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Ketosis May Result From

Ketosis

Ketosis

Tweet Ketosis is a state the body may find itself in either as a result of raised blood glucose levels or as a part of low carb dieting. Low levels of ketosis is perfectly normal. However, high levels of ketosis in the short term can be serious and the long term effects of regular moderate ketosis are only partially known at the moment. What is ketosis? Ketosis is a state the body goes into if it needs to break down body fat for energy. The state is marked by raised levels of ketones in the blood which can be used by the body as fuel. Ketones which are not used for fuel are excreted out of the body via the kidneys and the urine. Is ketosis the same as ketoacidosis? There is often confusion as to the difference between ketosis and ketoacidosis. Ketosis is the state whereby the body is producing ketones. In ketosis, the level of ketones in the blood can be anything between normal to very high. Diabetic ketoacidosis, also known as DKA, only describes the state in which the level of ketones is either high or very high. In ketoacidosis, the amount of ketones in the blood is sufficient to turn the blood acidic, which is a dangerous medical state. When does ketosis occur? Ketosis will take place when the body needs energy and there is not sufficient glucose available for the body. This can typically happen when the body is lacking insulin and blood glucose levels become high. Other causes can be the result of being on a low carb diet. A low level of carbohydrate will lead to low levels of insulin, and therefore the body will produce ketones which do not rely on insulin to get into and fuel the body’s cells. A further cause of ketosis, less relevant to people with diabetes, is a result of excessive alcohol consumption. Is ketosis dangerous? The NHS describes ketosis as a pote Continue reading >>

Ketosis Vs. Ketoacidosis: What You Should Know

Ketosis Vs. Ketoacidosis: What You Should Know

Despite the similarity in name, ketosis and ketoacidosis are two different things. Ketoacidosis refers to diabetic ketoacidosis (DKA) and is a complication of type 1 diabetes mellitus. It’s a life-threatening condition resulting from dangerously high levels of ketones and blood sugar. This combination makes your blood too acidic, which can change the normal functioning of internal organs like your liver and kidneys. It’s critical that you get prompt treatment. DKA can occur very quickly. It may develop in less than 24 hours. It mostly occurs in people with type 1 diabetes whose bodies do not produce any insulin. Several things can lead to DKA, including illness, improper diet, or not taking an adequate dose of insulin. DKA can also occur in individuals with type 2 diabetes who have little or no insulin production. Ketosis is the presence of ketones. It’s not harmful. You can be in ketosis if you’re on a low-carbohydrate diet or fasting, or if you’ve consumed too much alcohol. If you have ketosis, you have a higher than usual level of ketones in your blood or urine, but not high enough to cause acidosis. Ketones are a chemical your body produces when it burns stored fat. Some people choose a low-carb diet to help with weight loss. While there is some controversy over their safety, low-carb diets are generally fine. Talk to your doctor before beginning any extreme diet plan. DKA is the leading cause of death in people under 24 years old who have diabetes. The overall death rate for ketoacidosis is 2 to 5 percent. People under the age of 30 make up 36 percent of DKA cases. Twenty-seven percent of people with DKA are between the ages of 30 and 50, 23 percent are between the ages of 51 and 70, and 14 percent are over the age of 70. Ketosis may cause bad breath. Ket Continue reading >>

What Is Good For Heavy Metal Detoxification? And Does Going Into Ketosis Help?

What Is Good For Heavy Metal Detoxification? And Does Going Into Ketosis Help?

Let me start with mercury because in some ways it is the most difficult heavy metal to excrete efficiently. Mercury bonds efficiently to sulfur, much better than it bonds to oxygen. Lead bonds to oxygen better, and this defines a critical difference in detox between different heavy metals. The body can have a high mercury burden and be asymptomatic. Teenagers with idiopathic dilated cardiomyopathy suddenly drop dead; that's how we find out they have toxic mercury burdens in their heart muscles. In humans, mercury is detoxified by binding to glutathione (GSH), which binds to mercury (Hg) by its sulfur (S) atoms. Glutathione is abbreviated GSH to emphasize the sulfhydryl (SH) active group, which when it bonds to mercury becomes GS-Hg-SG (two bonds to the sulfur (S) of glutathione). The H of GSH is replaced with mercury. This bound form of mercury is our body's primary mercury-defense mechanism, for storage in the cells and for elimination through the liver into the bile. The latter is where the problem begins. When mercury enters the digestive tract in bile, it runs into microorganisms. Bacteria hate mercury in the glutathione-bound form. It gets into their systems very efficiently, wreaks havoc, and they use an entirely different detox mechanism: methylation. They convert the GS-Hg-SG into methylmercury, which is eliminated by the bacteria into the gut and diffuses back into our bodies. Ouch. Because methyl mercury readily crosses the blood-brain barrier, very ouch. This is why you shouldn't get mercury chelated by your local alternative doctor with an IV. When too aggressive, IVs "stir up" too much of the mercury and it relocates in ways that aggravate many toxicity symptoms. This does not apply to lead, which IV chelates quite well. I wish I had better news to relate r Continue reading >>

Ketosis Vs. Ketoacidosis (dka): What Is The Difference?

Ketosis Vs. Ketoacidosis (dka): What Is The Difference?

Let’s break it down so that you can understand exactly what ketosis is and how it differs from ketoacidosis. But the states they refer to are nothing alike. In this case, maybe mistakes are understandable. Many people who believe that ketosis is dangerous are mixing it up with another state called "ketoacidosis." The two words do sound very similar. And some people simply make mistakes. Profit motives tend to muddy up the works when it comes to getting clear, factual information about your health. Well, there are a lot of individuals and companies which all have their own goals and motivations. Where do these misperceptions come from? Here’s the thing though … that is all misinformation. You then Googled something like, "low carb dangerous" and found a list of link-bait articles informing you that low-carb is a ketogenic diet, and ketosis is a dangerous metabolic state which can be fatal. And then maybe someone said something to you like, "What are you thinking? Low-carb is a dangerous diet." If you are thinking about starting a low-carb diet, maybe you have mentioned it to some of your family or friends. By the time you finish reading this article, you will understand why low-carb is a safe diet. Continue reading >>

Ketosis

Ketosis

Tweet Ketosis is a state the body may find itself in either as a result of raised blood glucose levels or as a part of low carb dieting. Low levels of ketosis is perfectly normal. However, high levels of ketosis in the short term can be serious and the long term effects of regular moderate ketosis are only partially known at the moment. What is ketosis? Ketosis is a state the body goes into if it needs to break down body fat for energy. The state is marked by raised levels of ketones in the blood which can be used by the body as fuel. Ketones which are not used for fuel are excreted out of the body via the kidneys and the urine. Is ketosis the same as ketoacidosis? There is often confusion as to the difference between ketosis and ketoacidosis. Ketosis is the state whereby the body is producing ketones. In ketosis, the level of ketones in the blood can be anything between normal to very high. Diabetic ketoacidosis, also known as DKA, only describes the state in which the level of ketones is either high or very high. In ketoacidosis, the amount of ketones in the blood is sufficient to turn the blood acidic, which is a dangerous medical state. When does ketosis occur? Ketosis will take place when the body needs energy and there is not sufficient glucose available for the body. This can typically happen when the body is lacking insulin and blood glucose levels become high. Other causes can be the result of being on a low carb diet. A low level of carbohydrate will lead to low levels of insulin, and therefore the body will produce ketones which do not rely on insulin to get into and fuel the body’s cells. A further cause of ketosis, less relevant to people with diabetes, is a result of excessive alcohol consumption. Is ketosis dangerous? The NHS describes ketosis as a pote Continue reading >>

What Is Ketosis And How Effective Is It In Fat Loss?

What Is Ketosis And How Effective Is It In Fat Loss?

Ketosis represents a state of the organism characterized by the controlled and regulated production of ketone bodies in the blood via various metabolic processes.During very low carbohydrate intake, reduced insulin levels leads to a reduction in lipogenesis and fat accumulation. After several days of fasting, glucose reserves become insufficient both for normal fat oxidation and for the proper functioning of the brain. As the central nervous system is not able to use fatty acids for its energy because they cannot cross the blood-brain barrier,it normally utilizes glucose. Low carbohydrate intake forces the brain to find alternative energy source derived from the overproduction of acetyl coenzyme A (CoA). The production of ketone bodies in a process called ketogenesis ensues. Ketosis is a completely physiological mechanism and it needs to be differentiated from the pathological ketoacidosis seen in type 1 diabetes. Physiological ketosis that arises as a resultof ketogenic diets is characterized by ketone bodies in blood reaching a maximum level of 8 mmol/l with no change in pH, compared to uncontrolled diabetic ketoacidosis where their level can exceed 20 mmol/l and result in a lower blood pH.Ketone body metabolismThe term “ketone bodies” refers to three specific compounds: acetone, acetoacetate and beta-hydroxybutyrate (or beta-hydroxybutyric acid). The circulating levels of ketone bodies dependboth on their rate of production (i.e.ketogenesis) and their rate of utilization (i.e.ketolysis). They are of vital importance to the brain, which is unable to derive energy from other sources whenblood glucose levels are low. In healthy adults, the liver is able to produce 185 grams of ketone bodies eachday. The main ketone body produced is acetoacetate, but the primary circ Continue reading >>

What Is A Ketogenic Diet?

What Is A Ketogenic Diet?

So what is a ketogenic diet? Despite its popularity in today’s society, few truly understand what a ketogenic diet is. One of the best definitions I’ve come across is by a colleague of mine who stated that, “A ketogenic diet is one in which glucogenic substrates (non-fiber carbohydrates and glucogenic amino acids) are low enough to force the body to primarily rely on fat as substrate.” The ketogenic diet is traditionally a high-fat, moderate-protein, and very low-carbohydrate diet and through the appropriate balance of these three macronutrients (protein, fat, carbohydrates), we are able to alter our energy utilization and enter a unique metabolic state known as nutritional ketosis. Nutritional ketosis, not to be confused with diabetic ketoacidosis, is a state in which the body switches its preferred fuel source from carbohydrates to fat, which results in the production of an additional fuel source known as ketones or ketone bodies. These ketones can be rapidly broken down for energy production by various tissues throughout the body. As stated above, the ketogenic diet allows the body to use an alternative fuel source (i.e. ketones) to meet the demands of the body. The adaptations that allow us to enter ketosis take time, and this transition period is often referred to as keto-adaptation. Once keto-adaptation occurs, you are considered to be “fat-adapted”. There are several ways in which the body can enter a state of ketosis, with the most common being a ketogenic diet. When attempting to enter ketosis through dietary manipulation, it is essential to keep in mind the recommended fat, protein, and carbohydrate intakes. As with most diets, there is no “one-size-fits-all approach” for a ketogenic diet. The ratios and amounts of each macronutrient of the die Continue reading >>

I Want To Lose My Weight, But My Schedule Is Too Tight For Me To Go Out For Jogging Or Exercises. Is There Some Way Where I Can Lose My Weight In My Daily Routine, Like Some Diet Tips?

I Want To Lose My Weight, But My Schedule Is Too Tight For Me To Go Out For Jogging Or Exercises. Is There Some Way Where I Can Lose My Weight In My Daily Routine, Like Some Diet Tips?

Walking is OK for circulation and lymphatic flow, but it has a suppressing effect on weight loss. Timewise, you'd be more likely to get weight loss results from interval training. A few minutes of intense exercise, with heart-rate recover afterwards, builds aerobic fitness way more efficiently than walking. So walking that you have to do is OK (walking to your car, walking through the grocery store, walking to the file room), but elective walking will largely waste your time. Buy a heart rate wrist watch and spend 5-9 minutes per day doing intense exercise (sprinting, vigorous dancing, fill in the blank) under the guidance of your heart rate and recovery rate. Diet tips are plentiful. The questions are (1) whether they work for you, and (2) whether they are sustainable (the weight lost stays lost). These could be: A. Switching to coconut oil as a dietary staple. Eliminate the standard temperate vegetable oils from your diet. Tropical oils have a high content of medium-chain triglycerides (MCTs), which are too fluid to store as is in fat cells, and the freed MCTs are passively transported into cells and mitochondria for beta oxidation (fat burning). This plays to item B. Mammals eating equivalent calories lose weight on MCT fat and gain weight on long-chain fat. B. Avoid overeating carbohydrates (except rarely). Carbs are converted into fat by the body when they exceed caloric needs. The body has two diet-dependent metabolic energy states (1) carb-burning mode (the default system) where fat is synthesized from excess carb, and (2) fat-burning mode (the back-up system) where carb is synthesized from fat-derived glycerol and amino acids. Avoiding eating excess carbs all the time keeps you from getting stuck in the default energy mode. And periodic carb loading exercises th Continue reading >>

Does Ketosis (from A Fat-rich Diet) Affect Body Temperature?

Does Ketosis (from A Fat-rich Diet) Affect Body Temperature?

One finds a minor increase in metabolism early in ketosis, especially so when consuming MCTs. MCTs are converted into ketone bodies in their first pass through the liver. Humans do not store those well and metabolize them fairly quickly. Something similar happens with consumed ethanol. Ask yourself why metabolism decreases after dieting. How does the hypothalamus detect food shortage? It can’t do so from circulating ketone bodies or free fatty acids. Those are maintained from fat stores even when one is starving. It does that through glucose and insulin levels. On a strict ketogenic diet, I was found to have both low TSH and low T4. Normally, if T4 is low, TSH is raised to restore the required metabolism. Low T4 results in decreased basal metabolism. My condition was called central hypothyroidism and commonly seen only in patients who have suffered major disease or trauma. It reversed on restoration of a more normal diet. A true ketogenic diet is rather extreme in that it requires restriction of protein as well as carbs. Roughly half of ingested protein becomes glucose on its first pass through the liver. Continue reading >>

Metabolic Effects Of The Very-low-carbohydrate Diets: Misunderstood

Metabolic Effects Of The Very-low-carbohydrate Diets: Misunderstood "villains" Of Human Metabolism

Go to: The Ketone Bodies are an Important Fuel The hormonal changes associated with a low carbohydrate diet include a reduction in the circulating levels of insulin along with increased levels of glucagon. This activates phosphoenolpyruvate carboxykinase, fructose 1,6-biphosphatase, and glucose 6-phosphatase and also inhibits pyruvate kinase, 6-phosphofructo-1-kinase, and glucokinase. These changes indeed favor gluconeogenesis. However, the body limits glucose utilization to reduce the need for gluconeogenesis. In the liver in the well-fed state, acetyl CoA formed during the β-oxidation of fatty acids is oxidized to CO2 and H2O in the citric acid cycle. However, when the rate of mobilization of fatty acids from adipose tissue is accelerated, as, for example, during very low carbohydrate intake, the liver converts acetyl CoA into ketone bodies: Acetoacetate and 3-hydroxybutyrate. The liver cannot utilize ketone bodies because it lacks the mitochondrial enzyme succinyl CoA:3-ketoacid CoA transferase required for activation of acetoacetate to acetoacetyl CoA [3]. Therefore, ketone bodies flow from the liver to extra-hepatic tissues (e.g., brain) for use as a fuel; this spares glucose metabolism via a mechanism similar to the sparing of glucose by oxidation of fatty acids as an alternative fuel. Indeed, the use of ketone bodies replaces most of the glucose required by the brain. Not all amino acid carbon will yield glucose; on average, 1.6 g of amino acids is required to synthesize 1 g of glucose [4]. Thus, to keep the brain supplied with glucose at rate of 110 to 120 g/day, the breakdown of 160 to 200 g of protein (close to 1 kg of muscle tissue) would be required. This is clearly undesirable, and the body limits glucose utilization to reduce the need for gluconeogenesis Continue reading >>

Ketosis Vs. Ketoacidosis

Ketosis Vs. Ketoacidosis

If you are thinking about starting a low-carb diet, maybe you have mentioned it to some of your family or friends. And then maybe someone said something to you like, "What are you thinking? Low-carb is a dangerous diet. You then Googled something like, "low carb dangerous" and found a list of link-bait articles informing you that low-carb is a ketogenic diet, and ketosis is a dangerous metabolic state which can be fatal. Here’s the thing though … that is all misinformation. Where do these misperceptions come from? Well, there are a lot of individuals and companies which all have their own goals and motivations. Profit motives tend to muddy up the works when it comes to getting clear, factual information about your health. And some people simply make mistakes. In this case, maybe mistakes are understandable. Many people who believe that ketosis is dangerous are mixing it up with another state called "ketoacidosis." The two words do sound very similar. Let’s break it down so that you can understand exactly what ketosis is and how it Ketosis is a metabolic state where you get most of your daily fuel from fat instead of carbs. Your body becomes ketogenic when it has limited access to glucose and needs to turn to another energy source for primary fuel. If you eat a very low-carb diet, you are restricting the glucose available to your body, which causes your body to turn to fat to burn. This may result in a state of ketosis. Note that not all low-carb diets produce a ketogenic state. It depends on how much you restrict your carbohydrate intake. If you are eating between 20-50 grams of carbohydrates per day, you will generally go into a ketogenic state. If you eat more than that, you may never actually establish ketosis. Where does the name "ketosis" come from While you Continue reading >>

Ketosis

Ketosis

There is a lot of confusion about the term ketosis among medical professionals as well as laypeople. It is important to understand when and why nutritional ketosis occurs, and why it should not be confused with the metabolic disorder we call ketoacidosis. Ketosis is a metabolic state where the liver produces small organic molecules called ketone bodies. Most cells in the body can use ketone bodies as a source of energy. When there is a limited supply of external energy sources, such as during prolonged fasting or carbohydrate restriction, ketone bodies can provide energy for most organs. In this situation, ketosis can be regarded as a reasonable, adaptive physiologic response that is essential for life, enabling us to survive periods of famine. Nutritional ketosis should not be confused with ketoacidosis, a metabolic condition where the blood becomes acidic as a result of the accumulation of ketone bodies. Ketoacidosis can have serious consequences and may need urgent medical treatment. The most common forms are diabetic ketoacidosis and alcoholic ketoacidosis. What Is Ketosis? The human body can be regarded as a biologic machine. Machines need energy to operate. Some use gasoline, others use electricity, and some use other power resources. Glucose is the primary fuel for most cells and organs in the body. To obtain energy, cells must take up glucose from the blood. Once glucose enters the cells, a series of metabolic reactions break it down into carbon dioxide and water, releasing energy in the process. The body has an ability to store excess glucose in the form of glycogen. In this way, energy can be stored for later use. Glycogen consists of long chains of glucose molecules and is primarily found in the liver and skeletal muscle. Liver glycogen stores are used to mai Continue reading >>

What Is It Like To Go On A Ketogenic Diet?

What Is It Like To Go On A Ketogenic Diet?

It's do-able. Some people love it and some people hate it. Personally, I find that nutritional ketosis is almost ideal for me, whereas "normal" eating with lots of carbs in my diet leads to feelings of non-satiety, drowsiness, mood swings, insulin spikes, bloating, and sometimes nausea. A ketogenic diet consists of 70-80% calories from fat, 15-25% calories from protein, and 0-5% calories from net carbohydrates (carbs). You must restrict your daily net carbs to 20-40g daily. (total grams carbs) - (grams fiber) = (net grams carbs) Your transition period depends on a few factors: how strictly you limit your carbohydrate intake, how much energy you expend day-to-day, and how much energy in the form of glucose and glycogen you have stored in your body currently. My transition period takes 3 days. Day 1: This is an easy day. Your blood is still filled with circulating glucose, and any deficit will be taken from the glycogen in your liver to be converted to glucose. You may feel hunger pangs by the afternoon, and a small dip in insulin, which will feel normal to you because this is what happens every day on a normal diet and you are used to it. Day 2: This is an easy day, too. Your body is happily pulling glycogen from your liver, converting it to glucose, and all is well. Any small amount of carbs that you consume are burned away, nothing is being stored. You may feel the typical afternoon slowdown and hunger, as on day 1. Day 3: Hard day. Your body has been (or is nearly) depleted of glucose and glycogen. The small amount of carbs that you consume are not enough to fuel your brain. You have a feeling of satiety from all the fat you are consuming, but you may feel achy, have headaches, and feel sluggish. Your body is alerting you to the lack of glucose and glycogen. It will t Continue reading >>

Insulin Sensitivity And Glucose Tolerance Are Altered By Maintenance On A Ketogenic Diet

Insulin Sensitivity And Glucose Tolerance Are Altered By Maintenance On A Ketogenic Diet

The ketogenic diet (KD) is a low-carbohydrate, high-fat diet that is used for a variety of health-related effects. This type of diet is effective at suppressing seizure activity in children with refractory epilepsy (1) and has perhaps more commonly been implemented as a dietary strategy by which weight maintenance or weight loss is the desired outcome. It has been demonstrated that restriction of dietary carbohydrates results in positive effects on cardiovascular parameters. Consuming this type of diet favorably affects body adiposity and improves features of metabolic syndrome in humans (2,3,4,5,6). Although studies evaluating the efficacy and metabolic effects of KDs have increased in recent years, the effects of macronutrient-controlled diets remain controversial in the literature. Insulin has potent short-term and long-term effects on energy intake and glucose homeostasis. In the short term, insulin release is cephalic; the brain initiates insulin secretion by directing messages through the vagus nerves to the pancreas as opposed to direct pancreatic stimulation of insulin-secreting cells. Cephalic insulin is most readily observed at the onset of a meal and consists of a short burst of insulin that is preabsorptive with regard to the ingested food. After consumption of a meal, insulin secretion increases and is sustained, because one of insulin’s roles is to prepare the body for the increase in glucose that accompanies food intake and to control the increased levels and use of glucose (7). In the long term, insulin’s role as an adiposity signal is well known, with increased plasma insulin levels resulting from increased body weight. Together, the short- and long-term effects of insulin allow for proper glucose homeostasis and assist in the regulation of body wei Continue reading >>

Why Do Some People Believe A High Fat Diet, With The Intent To Limit Carbohydrates To Induce A State Of Ketosis And Allow The Body To Run Predominantly Off Of Fat For Energy, Is Ideal For Optimal Health?

Why Do Some People Believe A High Fat Diet, With The Intent To Limit Carbohydrates To Induce A State Of Ketosis And Allow The Body To Run Predominantly Off Of Fat For Energy, Is Ideal For Optimal Health?

Some of us have found with a series of self experiments that we feel better on low carb higher fat diets. Over time I've tried being a vegan, being a vegetarian, raw foods, eating just a whole foods diet, high whole grains..... so on and on. After several years on LCHF I've found that eliminating the vast majority of carbs helps 1) keep my blood sugar in a reasonable range - this has such a huge range of health effects that I won't even try to list them. 2) results in a very low triglyceride level and high HDL cholesterol level 3) keeps my moods even. Anxiety and depression have virtually disappeared. Ketosis is known for being beneficial for a variety of neurological problems. When I have slipped off eating this way a variety of unpleasant symptoms return. My diet is highly nutrient rich - I eat pastured/grass fed meats and eggs, wild fish, a huge variety of green vegetables - primarily leafy, butter, cheese and other fats from healthy animals, healthy vegetable fats - coconut, avocado, olives. Some nuts, limited quantities of berries, lots of herbs, brightly colored veg that aren't too high in carbs. This kind of diet can be appropriate for many people, not just Inuits! It may or may not be related to genetics (my guess would be probably), but this could include many groups. My background is primarily northern European, with most of my ancestors likely being exposed to agriculture no more that 3 to 5,000 years ago. There are cases of Pacific Island groups who had traditionally a diet very high in coconut fats. When moving to NZ and eating a lower fat diet, they suffer tremendously from obesity, T2 diabetes and other modern illnesses. There is considerable scientific evidence that LCHF diets are beneficial for a variety of conditions. Rather than try to cite all those Continue reading >>

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