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Ketosis Metabolism

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Ketosis

Not to be confused with Ketoacidosis. Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides energy. Ketosis is a result of metabolizing fat to provide energy. Ketosis is a nutritional process characterised by serum concentrations of ketone bodies over 0.5 mM, with low and stable levels of insulin and blood glucose.[1][2] It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides[3]). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate,[4] and the levels of ketone bodies are regulated mainly by insulin and glucagon.[5] Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder. Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet (ketogenic diet), and deliberately induced ketosis serves as a medical i Continue reading >>

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Popular Questions

  1. austinpsycho

    So I have discovered, and devoured quite a few episodes of 2 keto dudes. There's some really great information about the metabolic rate and how it relates to longer fasts. Maybe I just haven't gotten far enough in the show yet, but I am really interested in how the metabolism responds to both intermittent fasting, and more generally, how the presumably lower calorie count maintained on keto affects said rate.
    I've been on keto for about a month now, and I worry that as I eat less, my body will become more efficient with those calories, and I'll need to eat even less and so on. I very much appreciate any information you guys can provide, or point me at. Thanks so much.

  2. devhammer

    austinpsycho:


    I am really interested in how the metabolism responds to both intermittent fasting, and more generally, how the presumably lower calorie count maintained on keto affects said rate.
    This would be an incorrect assumption, at least to the extent that the point of keto and/or IF is not to reduce calories. For those who have a good deal of body fat from which to draw energy, once they've gotten insulin sufficiently low to make that energy source available, reduced foot intake may be an effect of keto. Hopefully, that distinction is clear. The point is not to maintain a "lower calorie count". The point is to eat fewer foods (i.e. carbs) that stimulate insulin production, and more foods that don't (i.e. fat) while eating sufficient protein to maintain lean body mass.
    austinpsycho:


    I worry that as I eat less, my body will become more efficient with those calories, and I'll need to eat even less and so on.
    If you restrict calories, your body doesn't "become more efficient" per se. It slows your metabolism to compensate. So you may feel cold or sluggish, or other effects. But if you eat a well-formulated ketogenic diet, how much you eat is determined by whether or not you are sated.
    You'll see this formula repeated often, because it is easy to remember, easy for most folks to follow, and it usually works:
    No more than 20g of carbs per day (important, not a percentage, but a hard limit of 20g, which will allow most folks to get into ketosis)
    Sufficient protein to maintain lean body mass (approx. 0.5-1g per kg of lean body mass)
    Fat to sateity.

    Don't worry about calories. And if you've only been at this for a month, don't worry about fasting yet. Keep it simple, and KCKO (Keep Calm and Keto On).

  3. BGdiving

    devhammer:


    Don't worry about calories. And if you've only been at this for a month, don't worry about fasting yet. Keep it simple, and KCKO (Keep Calm and Keto On).

    It almost seems like most people doing Keto need to fast in order to continue loosing weight. When I was doing "my version" of the Atkins induction diet I definitely felt like I ate more and more often was never hungry and could loose weight as long as I was consistent. I hate food journaling, but for the 8 or 10 days that I did journal I was eating at least a couple of large meals a day and some low carb snacking. Several of those days I had a late night 20 oz rib eye and logged a little over 5000 calories per day and was loosing weight rapidly (didn't loose on 6000+ cal days) and this is after I had already lost over 100 pounds. BUT now after I started some intermittent fasting and backing down on the protein consumption I feel as if my metabolism has slowed way down and I have to be much more restrictive in how much I eat if I want to loose weight or even hold even. I do Not feel lethargic and I definitely am not cold just seems I have messed up my metabolism like @austinpsycho is concerned about, definitely cheaper I don't snack during the day and I skip meals but kind of inconvenient and discouraging having to be more restrictive if I don't want to gain weight say nothing of trying to loose those extra pounds I still need to get rid of.

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