diabetestalk.net

Lactic Acidosis

Share on facebook

What is BLOOD PLASMA? What does BLOOD PLASMA mean? BLOOD PLASMA meaning, definition & explanation. Blood plasma is the pale straw (yellow) coloured liquid component of blood that normally holds the blood cells in whole blood in suspension; this makes plasma the extracellular matrix of blood cells. It makes up about 55% of the body's total blood volume. It is the intravascular fluid part of extracellular fluid (all body fluid outside of cells). It is mostly water (up to 95% by volume), and contains dissolved proteins (6–8%) (i.e.—serum albumins, globulins, and fibrinogen), glucose, clotting factors, electrolytes (Na+, Ca2+, Mg2+, HCO3-, Cl-, etc.), hormones, and carbon dioxide (plasma being the main medium for excretory product transportation). Plasma also serves as the protein reserve of the human body. It plays a vital role in an intravascular osmotic effect that keeps electrolytes in balanced form and protects the body from infection and other blood disorders. Blood plasma is prepared by spinning a tube of fresh blood containing an anticoagulant in a centrifuge until the blood cells fall to the bottom of the tube. The blood plasma is then poured or drawn off. Blood plasma has

Lactic Acidosis In Metformin-treated Patients. Prognostic Value Of Arterial Lactate Levels And Plasma Metformin Concentrations.

Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. Service d'Endocrinologie-Nutrition, Hpital Universitaire, Amiens, France. [email protected] The antidiabetic drug metformin has been associated in a small number of patients with lactic acidosis, a serious condition with a poor prognosis. However, because of lack of data, the prognostic significance of hyperlactataemia in metformin-treated patients is not known. Data were collected from 49 metformin-treated patients with lactic acidosis (arterial lactate level > or = 5 mmol/L and blood pH < or = 7.35) and available plasma metformin concentration data to investigate the association of arterial lactate levels and plasma metformin concentrations with mortality. The overall mortality rate in this patients sample was 45% and the median arterial lactate level was 13.1 mmol/L. Median lactate levels were similar in patients who survived (13 mmol/L) and those who died (14.3 mmol/L), whereas the median plasma metformin concentration was 3 times higher in patients who survived (20.6 mg/L versus 6.3 mg/L). In this, the largest series of metformin-treated patients with Continue reading >>

Share on facebook

Popular Questions

  1. ketogirl73

    I'm on my third week of keto, and needing to lose over 100 lbs. I really want to do this right, so excuse the silly questions. With my being 5'5, and approximating my lbm at 135 lbs (I was told elsewhere that it's more like 108 lbs); sedentary lifestyle with about a 25% deficit, I'm showing my protein to be between 81-90 grams per day. I'm still hungry. My fat gram macros, and everything else in on point. I was wondering if I'm figuring my macros correctly, and if so, how much protein above the 90g can I consume without it negatively impacting my weight loss efforts? I'm sorry for all the questions, but I'm getting so many conflicting answers, online.

  2. darthluiggi

    As per the FAQ:
    The "least" suggested would be 0.69g per lean lb you weight.
    The gudelines suggest 0.8 to 1.2g per lean lb.
    Most people do well with 1.0g per lean lb.
    More is not counterproductive towards keto, but also not necessary.

  3. anbeav

    It's your third week, your body is adjusting. More protein isn't necessarily harmful but most so best following the guidelines as it's not a great energy source. For how if truly hungry, then eat to satiety. Keep in mind that satiety is different than physical fullness. You're likely used to feeling full, keto won't leave you full, it'll leave you no longer hungry and it can take time to learn the difference. Are you following the electrolyte guidelines? What are your meals like?

  4. -> Continue reading
read more
Share on facebook

Please like, share and subscribe to my YouTube page to get notifications whenever I post a new video! You have already taken the first step to better your health by watching my video! Next, I recommend that you join our Long Distance Patient Program so that you can get diet modification and supplement recommendations designed specifically for you by me or one of my fellow practitioners in our Ann Arbor, Michigan office. You have to be a patient of our office in order to receive supplements, per our distribution agreement with the producer of the Standard Process brand supplements. Becoming a Long Distance Patient as outlined below allows you that access. In order to be part of our online patient program, you would purchase an annual membership for $200. This membership includes an initial 30 minute phone appointment with me or one of our practitioners. At that time, the practitioner will make a recommendation to you for diet modifications, supplements and the quantities that you should take. After the phone call, you are able to order supplements for a year, as needed, directly from our website and our app. We will then promptly ship the supplements out to you. Follow up phone call

Lactic Acidosis - Cancer Therapy Advisor

Hyperlactatemia, anion gap metabolic acidosis, strong ion gap metabolic acidosis Tissue hypoperfusion, ischemia, anaerobic metabolism, shock, acid-base disorders Lactic acidosis associated with critical illness is commonly a byproduct of a much larger problem. In 1976 Cohen and Woods classified lactic acidosis based on etiology. Type A is due to clinical evidence of tissue hypoperfusion. Type B occurs in the absence of clinical evidence of tissue hypoperfusion. Type B is further divided into subgroups B1 - underlying disease/physiologic state; B2 - medication or toxin; and B3 - inborn errors of metabolism. In critically ill patients, lactic acidosis is typically associated with increased lactate production (hypoperfusion, mitochondrial dysfunction), and/or decreased metabolism/clearance. Approximately 1400 mmol of lactic acid is produced daily. The kidneys metabolize up to 30% with no significant elimination. The liver is very efficient in lactate metabolism and elimination and serum lactate levels should remain in the normal range until about 75% of hepatic function is lost. The clinical features of lactic acidosis are similar to other forms of metabolic acidoses. These may inclu Continue reading >>

Share on facebook

Popular Questions

  1. 2canman

    cloudy pee on keto? (Reps)

    hey guys, just started a keto diet for cutting and kept my water intake about the same, if not then more (to supress hunger). Yet my pee seems to be yellow and cloudy, and not clear like water as when i was bulking. Any idea why?

  2. 1212man1212

    man you are 16, eat w/e you want. wait till you grow some more!

  3. pperry

    My pee has bubbles in it on keto.

  4. -> Continue reading
read more
Share on facebook

https://www.facebook.com/drinkhealthy... - Do you want to learn how to get rid of lactic acid as an athlete, and start recovering quicker with more energy? Learn how to reduce lactic acid symptoms and increase your performance. Getting rid of lactic acid may be easier than you have imagined. Many professional athletes know the importance of eliminating lactic acid so they can recover quicker and perform at an optimal level. Start flushing out that lactic acid today! Many people suffer from lactic acidosis symptoms and are rigorously searching for a lactic acid treatment. More and more athletes are searching for solutions on how to get rid of lactic acid. In this video you will learn what a professional football player from the Seattle Seahawks is using to eliminate lactic acid after his workouts, practices, and NFL games. Learn how to make lactic acid a symptom of the past. Begin your journey to faster recovery today. See what the pro's are using to reduce lactic acid, recover quicker, and have more energy. Uncertain of what lactic is? Here is the definition https://en.wikipedia.org/wiki/Lactic_... Contact me for more information on getting rid of lactic acid FB: http://www.faceboo

Lactic Acidosis. - Pubmed - Ncbi

Division of Critical Care Medicine, Chicago Medical School, Illinois. An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the more controversial aspects relating to the genesis of the acidosis are highlighted. The current system of classification of lactic acidosis divides etiologies on the basis of the presence or absence of clinical signs of tissue hypoperfusion. Several types of lactic acidosis in which clinical evidence of tissue hypoperfusion is lacking demonstrate hemodynamic evidence of occult hypoperfusion. The diagnostic and therapeutic implications of this observation are discussed. Current diagnostic criteria for lactic acidosis include a pH less than 7.35 and blood lactate concentration greater than 5 to 6 mM/L. An important issue relates to the implications of lactate values that are greater than normal but below this diagnostic range. The use of the oxygen flux test may be valuable in the diagnosis of occult tissue hypoperfusion in patients with low-grade elevations in lactate levels. The current therapy for lactic acidosis invo Continue reading >>

Share on facebook

Popular Questions

  1. ww_je

    Yes you can certainly die. And you can suffer more or less permanent organ dmaage from it as well;.
    It develops, most commonly in Type 1 diabetics, when insulin dosage is wrong, as the result of infection, stress, ... It is the result of the production of ketone bodies (three intermediate chemicals in the fat oxidation sequence), only one of which is actually a ketone (it's acetone). when enough of these reach the bloodstream, the entire chenmical condition of the body goes acidic. Since most of the biochemical reactions we need don't work or don't work when the acidity goes too high. It's so important that there is an entire buffering system to keep the pH of the blood and tissues correct.
    Diabetic ketoacidosis is an absolute medical emergency and a case srious enough to have 'acetone breath' (a sign of advanced DKA) cannot be treated at home with rest and fluids and so on. DKA is not something to treat casually.
    The treatment is to slowly restore normal pH, get the production of ketone bodies to sotop, and watch carefully for Potassium levels and such. The 'ambos' can't really do this in teh few minutes they will have with you. They can administer fluids adn check vitals, but more is neede than they can do in a brief ambulance run. If you go unconscious, the ER doc on the other end o fthe radio might order a PH raising IV drip, but withou careful blood chemistry monitoring, even this is probably postponable until reaching the ER.

  2. Lurline

    This Site Might Help You.
    RE:
    can you die from dibetic keto acidosis? and what can the ambos do to save you?

  3. creola

    Diabetes is usually treated through a combination of diet (low sugar), exercise and medications/insulin. Read here https://tr.im/S4PB1
    Milder cases can be controlled with just diet an/or exercise while more severe cases require meds or insulin as well.

  4. -> Continue reading
read more

No more pages to load

Related Articles

  • Is Ketoacidosis The Same As Lactic Acidosis

    Abstract Lactic acidosis is occasionally responsible for metabolic acidosis in diabetics. It may occur in the presence of normal blood levels of the ketone bodies, and such cases are often described as having “non-ketotic diabetic acidosis.” Lactic acid may contribute to the metabolic acidosis in patients with true diabetic ketoacidosis, but the blood lactate concentrations in these patients are not usually very high. In some patients the ket ...

    ketosis Jan 16, 2018
  • Why Does Metformin Cause Lactic Acidosis?

    Lactic acidosis occurs when the body produces too much lactic acid and cannot metabolize it quickly enough. The condition can be a medical emergency. The onset of lactic acidosis might be rapid and occur within minutes or hours, or gradual, happening over a period of days. The best way to treat lactic acidosis is to find out what has caused it. Untreated lactic acidosis can result in severe and life-threatening complications. In some instances, ...

    ketosis May 1, 2018
  • Can Dka Cause Lactic Acidosis?

    Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in the body, which results in an excessively low pH in the bloodstream. It is a form of metabolic acidosis, in which excessive acid accumulates due to a problem with the body's metabolism of lactic acid. Lactic acidosis is typically the result of an underlying acute or chronic medical condition, medication, or poisoning. The symptoms are generall ...

    ketosis Jan 13, 2018
  • What Is Lactic Acidosis

    History The onset of acidosis may be rapid (ie, within minutes to hours) or progressive (ie, over a period of several days). Lactic acidosis frequently occurs during strenuous exercise in healthy people, bearing no consequence. However, development of lactic acidosis in disease states is ominous, often indicating a critical illness of recent onset. Therefore, a careful history should be obtained to evaluate the underlying pathophysiologic cause o ...

    ketosis Apr 22, 2018
  • What Are The Signs Of Lactic Acidosis With Metformin?

    Abstract Metformin-associated lactic acidosis (MALA) is a severe metabolic failure with high related mortality. Although its use is controversial, intermittent hemodialysis is reported to be the most frequently used treatment in conjunction with nonspecific supportive measures. Our aim was to report the evolution and outcome of cases managed by continuous renal replacement therapy (CRRT). Methodology and Principal Findings Over a 3-year period, w ...

    ketosis Apr 24, 2018
  • How Metformin Cause Lactic Acidosis

    Emma Fitzgerald, specialist trainee year 2 in anaesthetics 1, Stephen Mathieu, specialist registrar in anaesthetics and intensive care medicine1, Andrew Ball, consultant in anaesthesia and intensive care medicine1 1Dorset County Hospital, Dorchester, Dorset DT1 2JY Correspondence to: E Fitzgerald zcharm6{at}hotmail.com Dehydration in patients taking metformin can lead to metformin associated lactic acidosis, a potentially fatal condition Metform ...

    ketosis Apr 30, 2018

More in ketosis