugar. In a ketogenic diet, such as Atkins ... or diets used for treating epilepsy in children, the tiny amounts of glucose required for some select functions can be met by consuming a minimum amount of carbs - or can be manufactured in the liver from PROTEIN. When your body is producing ketones, and using them for fuel, this is called "ketosis".
    How will ketosis help me to lose weight?
    Most reducing diets restrict calorie intake, so you lose weight but some of that is fat and some of it is lean muscle tissue as well. Less muscle means slowed metabolism, which makes losing weight more difficult and gaining it back all too easy. Ketosis will help you to lose FAT.
    Being in ketosis means that your body's primary source of energy is fat (in the form of ketones). When you consume adequate protein as well, there's no need for the body to break down its muscle tissue. Ketosis also tends to accelerate fat loss --- once the liver converts fat to ketones, it can't be converted back to fat, and so is excreted.
    But, isn't ketosis dangerous?
    Being in ketosis by following a low carbohydrate diet is NOT dangerous. The human body was designed to use ketones very efficiently as fuel in the absence of glucose. However, the word ketosis is often confused with a similar word, ketoacidosis.
    Ketoacidosis is a dangerous condition for diabetics, and the main element is ACID not ketones. The blood pH becomes dangerously acidic because of an extremely high blood SUGAR level (the diabetic has no insulin, or doesn't respond to insulin .... so blood sugar rises ... ketones are produced by the body to provide the fuel necessary for life, since the cells can't use the sugar). It's the high blood sugar, and the acid condition that is so dangerous. Ketones just happen to be a part of the picture, and are a RESULT of the condition, not the CAUSE. Diabetics can safely follow a ketogenic diet to lose fat weight ... but they must be closely monitored by their health care provider, and blood sugars need to be kept low, and stable.
    How do the ketone test strips work, and where can I get them?
    Ketone urine-testing strips, also called Ketostix or just ketone sticks ... are small plastic strips that have a little absorptive pad on the end. This contains a special chemical that will change colour in the presence of ketones in the urine. The strips may change varying shades of pink to purple, or may not change colour at all. The container will have a scale on the label, with blocks of colour for you to compare the strip after a certain time lapse, usually 15 seconds. Most folks simply hold a strip in the flow of urine. Other folks argue that the force of the flow can "wash" some of the chemical away, and advise that a sample of urine be obtained in a cup or other container, then the strip dipped into it.
    The chemical reagent is very sensitive to moisture, including what's in the air. It's important to keep the lid of the container tightly closed at all times, except for when you're getting a strip to take a reading. Make sure your fingers are dry before you go digging in! They also have an expiry date, so make note of this when you purchase the strips ... that's for the UNopened package. Once opened, they have a shelf-life of about 6 months -- you may wish to write the date you opened on the label for future reference.
    Ketone test strips can be purchased at any pharmacy, and are usually kept with the diabetic supplies. In some stores they're kept behind the counter, so if you don't see them on the shelf, just ask the pharmacist; you don't need a prescription to buy them.
    I'm following Induction strictly; why won't my strips turn purple?
    Ketones will spill into the urine ONLY when there is more in the blood than is being used as fuel by the body at that particular moment.
    You may have exercised or worked a few hours previously, so your muscles would have used up the ketones as fuel, thus there will be no excess. You may have had a lot of liquids to drink, so the urine is more diluted. Perhaps the strips are not fresh, or the lid was not on tight and some moisture from the atmosphere got in.
    Some low carbers NEVER show above trace or negative even ... yet they burn fat and lose weight just fine. If you're losing weight, and your clothes are getting looser, you're feeling well and not hungry all the time .. then you are successfully in ketosis. Don't get hung up on the strips; they're just a guide, nothing more.
    Will I lose weight faster if the strips show dark purple all the time?
    No. Testing in the darkest purple range all the time is usually a sign of dehydration -- the urine is too concentrated. You need to drink more water to dilute it, and keep the kidneys flushed.
    The liver will make ketones from body fat, the fat you EAT, and from alcohol --- the ketone strips have no way of distinguishing the source of the ketones. So, if you test every day after dinner, and dinner usually contains a lot of fat, then you may very well test for large amounts of ketones all the time. However this does not indicate that any BODY fat was burned.
    The strips only indicate what's happening in the urine. Ketosis happens in the blood and body tissues. If you're showing even a small amount, then you are in ketosis, and fat-burning is taking place. Don't get hung up on the ketone sticks.
    Does caffeine affect ketosis?
    This is questionable. There ARE a few studies that suggest caffeine may cause blood sugar to rise, with consequent effect on insulin ... The studies involve consuming 50 gm glucose orally, followed by a dose of caffeine. This is quite different from a low carber, who is consuming only 20 gm carbs, in the form of high-fiber vegetables, spread throughout the day.
    Many low carbers continue to enjoy caffeine-containing beverages with no serious impact on their weight-loss efforts. However, there are some sensitive individuals ... and persons who are extremely insulin resistant may need to restrict or even eliminate all caffeine. If you have been losing successfully then find your weight loss stalled for a month or two, and you are following your program to the letter, you might consider stopping all caffeine for a while, to see if that will get things started again.
    Will drinking alcohol affect ketosis?
    No and yes. The liver can make ketones out of alcohol, so technically, when you drink you'll continue to produce ketones and so will remain in ketosis. The problem is ... alcohol converts more easily to ketones than fatty acids, so your liver will use the alchol first, in preference to fat. Thus, when you drink, basically your FAT burning is put on hold until all the alcohol is out of your system.
    This rapid breakdown of alcohol into ketones and acetaldehyde (the intoxicating by-product) ... tends to put low carbers at risk for quicker intoxication ... especially if no other food is consumed to slow absorption.
    RESOURCES
    Atkinscenter Official Website ... FAQ page, (select Ketosis)
    Ketosis ... from the Low Carb Diet and Exercise List
    Ketosis and Lipolysis ... from Low Carb Retreat
    I believe Gary Taubes!
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Lactic Acidosis

hyperlactaemia: a level from 2 to 5 mmol/L normal production is 20 mmols/kg/day, enters the circulation and undergoes hepatic and renal metabolism (Cori cycle) all tissues can produce lactate under anaerobic conditions lactic acid has a pK value of about 4 so it is fully dissociated into lactate and H+ at body pH (i.e. it is a strong ion) during heavy exercise, the skeletal muscles contribute most of the much increased circulating lactate during pregnancy, the placenta is an important producer of lactate (can pass to fetus as well) major source in sepsis and ARDS is the lung lactate is metabolised predominantly in the liver (60%) and kidney (30%) the heart can also use lactate for ATP production 50% is converted into glucose (gluconeogenesis) and 50% into CO2 and water (citric acid cycle) this results in no net acid accumulation but requires aerobic metabolism the small amount of lactate that is renally filtered (180mmol/day) is fully reabsorbed (ii) impaired hepatic metabolism of lactate (large capacity to clear) clinically there is often a combination of the above to produce a persistent lactic acidosis anaerobic muscular activity (sprinting, generalised convulsions) tissue hypo Continue reading >>

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  1. benmoore

    Just a simple question really:

    Would taking a medium dose of BCAA's (10g) before a morning fasted walk on a diet similiar to that of the Velocity Diet interfere with ketosis/fat loss due to the production of an insulin spike?

  2. RSGZ

    I don't think so, the benefits would overpower any negatives.

  3. weib

    No it won't, insulin spike with BCAA is just plain insulin no glucose or blood sugar involve.

    Ketosis is a process of being starved out from any form of glucose and glycogen, the body then use fats as fuel...yada yada yada

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This video discusses the reaction mechanism for the oxidation of NaDH to NAD+ and the reduction of acetaldehyde into an alcohol such as ethanol.

Chronic Lactic Acidosis In An Adult: A New Syndrome Associated With An Altered Redox State Of Certain Nad/nadh Coupled Reactions - Sciencedirect

Volume 48, Issue 1 , January 1970, Pages 104-112 Chronic lactic acidosis in an adult: A new syndrome associated with an altered redox state of certain NAD/NADH coupled reactions Author links open overlay panel Karl E.SussmanM.D. Get rights and content Chronically elevated blood lactic acid, pyruvic acid and increased L:P ratios have been found in a twenty-eight year old woman with episodic acidosis. The patient has no other associated disease. Alcohol ingestion increases the hyperlacticacidemia and exacerbates the patient's symptoms of weakness and easy fatiguability. Moderate exercise increases blood lactic acid levels from 3,1 to 10.2 M per ml and lowers arterial blood pH from 7.4 to 7.26. Hyperuricemia is present due to depressed uric acid clearance. Certain NAD/NADH coupled metabolic reactions are clearly shifted towards the reduced state (lactate/pyruvate, -glycerophosphate dihydroxyacetone phosphate and galactose-glucose interconversion). Skeletal muscle and liver demonstrate normal total NAD/NADH content and partition of these pyridine nucleotides. Four members of the patient's maternal family have an abnormal lactate response to the combination of alcohol ingestion and exe Continue reading >>

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  1. hxy

    Too much protein can kick you out of ketosis

    Quote from Lyle McDonald - The Ketogenic Diet:
    -To briefly recap, during the first weeks of ketosis, approximately 75 grams of glucose must
    be produced (the other 18 grams of glucose coming from the conversion of glycerol to glucose) to
    satisfy the brain�s requirements of ~100 grams of glucose per day. After approximately 3 weeks
    of ketosis, the brain�s glucose requirements drop to approximately 40 grams of glucose. Of this,
    18 grams are derived from the conversion of glycerol, leaving 25 grams of glucose to be made
    from protein.
    Since 58% of all dietary protein will appear in the bloodstream as glucose (3), we can
    determine how much dietary protein is required by looking at different protein intakes and how
    much glucose is produced.
    Protein intake and grams of glucose produced *
    Protein intake (grams) converted into Glucose (grams)
    50---> 27
    100-----> 58
    125----->72.5
    150----->87
    175------->101.5
    200-------->116
    * Assuming a 58% conversion rate
    Summery: dieters should consume zero Carbs on 150g protein diet since protein will provide 87g glucose by process called gluconeogenesis and other glucose will come from fat burning or you should lower protein intake and increase glucose intake from food.

  2. Atavis

    If you do that, you need to eat more protein. Better to eat a few carbs to compensate for the protein loss.
    Worth a read: How Many Carbohydrates Do You Need?

    Originally Posted by Lyle
    Early research into the topic of starvation and low-carbohydrate dieting found that as few as 15 grams of carbohydrates per day can limit nitrogen loss in the body. And raising carbohydrate intake to 50 grams per day severely limits the need for the body to use amino acids for gluoconeogenesis (which is why I suggested setting daily carbs on the low-carb days of The Ultimate Diet 2.0 at 50 grams).
    This occurs via at least two mechanisms:
    1. The increased carb intake maintains blood glucose and insulin at a higher level (inhibiting cortisol release).
    2. The carbohydrate provides glucose for the brain, limiting the need to break down body protein.
    Basically, in the context of dieting, dieters can either jack up dietary protein to cover the increased carbohydrate requirements of dieting or simply eat slightly more carbohydrates to provide them directly. Both have the same end-result. 15-50 grams per day limits the body’s need to break down protein and will allow protein requirements to be set lower than a diet providing essentially zero carbohydrates per day.
    ...snip...
    So, summing up mid-article, the absolute requirement for carbohydrates is zero grams per day. However, depending on protein intake, a practical minimum for carbs lies between 50 grams/day (if someone functions well in ketosis) to 100-120 grams per day (if they don’t function well in ketosis). Let me mention very specifically that I’m not suggesting those numbers are a recommended level, I’m simply using them to represent a practical minimum value.


    Both approaches can work though, as evidenced by the RFL diet he has. Personally, I like the ability to eat a more varied diet when I want.

  3. hxy

    Thnx its true worth reading, my protein intake at 125g and my carbs at 10g which supply the body with 87g glucose and the deficient glucose comes from burned fat.

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