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Lactic Acidosis

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Lactate And Lactic Acidosis

The integrity and function of all cells depend on an adequate supply of oxygen. Severe acute illness is frequently associated with inadequate tissue perfusion and/or reduced amount of oxygen in blood (hypoxemia) leading to tissue hypoxia. If not reversed, tissue hypoxia can rapidly progress to multiorgan failure and death. For this reason a major imperative of critical care is to monitor tissue oxygenation so that timely intervention directed at restoring an adequate supply of oxygen can be implemented. Measurement of blood lactate concentration has traditionally been used to monitor tissue oxygenation, a utility based on the wisdom gleaned over 50 years ago that cells deprived of adequate oxygen produce excessive quantities of lactate. The real-time monitoring of blood lactate concentration necessary in a critical care setting was only made possible by the development of electrode-based lactate biosensors around a decade ago. These biosensors are now incorporated into modern blood gas analyzers and other point-of-care analytical instruments, allowing lactate measurement by non-laboratory staff on a drop (100 L) of blood within a minute or two. Whilst blood lactate concentration i Continue reading >>

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Popular Questions

  1. Likhita Iyer

    how can differentiate between aldehyde and ketone

  2. Shukla Paladhi

    Dear user,
    Aldehydes and ketones can be differentiated as under.
    Test
    Aldehydes
    Ketones
    Tollen’s reagent test
    +ve
    Aldehydes reduce Tollens’ reagent to form shiny silver mirror.
    -ve
    Ketones do not reduce Tollens’ reagent and hence, there is no formation of shiny silver mirror.
    Fehling’s solution test
    +ve
    Aldehydes reduce Fehling’s solution to form red precipitates of cuprous oxide.
    -ve
    Ketones do not reduce Fehling’s solution and hence, there is no of red precipitate formation.
    Schiff’s reagent test
    +ve
    Aldehydes restore the pink colour of Schiff’s reagent.
    -ve
    Ketones do not restore the pink colour of Schiff’s reagent.
    Reduction with LiAlH4
    Aldehydes get reduced to primary alcohols in presence of LiAlH4.
    Ketones get reduced to secondary alcohols in presence of LiAlH4.
    Hope, this answers your question.

    Cheers!!

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