Pregnancy Toxemia In Ewes And Does
Pregnancy toxemia affects ewes and does during late gestation and is characterized by partial anorexia and depression, often with neurologic signs, progressing to recumbency and death. It is seen more often in animals carrying multiple fetuses. Generally, clinically affected animals have other risk factors, at either the individual or flock/herd level. Epidemiology and Pathogenesis: The primary predisposing cause of pregnancy toxemia is inadequate nutrition during late gestation, usually because of insufficient energy density of the ration and decreased rumen capacity as a result of fetal growth. In the last 4 wk of gestation, metabolizable energy requirements rise dramatically. For example, the energy requirement of a 70-kg ewe carrying a single lamb is 2.8 Mcal/day in early gestation compared with 3.45 Mcal/day in late gestation, or an increase of 23%. This change is more dramatic in ewes bearing twins, with an energy requirement of 3.22 Mcal/day in early and 4.37 Mcal/day in late gestation (36% increase), and in ewes bearing triplets, with an energy requirement of 3.49 Mcal/day in early and 4.95 Mcal/day in late gestation (42% increase). Dairy goats have similar changes in needs. In late gestation, the liver increases gluconeogenesis to facilitate glucose availability to the fetuses. Each fetus requires 30–40 g of glucose/day in late gestation, which represents a significant percentage of the ewe’s glucose production and which is preferentially directed to supporting the fetuses rather than the ewe. Mobilization of fat stores is increased in late gestation as a way to assure adequate energy for the increased demands of the developing fetus(es) and impending lactation. However, in a negative energy balance, this increased mobilization may overwhelm the liver’s c Continue reading >>
Ketosis During Pregnancy
So I did a urine dip stick test and my ketones were really high (the second highest) and I also had elevated protein and bilirubin. I'm only 7 weeks pregnant and I've been very nauseous but no vomiting. I really can't stomach eating very much at all and I've lost 10 lbs in the last 3 weeks! With my daughter, I also had morning sickness but lost about 12 lbs over 3 months. The only difference between this pregnancy and the last is that I'm paleo now, and I wasn't with my daughter. I'm wondering if anyone else has had this? Should I be eating the most sugary foods I can manage? I'm not sure what to do. I haven't gone to the doctor about it yet, but I'm planning on making an appointment if things don't get better in a couple of days. Continue reading >>
Is Keto Dangerous While Pregnant, Breastfeeding, Or For Children?
A question I’ve come across seemingly increasingly in the past few months, is a variation of, is it safe for kids to eat keto, including women during pregnancy and breastfeeding? This is where a simple disambiguation between a well and poorly formulated diet should end the discussion but let’s dig a little bit deeper into the concerns themselves, studies on children, the validity thereof, what a good diet is and context. One of the applications of a well formulated ketogenic diet has been in treatment of PCOS with much success, though more research is needed. You can search for yourself to find more info on this and the specifics with lots of other blogs and anecdotes covering it out there, but between weight loss and improved hormone regulation from better food choices it’s a way to manage symptoms and issues associated with the disorder. Many women who see improvements have noted they end up with a surprise pregnancy after starting low carb. Though usually planned or at least semi-planned, you can find near endless anecdotes of despite several years of trying, a sudden ketobaby happened after a few weeks or months of low carb. Just search through //www.reddit.com/r/xxketo and /r/ketobabies for personal accounts thereof. If you’ve done prior research into keto, you should already know that improvements in endocrine function are one of the benefits with plenty of evidence to support it. So if you’ve found yourself with a surprise baby thanks to keto the next question is, can you, should you, or is it dangerous to continue while pregnant? Ketosis and Pregnancy: Thanks to Japan and low carb as a treatment for diabetes we do have some research done regarding the application of a low carb diet in pregnant mothers on ketone levels and their role. Aside from this, c Continue reading >>
What Is Ketosis?
"Ketosis" is a word you'll probably see when you're looking for information on diabetes or weight loss. Is it a good thing or a bad thing? That depends. Ketosis is a normal metabolic process, something your body does to keep working. When it doesn't have enough carbohydrates from food for your cells to burn for energy, it burns fat instead. As part of this process, it makes ketones. If you're healthy and eating a balanced diet, your body controls how much fat it burns, and you don't normally make or use ketones. But when you cut way back on your calories or carbs, your body will switch to ketosis for energy. It can also happen after exercising for a long time and during pregnancy. For people with uncontrolled diabetes, ketosis is a sign of not using enough insulin. Ketosis can become dangerous when ketones build up. High levels lead to dehydration and change the chemical balance of your blood. Ketosis is a popular weight loss strategy. Low-carb eating plans include the first part of the Atkins diet and the Paleo diet, which stress proteins for fueling your body. In addition to helping you burn fat, ketosis can make you feel less hungry. It also helps you maintain muscle. For healthy people who don't have diabetes and aren't pregnant, ketosis usually kicks in after 3 or 4 days of eating less than 50 grams of carbohydrates per day. That's about 3 slices of bread, a cup of low-fat fruit yogurt, or two small bananas. You can start ketosis by fasting, too. Doctors may put children who have epilepsy on a ketogenic diet, a special high-fat, very low-carb and protein plan, because it might help prevent seizures. Adults with epilepsy sometimes eat modified Atkins diets. Some research suggests that ketogenic diets might help lower your risk of heart disease. Other studies show sp Continue reading >>
Overview Of Ketosis In Cattle
(Acetonemia, Ketonemia) By Thomas H. Herdt, DVM, MS, DACVN, DACVIM, Professor, Department of Large Animal Clinical Sciences and Diagnostic Center for Population and Animal Health, Michigan State University Ketosis is a common disease of adult cattle. It typically occurs in dairy cows in early lactation and is most consistently characterized by partial anorexia and depression. Rarely, it occurs in cattle in late gestation, at which time it resembles pregnancy toxemia of ewes (see Pregnancy Toxemia in Ewes and Does). In addition to inappetence, signs of nervous dysfunction, including pica, abnormal licking, incoordination and abnormal gait, bellowing, and aggression, are occasionally seen. The condition is worldwide in distribution but is most common where dairy cows are bred and managed for high production. Etiology and Pathogenesis: The pathogenesis of bovine ketosis is incompletely understood, but it requires the combination of intense adipose mobilization and a high glucose demand. Both of these conditions are present in early lactation, at which time negative energy balance leads to adipose mobilization, and milk synthesis creates a high glucose demand. Adipose mobilization is accompanied by high blood serum concentrations of nonesterified fatty acids (NEFAs). During periods of intense gluconeogenesis, a large portion of serum NEFAs is directed to ketone body synthesis in the liver. Thus, the clinicopathologic characterization of ketosis includes high serum concentrations of NEFAs and ketone bodies and low concentrations of glucose. In contrast to many other species, cattle with hyperketonemia do not have concurrent acidemia. The serum ketone bodies are acetone, acetoacetate, and β-hydroxybutyrate (BHB). There is speculation that the pathogenesis of ketosis cases oc Continue reading >>
Ketosis During Pregnancy – Is It Safe?
Ketosis is a state of metabolism in adults where the energy is supplied to the body by ketones present in the blood rather than glycolysis, where the energy comes from glucose. People often land up in a dilemma while judging whether ketosis is safe during pregnancy or not. The diet of a woman has to undergo certain changes in case she nears pregnancy. However, you should be aware of the effects of ketosis before you opt for such a diet. The body of a woman undergoes a lot of changes during pregnancy. Food choices are important when she tries to conceive. Here, you will have a detailed information about ketosis before and during pregnancy. Ketosis before Pregnancy Although people think that ketosis during pregnancy is harmful, in reality, it can help you get pregnant. If you want to draw your energy from ketone particles, you should plan a ketogenic diet. For an ordinary person, it is safe and even women trying to get pregnant can stick to such a meal. These meals are low-carb diets, and people can switch to these diets when they get pregnant. Well, it is important to know that ketosis is safe before you get pregnant. However, the norms are a bit different during pregnancy and you should stick to the rules. Read on to know whether it is safe during pregnancy or not. If you had heard that ketosis is harmful during pregnancy, you might be confusing it with diabetic ketoacidosis (DKA). This is completely different from ketosis that we are speaking of here. DKA has no relevance with nutritional ketosis and it is a far more harmful syndrome. It occurs in diabetic people where the level of insulin is not managed properly. It disrupts the balance of acid and base in the body. The level of blood sugar in the case of DKA is around three times the normal conditions. This situation Continue reading >>
Ketosis: What Is Ketosis?
Ketosis is a normal metabolic process. When the body does not have enough glucose for energy, it burns stored fats instead; this results in a build-up of acids called ketones within the body. Some people encourage ketosis by following a diet called the ketogenic or low-carb diet. The aim of the diet is to try and burn unwanted fat by forcing the body to rely on fat for energy, rather than carbohydrates. Ketosis is also commonly observed in patients with diabetes, as the process can occur if the body does not have enough insulin or is not using insulin correctly. Problems associated with extreme levels of ketosis are more likely to develop in patients with type 1 diabetes compared with type 2 diabetes patients. Ketosis occurs when the body does not have sufficient access to its primary fuel source, glucose. Ketosis describes a condition where fat stores are broken down to produce energy, which also produces ketones, a type of acid. As ketone levels rise, the acidity of the blood also increases, leading to ketoacidosis, a serious condition that can prove fatal. People with type 1 diabetes are more likely to develop ketoacidosis, for which emergency medical treatment is required to avoid or treat diabetic coma. Some people follow a ketogenic (low-carb) diet to try to lose weight by forcing the body to burn fat stores. What is ketosis? In normal circumstances, the body's cells use glucose as their primary form of energy. Glucose is typically derived from dietary carbohydrates, including: sugar - such as fruits and milk or yogurt starchy foods - such as bread and pasta The body breaks these down into simple sugars. Glucose can either be used to fuel the body or be stored in the liver and muscles as glycogen. If there is not enough glucose available to meet energy demands, th Continue reading >>
Pregnancy Toxaemia And
Contents Industry Background Management Nutrition Animal Health Breeding Fibre Production Fibre Marketing Meat Production and Marketing Pasture and Weed Control Economic Analysis Tanning Skins ketosis in goats The diseases pregnancy toxaemia and ketosis can cause severe problems in goats. While the diseases are clinically different and occur during different stages of pregnancy and lactation, the basis of the disorder is essentially the same: a decrease in blood sugar levels and an increase in ketones. In ruminants, glucose is synthesised mainly from propionic acid (a volatile fatty acid produced in the rumen) and from amino acids. The amount of glucose that is absorbed directly depends on how much dietary carbohydrate escapes rumen fermentation and is digested in the small intestine. This form of glucose uptake varies with different feeds as well as their treatment. Ruminants can use products from rumen fermentation, such as volatile fatty acids, for most of their energy requirements. However, the nervous system, kidneys, mammary gland and foetus have a direct requirement for glucose. During periods of peak glucose requirement (late pregnancy and early lactation) problems may arise due to a glucose deficiency. The incidence of pregnancy toxaemia and ketosis varies with the two main types of goats. In dairy goats with a genetic potential for high milk production, ketosis may be a potential problem; in non-milch goats (Angora, Cashmere and meat) pregnancy toxaemia is more common. PREGNANCY TOXAEMIA Main causes The most important cause of pregnancy toxaemia is a decline in the plane of nutrition during the last six to eight weeks of pregnancy. This places the pregnant female in a difficult situation because the developing foetus imposes an unremitting drain on available m Continue reading >>
Pregnancy Toxemia (ketosis) In Ewes And Does – 1.630
by S. LeValley1 (8/2010) Quick Facts… Pregnancy toxemia in sheep and goats is also known as pregnancy disease, lambing sickness and twin-lamb/kid disease. The principal cause of pregnancy toxemia is low blood sugar (glucose). Onset of the disease is often triggered by one of several types of stress including nutritional or inclement weather. The disease is most prevalent in ewes and does carrying two or more lambs or kids. The disease also affects ewes and does that are extremely fat or excessively thin. The best preventive measure is increased feeding of high energy concentrates and grains during the last month of pregnancy. Occurrence and Causes Pregnancy toxemia in sheep and goats has also been called ketosis, lambing/kidding sickness, pregnancy disease and twin-lamb/kid disease. It occurs in all parts of the world and is an often fatal disease occurring only during the last month of pregnancy. Death occurs in two to 10 days in about 80 percent of the cases. It most often affects ewes/does pregnant with twins or triplets and is characterized by low blood sugar (glucose). Economic losses because of the disease have been considerable and it is the most commonly occurring metabolic disease of sheep and goats. It is generally accepted that the basic cause of pregnancy toxemia is a disturbance of carbohydrate or sugar metabolism. In earlier phases of the disease, blood glucose concentrations are less than 30 and may be as low as 10 mg/100 ml (normal 40-60). Blood ketone bodies, on the other hand, are usually greater than 15 and occasionally may be as high as 80 mg/100 ml (normal 1-4). The free fatty acid content of the blood plasma also is increased, meaning that body fat is being broken down and used for energy. Since glucose is essential for proper functioning of the Continue reading >>
Ketogenic Lifestyle Side-effect: Pregnancy
Be warned, a ketogenic diet may cause pregnancy . . . ! Infertility and poly-cystic ovarian syndrome (PCOS) is a common occurrence in women with insulin resistance, pre-diabetes and diabetes. When treated with a ketogenic lifestyle, these symptoms often improve dramatically, and in fact, I’ve had a number of women in my medical practice, previously unable to conceive due to PCOS, get pregnant after changing to a ketogenic diet. We discuss PCOS, as well as CrossFit, NSAIDs, Toxic Mold, And Calorie Restriction On Keto-Talk this week. Tune in here on you computer or down-load today’s podcast on iTunes for free. You won’t be sorry. Continue reading >>
Ketosis: Symptoms, Signs & More
Every cell in your body needs energy to survive. Most of the time, you create energy from the sugar (glucose) in your bloodstream. Insulin helps regulate glucose levels in the blood and stimulate the absorption of glucose by the cells in your body. If you don’t have enough glucose or insufficient insulin to get the job done, your body will break down fat instead for energy. This supply of fat is an alternative energy source that keeps you from starvation. When you break down fat, you produce a compound called a ketone body. This process is called ketosis. Insulin is required by your cells in order to use the glucose in your blood, but ketones do not require insulin. The ketones that don’t get used for energy pass through your kidneys and out through your urine. Ketosis is most likely to occur in people who have diabetes, a condition in which the body produces little or no insulin. Ketosis and Ketoacidosis: What You Need To Know Ketosis simply means that your body is producing ketone bodies. You’re burning fat instead of glucose. Ketosis isn’t necessarily harmful to your health. If you don’t have diabetes and you maintain a healthy diet, it’s unlikely to be a problem. While ketosis itself isn’t particularly dangerous, it’s definitely something to keep an eye on, especially if you have diabetes. Ketosis can be a precursor to ketoacidosis, also known as diabetic ketoacidosis. Ketoacidosis is a condition in which you have both high glucose and high ketone levels. Having ketoacidosis results in your blood becoming too acidic. It’s more common for those with type 1 diabetes rather than type 2. Once symptoms of ketoacidosis begin, they can escalate very quickly. Symptoms include: breath that smells fruity or like nail polish or nail polish remover rapid breat Continue reading >>
Diabetic Ketoacidosis In Pregnancy
Diabetic ketoacidosis is a serious metabolic complication of diabetes with high mortality if undetected. Its occurrence in pregnancy compromises both the fetus and the mother profoundly. Although predictably more common in patients with type 1 diabetes, it has been recognised in those with type 2 diabetes as well as gestational diabetes, especially with the use of corticosteroids for fetal lung maturity and β2-agonists for tocolysis.1–3 Diabetic ketoacidosis usually occurs in the second and third trimesters because of increased insulin resistance, and is also seen in newly presenting type 1 diabetes patients. With increasing practice of antepartum diabetes screening and the availability of early and frequent prenatal care/surveillance, the incidence and outcomes of diabetic ketoacidosis in pregnancy have vastly improved. However, it still remains a major clinical problem in pregnancy since it tends to occur at lower blood glucose levels and more rapidly than in non-pregnant patients often causing delay in the diagnosis. The purpose of this article is to illustrate a typical patient who may present with diabetic ketoacidosis in pregnancy and review the literature on this relatively uncommon condition and provide an insight into the pathophysiology and management. MAGNITUDE OF THE PROBLEM In non-pregnant patients with type 1 diabetes, the incidence of diabetic ketoacidosis is about 1–5 episodes per 100 per year with mortality averaging 5%–10%.4 The incidence rates of diabetic ketoacidosis in pregnancy and the corresponding fetal mortality rates from different retrospective studies5–8 are summarised in the table 1. As is evident from the table, both the incidence and rates of fetal loss in pregnancies have fallen in recent times compared with those before. In 1963 Continue reading >>
Effects Of A Ketogenic Diet During Pregnancy On Embryonic Growth In The Mouse
Go to: The increasing use of the ketogenic diet (KD), particularly by women of child-bearing age, raises a question about its suitability during gestation. To date, no studies have thoroughly investigated the direct implications of a gestational ketogenic diet on embryonic development. To fill this knowledge gap we imaged CD-1 mouse embryos whose mothers were fed either a Standard Diet (SD) or a KD 30 days prior to, as well as during gestation. Images were collected at embryonic days (E) 13.5 using Optical Projection Tomography (OPT) and at E17.5 using Magnetic Resonance Imaging (MRI). An anatomical comparison of the SD and KD embryos revealed that at E13.5 the average KD embryo was volumetrically larger, possessed a relatively larger heart but smaller brain, and had a smaller pharynx, cervical spinal cord, hypothalamus, midbrain, and pons, compared with the average SD embryo. At E17.5 the KD embryo was found to be volumetrically smaller with a relatively smaller heart and thymus, but with enlarged cervical spine, thalamus, midbrain and pons. A ketogenic diet during gestation results in alterations in embryonic organ growth. Such alterations may be associated with organ dysfunction and potentially behavioral changes in postnatal life. Keywords: Ketogenic diet, Low-carbohydrate diet, Embryonic development, CD-1 mouse, Mouse imaging, Optical projection tomography, Magnetic resonance imaging An illustration of the animal-to-animal variation within the SD group at E13.5. The coloured traces are outlines of all linearly-aligned individual SD images, and the white region is a mask of the final average image. Click on the image to see a larger version. Embryonic size difference at E17.5. (A) A consensus average of all E17.5 embryos constructed using the SD and KD MRI embryo im Continue reading >>
Ketosis In Goats: What Is It And How To Prevent It?
Inside: Ketosis in goats: how to prevent this condition, the symptoms and the treatment. It is preventable and you can help your goat avoid it. This is one post in our Raising Goats series. Although I worked in an Alzheimer home in Boise when I was going to school, I can’t say that I had or gained a passion for the medical side of life. Truly, it was a wonderful experience working with and helping the residents but it wouldn’t become a long-term profession. So, when I first heard the word “ketosis”, I said, “huh??” But it is an important term to know when you are dealing with goats who have recently kidded and their health. As a goat owner, it is your primary responsibility to provide your goats with adequate nutrition so that you never have to work on the treatment side of these problematic conditions. Let’s start off by answering the question: It is a metabolic condition after kidding Ketosis is a metabolic problem caused by an animal living on its own body reserves because it has stopped eating food. The higher nutritional needs of a doe continue as they did in the last weeks of her pregnancy because now she is producing large quantities of milk. So a doe in the early stages of lactation may experience a net loss of energy. Usually, four to six weeks after kidding, the doe’s hormonal stimuli for lactation overcomes the effects of inadequate food intake. Ketosis in goats can be a very detrimental condition for your herd. What else do you need to know about this condition? • Prevention is key: • Never should the doe be excessively fat. • Any changes in diet should be introduced slowly. The addition of protein grain concentrate not only is important for the health of the doe and kid during pregnancy but for the health of the goat as she begins l Continue reading >>
Case Of Nondiabetic Ketoacidosis In Third Term Twin Pregnancy | The Journal Of Clinical Endocrinology & Metabolism | Oxford Academic
We provided appropriate management with fluid infusion after cesarean delivery. The patient and her two daughters survived, and no disabilities were foreseen. Alcohol, methanol, and lactic acid levels were normal. No signs of renal disease or diabetes were present. Pathological examination revealed no abnormalities of the placentae. Toxicological tests revealed a salicylate level of less than 5 mg/liter, an acetaminophen level of less than 1 mg/liter, and an acetone level of 300 mg/liter (reference, 520 mg/liter). We present a case of third term twin pregnancy with high anion gap metabolic acidosis due to (mild) starvation. Starvation, obesity, third term twin pregnancy, and perhaps a gastroenteritis were the ultimate provoking factors. In the light of the erroneous suspicion of sepsis and initial fluid therapy lacking glucose, one wonders whether, under a different fluid regime, cesarean section could have been avoided. Severe ketoacidosis in the pregnant woman is associated with impaired neurodevelopment. It therefore demands early recognition and immediate intervention. A 26-yr-old patient was admitted to our hospital complaining of rapid progressive dyspnea and abdominal discomfort. She was pregnant with dichorial, diamniotic twins for 35 wk and 4 d. Medical history showed that she was heterozygous for hemochromatosis. Two years before, she had given birth to a healthy girl of 3925 g by cesarean section, and 1 yr before, she had had a spontaneous abortion. Her preadmission outpatient surveillance revealed slightly elevated blood pressure varying from 132158 mm Hg systolic and 7995 mm Hg diastolic. Glucose and glycosylated hemoglobin were tested at 24 wk and were normal at 4.6 mmol/liter and 5.4% (36 mmol/mol), respectively. Urine analysis at the outpatient obstetri Continue reading >>
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