diabetestalk.net

Lactic Acidosis Causes

Share on facebook

Review Metformin-associated Lactic Acidosis: Current Perspectives On Causes And Risk

Abstract Although metformin has become a drug of choice for the treatment of type 2 diabetes mellitus, some patients may not receive it owing to the risk of lactic acidosis. Metformin, along with other drugs in the biguanide class, increases plasma lactate levels in a plasma concentration-dependent manner by inhibiting mitochondrial respiration predominantly in the liver. Elevated plasma metformin concentrations (as occur in individuals with renal impairment) and a secondary event or condition that further disrupts lactate production or clearance (e.g., cirrhosis, sepsis, or hypoperfusion), are typically necessary to cause metformin-associated lactic acidosis (MALA). As these secondary events may be unpredictable and the mortality rate for MALA approaches 50%, metformin has been contraindicated in moderate and severe renal impairment since its FDA approval in patients with normal renal function or mild renal insufficiency to minimize the potential for toxic metformin levels and MALA. However, the reported incidence of lactic acidosis in clinical practice has proved to be very low (< 10 cases per 100,000 patient-years). Several groups have suggested that current renal function cutof Continue reading >>

Share on facebook

Popular Questions

  1. swt_tease

    My very sweet, supportive DH broke the news to me today that my breath stinks since going on this liquid diet.
    Is this a common thing?
    I didn't have bad breath before.
    ::: Help ::: (Keeping my mouth covered with my hand!)
    Kimberly

  2. Andie

    I didn't do the "liquid diet" except post op....and yes my breath STANK!!! It has something to do with Ketosis...and your body burning the fat and expelling it through your mouth. Wish I could help ya...I bought stock in sugar free mints and sucked on em like crazy and brushed my teeth and used mouth wash any time I went potty. Hang in there...things will get back to normal eventually!!

  3. katzz87

    I didn't have a pre-op diet...but let me tell you post-op I could have taken paint off of the walls! It tastes sickly sweet and stinky at the same time...KETOSIS! But it tells you that you're losing weight...and it gets better, I promise!
    The first month is bad, then it slowly fades after time (unless we just get used to it and I'm still having stinky breath and don't know it...)
    Cathy

  4. -> Continue reading
read more close

Related Articles

  • Lactic Acidosis Causes

    Volume 48, Issue 1 , January 1970, Pages 104-112 Chronic lactic acidosis in an adult: A new syndrome associated with an altered redox state of certain NAD/NADH coupled reactions Author links open overlay panel Karl E.SussmanM.D. Get rights and content Chronically elevated blood lactic acid, pyruvic acid and increased L:P ratios have been found in a twenty-eight year old woman with episodic acidosis. The patient has no other associated disease. A ...

    ketosis Sep 22, 2018
  • What Causes Lactic Acidosis In Diabetics?

    Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. Under certain conditions, too much metformin can cause lactic acidosis. The symptoms of lactic acidosis are severe and quick to appear. They usually occur when other health problems not related to the medicine are pr ...

    ketosis Sep 22, 2018
  • Why Does Metformin Cause Lactic Acidosis?

    Publications Published: July 1998 Information on this subject has been updated. Read the most recent information. Dr P Pillans,former Medical Assessor, Centre for Adverse Reactions Monitoring (CARM), Dunedin Metformin is a useful anti-hyperglycaemic agent but significant mortality is associated with drug-induced lactic acidosis. Significant renal and hepatic disease, alcoholism and conditions associated with hypoxia (eg. cardiac and pulmonary dis ...

    ketosis May 1, 2018
  • Is Ketoacidosis The Same As Lactic Acidosis

    Hyperglycaemic crises are discussed together followed by a separate section on lactic acidosis. DIABETIC KETOACIDOSIS (DKA) AND HYPERGLYCAEMIC HYPEROSMOLAR STATE (HHS) Definitions DKA has no universally agreed definition. Alberti proposed the working definition of “severe uncontrolled diabetes requiring emergency treatment with insulin and intravenous fluids and with a blood ketone body concentration of >5 mmol/l”.1 Given the limited availabi ...

    ketosis Jan 16, 2018
  • Causes Of Lactic Acidosis

    hyperlactaemia: a level from 2 to 5 mmol/L normal production is 20 mmols/kg/day, enters the circulation and undergoes hepatic and renal metabolism (Cori cycle) all tissues can produce lactate under anaerobic conditions lactic acid has a pK value of about 4 so it is fully dissociated into lactate and H+ at body pH (i.e. it is a strong ion) during heavy exercise, the skeletal muscles contribute most of the much increased circulating lactate during ...

    ketosis Sep 22, 2018
  • What Causes Lactic Acidosis And What Are The Symptoms?

    Many people with gut issues suffer from cogitative issues and body-wide symptoms, along with the gastrointestinal hell they’re going through. One of the reasons is often high levels of D-lactic acid. A few definitions acidosis – an abnormal decrease in pH levels. If systemic this is usually only a tenth of a pH level, or so, high. lactic acid (lactate) – an organic compound formed from fermentation, as well as by humans during normal metabo ...

    diabetes Apr 24, 2018

Popular Articles

More in ketosis