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Ketosis Nitric Oxide

#158 Jan Venter, Md – How Ketogenic Diets Improves Memory & Brain Health

#158 Jan Venter, Md – How Ketogenic Diets Improves Memory & Brain Health

Listen to the Audio MP3 About Dr. Jan Venter Dr. Jan Venter is a board-certified Family Physician at our False Creek Health Centre. His past positions have included Physician at Shaughnessy Health, and Medical Director at Fusium Medical and Grandeur of the Seas. Dr. Venter obtained his Bachelor’s Degree in Medicine and Surgery from the University of the Orange Free State, South Africa, later to receive his Masters in Family Medicine. He is certified by the Canadian Family Practice, Medical Council of Canada and the Institute for Functional Medicine. He is the founder of Fusium Medical and Brain Vault Health Systems. Fluent in both German and Afrikaans, Dr. Venter believes personalized medicine is the future of medicine and that patient-centred care is key. Connect with Jan www.falsecreekhealthcare.com www.facebook.com/jan.venter Books and Products Discussed in this Episode PQQ Lozenge | 30 Lozenges | Provides 20 mg Pyrroloquinoline Quinone (PQQ) per Lozenge | Physician Formulated | Seeking Health Show Notes 02:05 Dr. Venter’s Brain Health Journey: Dr. Venter saw many patients from vehicle accidents with traumatic brain injury. There was no effective means of assessment. Treatment was a mixture of two antidepressants and hope for recovery. This was not good enough for Dr. Venter, so he dug deeper. A friend was using neurofeedback for evaluating fibromyalgia and chronic fatigue syndrome. It was a non-invasive way to see within the brain. EEG also intrigued him. The equipment became cheaper and smaller. It is a way to capture live data and compare it to a database to evaluate brain health: cognition, depression, concussion, ADD and more. 04:39 Neurofeedback and Quantitative EEG: These modalities assess electrical activity in the brain. EEG was a breakthrough in neuroph Continue reading >>

22 Foods To Eat On A Ketogenic Diet

22 Foods To Eat On A Ketogenic Diet

A ketogenic diet is a low-carb, moderate-protein and high-fat nutrition plan. This article addresses some of the best foods to eat on a ketogenic diet. Following a ketogenic diet has been effectively shown to improve cardiovascular health, regulate the endocrine system, stabilize blood glucose levels, support weight loss, improve insulin sensitivity in people with type-2 diabetes and even treat neurological dysfunction (8, 9). Additionally, a ketogenic diet can improve your energy, cognitive acceleration and overall daily performance. Most people feel their best when in a state of mild-ketosis. One of the big challenges, is that most people have been raised on higher carb comfort foods. So rather than focusing on what foods you will miss, shift your energy to all the great foods you can enjoy. Here are 22 foods to eat on a ketogenic diet that you will LOVE! 1. Lemons & Limes: Most citrus fruits are packed with sugar. Lemons and limes however offer you the pleasure of a low-glycemic fruit to enjoy regularly and are rich in anti-inflammatory nutrients like citric acid, vitamin C and bioflavonoids. (1) Citric acid helps stabilize blood sugar levels and combat the inflammatory effects of sugar while also serving as an alkalizing agents for the body. Lemons and limes are some of the best foods you can use daily to help detoxify the gastrointestinal tract because of their natural antiseptic properties. Add a fresh squeeze of lemon or lime to your water throughout the day and use in many food preparations such as meat marinades and dressings. 2. Herbs: Herbs pact some of the most powerful antioxidants. Bitter herbs like ginger, turmeric, and parsley stimulate digestive function by improving gut health. They support enzyme and bile secretion from the liver as well as the gallbl Continue reading >>

Arginine And Nitric Oxide Synthesis In The Pathogenesis Of Ketosis-prone Diabetes

Arginine And Nitric Oxide Synthesis In The Pathogenesis Of Ketosis-prone Diabetes

Patients with KPD represent a unique subset of type 2 diabetes in which obese/overweight patients present with diabetic ketoacidosis despite absence of humoral or cellular ? cell autoimmunity, implying unique and profound ? cell dysfunction of unknown. In this project we propose to test the general hypothesis that the severe but partially reversible and intermittent ? cell dysfunction in KPD is mediated through diminished availability of arginine for NO synthesis, which in turn impairs insulin secretion. Specific hypotheses to be tested are: 1. Compared to healthy subjects and """"""""usual"""""""", non-ketosis-prone T2D patients, KPD patients have decreased intracellular arginine availability due to a) increased arginine catabolism caused by elevated plasma arginase activity, and b) decreased arginine synthesis due to diminished citrulline synthesis and efflux from the intestine. 2. Due to diminished arginine availability, KPD patients have impaired glucose-stimulated insulin secretion, as well as impaired endothelial function;however the insulin response to arginine + glucose is normal. 3. Enhancement of intracellular arginine availability will result in improved glucose-stimulated insulin secretion in KPD patients. However, due to increased arginine catabolism by arginase, this can be achieved more effectively by dietary citrulline supplementation than by dietary arginine supplementation. Using stable isotope tracer methods these hypotheses will be tested in groups of KPD patients, type 2 diabetics and healthy controls by achieving the following aims: Aim 1 a. Measure under basal conditions and following a hyperglycemic clamp, a) arginine flux, de novo synthesis from citrulline, release from protein breakdown, rate of conversion to ornithine and to NO;b) ornithine an Continue reading >>

Why Be In Ketosis? Headaches, Bp, Nitrous Oxide

Why Be In Ketosis? Headaches, Bp, Nitrous Oxide

Click on Bacon Boy to get a printable PDF and then take your most creative selfie with him. Then share your art on Facebook, Instagram or Twitter and include: Continue reading >>

Increased Nitric Oxide Caused By The Ketogenic Diet Reduces The Onset Time Of Kainic Acid-induced Seizures In Icr Mice.

Increased Nitric Oxide Caused By The Ketogenic Diet Reduces The Onset Time Of Kainic Acid-induced Seizures In Icr Mice.

Abstract Although the antiepileptic effects of the ketogenic diet (KD) are well documented, the mechanisms underlying this action remain obscure. Nitric oxide (NO) has long been thought to play a role in regulating seizures. However, the effects of the KD on endogenous NO production have not been characterized. Therefore, the present study was designed to examine the effect of the KD on endogenous NO production, as well as the precise role of NO in kainic acid (KA)-induced seizures, in male ICR mice. We first found that preadministration of the KD for 4 weeks increased endogenous NO generation in the hippocampus. We also demonstrated that the increase in NO induced by the KD resulted from increased neuronal NO synthase (nNOS) activity and exerted an antiepileptic effect on KA-induced seizures, based on the results of experiments using NOS-knockout mice and two NOS inhibitors, N-omega-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI). These data suggest that the antiepileptic effects of the KD might be mediated, at least in part, by increased NO levels in the hippocampus. Continue reading >>

The Top Twelve (dirty Dozen) Potential Dangers Of A Low Carb Diet:

The Top Twelve (dirty Dozen) Potential Dangers Of A Low Carb Diet:

Low Carb (or Ketogenic) Diets are incredibly popular right now here in the U.S. and I see men on that diet all the time on Peak Testosterone Forum. Altthough, Low Carb Diets have been around for decades with various names and in various forms, they have recently flourished as never before due to the fact that a significant number of doctors and researchers have become apostles of the movement. Weight loss is rapid, due to loss of water attached to glycogen stores, and lipids usually improve in some positive ways, such as rising HDL and falling triglycerides. If you're a meat and dairy lover, this diet seems like a dream-come-true. But behind the scenes, ugly side effects and research have been surfacing and literally tens of millions have jumped aboard. I see over and over men that show up on The Forum with standard symptoms that they assume are testosterone or estradiol related. In fact, I find that they are likely experiencing one or more of the common side effects of Low Carb Diets. Some men even get incredibly ill, and I did an interview with one of them here: A Low Carb Diet Made Me Sick. To be clear, I am NOT saying that all of these side effects occur in all men on a Low Carb Diet. I am just saying that they occur often enough that men should be aware and monitoring themselves. Plus, many men on a Low Carb Diet are feeling terrible and do not know why. For all these reasons, I urge you to read for yourselves 1. Heart Palpitations and Arrhythmias. Perhaps the most dangerous aspect of a low carb diet are the ketones. What?!? That's not what you heard, right? Low carb bloggers love to go on and on about the benefits of ketones - and there are some - but there is also a dark side. (Low carb diets are labelled ketogenic, becausse ketone levels in the blood are elevate Continue reading >>

What Happens When You Eat Nothing But Bacon For 30 Days Straight? [interview]

What Happens When You Eat Nothing But Bacon For 30 Days Straight? [interview]

Meet Dan Quibell, the man behind The Bacon Experiment, a 30-day bacon fast (or feast…?). For 30 days straight, Dan consumed nothing but bacon, and the results will shock you! The Bacon Experiment came into my radar through a Facebook group focused on the ketogenic lifestyle. This was all around the time I had just got back on the keto wagon; the timing really couldn’t have been more perfect. While I found the experiment to be a bit extreme, I was intrigued and inspired by the determination displayed and the results achieved. I felt a genuine sense of camaraderie among the folks in his group. It’s a community of like-minded low carb folks that encourage and motivate each other. If you’ve got a Facebook, you’ve got to go check it out! And for those interested in conducting your own bacon experiment, you can download this free PDF walk-through and guidelines to ensure you are on the right track. Recently, I reached out to Dan for an interview to pick his brain about The Bacon Experiment and ketogenic living. He graciously agreed! Thank you so much for taking the time to answer my questions, Dan. Walk me through The Bacon Experiment step-by-step. What were your goals and expectations going into this? Dan: The Bacon Experiment was me eating nothing but bacon for an entire month. Two pounds of bacon, or roughly 30 pieces, every day. The goal here was to get people’s attention using BACON, then try to teach them something about low carb and ketogenic diets and all the benefits that come with it. Cutting out carbs has been life-changing for me, and I wanted others to benefit as well. I expected that even though I was eating 2500 calories a day, an increase of 500 calories a day for me, that I would not gain much weight, I already knew that eating fat and protein doe Continue reading >>

Ketogenic Diet Decreases Oxidative Stress And Improves Mitochondrial Respiratory Complex Activity

Ketogenic Diet Decreases Oxidative Stress And Improves Mitochondrial Respiratory Complex Activity

Cerebral metabolism of ketones after traumatic brain injury (TBI) improves neuropathology and behavior in an age-dependent manner. Neuroprotection is attributed to improved cellular energetics, although other properties contribute to the beneficial effects. Oxidative stress is responsible for mitochondrial dysfunction after TBI. Ketones decrease oxidative stress, increase antioxidants and scavenge free radicals. It is hypothesized that ketogenic diet (KD) will decrease post-TBI oxidative stress and improve mitochondria. Postnatal day 35 (PND35) male rats were given sham or controlled cortical impact (CCI) injury and placed on standard (STD) or KD. Ipsilateral cortex homogenates and mitochondria were assayed for markers of oxidative stress, antioxidant expression and mitochondrial function. Oxidative stress was significantly increased at 6 and 24 h post-injury and attenuated by KD while inducing protein expression of antioxidants, NAD(P)H dehydrogenase quinone 1 (NQO1) and superoxide dismutase (SOD1/2). Complex I activity was inhibited in STD and KD groups at 6 h and normalized by 24 h. KD significantly improved Complex II–III activity that was reduced in STD at 6 h. Activity remained reduced at 24 h in STD and unchanged in KD animals. These results strongly suggest that ketones improve post-TBI cerebral metabolism by providing alternative substrates and through antioxidant properties, preventing oxidative stress-mediated mitochondrial dysfunction. 1. Hall, ED, Vaishnav, RA, Mustafa, AG. Antioxidant therapies for traumatic brain injury. Neurotherapeutics 2010; 7: 51–61. Google Scholar, Crossref, Medline 2. Hall, ED, Andrus, PK, Yonkers, PA. Brain hydroxyl radical generation in acute experimental head injury. J Neurochem 1993; 60: 588–594. Google Scholar, Crossref, Continue reading >>

Benefits Of Keto Diet And Therapeutic Ketosis For Body Oxygen Levels

Benefits Of Keto Diet And Therapeutic Ketosis For Body Oxygen Levels

Module 11-6. Nutrients and diet for better body oxygenation The ketogenic diet (definition) is a high-fat, low-carb, moderate-protein diet that is used with the purpose to use fats as the main energy source due to the metablic state called "ketosis". This diet relates to LCHF (low-carohydrate high-fat) diets. Keto-adaptation (definition) is a transitional period that allows the body to metabolically adapt to using fats as the main fuel for the brain, heart and other tissues of the body. It usually lasts about 2-4 weeks. Keto-adaptation can be reduced to less than 1-2 days for people with 60+ s MCP and is probably present naturally for those who have 90+ s CP 24/7. Ketosis (definition) is a metabolic state where body cells use energy supply that comes mainly from ketone bodies in the blood rather than blood glucose. Ketosis and reliance on fats as the main energy source had been the most common physiological metabolic features during evolution of human beings. Dramatic increase in consumption of grains became possible due to evolvement of agriculture to its modern aggressive forms. Who will benefit from ketosis: overweight, type 1 and 2 diabetes, cancer, leukemia, heart disease, any neurological disorder (including epilepsy, Parkinson, Alzheimer, MS or multiple sclerosis, senile dementia, schizophrenia, and depression), any digestive disorder (including IBD or Crohn's disease and ulcerative colitis, gastritis, IBS, liver cirrhosis, and hepatitis), any respiratory problem (asthma, bronchitis, COPD, emphysema, etc.) and any other inflammatory condition - or about 90% of overall population. If we measure the total amount of glucose in human blood, it would be about 5-10 g or only 1-2 teaspoons. When eating an ordinary meal, a person often consumes 10-30 times more carbs tha Continue reading >>

Research Report Increased Nitric Oxide Caused By The Ketogenic Diet Reduces The Onset Time Of Kainic Acid-induced Seizures In Icr Mice

Research Report Increased Nitric Oxide Caused By The Ketogenic Diet Reduces The Onset Time Of Kainic Acid-induced Seizures In Icr Mice

Abstract Although the antiepileptic effects of the ketogenic diet (KD) are well documented, the mechanisms underlying this action remain obscure. Nitric oxide (NO) has long been thought to play a role in regulating seizures. However, the effects of the KD on endogenous NO production have not been characterized. Therefore, the present study was designed to examine the effect of the KD on endogenous NO production, as well as the precise role of NO in kainic acid (KA)-induced seizures, in male ICR mice. We first found that preadministration of the KD for 4 weeks increased endogenous NO generation in the hippocampus. We also demonstrated that the increase in NO induced by the KD resulted from increased neuronal NO synthase (nNOS) activity and exerted an antiepileptic effect on KA-induced seizures, based on the results of experiments using NOS-knockout mice and two NOS inhibitors, N-ω-nitro-l-arginine methyl ester (l-NAME) and 7-nitroindazole (7-NI). These data suggest that the antiepileptic effects of the KD might be mediated, at least in part, by increased NO levels in the hippocampus. Continue reading >>

Bioenergetic State Regulates Innate Inflammatory Responses Through The Transcriptional Co-repressor Ctbp

Bioenergetic State Regulates Innate Inflammatory Responses Through The Transcriptional Co-repressor Ctbp

The innate inflammatory response contributes to secondary injury in brain trauma and other disorders. Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflammatory response, but how this occurs is unclear. Here, we show that glucose metabolism regulates pro-inflammatory NF-κB transcriptional activity through effects on the cytosolic NADH:NAD+ ratio and the NAD(H) sensitive transcriptional co-repressor CtBP. Reduced glucose availability reduces the NADH:NAD+ ratio, NF-κB transcriptional activity, and pro-inflammatory gene expression in macrophages and microglia. These effects are inhibited by forced elevation of NADH, reduced expression of CtBP, or transfection with an NAD(H) insensitive CtBP, and are replicated by a synthetic peptide that inhibits CtBP dimerization. Changes in the NADH:NAD+ ratio regulate CtBP binding to the acetyltransferase p300, and regulate binding of p300 and the transcription factor NF-κB to pro-inflammatory gene promoters. These findings identify a mechanism by which alterations in cellular glucose metabolism can influence cellular inflammatory responses. Microglia and macrophages are innate immune responders to infection, tissue damage, and other stressors. The early phase of this response involves release of pro-inflammatory cytokines, nitric oxide, and metalloproteinases, along with alterations in cell morphology and surface protein expression1, 2. Although these responses are adaptive in the setting of infection, they can be deleterious in non-infectious injuries such as stroke and head trauma. Accordingly, factors that suppress the acute inflammatory reaction also reduce tissue loss and improve functional outcomes in animal models of non-infectious brain injury3, 4. Inflammatory responses are Continue reading >>

The Ketogenic Keys To Optimal Health

The Ketogenic Keys To Optimal Health

If you or a loved one has been struggling with low energy, excess weight or a chronic or degenerative disease — or if you simply want to optimize your health and longevity — Mitochondrial Metabolic Therapy (MMT) can help Hay House is now offering my MMT online course, in which you will learn scientifically validated strategies to boost your mitochondrial function, which is foundational for good health and disease prevention Benefits of MMT include weight loss, reduced inflammation and lower cancer risk, increased muscle mass, improved insulin sensitivity, mental clarity and improved longevity By Dr. Mercola If you or a loved one has been struggling with low energy, excess weight or a chronic or degenerative disease like type 2 diabetes, Alzheimer's or cancer — or if you simply want to optimize your health and longevity — I have great news for you. In an earlier article, I announced that my book, "Fat for Fuel," would be complemented by an online course on Mitochondrial Metabolic Therapy (MMT) — a collaboration with nutritionist Miriam Kalamian, who specializes in nutritional ketosis. That course is now available, and for a limited time, you'll receive a $100 discount and over $200 in bonuses, plus free access to a future audio webinar that is currently being put together. I'm proud to say, there's really nothing else like it out there. The course consists of seven comprehensive lessons to teach you the keys to fighting chronic disease and optimizing your health and longevity. If you or someone you love has cancer, it will also augment any oncological treatment you might be undergoing. MMT is a whole new way of looking at nutrition, merging decades of my own research with the latest science on mitochondrial health, all of which has been peer-reviewed by more th Continue reading >>

Top 5 Ingredients To Boost A Ketogenic Diet

Top 5 Ingredients To Boost A Ketogenic Diet

The ketogenic diet is one of the most popular dietary trends for a successful weight loss. It can also be helpful in boosting your overall health, allowing you to avoid carbohydrate crashes while maintaining high energy levels. If you’ve been considering beginning a ketogenic diet, supplementation can play a key role in helping you achieve ketosis while avoiding the dreaded “keto flu.” Let’s take a look at the top 5 ingredients that can help you maximize the benefits of a ketogenic diet. MCT Powder The ketogenic diet is all about increasing your fat intake while eliminating most carbohydrates. Your protein consumption will be moderate. One of the best ways to push your body into a ketogenic state is with medium chain triglyceride powder. Medium chain triglycerides are fatty acids that promote ketosis. Aside from being helpful for the ketogenic diet, MCT powder may also boost weight loss and decrease your risk for cardiovascular disease. (1-2) HMB Next up is beta-hydroxy beta-methylbutyrate, more commonly known as HMB. This metabolite of the essential amino acid, Leucine, may not push your body into a state of ketosis; however, it is necessary to protect lean muscle tissue. When you make the dietary changes to dramatically lower carbohydrate stores, you need to ensure that your body is able to do so without jeopardizing muscle tissue. Too much dietary protein can be used to make glucose and this is what you want to avoid. The solution is HMB. HMB can help to trigger protein synthesis while protecting and promoting lean muscle tissue without the need for high levels of dietary protein. (3-4) Ready to make your own ketogenic booster? Now you can with the Amino Z Supplement Builder! Mix HMB and MCT Powder along with several other ketogenic ingredients for keto succe Continue reading >>

Keto Tip: Eat More Salt On A Ketogenic Diet!

Keto Tip: Eat More Salt On A Ketogenic Diet!

I said last week that most issues with the Ketogenic Diet can be fixed by doing one of three things; drink more water, eat more salt, or eat more fat. Last week we talked about water, now let’s talk about salt. Of all the things that were difficult for me to start to do once I started eating on a Ketogenic diet, it was probably upping my salt intake that really messed with me the most. All my life I have had high blood pressure and of course, the first thing the Docs tell you to do is cut your salt intake. You may have heard of the DASH diet that consists primarily of veggies, lean protein, low fat dairy, fruits and whole grains and no added sodium. Well guess what that diet also happens to be low in? That’s right, our old friend sugar. And according to a 2010 University of Louisiana study, reducing your dietary sugar has a much bigger impact on your BP than added salt. Why is that? Here are 3 reasons. Hydrophilic Effects of Sugar One reason is that sugar is hydrophilic, in other words it tends to absorb water. So if you have high levels of blood sugar it will tend to absorb water creating a larger volume of fluid in your veins and arteries. This increased volume raises blood pressure. Insulin Resistance Blocks Magnesium Insulin helps your body store magnesium but if you are insulin resistant (and if you are obese, you are by definition insulin resistant) your cells wont take up the insulin or the magnesium that come along with it. Magnesium stored in cells relaxes your muscles and without it, the blood vessels become more rigid which increases blood pressure. On a personal note, once I started taking these Magnesium supplements I saw a huge drop in my overall BP as well as an easier time sleeping through the night. Fructose Elevates Uric Acid The metabolization of Continue reading >>

Effects Of Elevated Parameters Of Subclinical Ketosis On The Immune System Of Dairy Cows: In Vivo And In Vitro Results

Effects Of Elevated Parameters Of Subclinical Ketosis On The Immune System Of Dairy Cows: In Vivo And In Vitro Results

Using an established model in which subclinical ketosis is induced, the response of differential blood counts and levels of various haematological variables, including the inflammatory marker haptoglobin (Hp), were tested over the last six weeks of parturition until the 56th day post-partum in cows with lower or higher body condition scores (LBC and HBC, respectively; n = 9/group). Animals in the HBC group evidenced subclinical ketosis whereas LBC animals were metabolically healthy. For in vitro examination with ß-hydroxybutyrate (BHB) as a further stimulus, peripheral blood mononuclear cell (PBMC) counts of cows with and without subclinical ketosis (n = 5/group) were observed. Counts of leucocytes, granulocytes and lymphocytes (LY) peaked at day 1 post-partum in HBC cows, with a more marked increase in heifers. In subclinical ketosis LY count increased again, with significantly higher values in the HBC group. The red blood cell (RBC) profile was affected by parity (counts were higher in heifers). Hp showed a positive linear correlation with BHB and non-esterified fatty acids (NEFA; R2 = 0.41). PBMC from cows that were not pre-stressed with subclinical ketosis were more sensitive to increasing levels of BHB in vitro, as evidenced by both their higher proliferative capability and increased release of nitric oxide (NO). In summary, cows with subclinical ketosis showed a heightened immune response compared with metabolically healthy individuals, based on increased LY counts, increasing stimulative properties of PBMC and a relationship between Hp and typically increased values of BHB and NEFA. Concentrations of BHB in vivo during subclinical ketosis did not alter the proliferative capability of bovine PBMC in vitro, which was first significantly decreased at a dosage of 5 Continue reading >>

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